1DVNA

Latent form of plasminogen activator inhibitor-1 (pai-1)
Total Genus 115
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
115
sequence length
379
structure length
379
Chain Sequence
VHHPPSYVAHLASDFGVRVFQQVAQASKDRNVVFSPYGVASVLAMLQLTTGGETQQQIQAAMGFKIDDKGMAPALRHLYKELMGPWNKDEISTTDAIFVQRDLKLVQGFMPHFFRLFRSTVKQVDFSEVERARFIINDWVKTHTKGMISNLLGKGAVDQLTRLVLVNALYFNGQWKTPFPDSSTHRRLFHKSDGSTVSVPMMAQTNKFNYTEFTTPDGHYYDILELPYHGDTLSMFIAAPYEKEVPLSALTNILSAQLISHWKGNMTRLPRLLVLPKFSLETEVDLRKPLENLGMTDMFRQFQADFTSLSDQEPLHVAQALQKVKIEVNESGTVASSSTAVIVSARMAPEEIIMDRPFLFVVRHNPTGTVLFMGQVMEP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structures of active and latent PAI-1: a possible stabilizing role for chloride ions.
pubmed doi rcsb
molecule keywords PLASMINOGEN ACTIVATOR INHIBITOR-1
molecule tags Blood clotting
source organism Homo sapiens
total genus 115
structure length 379
sequence length 379
ec nomenclature
pdb deposition date 2000-01-21

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00079 Serpin Serpin (serine protease inhibitor)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.30.39.10 Mainly Beta Roll Alpha-1-antitrypsin; domain 1 Alpha-1-antitrypsin, domain 1 1dvnA02
3.30.497.10 Alpha Beta 2-Layer Sandwich Antithrombin; Chain I, domain 2 Antithrombin, subunit I, domain 2 1dvnA01
1SNGA 3VVJA 1ATHA 2WXZA 2B4XI 4EB1L 1YXAA 2DUTA 1OVAC 1F0CA 4ROAA 5EI0A 2WY1A 2XN5A 3CAAA 1DZGL 1HLEA 4Y3KA 1DZHI 2PEEA 1OYHI 2BEHI 2ZNHA 1WZ9A 4YIAA 3STOA 5CE0A 3ZHAA 2WXZC 2ACHA 3PZFA 8APIA 1JMOA 1LK6I 3F5NA 3Q02A 1MTPA 2OAYA 1HP7A 2D26A 3EVJI 4IF8A 4AU4A 2VH4A 1T1FA 1E05I 3CWLA 1ANTI 4C41A 4RO9A 1E04I 2V95A 2XN7A 1QMBA 2XN3A 3PB1I 4P0OA 2CEOA 2WXYC 4IC0A 4ZK3A 1OPHA 2VDYA 2OL2A 4EB1I 2ARQA 2QUGA 3KCGI 2RIWA 1JVQI 4BB2A 1ATTA 1DZGI 2WY0C 1AZXI 1EZXA 4ROBA 4AU2A 1A7CA 3DRMA 4KDSA 3F1SA 3F02A 5C98A 1JRRA 2ZV6A 1E03I 4P0FA 2HIJL 4AU3A 1XU8A 5CDXA 3Q03A 1LQ8A 5CDZA 1OVAB 1B3KA 1M93B 4AFXA 4DTEA 3R4LA 1C8OA 3UT3A 1OYHL 5INWA 1LJ5A 4DY7C 1OC0A 4R9IA 2H4QA 3DRUA 1C5GA 1SR5A 3OZQA 1QLPA 9PAIA 4X30A 1IZ2A 3LW2A 1QMNA 4PYWA 2H4PA 2PEFA 3CWMA 3DLWA 4G8OA 1PSIA 2B5TI 1SEKA 4G8RA 2GD4C 2VDXA 1K9OI 2WXXA 3NDFA 1OO8A 1BY7A 1BR8I 2B4XL 1TB6I 4RSQA 4AJUA 3B9FI 4ZK0A 2WXWA 1JJOC 2HIJI 4DY0A 1AS4A 4AJTA 4AQHA 1JTIA 1XQGA 1DVNA 1DZHL 3DY0A 4AU3B 7APIA 5HGCA 4CAAA 2BEHL 1DVMA 4GA7A 4Y40A 1ATUA 1R1LI 2ARRA 2ANTI 3FGQA 1UHGA 1XQJA 1IMVA 3T1PA 9APIA 2HI9A 3NDDA 5IO1A 1OVAA 1JMJA 3NE4A 4C49A 3H5CA 3CVMA 2RIVA 2H4RA 1KCTA 3LE2A 2R9YA 5BRRI 3EOXA 2XN6A 1D5SA 1NQ9I 1DB2A 3NDAA
chains in the Genus database with same CATH superfamily
1SNGA 3VVJA 1ATHA 2WXZA 2B4XI 4EB1L 1YXAA 2DUTA 1OVAC 1F0CA 4ROAA 5EI0A 2WY1A 2XN5A 3CAAA 1DZGL 1HLEA 4Y3KA 1DZHI 2PEEA 1OYHI 2BEHI 2ZNHA 1WZ9A 4YIAA 3STOA 5CE0A 3ZHAA 2WXZC 2ACHA 3PZFA 8APIA 1JMOA 1LK6I 3F5NA 3Q02A 1MTPA 2OAYA 1HP7A 2D26A 3EVJI 4IF8A 4AU4A 2VH4A 1T1FA 1E05I 3CWLA 1ANTI 4C41A 4RO9A 1E04I 2V95A 2XN7A 1QMBA 2XN3A 3PB1I 4P0OA 2CEOA 2WXYC 4IC0A 4ZK3A 1OPHA 2VDYA 2OL2A 4EB1I 2ARQA 2QUGA 3KCGI 2RIWA 1JVQI 4BB2A 1ATTA 1DZGI 2WY0C 1AZXI 1EZXA 4ROBA 4AU2A 1A7CA 3DRMA 4KDSA 3F1SA 3F02A 5C98A 1JRRA 2ZV6A 1E03I 4P0FA 2HIJL 4AU3A 1XU8A 5CDXA 3Q03A 1LQ8A 5CDZA 1OVAB 1B3KA 1M93B 4AFXA 4DTEA 3R4LA 1C8OA 3UT3A 1OYHL 5INWA 1LJ5A 4DY7C 1OC0A 4R9IA 2H4QA 3DRUA 1C5GA 1SR5A 3OZQA 1QLPA 9PAIA 4X30A 1IZ2A 3LW2A 1QMNA 4PYWA 2H4PA 2PEFA 3CWMA 3DLWA 4G8OA 1PSIA 2B5TI 1SEKA 4G8RA 2GD4C 2VDXA 1K9OI 2WXXA 3NDFA 1OO8A 1BY7A 1BR8I 2B4XL 1TB6I 4RSQA 4AJUA 3B9FI 4ZK0A 2WXWA 1JJOC 2HIJI 4DY0A 1AS4A 4AJTA 4AQHA 1JTIA 1XQGA 1DVNA 1DZHL 3DY0A 4AU3B 7APIA 5HGCA 4CAAA 2BEHL 1DVMA 4GA7A 4Y40A 1ATUA 1R1LI 2ARRA 2ANTI 3FGQA 1UHGA 1XQJA 1IMVA 3T1PA 9APIA 2HI9A 3NDDA 5IO1A 1OVAA 1JMJA 3NE4A 4C49A 3H5CA 3CVMA 2RIVA 2H4RA 1KCTA 3LE2A 2R9YA 5BRRI 3EOXA 2XN6A 1D5SA 1NQ9I 1DB2A 3NDAA
chains in the Genus database with same CATH topology
1SNGA 3VVJA 1ATHA 2WXZA 2B4XI 4EB1L 1YXAA 2DUTA 1OVAC 1F0CA 4ROAA 5EI0A 2WY1A 2XN5A 3CAAA 1DZGL 1HLEA 4Y3KA 1DZHI 2PEEA 1OYHI 2BEHI 2ZNHA 1WZ9A 4YIAA 3STOA 5CE0A 3ZHAA 2WXZC 2ACHA 3PZFA 8APIA 1JMOA 1LK6I 3F5NA 3Q02A 1MTPA 2OAYA 1HP7A 2D26A 3EVJI 4IF8A 4AU4A 2VH4A 1T1FA 1E05I 3CWLA 1ANTI 4C41A 4RO9A 1E04I 2V95A 2XN7A 1QMBA 2XN3A 3PB1I 4P0OA 2CEOA 2WXYC 4IC0A 4ZK3A 1OPHA 2VDYA 2OL2A 4EB1I 2ARQA 2QUGA 3KCGI 2RIWA 1JVQI 4BB2A 1ATTA 1DZGI 2WY0C 1AZXI 1EZXA 4ROBA 4AU2A 1A7CA 3DRMA 4KDSA 3F1SA 3F02A 5C98A 1JRRA 2ZV6A 1E03I 4P0FA 2HIJL 4AU3A 1XU8A 5CDXA 3Q03A 1LQ8A 5CDZA 1OVAB 1B3KA 1M93B 4AFXA 4DTEA 3R4LA 1C8OA 3UT3A 1OYHL 5INWA 1LJ5A 4DY7C 1OC0A 4R9IA 2H4QA 3DRUA 1C5GA 1SR5A 3OZQA 1QLPA 9PAIA 4X30A 1IZ2A 3LW2A 1QMNA 4PYWA 2H4PA 2PEFA 3CWMA 3DLWA 4G8OA 1PSIA 2B5TI 1SEKA 4G8RA 2GD4C 2VDXA 1K9OI 2WXXA 3NDFA 1OO8A 1BY7A 1BR8I 2B4XL 1TB6I 4RSQA 4AJUA 3B9FI 4ZK0A 2WXWA 1JJOC 2HIJI 4DY0A 1AS4A 4AJTA 4AQHA 1JTIA 1XQGA 1DVNA 1DZHL 3DY0A 4AU3B 7APIA 5HGCA 4CAAA 2BEHL 1DVMA 4GA7A 4Y40A 1ATUA 1R1LI 2ARRA 2ANTI 3FGQA 1UHGA 1XQJA 1IMVA 3T1PA 9APIA 2HI9A 3NDDA 5IO1A 1OVAA 1JMJA 3NE4A 4C49A 3H5CA 3CVMA 2RIVA 2H4RA 1KCTA 3LE2A 2R9YA 5BRRI 3EOXA 2XN6A 1D5SA 1NQ9I 1DB2A 3NDAA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1SNG A;  3VVJ A;  1ATH A;  2WXZ A;  2B4X I;  4EB1 L;  1YXA A;  2DUT A;  1OVA C;  1F0C A;  4ROA A;  5EI0 A;  2WY1 A;  2XN5 A;  3CAA A;  1DZG L;  1HLE A;  4Y3K A;  1DZH I;  2PEE A;  1OYH I;  2BEH I;  2ZNH A;  1WZ9 A;  4YIA A;  3STO A;  5CE0 A;  3ZHA A;  2WXZ C;  2ACH A;  3PZF A;  8API A;  1JMO A;  1LK6 I;  3F5N A;  3Q02 A;  1MTP A;  2OAY A;  1HP7 A;  2D26 A;  3EVJ I;  4IF8 A;  4AU4 A;  2VH4 A;  1T1F A;  1E05 I;  3CWL A;  1ANT I;  4C41 A;  4RO9 A;  1E04 I;  2V95 A;  2XN7 A;  1QMB A;  2XN3 A;  3PB1 I;  4P0O A;  2CEO A;  2WXY C;  4IC0 A;  4ZK3 A;  1OPH A;  2VDY A;  2OL2 A;  4EB1 I;  2ARQ A;  2QUG A;  3KCG I;  2RIW A;  1JVQ I;  4BB2 A;  1ATT A;  1DZG I;  2WY0 C;  1AZX I;  1EZX A;  4ROB A;  4AU2 A;  1A7C A;  3DRM A;  4KDS A;  3F1S A;  3F02 A;  5C98 A;  1JRR A;  2ZV6 A;  1E03 I;  4P0F A;  2HIJ L;  4AU3 A;  1XU8 A;  5CDX A;  3Q03 A;  1LQ8 A;  5CDZ A;  1OVA B;  1B3K A;  1M93 B;  4AFX A;  4DTE A;  3R4L A;  1C8O A;  3UT3 A;  1OYH L;  5INW A;  1LJ5 A;  4DY7 C;  1OC0 A;  4R9I A;  2H4Q A;  3DRU A;  1C5G A;  1SR5 A;  3OZQ A;  1QLP A;  9PAI A;  4X30 A;  1IZ2 A;  3LW2 A;  1QMN A;  4PYW A;  2H4P A;  2PEF A;  3CWM A;  3DLW A;  4G8O A;  1PSI A;  2B5T I;  1SEK A;  4G8R A;  2GD4 C;  2VDX A;  1K9O I;  2WXX A;  3NDF A;  1OO8 A;  1BY7 A;  1BR8 I;  2B4X L;  1TB6 I;  4RSQ A;  4AJU A;  3B9F I;  4ZK0 A;  2WXW A;  1JJO C;  2HIJ I;  4DY0 A;  1AS4 A;  4AJT A;  4AQH A;  1JTI A;  1XQG A;  1DVN A;  1DZH L;  3DY0 A;  4AU3 B;  7API A;  5HGC A;  4CAA A;  2BEH L;  1DVM A;  4GA7 A;  4Y40 A;  1ATU A;  1R1L I;  2ARR A;  2ANT I;  3FGQ A;  1UHG A;  1XQJ A;  1IMV A;  3T1P A;  9API A;  2HI9 A;  3NDD A;  5IO1 A;  1OVA A;  1JMJ A;  3NE4 A;  4C49 A;  3H5C A;  3CVM A;  2RIV A;  2H4R A;  1KCT A;  3LE2 A;  2R9Y A;  5BRR I;  3EOX A;  2XN6 A;  1D5S A;  1NQ9 I;  1DB2 A;  3NDA A; 
#chains in the Genus database with same CATH topology
 1SNG A;  3VVJ A;  1ATH A;  2WXZ A;  2B4X I;  4EB1 L;  1YXA A;  2DUT A;  1OVA C;  1F0C A;  4ROA A;  5EI0 A;  2WY1 A;  2XN5 A;  3CAA A;  1DZG L;  1HLE A;  4Y3K A;  1DZH I;  2PEE A;  1OYH I;  2BEH I;  2ZNH A;  1WZ9 A;  4YIA A;  3STO A;  5CE0 A;  3ZHA A;  2WXZ C;  2ACH A;  3PZF A;  8API A;  1JMO A;  1LK6 I;  3F5N A;  3Q02 A;  1MTP A;  2OAY A;  1HP7 A;  2D26 A;  3EVJ I;  4IF8 A;  4AU4 A;  2VH4 A;  1T1F A;  1E05 I;  3CWL A;  1ANT I;  4C41 A;  4RO9 A;  1E04 I;  2V95 A;  2XN7 A;  1QMB A;  2XN3 A;  3PB1 I;  4P0O A;  2CEO A;  2WXY C;  4IC0 A;  4ZK3 A;  1OPH A;  2VDY A;  2OL2 A;  4EB1 I;  2ARQ A;  2QUG A;  3KCG I;  2RIW A;  1JVQ I;  4BB2 A;  1ATT A;  1DZG I;  2WY0 C;  1AZX I;  1EZX A;  4ROB A;  4AU2 A;  1A7C A;  3DRM A;  4KDS A;  3F1S A;  3F02 A;  5C98 A;  1JRR A;  2ZV6 A;  1E03 I;  4P0F A;  2HIJ L;  4AU3 A;  1XU8 A;  5CDX A;  3Q03 A;  1LQ8 A;  5CDZ A;  1OVA B;  1B3K A;  1M93 B;  4AFX A;  4DTE A;  3R4L A;  1C8O A;  3UT3 A;  1OYH L;  5INW A;  1LJ5 A;  4DY7 C;  1OC0 A;  4R9I A;  2H4Q A;  3DRU A;  1C5G A;  1SR5 A;  3OZQ A;  1QLP A;  9PAI A;  4X30 A;  1IZ2 A;  3LW2 A;  1QMN A;  4PYW A;  2H4P A;  2PEF A;  3CWM A;  3DLW A;  4G8O A;  1PSI A;  2B5T I;  1SEK A;  4G8R A;  2GD4 C;  2VDX A;  1K9O I;  2WXX A;  3NDF A;  1OO8 A;  1BY7 A;  1BR8 I;  2B4X L;  1TB6 I;  4RSQ A;  4AJU A;  3B9F I;  4ZK0 A;  2WXW A;  1JJO C;  2HIJ I;  4DY0 A;  1AS4 A;  4AJT A;  4AQH A;  1JTI A;  1XQG A;  1DVN A;  1DZH L;  3DY0 A;  4AU3 B;  7API A;  5HGC A;  4CAA A;  2BEH L;  1DVM A;  4GA7 A;  4Y40 A;  1ATU A;  1R1L I;  2ARR A;  2ANT I;  3FGQ A;  1UHG A;  1XQJ A;  1IMV A;  3T1P A;  9API A;  2HI9 A;  3NDD A;  5IO1 A;  1OVA A;  1JMJ A;  3NE4 A;  4C49 A;  3H5C A;  3CVM A;  2RIV A;  2H4R A;  1KCT A;  3LE2 A;  2R9Y A;  5BRR I;  3EOX A;  2XN6 A;  1D5S A;  1NQ9 I;  1DB2 A;  3NDA A; 
#chains in the Genus database with same CATH homology
 1SNG A;  3VVJ A;  1ATH A;  2WXZ A;  2B4X I;  4EB1 L;  1YXA A;  2DUT A;  1OVA C;  1F0C A;  4ROA A;  5EI0 A;  2WY1 A;  2XN5 A;  3CAA A;  1DZG L;  1HLE A;  4Y3K A;  1DZH I;  2PEE A;  1OYH I;  2BEH I;  2ZNH A;  1WZ9 A;  4YIA A;  3STO A;  5CE0 A;  3ZHA A;  2WXZ C;  2ACH A;  3PZF A;  8API A;  1JMO A;  1LK6 I;  3F5N A;  3Q02 A;  1MTP A;  2OAY A;  1HP7 A;  2D26 A;  3EVJ I;  4IF8 A;  4AU4 A;  2VH4 A;  1T1F A;  1E05 I;  3CWL A;  1ANT I;  4C41 A;  4RO9 A;  1E04 I;  2V95 A;  2XN7 A;  1QMB A;  2XN3 A;  3PB1 I;  4P0O A;  2CEO A;  2WXY C;  4IC0 A;  4ZK3 A;  1OPH A;  2VDY A;  2OL2 A;  4EB1 I;  2ARQ A;  2QUG A;  3KCG I;  2RIW A;  1JVQ I;  4BB2 A;  1ATT A;  1DZG I;  2WY0 C;  1AZX I;  1EZX A;  4ROB A;  4AU2 A;  1A7C A;  3DRM A;  4KDS A;  3F1S A;  3F02 A;  5C98 A;  1JRR A;  2ZV6 A;  1E03 I;  4P0F A;  2HIJ L;  4AU3 A;  1XU8 A;  5CDX A;  3Q03 A;  1LQ8 A;  5CDZ A;  1OVA B;  1B3K A;  1M93 B;  4AFX A;  4DTE A;  3R4L A;  1C8O A;  3UT3 A;  1OYH L;  5INW A;  1LJ5 A;  4DY7 C;  1OC0 A;  4R9I A;  2H4Q A;  3DRU A;  1C5G A;  1SR5 A;  3OZQ A;  1QLP A;  9PAI A;  4X30 A;  1IZ2 A;  3LW2 A;  1QMN A;  4PYW A;  2H4P A;  2PEF A;  3CWM A;  3DLW A;  4G8O A;  1PSI A;  2B5T I;  1SEK A;  4G8R A;  2GD4 C;  2VDX A;  1K9O I;  2WXX A;  3NDF A;  1OO8 A;  1BY7 A;  1BR8 I;  2B4X L;  1TB6 I;  4RSQ A;  4AJU A;  3B9F I;  4ZK0 A;  2WXW A;  1JJO C;  2HIJ I;  4DY0 A;  1AS4 A;  4AJT A;  4AQH A;  1JTI A;  1XQG A;  1DVN A;  1DZH L;  3DY0 A;  4AU3 B;  7API A;  5HGC A;  4CAA A;  2BEH L;  1DVM A;  4GA7 A;  4Y40 A;  1ATU A;  1R1L I;  2ARR A;  2ANT I;  3FGQ A;  1UHG A;  1XQJ A;  1IMV A;  3T1P A;  9API A;  2HI9 A;  3NDD A;  5IO1 A;  1OVA A;  1JMJ A;  3NE4 A;  4C49 A;  3H5C A;  3CVM A;  2RIV A;  2H4R A;  1KCT A;  3LE2 A;  2R9Y A;  5BRR I;  3EOX A;  2XN6 A;  1D5S A;  1NQ9 I;  1DB2 A;  3NDA A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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