2BEHI

Crystal structure of antithrombin variant s137a/v317c/t401c with plasma latent antithrombin
Total Genus 124
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
124
sequence length
428
structure length
413
Chain Sequence
PVDICTAKPRDIPMNPMCIYRSPEKKPEATNRRVWELSKANSRFATTFYQHLADSKNDNDNIFLSPLSISTAFAMTKLGACNDTLQQLMEVFKFDTISEKTSDQIHFFFAKLNCRLYRKANKASKLVSANRLFGDKSLTFNETYQDISELVYGAKLQPLDFKENAEQSRAAINKWVSNKTEGRITDVIPSEAINELTVLVLVNTIYFKGLWKSKFSPENTRKELFYKADGESCSASMMYQEGKFRYRRVAEGTQVLELPFKGDDITMVLILPKPEKSLAKVEKELTPEVLQEWLDELEEMMLCVHMPRFRIEDGFSLKEQLQDMGLVDLFSPEKSKLPGIVADLYVSDAFHKAFLEVNEEGSEAAASTAVVIAGRSLNPNRVCFKANRPFLVFIREVPLNTIIFMGRVANPCV
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal structure of monomeric native antithrombin reveals a novel reactive center loop conformation.
pubmed doi rcsb
molecule keywords Antithrombin-III
molecule tags Blood clotting
source organism Homo sapiens
total genus 124
structure length 413
sequence length 428
ec nomenclature
pdb deposition date 2005-10-24

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
I PF00079 Serpin Serpin (serine protease inhibitor)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.30.39.10 Mainly Beta Roll Alpha-1-antitrypsin; domain 1 Alpha-1-antitrypsin, domain 1 2behI02
3.30.497.10 Alpha Beta 2-Layer Sandwich Antithrombin; Chain I, domain 2 Antithrombin, subunit I, domain 2 2behI01
3F1SA 4G8OA 4RO9A 2WXXA 4IF8A 2B4XI 2DUTA 2CEOA 1E04I 3DRMA 4G8RA 2VH4A 2HIJL 5IO1A 2BEHL 1SEKA 1A7CA 4DY7C 4C41A 1HLEA 2HI9A 2H4PA 2B4XL 3Q02A 2ZNHA 4KDSA 4X30A 1OC0A 1JTIA 1IMVA 1AZXI 1OO8A 2OL2A 3EOXA 2RIWA 3OZQA 4Y3KA 3LW2A 3NDDA 2PEFA 3Q03A 1ANTI 3B9FI 3DRUA 1JVQI 3R4LA 1M93B 3NDFA 2QUGA 4GA7A 4EB1L 2BEHI 3CVMA 4ZK3A 3CWLA 2ACHA 1EZXA 1DVNA 1SNGA 3NE4A 5HGCA 4AFXA 1F0CA 2H4RA 1E05I 2RIVA 4ROAA 3F5NA 3T1PA 3VVJA 3F02A 1ATUA 2R9YA 1KCTA 1ATTA 1DVMA 4AJTA 4DTEA 2WXYC 4ZK0A 1B3KA 2XN3A 3H5CA 5CDXA 1WZ9A 2XN7A 1AS4A 3FGQA 1E03I 4EB1I 1YXAA 1LK6I 9PAIA 1D5SA 1DZHI 3PB1I 1XU8A 2ZV6A 1OVAC 3UT3A 1BR8I 1JJOC 2PEEA 2XN5A 3KCGI 4Y40A 3STOA 4BB2A 4AJUA 2XN6A 1DZHL 1JMJA 5INWA 1JMOA 1TB6I 1LQ8A 4RSQA 5BRRI 4AU2A 2ANTI 2WY0C 2D26A 1QMNA 3EVJI 3DLWA 1UHGA 3ZHAA 5CDZA 1NQ9I 4P0FA 2WXZC 3CAAA 1T1FA 1OVAB 4AU3B 2VDXA 1PSIA 2VDYA 4P0OA 2B5TI 5C98A 1BY7A 2WXWA 4AU4A 1OYHL 4IC0A 1XQGA 1MTPA 2V95A 5EI0A 1SR5A 1K9OI 1OPHA 1XQJA 8APIA 3CWMA 1LJ5A 1OVAA 4AU3A 2WY1A 1C5GA 4R9IA 4C49A 2H4QA 1QMBA 3DY0A 1HP7A 2GD4C 4ROBA 9APIA 1DZGI 1C8OA 3LE2A 1JRRA 4AQHA 1ATHA 1QLPA 4PYWA 1OYHI 1R1LI 2ARQA 1DZGL 1DB2A 7APIA 2OAYA 2WXZA 3NDAA 4DY0A 3PZFA 2ARRA 4CAAA 4YIAA 2HIJI 5CE0A 1IZ2A
chains in the Genus database with same CATH superfamily
3F1SA 4G8OA 4RO9A 2WXXA 4IF8A 2B4XI 2DUTA 2CEOA 1E04I 3DRMA 4G8RA 2VH4A 2HIJL 5IO1A 2BEHL 1SEKA 1A7CA 4DY7C 4C41A 1HLEA 2HI9A 2H4PA 2B4XL 3Q02A 2ZNHA 4KDSA 4X30A 1OC0A 1JTIA 1IMVA 1AZXI 1OO8A 2OL2A 3EOXA 2RIWA 3OZQA 4Y3KA 3LW2A 3NDDA 2PEFA 3Q03A 1ANTI 3B9FI 3DRUA 1JVQI 3R4LA 1M93B 3NDFA 2QUGA 4GA7A 4EB1L 2BEHI 3CVMA 4ZK3A 3CWLA 2ACHA 1EZXA 1DVNA 1SNGA 3NE4A 5HGCA 4AFXA 1F0CA 2H4RA 1E05I 2RIVA 4ROAA 3F5NA 3T1PA 3VVJA 3F02A 1ATUA 2R9YA 1KCTA 1ATTA 1DVMA 4AJTA 4DTEA 2WXYC 4ZK0A 1B3KA 2XN3A 3H5CA 5CDXA 1WZ9A 2XN7A 1AS4A 3FGQA 1E03I 4EB1I 1YXAA 1LK6I 9PAIA 1D5SA 1DZHI 3PB1I 1XU8A 2ZV6A 1OVAC 3UT3A 1BR8I 1JJOC 2PEEA 2XN5A 3KCGI 4Y40A 3STOA 4BB2A 4AJUA 2XN6A 1DZHL 1JMJA 5INWA 1JMOA 1TB6I 1LQ8A 4RSQA 5BRRI 4AU2A 2ANTI 2WY0C 2D26A 1QMNA 3EVJI 3DLWA 1UHGA 3ZHAA 5CDZA 1NQ9I 4P0FA 2WXZC 3CAAA 1T1FA 1OVAB 4AU3B 2VDXA 1PSIA 2VDYA 4P0OA 2B5TI 5C98A 1BY7A 2WXWA 4AU4A 1OYHL 4IC0A 1XQGA 1MTPA 2V95A 5EI0A 1SR5A 1K9OI 1OPHA 1XQJA 8APIA 3CWMA 1LJ5A 1OVAA 4AU3A 2WY1A 1C5GA 4R9IA 4C49A 2H4QA 1QMBA 3DY0A 1HP7A 2GD4C 4ROBA 9APIA 1DZGI 1C8OA 3LE2A 1JRRA 4AQHA 1ATHA 1QLPA 4PYWA 1OYHI 1R1LI 2ARQA 1DZGL 1DB2A 7APIA 2OAYA 2WXZA 3NDAA 4DY0A 3PZFA 2ARRA 4CAAA 4YIAA 2HIJI 5CE0A 1IZ2A
chains in the Genus database with same CATH topology
3F1SA 4G8OA 4RO9A 2WXXA 4IF8A 2B4XI 2DUTA 2CEOA 1E04I 3DRMA 4G8RA 2VH4A 2HIJL 5IO1A 2BEHL 1SEKA 1A7CA 4DY7C 4C41A 1HLEA 2HI9A 2H4PA 2B4XL 3Q02A 2ZNHA 4KDSA 4X30A 1OC0A 1JTIA 1IMVA 1AZXI 1OO8A 2OL2A 3EOXA 2RIWA 3OZQA 4Y3KA 3LW2A 3NDDA 2PEFA 3Q03A 1ANTI 3B9FI 3DRUA 1JVQI 3R4LA 1M93B 3NDFA 2QUGA 4GA7A 4EB1L 2BEHI 3CVMA 4ZK3A 3CWLA 2ACHA 1EZXA 1DVNA 1SNGA 3NE4A 5HGCA 4AFXA 1F0CA 2H4RA 1E05I 2RIVA 4ROAA 3F5NA 3T1PA 3VVJA 3F02A 1ATUA 2R9YA 1KCTA 1ATTA 1DVMA 4AJTA 4DTEA 2WXYC 4ZK0A 1B3KA 2XN3A 3H5CA 5CDXA 1WZ9A 2XN7A 1AS4A 3FGQA 1E03I 4EB1I 1YXAA 1LK6I 9PAIA 1D5SA 1DZHI 3PB1I 1XU8A 2ZV6A 1OVAC 3UT3A 1BR8I 1JJOC 2PEEA 2XN5A 3KCGI 4Y40A 3STOA 4BB2A 4AJUA 2XN6A 1DZHL 1JMJA 5INWA 1JMOA 1TB6I 1LQ8A 4RSQA 5BRRI 4AU2A 2ANTI 2WY0C 2D26A 1QMNA 3EVJI 3DLWA 1UHGA 3ZHAA 5CDZA 1NQ9I 4P0FA 2WXZC 3CAAA 1T1FA 1OVAB 4AU3B 2VDXA 1PSIA 2VDYA 4P0OA 2B5TI 5C98A 1BY7A 2WXWA 4AU4A 1OYHL 4IC0A 1XQGA 1MTPA 2V95A 5EI0A 1SR5A 1K9OI 1OPHA 1XQJA 8APIA 3CWMA 1LJ5A 1OVAA 4AU3A 2WY1A 1C5GA 4R9IA 4C49A 2H4QA 1QMBA 3DY0A 1HP7A 2GD4C 4ROBA 9APIA 1DZGI 1C8OA 3LE2A 1JRRA 4AQHA 1ATHA 1QLPA 4PYWA 1OYHI 1R1LI 2ARQA 1DZGL 1DB2A 7APIA 2OAYA 2WXZA 3NDAA 4DY0A 3PZFA 2ARRA 4CAAA 4YIAA 2HIJI 5CE0A 1IZ2A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3F1S A;  4G8O A;  4RO9 A;  2WXX A;  4IF8 A;  2B4X I;  2DUT A;  2CEO A;  1E04 I;  3DRM A;  4G8R A;  2VH4 A;  2HIJ L;  5IO1 A;  2BEH L;  1SEK A;  1A7C A;  4DY7 C;  4C41 A;  1HLE A;  2HI9 A;  2H4P A;  2B4X L;  3Q02 A;  2ZNH A;  4KDS A;  4X30 A;  1OC0 A;  1JTI A;  1IMV A;  1AZX I;  1OO8 A;  2OL2 A;  3EOX A;  2RIW A;  3OZQ A;  4Y3K A;  3LW2 A;  3NDD A;  2PEF A;  3Q03 A;  1ANT I;  3B9F I;  3DRU A;  1JVQ I;  3R4L A;  1M93 B;  3NDF A;  2QUG A;  4GA7 A;  4EB1 L;  2BEH I;  3CVM A;  4ZK3 A;  3CWL A;  2ACH A;  1EZX A;  1DVN A;  1SNG A;  3NE4 A;  5HGC A;  4AFX A;  1F0C A;  2H4R A;  1E05 I;  2RIV A;  4ROA A;  3F5N A;  3T1P A;  3VVJ A;  3F02 A;  1ATU A;  2R9Y A;  1KCT A;  1ATT A;  1DVM A;  4AJT A;  4DTE A;  2WXY C;  4ZK0 A;  1B3K A;  2XN3 A;  3H5C A;  5CDX A;  1WZ9 A;  2XN7 A;  1AS4 A;  3FGQ A;  1E03 I;  4EB1 I;  1YXA A;  1LK6 I;  9PAI A;  1D5S A;  1DZH I;  3PB1 I;  1XU8 A;  2ZV6 A;  1OVA C;  3UT3 A;  1BR8 I;  1JJO C;  2PEE A;  2XN5 A;  3KCG I;  4Y40 A;  3STO A;  4BB2 A;  4AJU A;  2XN6 A;  1DZH L;  1JMJ A;  5INW A;  1JMO A;  1TB6 I;  1LQ8 A;  4RSQ A;  5BRR I;  4AU2 A;  2ANT I;  2WY0 C;  2D26 A;  1QMN A;  3EVJ I;  3DLW A;  1UHG A;  3ZHA A;  5CDZ A;  1NQ9 I;  4P0F A;  2WXZ C;  3CAA A;  1T1F A;  1OVA B;  4AU3 B;  2VDX A;  1PSI A;  2VDY A;  4P0O A;  2B5T I;  5C98 A;  1BY7 A;  2WXW A;  4AU4 A;  1OYH L;  4IC0 A;  1XQG A;  1MTP A;  2V95 A;  5EI0 A;  1SR5 A;  1K9O I;  1OPH A;  1XQJ A;  8API A;  3CWM A;  1LJ5 A;  1OVA A;  4AU3 A;  2WY1 A;  1C5G A;  4R9I A;  4C49 A;  2H4Q A;  1QMB A;  3DY0 A;  1HP7 A;  2GD4 C;  4ROB A;  9API A;  1DZG I;  1C8O A;  3LE2 A;  1JRR A;  4AQH A;  1ATH A;  1QLP A;  4PYW A;  1OYH I;  1R1L I;  2ARQ A;  1DZG L;  1DB2 A;  7API A;  2OAY A;  2WXZ A;  3NDA A;  4DY0 A;  3PZF A;  2ARR A;  4CAA A;  4YIA A;  2HIJ I;  5CE0 A;  1IZ2 A; 
#chains in the Genus database with same CATH topology
 3F1S A;  4G8O A;  4RO9 A;  2WXX A;  4IF8 A;  2B4X I;  2DUT A;  2CEO A;  1E04 I;  3DRM A;  4G8R A;  2VH4 A;  2HIJ L;  5IO1 A;  2BEH L;  1SEK A;  1A7C A;  4DY7 C;  4C41 A;  1HLE A;  2HI9 A;  2H4P A;  2B4X L;  3Q02 A;  2ZNH A;  4KDS A;  4X30 A;  1OC0 A;  1JTI A;  1IMV A;  1AZX I;  1OO8 A;  2OL2 A;  3EOX A;  2RIW A;  3OZQ A;  4Y3K A;  3LW2 A;  3NDD A;  2PEF A;  3Q03 A;  1ANT I;  3B9F I;  3DRU A;  1JVQ I;  3R4L A;  1M93 B;  3NDF A;  2QUG A;  4GA7 A;  4EB1 L;  2BEH I;  3CVM A;  4ZK3 A;  3CWL A;  2ACH A;  1EZX A;  1DVN A;  1SNG A;  3NE4 A;  5HGC A;  4AFX A;  1F0C A;  2H4R A;  1E05 I;  2RIV A;  4ROA A;  3F5N A;  3T1P A;  3VVJ A;  3F02 A;  1ATU A;  2R9Y A;  1KCT A;  1ATT A;  1DVM A;  4AJT A;  4DTE A;  2WXY C;  4ZK0 A;  1B3K A;  2XN3 A;  3H5C A;  5CDX A;  1WZ9 A;  2XN7 A;  1AS4 A;  3FGQ A;  1E03 I;  4EB1 I;  1YXA A;  1LK6 I;  9PAI A;  1D5S A;  1DZH I;  3PB1 I;  1XU8 A;  2ZV6 A;  1OVA C;  3UT3 A;  1BR8 I;  1JJO C;  2PEE A;  2XN5 A;  3KCG I;  4Y40 A;  3STO A;  4BB2 A;  4AJU A;  2XN6 A;  1DZH L;  1JMJ A;  5INW A;  1JMO A;  1TB6 I;  1LQ8 A;  4RSQ A;  5BRR I;  4AU2 A;  2ANT I;  2WY0 C;  2D26 A;  1QMN A;  3EVJ I;  3DLW A;  1UHG A;  3ZHA A;  5CDZ A;  1NQ9 I;  4P0F A;  2WXZ C;  3CAA A;  1T1F A;  1OVA B;  4AU3 B;  2VDX A;  1PSI A;  2VDY A;  4P0O A;  2B5T I;  5C98 A;  1BY7 A;  2WXW A;  4AU4 A;  1OYH L;  4IC0 A;  1XQG A;  1MTP A;  2V95 A;  5EI0 A;  1SR5 A;  1K9O I;  1OPH A;  1XQJ A;  8API A;  3CWM A;  1LJ5 A;  1OVA A;  4AU3 A;  2WY1 A;  1C5G A;  4R9I A;  4C49 A;  2H4Q A;  1QMB A;  3DY0 A;  1HP7 A;  2GD4 C;  4ROB A;  9API A;  1DZG I;  1C8O A;  3LE2 A;  1JRR A;  4AQH A;  1ATH A;  1QLP A;  4PYW A;  1OYH I;  1R1L I;  2ARQ A;  1DZG L;  1DB2 A;  7API A;  2OAY A;  2WXZ A;  3NDA A;  4DY0 A;  3PZF A;  2ARR A;  4CAA A;  4YIA A;  2HIJ I;  5CE0 A;  1IZ2 A; 
#chains in the Genus database with same CATH homology
 3F1S A;  4G8O A;  4RO9 A;  2WXX A;  4IF8 A;  2B4X I;  2DUT A;  2CEO A;  1E04 I;  3DRM A;  4G8R A;  2VH4 A;  2HIJ L;  5IO1 A;  2BEH L;  1SEK A;  1A7C A;  4DY7 C;  4C41 A;  1HLE A;  2HI9 A;  2H4P A;  2B4X L;  3Q02 A;  2ZNH A;  4KDS A;  4X30 A;  1OC0 A;  1JTI A;  1IMV A;  1AZX I;  1OO8 A;  2OL2 A;  3EOX A;  2RIW A;  3OZQ A;  4Y3K A;  3LW2 A;  3NDD A;  2PEF A;  3Q03 A;  1ANT I;  3B9F I;  3DRU A;  1JVQ I;  3R4L A;  1M93 B;  3NDF A;  2QUG A;  4GA7 A;  4EB1 L;  2BEH I;  3CVM A;  4ZK3 A;  3CWL A;  2ACH A;  1EZX A;  1DVN A;  1SNG A;  3NE4 A;  5HGC A;  4AFX A;  1F0C A;  2H4R A;  1E05 I;  2RIV A;  4ROA A;  3F5N A;  3T1P A;  3VVJ A;  3F02 A;  1ATU A;  2R9Y A;  1KCT A;  1ATT A;  1DVM A;  4AJT A;  4DTE A;  2WXY C;  4ZK0 A;  1B3K A;  2XN3 A;  3H5C A;  5CDX A;  1WZ9 A;  2XN7 A;  1AS4 A;  3FGQ A;  1E03 I;  4EB1 I;  1YXA A;  1LK6 I;  9PAI A;  1D5S A;  1DZH I;  3PB1 I;  1XU8 A;  2ZV6 A;  1OVA C;  3UT3 A;  1BR8 I;  1JJO C;  2PEE A;  2XN5 A;  3KCG I;  4Y40 A;  3STO A;  4BB2 A;  4AJU A;  2XN6 A;  1DZH L;  1JMJ A;  5INW A;  1JMO A;  1TB6 I;  1LQ8 A;  4RSQ A;  5BRR I;  4AU2 A;  2ANT I;  2WY0 C;  2D26 A;  1QMN A;  3EVJ I;  3DLW A;  1UHG A;  3ZHA A;  5CDZ A;  1NQ9 I;  4P0F A;  2WXZ C;  3CAA A;  1T1F A;  1OVA B;  4AU3 B;  2VDX A;  1PSI A;  2VDY A;  4P0O A;  2B5T I;  5C98 A;  1BY7 A;  2WXW A;  4AU4 A;  1OYH L;  4IC0 A;  1XQG A;  1MTP A;  2V95 A;  5EI0 A;  1SR5 A;  1K9O I;  1OPH A;  1XQJ A;  8API A;  3CWM A;  1LJ5 A;  1OVA A;  4AU3 A;  2WY1 A;  1C5G A;  4R9I A;  4C49 A;  2H4Q A;  1QMB A;  3DY0 A;  1HP7 A;  2GD4 C;  4ROB A;  9API A;  1DZG I;  1C8O A;  3LE2 A;  1JRR A;  4AQH A;  1ATH A;  1QLP A;  4PYW A;  1OYH I;  1R1L I;  2ARQ A;  1DZG L;  1DB2 A;  7API A;  2OAY A;  2WXZ A;  3NDA A;  4DY0 A;  3PZF A;  2ARR A;  4CAA A;  4YIA A;  2HIJ I;  5CE0 A;  1IZ2 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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