4AU3B

Crystal structure of a hsp47-collagen complex
Total Genus 111
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
111
sequence length
380
structure length
364
Chain Sequence
MLSPKAATLAERSAGLAFSLYQAMAKDQAVENILLSPVVVASSLGLVSLGGKATTASQAKAVLSAEQLRDEEVHAGLGELLRSLSNVTWKLGSRLYGPSSVSFAEDFVRSSKQHYNCEHSKINFRDKRSALQSINEWAAQTTDGKLPEVTKDVERTDGALLVNAMFFKPHWDEKFHHKMVDNRGFMVTRSYTVGVTMMHRTGLYNYYDDEKEKLQIVEMPLAHKLSSLIILMPHHVEPLERLEKLLTKEQLKIWMGKMQKKAVAISLPKGVVEVTHDLQKHLAGLGLTEAIDKNKSDLSRMSGKKDLYLASVFHATAFEWDTEGNPRSPKLFYADHPFIFLVRDTQSGSLLFIGRLVRPKGDKM
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Molecular Basis for the Action of the Collagen-Specific Chaperone Hsp47/Serpinh1 and its Structure-Specific Client Recognition.
pubmed doi rcsb
molecule keywords SERPIN PEPTIDASE INHIBITOR, CLADE H (HEAT SHOCK PROTEIN 47 )
molecule tags Chaperone/peptide
source organism Canis lupus familiaris
total genus 111
structure length 364
sequence length 380
ec nomenclature
pdb deposition date 2012-05-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
B PF00079 Serpin Serpin (serine protease inhibitor)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.30.39.10 Mainly Beta Roll Alpha-1-antitrypsin; domain 1 Alpha-1-antitrypsin, domain 1 4au3B02
3.30.497.10 Alpha Beta 2-Layer Sandwich Antithrombin; Chain I, domain 2 Antithrombin, subunit I, domain 2 4au3B01
1E04I 2B5TI 2XN3A 2ZNHA 1TB6I 3CAAA 1ATUA 2VDXA 5EI0A 3F1SA 1AS4A 1MTPA 4C49A 2OL2A 1A7CA 2PEEA 1HP7A 2DUTA 1DZHL 4C41A 3Q03A 4KDSA 3F02A 3LE2A 4ROAA 2HIJI 3DRMA 4DY7C 1UHGA 1OO8A 2GD4C 4AJUA 2ARRA 4AU2A 1LQ8A 3NDFA 2ARQA 4ZK0A 2B4XL 4G8OA 4AU4A 1DZHI 1HLEA 2RIVA 4CAAA 1QLPA 2CEOA 3DY0A 1C8OA 1KCTA 1T1FA 4IF8A 4AU3B 2WXZA 4BB2A 1XQJA 3NE4A 5BRRI 4PYWA 1DVMA 1NQ9I 2RIWA 4GA7A 5INWA 2OAYA 4DY0A 2WXZC 1BR8I 2B4XI 2QUGA 2HI9A 3R4LA 3EVJI 3FGQA 1OPHA 1JRRA 1F0CA 3KCGI 1B3KA 2ACHA 2WXXA 4DTEA 2H4QA 2ANTI 3UT3A 2VH4A 4RSQA 2R9YA 1ATTA 1JJOC 4AQHA 5CE0A 1R1LI 1DZGL 1DB2A 3DLWA 5CDXA 3PZFA 3LW2A 1OVAA 1M93B 3NDAA 1WZ9A 3Q02A 4AJTA 4Y40A 5CDZA 4YIAA 1XU8A 1JTIA 3NDDA 3STOA 2H4PA 2BEHL 3CVMA 1DZGI 1OVAC 5IO1A 1QMNA 2H4RA 3F5NA 4ROBA 3T1PA 1YXAA 4Y3KA 1QMBA 1PSIA 1ATHA 1JVQI 1DVNA 1ANTI 2PEFA 2ZV6A 1SEKA 2D26A 3EOXA 9PAIA 1C5GA 1JMOA 4AU3A 5HGCA 3B9FI 4RO9A 2BEHI 4EB1L 2WXYC 1E05I 4P0FA 1LK6I 9APIA 1XQGA 4P0OA 2V95A 4ZK3A 7APIA 1D5SA 1OVAB 3DRUA 1K9OI 2WY0C 1OYHL 8APIA 4G8RA 1LJ5A 2XN5A 3VVJA 3OZQA 2XN7A 1AZXI 3CWMA 3H5CA 4EB1I 2WY1A 3PB1I 1IZ2A 1IMVA 1EZXA 1JMJA 1OC0A 2VDYA 2WXWA 2XN6A 4R9IA 3ZHAA 4AFXA 1SNGA 2HIJL 1E03I 1SR5A 4X30A 1BY7A 1OYHI 5C98A 3CWLA 4IC0A
chains in the Genus database with same CATH superfamily
1E04I 2B5TI 2XN3A 2ZNHA 1TB6I 3CAAA 1ATUA 2VDXA 5EI0A 3F1SA 1AS4A 1MTPA 4C49A 2OL2A 1A7CA 2PEEA 1HP7A 2DUTA 1DZHL 4C41A 3Q03A 4KDSA 3F02A 3LE2A 4ROAA 2HIJI 3DRMA 4DY7C 1UHGA 1OO8A 2GD4C 4AJUA 2ARRA 4AU2A 1LQ8A 3NDFA 2ARQA 4ZK0A 2B4XL 4G8OA 4AU4A 1DZHI 1HLEA 2RIVA 4CAAA 1QLPA 2CEOA 3DY0A 1C8OA 1KCTA 1T1FA 4IF8A 4AU3B 2WXZA 4BB2A 1XQJA 3NE4A 5BRRI 4PYWA 1DVMA 1NQ9I 2RIWA 4GA7A 5INWA 2OAYA 4DY0A 2WXZC 1BR8I 2B4XI 2QUGA 2HI9A 3R4LA 3EVJI 3FGQA 1OPHA 1JRRA 1F0CA 3KCGI 1B3KA 2ACHA 2WXXA 4DTEA 2H4QA 2ANTI 3UT3A 2VH4A 4RSQA 2R9YA 1ATTA 1JJOC 4AQHA 5CE0A 1R1LI 1DZGL 1DB2A 3DLWA 5CDXA 3PZFA 3LW2A 1OVAA 1M93B 3NDAA 1WZ9A 3Q02A 4AJTA 4Y40A 5CDZA 4YIAA 1XU8A 1JTIA 3NDDA 3STOA 2H4PA 2BEHL 3CVMA 1DZGI 1OVAC 5IO1A 1QMNA 2H4RA 3F5NA 4ROBA 3T1PA 1YXAA 4Y3KA 1QMBA 1PSIA 1ATHA 1JVQI 1DVNA 1ANTI 2PEFA 2ZV6A 1SEKA 2D26A 3EOXA 9PAIA 1C5GA 1JMOA 4AU3A 5HGCA 3B9FI 4RO9A 2BEHI 4EB1L 2WXYC 1E05I 4P0FA 1LK6I 9APIA 1XQGA 4P0OA 2V95A 4ZK3A 7APIA 1D5SA 1OVAB 3DRUA 1K9OI 2WY0C 1OYHL 8APIA 4G8RA 1LJ5A 2XN5A 3VVJA 3OZQA 2XN7A 1AZXI 3CWMA 3H5CA 4EB1I 2WY1A 3PB1I 1IZ2A 1IMVA 1EZXA 1JMJA 1OC0A 2VDYA 2WXWA 2XN6A 4R9IA 3ZHAA 4AFXA 1SNGA 2HIJL 1E03I 1SR5A 4X30A 1BY7A 1OYHI 5C98A 3CWLA 4IC0A
chains in the Genus database with same CATH topology
1E04I 2B5TI 2XN3A 2ZNHA 1TB6I 3CAAA 1ATUA 2VDXA 5EI0A 3F1SA 1AS4A 1MTPA 4C49A 2OL2A 1A7CA 2PEEA 1HP7A 2DUTA 1DZHL 4C41A 3Q03A 4KDSA 3F02A 3LE2A 4ROAA 2HIJI 3DRMA 4DY7C 1UHGA 1OO8A 2GD4C 4AJUA 2ARRA 4AU2A 1LQ8A 3NDFA 2ARQA 4ZK0A 2B4XL 4G8OA 4AU4A 1DZHI 1HLEA 2RIVA 4CAAA 1QLPA 2CEOA 3DY0A 1C8OA 1KCTA 1T1FA 4IF8A 4AU3B 2WXZA 4BB2A 1XQJA 3NE4A 5BRRI 4PYWA 1DVMA 1NQ9I 2RIWA 4GA7A 5INWA 2OAYA 4DY0A 2WXZC 1BR8I 2B4XI 2QUGA 2HI9A 3R4LA 3EVJI 3FGQA 1OPHA 1JRRA 1F0CA 3KCGI 1B3KA 2ACHA 2WXXA 4DTEA 2H4QA 2ANTI 3UT3A 2VH4A 4RSQA 2R9YA 1ATTA 1JJOC 4AQHA 5CE0A 1R1LI 1DZGL 1DB2A 3DLWA 5CDXA 3PZFA 3LW2A 1OVAA 1M93B 3NDAA 1WZ9A 3Q02A 4AJTA 4Y40A 5CDZA 4YIAA 1XU8A 1JTIA 3NDDA 3STOA 2H4PA 2BEHL 3CVMA 1DZGI 1OVAC 5IO1A 1QMNA 2H4RA 3F5NA 4ROBA 3T1PA 1YXAA 4Y3KA 1QMBA 1PSIA 1ATHA 1JVQI 1DVNA 1ANTI 2PEFA 2ZV6A 1SEKA 2D26A 3EOXA 9PAIA 1C5GA 1JMOA 4AU3A 5HGCA 3B9FI 4RO9A 2BEHI 4EB1L 2WXYC 1E05I 4P0FA 1LK6I 9APIA 1XQGA 4P0OA 2V95A 4ZK3A 7APIA 1D5SA 1OVAB 3DRUA 1K9OI 2WY0C 1OYHL 8APIA 4G8RA 1LJ5A 2XN5A 3VVJA 3OZQA 2XN7A 1AZXI 3CWMA 3H5CA 4EB1I 2WY1A 3PB1I 1IZ2A 1IMVA 1EZXA 1JMJA 1OC0A 2VDYA 2WXWA 2XN6A 4R9IA 3ZHAA 4AFXA 1SNGA 2HIJL 1E03I 1SR5A 4X30A 1BY7A 1OYHI 5C98A 3CWLA 4IC0A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1E04 I;  2B5T I;  2XN3 A;  2ZNH A;  1TB6 I;  3CAA A;  1ATU A;  2VDX A;  5EI0 A;  3F1S A;  1AS4 A;  1MTP A;  4C49 A;  2OL2 A;  1A7C A;  2PEE A;  1HP7 A;  2DUT A;  1DZH L;  4C41 A;  3Q03 A;  4KDS A;  3F02 A;  3LE2 A;  4ROA A;  2HIJ I;  3DRM A;  4DY7 C;  1UHG A;  1OO8 A;  2GD4 C;  4AJU A;  2ARR A;  4AU2 A;  1LQ8 A;  3NDF A;  2ARQ A;  4ZK0 A;  2B4X L;  4G8O A;  4AU4 A;  1DZH I;  1HLE A;  2RIV A;  4CAA A;  1QLP A;  2CEO A;  3DY0 A;  1C8O A;  1KCT A;  1T1F A;  4IF8 A;  4AU3 B;  2WXZ A;  4BB2 A;  1XQJ A;  3NE4 A;  5BRR I;  4PYW A;  1DVM A;  1NQ9 I;  2RIW A;  4GA7 A;  5INW A;  2OAY A;  4DY0 A;  2WXZ C;  1BR8 I;  2B4X I;  2QUG A;  2HI9 A;  3R4L A;  3EVJ I;  3FGQ A;  1OPH A;  1JRR A;  1F0C A;  3KCG I;  1B3K A;  2ACH A;  2WXX A;  4DTE A;  2H4Q A;  2ANT I;  3UT3 A;  2VH4 A;  4RSQ A;  2R9Y A;  1ATT A;  1JJO C;  4AQH A;  5CE0 A;  1R1L I;  1DZG L;  1DB2 A;  3DLW A;  5CDX A;  3PZF A;  3LW2 A;  1OVA A;  1M93 B;  3NDA A;  1WZ9 A;  3Q02 A;  4AJT A;  4Y40 A;  5CDZ A;  4YIA A;  1XU8 A;  1JTI A;  3NDD A;  3STO A;  2H4P A;  2BEH L;  3CVM A;  1DZG I;  1OVA C;  5IO1 A;  1QMN A;  2H4R A;  3F5N A;  4ROB A;  3T1P A;  1YXA A;  4Y3K A;  1QMB A;  1PSI A;  1ATH A;  1JVQ I;  1DVN A;  1ANT I;  2PEF A;  2ZV6 A;  1SEK A;  2D26 A;  3EOX A;  9PAI A;  1C5G A;  1JMO A;  4AU3 A;  5HGC A;  3B9F I;  4RO9 A;  2BEH I;  4EB1 L;  2WXY C;  1E05 I;  4P0F A;  1LK6 I;  9API A;  1XQG A;  4P0O A;  2V95 A;  4ZK3 A;  7API A;  1D5S A;  1OVA B;  3DRU A;  1K9O I;  2WY0 C;  1OYH L;  8API A;  4G8R A;  1LJ5 A;  2XN5 A;  3VVJ A;  3OZQ A;  2XN7 A;  1AZX I;  3CWM A;  3H5C A;  4EB1 I;  2WY1 A;  3PB1 I;  1IZ2 A;  1IMV A;  1EZX A;  1JMJ A;  1OC0 A;  2VDY A;  2WXW A;  2XN6 A;  4R9I A;  3ZHA A;  4AFX A;  1SNG A;  2HIJ L;  1E03 I;  1SR5 A;  4X30 A;  1BY7 A;  1OYH I;  5C98 A;  3CWL A;  4IC0 A; 
#chains in the Genus database with same CATH topology
 1E04 I;  2B5T I;  2XN3 A;  2ZNH A;  1TB6 I;  3CAA A;  1ATU A;  2VDX A;  5EI0 A;  3F1S A;  1AS4 A;  1MTP A;  4C49 A;  2OL2 A;  1A7C A;  2PEE A;  1HP7 A;  2DUT A;  1DZH L;  4C41 A;  3Q03 A;  4KDS A;  3F02 A;  3LE2 A;  4ROA A;  2HIJ I;  3DRM A;  4DY7 C;  1UHG A;  1OO8 A;  2GD4 C;  4AJU A;  2ARR A;  4AU2 A;  1LQ8 A;  3NDF A;  2ARQ A;  4ZK0 A;  2B4X L;  4G8O A;  4AU4 A;  1DZH I;  1HLE A;  2RIV A;  4CAA A;  1QLP A;  2CEO A;  3DY0 A;  1C8O A;  1KCT A;  1T1F A;  4IF8 A;  4AU3 B;  2WXZ A;  4BB2 A;  1XQJ A;  3NE4 A;  5BRR I;  4PYW A;  1DVM A;  1NQ9 I;  2RIW A;  4GA7 A;  5INW A;  2OAY A;  4DY0 A;  2WXZ C;  1BR8 I;  2B4X I;  2QUG A;  2HI9 A;  3R4L A;  3EVJ I;  3FGQ A;  1OPH A;  1JRR A;  1F0C A;  3KCG I;  1B3K A;  2ACH A;  2WXX A;  4DTE A;  2H4Q A;  2ANT I;  3UT3 A;  2VH4 A;  4RSQ A;  2R9Y A;  1ATT A;  1JJO C;  4AQH A;  5CE0 A;  1R1L I;  1DZG L;  1DB2 A;  3DLW A;  5CDX A;  3PZF A;  3LW2 A;  1OVA A;  1M93 B;  3NDA A;  1WZ9 A;  3Q02 A;  4AJT A;  4Y40 A;  5CDZ A;  4YIA A;  1XU8 A;  1JTI A;  3NDD A;  3STO A;  2H4P A;  2BEH L;  3CVM A;  1DZG I;  1OVA C;  5IO1 A;  1QMN A;  2H4R A;  3F5N A;  4ROB A;  3T1P A;  1YXA A;  4Y3K A;  1QMB A;  1PSI A;  1ATH A;  1JVQ I;  1DVN A;  1ANT I;  2PEF A;  2ZV6 A;  1SEK A;  2D26 A;  3EOX A;  9PAI A;  1C5G A;  1JMO A;  4AU3 A;  5HGC A;  3B9F I;  4RO9 A;  2BEH I;  4EB1 L;  2WXY C;  1E05 I;  4P0F A;  1LK6 I;  9API A;  1XQG A;  4P0O A;  2V95 A;  4ZK3 A;  7API A;  1D5S A;  1OVA B;  3DRU A;  1K9O I;  2WY0 C;  1OYH L;  8API A;  4G8R A;  1LJ5 A;  2XN5 A;  3VVJ A;  3OZQ A;  2XN7 A;  1AZX I;  3CWM A;  3H5C A;  4EB1 I;  2WY1 A;  3PB1 I;  1IZ2 A;  1IMV A;  1EZX A;  1JMJ A;  1OC0 A;  2VDY A;  2WXW A;  2XN6 A;  4R9I A;  3ZHA A;  4AFX A;  1SNG A;  2HIJ L;  1E03 I;  1SR5 A;  4X30 A;  1BY7 A;  1OYH I;  5C98 A;  3CWL A;  4IC0 A; 
#chains in the Genus database with same CATH homology
 1E04 I;  2B5T I;  2XN3 A;  2ZNH A;  1TB6 I;  3CAA A;  1ATU A;  2VDX A;  5EI0 A;  3F1S A;  1AS4 A;  1MTP A;  4C49 A;  2OL2 A;  1A7C A;  2PEE A;  1HP7 A;  2DUT A;  1DZH L;  4C41 A;  3Q03 A;  4KDS A;  3F02 A;  3LE2 A;  4ROA A;  2HIJ I;  3DRM A;  4DY7 C;  1UHG A;  1OO8 A;  2GD4 C;  4AJU A;  2ARR A;  4AU2 A;  1LQ8 A;  3NDF A;  2ARQ A;  4ZK0 A;  2B4X L;  4G8O A;  4AU4 A;  1DZH I;  1HLE A;  2RIV A;  4CAA A;  1QLP A;  2CEO A;  3DY0 A;  1C8O A;  1KCT A;  1T1F A;  4IF8 A;  4AU3 B;  2WXZ A;  4BB2 A;  1XQJ A;  3NE4 A;  5BRR I;  4PYW A;  1DVM A;  1NQ9 I;  2RIW A;  4GA7 A;  5INW A;  2OAY A;  4DY0 A;  2WXZ C;  1BR8 I;  2B4X I;  2QUG A;  2HI9 A;  3R4L A;  3EVJ I;  3FGQ A;  1OPH A;  1JRR A;  1F0C A;  3KCG I;  1B3K A;  2ACH A;  2WXX A;  4DTE A;  2H4Q A;  2ANT I;  3UT3 A;  2VH4 A;  4RSQ A;  2R9Y A;  1ATT A;  1JJO C;  4AQH A;  5CE0 A;  1R1L I;  1DZG L;  1DB2 A;  3DLW A;  5CDX A;  3PZF A;  3LW2 A;  1OVA A;  1M93 B;  3NDA A;  1WZ9 A;  3Q02 A;  4AJT A;  4Y40 A;  5CDZ A;  4YIA A;  1XU8 A;  1JTI A;  3NDD A;  3STO A;  2H4P A;  2BEH L;  3CVM A;  1DZG I;  1OVA C;  5IO1 A;  1QMN A;  2H4R A;  3F5N A;  4ROB A;  3T1P A;  1YXA A;  4Y3K A;  1QMB A;  1PSI A;  1ATH A;  1JVQ I;  1DVN A;  1ANT I;  2PEF A;  2ZV6 A;  1SEK A;  2D26 A;  3EOX A;  9PAI A;  1C5G A;  1JMO A;  4AU3 A;  5HGC A;  3B9F I;  4RO9 A;  2BEH I;  4EB1 L;  2WXY C;  1E05 I;  4P0F A;  1LK6 I;  9API A;  1XQG A;  4P0O A;  2V95 A;  4ZK3 A;  7API A;  1D5S A;  1OVA B;  3DRU A;  1K9O I;  2WY0 C;  1OYH L;  8API A;  4G8R A;  1LJ5 A;  2XN5 A;  3VVJ A;  3OZQ A;  2XN7 A;  1AZX I;  3CWM A;  3H5C A;  4EB1 I;  2WY1 A;  3PB1 I;  1IZ2 A;  1IMV A;  1EZX A;  1JMJ A;  1OC0 A;  2VDY A;  2WXW A;  2XN6 A;  4R9I A;  3ZHA A;  4AFX A;  1SNG A;  2HIJ L;  1E03 I;  1SR5 A;  4X30 A;  1BY7 A;  1OYH I;  5C98 A;  3CWL A;  4IC0 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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