4RSQA

2.9a resolution structure of srpn2 (k198c/e359c) from anopheles gambiae
Total Genus 109
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
109
sequence length
383
structure length
356
Chain Sequence
GPFQGQRQNEFDLMFVKEIFKNHNSNVVLSPFSVKILLTLIYEASDTSFGNTKRELSSVIQNDNIDHTRSYYKQLLESAQQDNKDYDLNIATNFFVDDFIEVINKYQQIANTHYHAMLEKVSYSNPTQTAATINNWVSEHTNGRLREIVTPDSLEGAVITLVNVIYFCGLWTYPFPEVNVKPFYGTRGKPTNAQYMEQNGQFYYDNSADLGAQILRLPYRGNKLAMYFILPNPDNTVNQVLDRINSASLHQALWYMEENEVNVTLPKFKFDFSEQLNEPLQQVGIREIFSQNASLPLLARGEVRVSRIFQKAGITINELGSCAVQIFNANRPFIFFIEDETLGTMLFAGKIENPVF
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural and Inhibitory Effects of Hinge Loop Mutagenesis in Serpin-2 from the Malaria Vector Anopheles gambiae.
pubmed doi rcsb
molecule keywords Serpin 2
molecule tags Hydrolase inhibitor
source organism Anopheles gambiae
total genus 109
structure length 356
sequence length 383
chains with identical sequence B, C, D, E, F, G, H, I, J, K, L
ec nomenclature
pdb deposition date 2014-11-10

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00079 Serpin Serpin (serine protease inhibitor)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.30.39.10 Mainly Beta Roll Alpha-1-antitrypsin; domain 1 Alpha-1-antitrypsin, domain 1 4rsqA01
3.30.497.10 Alpha Beta 2-Layer Sandwich Antithrombin; Chain I, domain 2 Antithrombin, subunit I, domain 2 4rsqA02
1DVNA 4G8RA 1XQGA 4YIAA 4IF8A 3Q02A 1ATTA 1LJ5A 2DUTA 2VDXA 4AJUA 3DRUA 3DRMA 5INWA 1QLPA 1UHGA 1PSIA 1KCTA 1OC0A 1AZXI 3B9FI 4R9IA 4AU3B 3VVJA 4AU4A 2HIJI 1ATHA 5CE0A 1F0CA 2PEFA 1YXAA 2ARRA 3DLWA 2H4RA 3F1SA 4IC0A 1DB2A 1OO8A 2V95A 2ARQA 1D5SA 1C5GA 1SNGA 3LW2A 2ACHA 4CAAA 3OZQA 1R1LI 1K9OI 1TB6I 1ANTI 1E03I 4RSQA 2GD4C 1AS4A 1OYHL 1LQ8A 4P0OA 2VH4A 4RO9A 4AFXA 3KCGI 4DTEA 4EB1I 1OVAB 2CEOA 3F02A 3NDFA 2BEHL 3EOXA 4AJTA 5CDZA 1OPHA 4AU2A 3STOA 2OL2A 4AU3A 4C49A 2WXXA 3LE2A 2ZNHA 5BRRI 1WZ9A 1M93B 2XN7A 3PZFA 3T1PA 1IZ2A 2RIWA 4P0FA 2BEHI 4KDSA 2B4XL 3UT3A 4Y40A 9APIA 1JMOA 2OAYA 5EI0A 2WY0C 2XN6A 2WXWA 3DY0A 3H5CA 1B3KA 3R4LA 4AQHA 1T1FA 4ROBA 3F5NA 9PAIA 2WXZA 4BB2A 4ZK3A 2R9YA 2B5TI 1JVQI 4C41A 1QMNA 1DZHL 1OVAA 4PYWA 2D26A 4ZK0A 2PEEA 1JTIA 1OYHI 1A7CA 1JJOC 2HI9A 3PB1I 1NQ9I 1IMVA 3NDAA 1BY7A 4ROAA 3CWMA 1SR5A 4DY0A 2HIJL 2RIVA 5IO1A 7APIA 5CDXA 1QMBA 3NDDA 2XN5A 3CVMA 4G8OA 2H4QA 2VDYA 1DVMA 2QUGA 2ZV6A 3ZHAA 2WXYC 1DZHI 2XN3A 1HP7A 4GA7A 4Y3KA 1DZGL 1XQJA 8APIA 5HGCA 1XU8A 2H4PA 1JMJA 3FGQA 1LK6I 5C98A 1MTPA 1E05I 1C8OA 2WXZC 2WY1A 1HLEA 1E04I 1SEKA 3NE4A 1BR8I 4X30A 1OVAC 1EZXA 2ANTI 4EB1L 3CAAA 2B4XI 1ATUA 1DZGI 4DY7C 1JRRA 3CWLA 3Q03A 3EVJI
chains in the Genus database with same CATH superfamily
1DVNA 4G8RA 1XQGA 4YIAA 4IF8A 3Q02A 1ATTA 1LJ5A 2DUTA 2VDXA 4AJUA 3DRUA 3DRMA 5INWA 1QLPA 1UHGA 1PSIA 1KCTA 1OC0A 1AZXI 3B9FI 4R9IA 4AU3B 3VVJA 4AU4A 2HIJI 1ATHA 5CE0A 1F0CA 2PEFA 1YXAA 2ARRA 3DLWA 2H4RA 3F1SA 4IC0A 1DB2A 1OO8A 2V95A 2ARQA 1D5SA 1C5GA 1SNGA 3LW2A 2ACHA 4CAAA 3OZQA 1R1LI 1K9OI 1TB6I 1ANTI 1E03I 4RSQA 2GD4C 1AS4A 1OYHL 1LQ8A 4P0OA 2VH4A 4RO9A 4AFXA 3KCGI 4DTEA 4EB1I 1OVAB 2CEOA 3F02A 3NDFA 2BEHL 3EOXA 4AJTA 5CDZA 1OPHA 4AU2A 3STOA 2OL2A 4AU3A 4C49A 2WXXA 3LE2A 2ZNHA 5BRRI 1WZ9A 1M93B 2XN7A 3PZFA 3T1PA 1IZ2A 2RIWA 4P0FA 2BEHI 4KDSA 2B4XL 3UT3A 4Y40A 9APIA 1JMOA 2OAYA 5EI0A 2WY0C 2XN6A 2WXWA 3DY0A 3H5CA 1B3KA 3R4LA 4AQHA 1T1FA 4ROBA 3F5NA 9PAIA 2WXZA 4BB2A 4ZK3A 2R9YA 2B5TI 1JVQI 4C41A 1QMNA 1DZHL 1OVAA 4PYWA 2D26A 4ZK0A 2PEEA 1JTIA 1OYHI 1A7CA 1JJOC 2HI9A 3PB1I 1NQ9I 1IMVA 3NDAA 1BY7A 4ROAA 3CWMA 1SR5A 4DY0A 2HIJL 2RIVA 5IO1A 7APIA 5CDXA 1QMBA 3NDDA 2XN5A 3CVMA 4G8OA 2H4QA 2VDYA 1DVMA 2QUGA 2ZV6A 3ZHAA 2WXYC 1DZHI 2XN3A 1HP7A 4GA7A 4Y3KA 1DZGL 1XQJA 8APIA 5HGCA 1XU8A 2H4PA 1JMJA 3FGQA 1LK6I 5C98A 1MTPA 1E05I 1C8OA 2WXZC 2WY1A 1HLEA 1E04I 1SEKA 3NE4A 1BR8I 4X30A 1OVAC 1EZXA 2ANTI 4EB1L 3CAAA 2B4XI 1ATUA 1DZGI 4DY7C 1JRRA 3CWLA 3Q03A 3EVJI
chains in the Genus database with same CATH topology
1DVNA 4G8RA 1XQGA 4YIAA 4IF8A 3Q02A 1ATTA 1LJ5A 2DUTA 2VDXA 4AJUA 3DRUA 3DRMA 5INWA 1QLPA 1UHGA 1PSIA 1KCTA 1OC0A 1AZXI 3B9FI 4R9IA 4AU3B 3VVJA 4AU4A 2HIJI 1ATHA 5CE0A 1F0CA 2PEFA 1YXAA 2ARRA 3DLWA 2H4RA 3F1SA 4IC0A 1DB2A 1OO8A 2V95A 2ARQA 1D5SA 1C5GA 1SNGA 3LW2A 2ACHA 4CAAA 3OZQA 1R1LI 1K9OI 1TB6I 1ANTI 1E03I 4RSQA 2GD4C 1AS4A 1OYHL 1LQ8A 4P0OA 2VH4A 4RO9A 4AFXA 3KCGI 4DTEA 4EB1I 1OVAB 2CEOA 3F02A 3NDFA 2BEHL 3EOXA 4AJTA 5CDZA 1OPHA 4AU2A 3STOA 2OL2A 4AU3A 4C49A 2WXXA 3LE2A 2ZNHA 5BRRI 1WZ9A 1M93B 2XN7A 3PZFA 3T1PA 1IZ2A 2RIWA 4P0FA 2BEHI 4KDSA 2B4XL 3UT3A 4Y40A 9APIA 1JMOA 2OAYA 5EI0A 2WY0C 2XN6A 2WXWA 3DY0A 3H5CA 1B3KA 3R4LA 4AQHA 1T1FA 4ROBA 3F5NA 9PAIA 2WXZA 4BB2A 4ZK3A 2R9YA 2B5TI 1JVQI 4C41A 1QMNA 1DZHL 1OVAA 4PYWA 2D26A 4ZK0A 2PEEA 1JTIA 1OYHI 1A7CA 1JJOC 2HI9A 3PB1I 1NQ9I 1IMVA 3NDAA 1BY7A 4ROAA 3CWMA 1SR5A 4DY0A 2HIJL 2RIVA 5IO1A 7APIA 5CDXA 1QMBA 3NDDA 2XN5A 3CVMA 4G8OA 2H4QA 2VDYA 1DVMA 2QUGA 2ZV6A 3ZHAA 2WXYC 1DZHI 2XN3A 1HP7A 4GA7A 4Y3KA 1DZGL 1XQJA 8APIA 5HGCA 1XU8A 2H4PA 1JMJA 3FGQA 1LK6I 5C98A 1MTPA 1E05I 1C8OA 2WXZC 2WY1A 1HLEA 1E04I 1SEKA 3NE4A 1BR8I 4X30A 1OVAC 1EZXA 2ANTI 4EB1L 3CAAA 2B4XI 1ATUA 1DZGI 4DY7C 1JRRA 3CWLA 3Q03A 3EVJI
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1DVN A;  4G8R A;  1XQG A;  4YIA A;  4IF8 A;  3Q02 A;  1ATT A;  1LJ5 A;  2DUT A;  2VDX A;  4AJU A;  3DRU A;  3DRM A;  5INW A;  1QLP A;  1UHG A;  1PSI A;  1KCT A;  1OC0 A;  1AZX I;  3B9F I;  4R9I A;  4AU3 B;  3VVJ A;  4AU4 A;  2HIJ I;  1ATH A;  5CE0 A;  1F0C A;  2PEF A;  1YXA A;  2ARR A;  3DLW A;  2H4R A;  3F1S A;  4IC0 A;  1DB2 A;  1OO8 A;  2V95 A;  2ARQ A;  1D5S A;  1C5G A;  1SNG A;  3LW2 A;  2ACH A;  4CAA A;  3OZQ A;  1R1L I;  1K9O I;  1TB6 I;  1ANT I;  1E03 I;  4RSQ A;  2GD4 C;  1AS4 A;  1OYH L;  1LQ8 A;  4P0O A;  2VH4 A;  4RO9 A;  4AFX A;  3KCG I;  4DTE A;  4EB1 I;  1OVA B;  2CEO A;  3F02 A;  3NDF A;  2BEH L;  3EOX A;  4AJT A;  5CDZ A;  1OPH A;  4AU2 A;  3STO A;  2OL2 A;  4AU3 A;  4C49 A;  2WXX A;  3LE2 A;  2ZNH A;  5BRR I;  1WZ9 A;  1M93 B;  2XN7 A;  3PZF A;  3T1P A;  1IZ2 A;  2RIW A;  4P0F A;  2BEH I;  4KDS A;  2B4X L;  3UT3 A;  4Y40 A;  9API A;  1JMO A;  2OAY A;  5EI0 A;  2WY0 C;  2XN6 A;  2WXW A;  3DY0 A;  3H5C A;  1B3K A;  3R4L A;  4AQH A;  1T1F A;  4ROB A;  3F5N A;  9PAI A;  2WXZ A;  4BB2 A;  4ZK3 A;  2R9Y A;  2B5T I;  1JVQ I;  4C41 A;  1QMN A;  1DZH L;  1OVA A;  4PYW A;  2D26 A;  4ZK0 A;  2PEE A;  1JTI A;  1OYH I;  1A7C A;  1JJO C;  2HI9 A;  3PB1 I;  1NQ9 I;  1IMV A;  3NDA A;  1BY7 A;  4ROA A;  3CWM A;  1SR5 A;  4DY0 A;  2HIJ L;  2RIV A;  5IO1 A;  7API A;  5CDX A;  1QMB A;  3NDD A;  2XN5 A;  3CVM A;  4G8O A;  2H4Q A;  2VDY A;  1DVM A;  2QUG A;  2ZV6 A;  3ZHA A;  2WXY C;  1DZH I;  2XN3 A;  1HP7 A;  4GA7 A;  4Y3K A;  1DZG L;  1XQJ A;  8API A;  5HGC A;  1XU8 A;  2H4P A;  1JMJ A;  3FGQ A;  1LK6 I;  5C98 A;  1MTP A;  1E05 I;  1C8O A;  2WXZ C;  2WY1 A;  1HLE A;  1E04 I;  1SEK A;  3NE4 A;  1BR8 I;  4X30 A;  1OVA C;  1EZX A;  2ANT I;  4EB1 L;  3CAA A;  2B4X I;  1ATU A;  1DZG I;  4DY7 C;  1JRR A;  3CWL A;  3Q03 A;  3EVJ I; 
#chains in the Genus database with same CATH topology
 1DVN A;  4G8R A;  1XQG A;  4YIA A;  4IF8 A;  3Q02 A;  1ATT A;  1LJ5 A;  2DUT A;  2VDX A;  4AJU A;  3DRU A;  3DRM A;  5INW A;  1QLP A;  1UHG A;  1PSI A;  1KCT A;  1OC0 A;  1AZX I;  3B9F I;  4R9I A;  4AU3 B;  3VVJ A;  4AU4 A;  2HIJ I;  1ATH A;  5CE0 A;  1F0C A;  2PEF A;  1YXA A;  2ARR A;  3DLW A;  2H4R A;  3F1S A;  4IC0 A;  1DB2 A;  1OO8 A;  2V95 A;  2ARQ A;  1D5S A;  1C5G A;  1SNG A;  3LW2 A;  2ACH A;  4CAA A;  3OZQ A;  1R1L I;  1K9O I;  1TB6 I;  1ANT I;  1E03 I;  4RSQ A;  2GD4 C;  1AS4 A;  1OYH L;  1LQ8 A;  4P0O A;  2VH4 A;  4RO9 A;  4AFX A;  3KCG I;  4DTE A;  4EB1 I;  1OVA B;  2CEO A;  3F02 A;  3NDF A;  2BEH L;  3EOX A;  4AJT A;  5CDZ A;  1OPH A;  4AU2 A;  3STO A;  2OL2 A;  4AU3 A;  4C49 A;  2WXX A;  3LE2 A;  2ZNH A;  5BRR I;  1WZ9 A;  1M93 B;  2XN7 A;  3PZF A;  3T1P A;  1IZ2 A;  2RIW A;  4P0F A;  2BEH I;  4KDS A;  2B4X L;  3UT3 A;  4Y40 A;  9API A;  1JMO A;  2OAY A;  5EI0 A;  2WY0 C;  2XN6 A;  2WXW A;  3DY0 A;  3H5C A;  1B3K A;  3R4L A;  4AQH A;  1T1F A;  4ROB A;  3F5N A;  9PAI A;  2WXZ A;  4BB2 A;  4ZK3 A;  2R9Y A;  2B5T I;  1JVQ I;  4C41 A;  1QMN A;  1DZH L;  1OVA A;  4PYW A;  2D26 A;  4ZK0 A;  2PEE A;  1JTI A;  1OYH I;  1A7C A;  1JJO C;  2HI9 A;  3PB1 I;  1NQ9 I;  1IMV A;  3NDA A;  1BY7 A;  4ROA A;  3CWM A;  1SR5 A;  4DY0 A;  2HIJ L;  2RIV A;  5IO1 A;  7API A;  5CDX A;  1QMB A;  3NDD A;  2XN5 A;  3CVM A;  4G8O A;  2H4Q A;  2VDY A;  1DVM A;  2QUG A;  2ZV6 A;  3ZHA A;  2WXY C;  1DZH I;  2XN3 A;  1HP7 A;  4GA7 A;  4Y3K A;  1DZG L;  1XQJ A;  8API A;  5HGC A;  1XU8 A;  2H4P A;  1JMJ A;  3FGQ A;  1LK6 I;  5C98 A;  1MTP A;  1E05 I;  1C8O A;  2WXZ C;  2WY1 A;  1HLE A;  1E04 I;  1SEK A;  3NE4 A;  1BR8 I;  4X30 A;  1OVA C;  1EZX A;  2ANT I;  4EB1 L;  3CAA A;  2B4X I;  1ATU A;  1DZG I;  4DY7 C;  1JRR A;  3CWL A;  3Q03 A;  3EVJ I; 
#chains in the Genus database with same CATH homology
 1DVN A;  4G8R A;  1XQG A;  4YIA A;  4IF8 A;  3Q02 A;  1ATT A;  1LJ5 A;  2DUT A;  2VDX A;  4AJU A;  3DRU A;  3DRM A;  5INW A;  1QLP A;  1UHG A;  1PSI A;  1KCT A;  1OC0 A;  1AZX I;  3B9F I;  4R9I A;  4AU3 B;  3VVJ A;  4AU4 A;  2HIJ I;  1ATH A;  5CE0 A;  1F0C A;  2PEF A;  1YXA A;  2ARR A;  3DLW A;  2H4R A;  3F1S A;  4IC0 A;  1DB2 A;  1OO8 A;  2V95 A;  2ARQ A;  1D5S A;  1C5G A;  1SNG A;  3LW2 A;  2ACH A;  4CAA A;  3OZQ A;  1R1L I;  1K9O I;  1TB6 I;  1ANT I;  1E03 I;  4RSQ A;  2GD4 C;  1AS4 A;  1OYH L;  1LQ8 A;  4P0O A;  2VH4 A;  4RO9 A;  4AFX A;  3KCG I;  4DTE A;  4EB1 I;  1OVA B;  2CEO A;  3F02 A;  3NDF A;  2BEH L;  3EOX A;  4AJT A;  5CDZ A;  1OPH A;  4AU2 A;  3STO A;  2OL2 A;  4AU3 A;  4C49 A;  2WXX A;  3LE2 A;  2ZNH A;  5BRR I;  1WZ9 A;  1M93 B;  2XN7 A;  3PZF A;  3T1P A;  1IZ2 A;  2RIW A;  4P0F A;  2BEH I;  4KDS A;  2B4X L;  3UT3 A;  4Y40 A;  9API A;  1JMO A;  2OAY A;  5EI0 A;  2WY0 C;  2XN6 A;  2WXW A;  3DY0 A;  3H5C A;  1B3K A;  3R4L A;  4AQH A;  1T1F A;  4ROB A;  3F5N A;  9PAI A;  2WXZ A;  4BB2 A;  4ZK3 A;  2R9Y A;  2B5T I;  1JVQ I;  4C41 A;  1QMN A;  1DZH L;  1OVA A;  4PYW A;  2D26 A;  4ZK0 A;  2PEE A;  1JTI A;  1OYH I;  1A7C A;  1JJO C;  2HI9 A;  3PB1 I;  1NQ9 I;  1IMV A;  3NDA A;  1BY7 A;  4ROA A;  3CWM A;  1SR5 A;  4DY0 A;  2HIJ L;  2RIV A;  5IO1 A;  7API A;  5CDX A;  1QMB A;  3NDD A;  2XN5 A;  3CVM A;  4G8O A;  2H4Q A;  2VDY A;  1DVM A;  2QUG A;  2ZV6 A;  3ZHA A;  2WXY C;  1DZH I;  2XN3 A;  1HP7 A;  4GA7 A;  4Y3K A;  1DZG L;  1XQJ A;  8API A;  5HGC A;  1XU8 A;  2H4P A;  1JMJ A;  3FGQ A;  1LK6 I;  5C98 A;  1MTP A;  1E05 I;  1C8O A;  2WXZ C;  2WY1 A;  1HLE A;  1E04 I;  1SEK A;  3NE4 A;  1BR8 I;  4X30 A;  1OVA C;  1EZX A;  2ANT I;  4EB1 L;  3CAA A;  2B4X I;  1ATU A;  1DZG I;  4DY7 C;  1JRR A;  3CWL A;  3Q03 A;  3EVJ I; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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