4EB1I

Hyperstable in-frame insertion variant of antithrombin
Total Genus 118
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
118
sequence length
436
structure length
411
Chain Sequence
VDICTAKPRDIPMNPMCIYRSPENRRVWELSKANSRFATTFYQHLADSKNDNDNIFLSPLSISTAFAMTKLGACNDTLQQLMEVFKFDTISEKTSDQIHFFFAKLNCRLYRKANKASKLVSANRLFGDKSLTFNETYQDISELVYGAKLQPLDFKENAEQSRAAINKWVSNKTEDVIPSEAINVLVLVNTRTSTVLVLVNTIYFKGLWKSKFSPENTRKELFYKADGESCSASMMYQEGKFRYRRVAEGTQVLELPFKGDDITMVLILPKPEKSLAKVEKELTPEVLQEWLDELEEMMLVVHMPRFRIEDGFSLKEQLQDMGLVDLFSPEKSKLPGIVADLYVSDAFHKAFLEVNEEGSEAAASTAVVIAGRSLNPNRVTFKANRPFLVFIREVPLNTIIFMGRVANPCVK
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Type II antithrombin deficiency caused by a large in-frame insertion: structural, functional and pathological relevance.
pubmed doi rcsb
molecule keywords Antithrombin-III
molecule tags Blood clotting
source organism Homo sapiens
total genus 118
structure length 411
sequence length 436
ec nomenclature
pdb deposition date 2012-03-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
I PF00079 Serpin Serpin (serine protease inhibitor)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.30.39.10 Mainly Beta Roll Alpha-1-antitrypsin; domain 1 Alpha-1-antitrypsin, domain 1 4eb1I02
3.30.497.10 Alpha Beta 2-Layer Sandwich Antithrombin; Chain I, domain 2 Antithrombin, subunit I, domain 2 4eb1I01
1JVQI 3CWLA 4IC0A 3F02A 4KDSA 4BB2A 2WY0C 1OVAA 4CAAA 2B4XI 5IO1A 2XN7A 2WXYC 4AU3B 1NQ9I 1JRRA 2B4XL 1OVAC 1ATUA 1OYHI 1OC0A 1C5GA 4X30A 4C49A 1QMNA 1SEKA 1MTPA 2H4QA 3T1PA 2VDYA 2ZNHA 1OYHL 4ZK0A 2OL2A 4ROAA 3VVJA 1XQJA 2WXXA 3EVJI 3NE4A 4AFXA 3H5CA 5CE0A 1OVAB 3R4LA 8APIA 3FGQA 1M93B 1LK6I 1IZ2A 5HGCA 3NDDA 1WZ9A 1OPHA 1XQGA 1IMVA 5EI0A 3ZHAA 1EZXA 4EB1I 1B3KA 3Q03A 1OO8A 4EB1L 3B9FI 2ANTI 1JTIA 2V95A 4RSQA 1DZHI 3EOXA 1D5SA 1DZGI 1AZXI 1K9OI 2H4RA 3DY0A 3NDFA 1BY7A 1DZGL 9PAIA 1LJ5A 2VDXA 1T1FA 2PEEA 1E04I 5INWA 7APIA 2XN3A 2WXZA 3LW2A 4PYWA 4Y40A 2WXWA 2CEOA 1PSIA 3STOA 4AJTA 1A7CA 4AU2A 1E05I 2WXZC 1DVMA 1AS4A 1C8OA 2ACHA 2GD4C 2VH4A 3DLWA 4IF8A 2BEHI 4RO9A 4DY7C 2DUTA 3F5NA 2R9YA 5C98A 2BEHL 2XN6A 2HI9A 3CVMA 2ARQA 2WY1A 4ROBA 4DTEA 1BR8I 1DZHL 3DRMA 9APIA 3KCGI 2D26A 2HIJI 2QUGA 1DB2A 1JMJA 3DRUA 4C41A 1TB6I 2RIWA 2HIJL 2B5TI 3Q02A 2RIVA 4AQHA 5CDZA 3CWMA 5CDXA 3PZFA 4YIAA 1ATHA 2OAYA 1DVNA 1QMBA 3NDAA 1SR5A 5BRRI 3UT3A 2ARRA 1SNGA 4Y3KA 4ZK3A 1JMOA 1HP7A 1LQ8A 1YXAA 3F1SA 2H4PA 3LE2A 1F0CA 4G8OA 4G8RA 1R1LI 4P0OA 4GA7A 4AJUA 4AU4A 4DY0A 1XU8A 2ZV6A 4AU3A 1UHGA 3OZQA 4P0FA 1JJOC 3PB1I 4R9IA 1ANTI 2XN5A 1HLEA 1QLPA 3CAAA 1ATTA 2PEFA 1E03I 1KCTA
chains in the Genus database with same CATH superfamily
1JVQI 3CWLA 4IC0A 3F02A 4KDSA 4BB2A 2WY0C 1OVAA 4CAAA 2B4XI 5IO1A 2XN7A 2WXYC 4AU3B 1NQ9I 1JRRA 2B4XL 1OVAC 1ATUA 1OYHI 1OC0A 1C5GA 4X30A 4C49A 1QMNA 1SEKA 1MTPA 2H4QA 3T1PA 2VDYA 2ZNHA 1OYHL 4ZK0A 2OL2A 4ROAA 3VVJA 1XQJA 2WXXA 3EVJI 3NE4A 4AFXA 3H5CA 5CE0A 1OVAB 3R4LA 8APIA 3FGQA 1M93B 1LK6I 1IZ2A 5HGCA 3NDDA 1WZ9A 1OPHA 1XQGA 1IMVA 5EI0A 3ZHAA 1EZXA 4EB1I 1B3KA 3Q03A 1OO8A 4EB1L 3B9FI 2ANTI 1JTIA 2V95A 4RSQA 1DZHI 3EOXA 1D5SA 1DZGI 1AZXI 1K9OI 2H4RA 3DY0A 3NDFA 1BY7A 1DZGL 9PAIA 1LJ5A 2VDXA 1T1FA 2PEEA 1E04I 5INWA 7APIA 2XN3A 2WXZA 3LW2A 4PYWA 4Y40A 2WXWA 2CEOA 1PSIA 3STOA 4AJTA 1A7CA 4AU2A 1E05I 2WXZC 1DVMA 1AS4A 1C8OA 2ACHA 2GD4C 2VH4A 3DLWA 4IF8A 2BEHI 4RO9A 4DY7C 2DUTA 3F5NA 2R9YA 5C98A 2BEHL 2XN6A 2HI9A 3CVMA 2ARQA 2WY1A 4ROBA 4DTEA 1BR8I 1DZHL 3DRMA 9APIA 3KCGI 2D26A 2HIJI 2QUGA 1DB2A 1JMJA 3DRUA 4C41A 1TB6I 2RIWA 2HIJL 2B5TI 3Q02A 2RIVA 4AQHA 5CDZA 3CWMA 5CDXA 3PZFA 4YIAA 1ATHA 2OAYA 1DVNA 1QMBA 3NDAA 1SR5A 5BRRI 3UT3A 2ARRA 1SNGA 4Y3KA 4ZK3A 1JMOA 1HP7A 1LQ8A 1YXAA 3F1SA 2H4PA 3LE2A 1F0CA 4G8OA 4G8RA 1R1LI 4P0OA 4GA7A 4AJUA 4AU4A 4DY0A 1XU8A 2ZV6A 4AU3A 1UHGA 3OZQA 4P0FA 1JJOC 3PB1I 4R9IA 1ANTI 2XN5A 1HLEA 1QLPA 3CAAA 1ATTA 2PEFA 1E03I 1KCTA
chains in the Genus database with same CATH topology
1JVQI 3CWLA 4IC0A 3F02A 4KDSA 4BB2A 2WY0C 1OVAA 4CAAA 2B4XI 5IO1A 2XN7A 2WXYC 4AU3B 1NQ9I 1JRRA 2B4XL 1OVAC 1ATUA 1OYHI 1OC0A 1C5GA 4X30A 4C49A 1QMNA 1SEKA 1MTPA 2H4QA 3T1PA 2VDYA 2ZNHA 1OYHL 4ZK0A 2OL2A 4ROAA 3VVJA 1XQJA 2WXXA 3EVJI 3NE4A 4AFXA 3H5CA 5CE0A 1OVAB 3R4LA 8APIA 3FGQA 1M93B 1LK6I 1IZ2A 5HGCA 3NDDA 1WZ9A 1OPHA 1XQGA 1IMVA 5EI0A 3ZHAA 1EZXA 4EB1I 1B3KA 3Q03A 1OO8A 4EB1L 3B9FI 2ANTI 1JTIA 2V95A 4RSQA 1DZHI 3EOXA 1D5SA 1DZGI 1AZXI 1K9OI 2H4RA 3DY0A 3NDFA 1BY7A 1DZGL 9PAIA 1LJ5A 2VDXA 1T1FA 2PEEA 1E04I 5INWA 7APIA 2XN3A 2WXZA 3LW2A 4PYWA 4Y40A 2WXWA 2CEOA 1PSIA 3STOA 4AJTA 1A7CA 4AU2A 1E05I 2WXZC 1DVMA 1AS4A 1C8OA 2ACHA 2GD4C 2VH4A 3DLWA 4IF8A 2BEHI 4RO9A 4DY7C 2DUTA 3F5NA 2R9YA 5C98A 2BEHL 2XN6A 2HI9A 3CVMA 2ARQA 2WY1A 4ROBA 4DTEA 1BR8I 1DZHL 3DRMA 9APIA 3KCGI 2D26A 2HIJI 2QUGA 1DB2A 1JMJA 3DRUA 4C41A 1TB6I 2RIWA 2HIJL 2B5TI 3Q02A 2RIVA 4AQHA 5CDZA 3CWMA 5CDXA 3PZFA 4YIAA 1ATHA 2OAYA 1DVNA 1QMBA 3NDAA 1SR5A 5BRRI 3UT3A 2ARRA 1SNGA 4Y3KA 4ZK3A 1JMOA 1HP7A 1LQ8A 1YXAA 3F1SA 2H4PA 3LE2A 1F0CA 4G8OA 4G8RA 1R1LI 4P0OA 4GA7A 4AJUA 4AU4A 4DY0A 1XU8A 2ZV6A 4AU3A 1UHGA 3OZQA 4P0FA 1JJOC 3PB1I 4R9IA 1ANTI 2XN5A 1HLEA 1QLPA 3CAAA 1ATTA 2PEFA 1E03I 1KCTA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1JVQ I;  3CWL A;  4IC0 A;  3F02 A;  4KDS A;  4BB2 A;  2WY0 C;  1OVA A;  4CAA A;  2B4X I;  5IO1 A;  2XN7 A;  2WXY C;  4AU3 B;  1NQ9 I;  1JRR A;  2B4X L;  1OVA C;  1ATU A;  1OYH I;  1OC0 A;  1C5G A;  4X30 A;  4C49 A;  1QMN A;  1SEK A;  1MTP A;  2H4Q A;  3T1P A;  2VDY A;  2ZNH A;  1OYH L;  4ZK0 A;  2OL2 A;  4ROA A;  3VVJ A;  1XQJ A;  2WXX A;  3EVJ I;  3NE4 A;  4AFX A;  3H5C A;  5CE0 A;  1OVA B;  3R4L A;  8API A;  3FGQ A;  1M93 B;  1LK6 I;  1IZ2 A;  5HGC A;  3NDD A;  1WZ9 A;  1OPH A;  1XQG A;  1IMV A;  5EI0 A;  3ZHA A;  1EZX A;  4EB1 I;  1B3K A;  3Q03 A;  1OO8 A;  4EB1 L;  3B9F I;  2ANT I;  1JTI A;  2V95 A;  4RSQ A;  1DZH I;  3EOX A;  1D5S A;  1DZG I;  1AZX I;  1K9O I;  2H4R A;  3DY0 A;  3NDF A;  1BY7 A;  1DZG L;  9PAI A;  1LJ5 A;  2VDX A;  1T1F A;  2PEE A;  1E04 I;  5INW A;  7API A;  2XN3 A;  2WXZ A;  3LW2 A;  4PYW A;  4Y40 A;  2WXW A;  2CEO A;  1PSI A;  3STO A;  4AJT A;  1A7C A;  4AU2 A;  1E05 I;  2WXZ C;  1DVM A;  1AS4 A;  1C8O A;  2ACH A;  2GD4 C;  2VH4 A;  3DLW A;  4IF8 A;  2BEH I;  4RO9 A;  4DY7 C;  2DUT A;  3F5N A;  2R9Y A;  5C98 A;  2BEH L;  2XN6 A;  2HI9 A;  3CVM A;  2ARQ A;  2WY1 A;  4ROB A;  4DTE A;  1BR8 I;  1DZH L;  3DRM A;  9API A;  3KCG I;  2D26 A;  2HIJ I;  2QUG A;  1DB2 A;  1JMJ A;  3DRU A;  4C41 A;  1TB6 I;  2RIW A;  2HIJ L;  2B5T I;  3Q02 A;  2RIV A;  4AQH A;  5CDZ A;  3CWM A;  5CDX A;  3PZF A;  4YIA A;  1ATH A;  2OAY A;  1DVN A;  1QMB A;  3NDA A;  1SR5 A;  5BRR I;  3UT3 A;  2ARR A;  1SNG A;  4Y3K A;  4ZK3 A;  1JMO A;  1HP7 A;  1LQ8 A;  1YXA A;  3F1S A;  2H4P A;  3LE2 A;  1F0C A;  4G8O A;  4G8R A;  1R1L I;  4P0O A;  4GA7 A;  4AJU A;  4AU4 A;  4DY0 A;  1XU8 A;  2ZV6 A;  4AU3 A;  1UHG A;  3OZQ A;  4P0F A;  1JJO C;  3PB1 I;  4R9I A;  1ANT I;  2XN5 A;  1HLE A;  1QLP A;  3CAA A;  1ATT A;  2PEF A;  1E03 I;  1KCT A; 
#chains in the Genus database with same CATH topology
 1JVQ I;  3CWL A;  4IC0 A;  3F02 A;  4KDS A;  4BB2 A;  2WY0 C;  1OVA A;  4CAA A;  2B4X I;  5IO1 A;  2XN7 A;  2WXY C;  4AU3 B;  1NQ9 I;  1JRR A;  2B4X L;  1OVA C;  1ATU A;  1OYH I;  1OC0 A;  1C5G A;  4X30 A;  4C49 A;  1QMN A;  1SEK A;  1MTP A;  2H4Q A;  3T1P A;  2VDY A;  2ZNH A;  1OYH L;  4ZK0 A;  2OL2 A;  4ROA A;  3VVJ A;  1XQJ A;  2WXX A;  3EVJ I;  3NE4 A;  4AFX A;  3H5C A;  5CE0 A;  1OVA B;  3R4L A;  8API A;  3FGQ A;  1M93 B;  1LK6 I;  1IZ2 A;  5HGC A;  3NDD A;  1WZ9 A;  1OPH A;  1XQG A;  1IMV A;  5EI0 A;  3ZHA A;  1EZX A;  4EB1 I;  1B3K A;  3Q03 A;  1OO8 A;  4EB1 L;  3B9F I;  2ANT I;  1JTI A;  2V95 A;  4RSQ A;  1DZH I;  3EOX A;  1D5S A;  1DZG I;  1AZX I;  1K9O I;  2H4R A;  3DY0 A;  3NDF A;  1BY7 A;  1DZG L;  9PAI A;  1LJ5 A;  2VDX A;  1T1F A;  2PEE A;  1E04 I;  5INW A;  7API A;  2XN3 A;  2WXZ A;  3LW2 A;  4PYW A;  4Y40 A;  2WXW A;  2CEO A;  1PSI A;  3STO A;  4AJT A;  1A7C A;  4AU2 A;  1E05 I;  2WXZ C;  1DVM A;  1AS4 A;  1C8O A;  2ACH A;  2GD4 C;  2VH4 A;  3DLW A;  4IF8 A;  2BEH I;  4RO9 A;  4DY7 C;  2DUT A;  3F5N A;  2R9Y A;  5C98 A;  2BEH L;  2XN6 A;  2HI9 A;  3CVM A;  2ARQ A;  2WY1 A;  4ROB A;  4DTE A;  1BR8 I;  1DZH L;  3DRM A;  9API A;  3KCG I;  2D26 A;  2HIJ I;  2QUG A;  1DB2 A;  1JMJ A;  3DRU A;  4C41 A;  1TB6 I;  2RIW A;  2HIJ L;  2B5T I;  3Q02 A;  2RIV A;  4AQH A;  5CDZ A;  3CWM A;  5CDX A;  3PZF A;  4YIA A;  1ATH A;  2OAY A;  1DVN A;  1QMB A;  3NDA A;  1SR5 A;  5BRR I;  3UT3 A;  2ARR A;  1SNG A;  4Y3K A;  4ZK3 A;  1JMO A;  1HP7 A;  1LQ8 A;  1YXA A;  3F1S A;  2H4P A;  3LE2 A;  1F0C A;  4G8O A;  4G8R A;  1R1L I;  4P0O A;  4GA7 A;  4AJU A;  4AU4 A;  4DY0 A;  1XU8 A;  2ZV6 A;  4AU3 A;  1UHG A;  3OZQ A;  4P0F A;  1JJO C;  3PB1 I;  4R9I A;  1ANT I;  2XN5 A;  1HLE A;  1QLP A;  3CAA A;  1ATT A;  2PEF A;  1E03 I;  1KCT A; 
#chains in the Genus database with same CATH homology
 1JVQ I;  3CWL A;  4IC0 A;  3F02 A;  4KDS A;  4BB2 A;  2WY0 C;  1OVA A;  4CAA A;  2B4X I;  5IO1 A;  2XN7 A;  2WXY C;  4AU3 B;  1NQ9 I;  1JRR A;  2B4X L;  1OVA C;  1ATU A;  1OYH I;  1OC0 A;  1C5G A;  4X30 A;  4C49 A;  1QMN A;  1SEK A;  1MTP A;  2H4Q A;  3T1P A;  2VDY A;  2ZNH A;  1OYH L;  4ZK0 A;  2OL2 A;  4ROA A;  3VVJ A;  1XQJ A;  2WXX A;  3EVJ I;  3NE4 A;  4AFX A;  3H5C A;  5CE0 A;  1OVA B;  3R4L A;  8API A;  3FGQ A;  1M93 B;  1LK6 I;  1IZ2 A;  5HGC A;  3NDD A;  1WZ9 A;  1OPH A;  1XQG A;  1IMV A;  5EI0 A;  3ZHA A;  1EZX A;  4EB1 I;  1B3K A;  3Q03 A;  1OO8 A;  4EB1 L;  3B9F I;  2ANT I;  1JTI A;  2V95 A;  4RSQ A;  1DZH I;  3EOX A;  1D5S A;  1DZG I;  1AZX I;  1K9O I;  2H4R A;  3DY0 A;  3NDF A;  1BY7 A;  1DZG L;  9PAI A;  1LJ5 A;  2VDX A;  1T1F A;  2PEE A;  1E04 I;  5INW A;  7API A;  2XN3 A;  2WXZ A;  3LW2 A;  4PYW A;  4Y40 A;  2WXW A;  2CEO A;  1PSI A;  3STO A;  4AJT A;  1A7C A;  4AU2 A;  1E05 I;  2WXZ C;  1DVM A;  1AS4 A;  1C8O A;  2ACH A;  2GD4 C;  2VH4 A;  3DLW A;  4IF8 A;  2BEH I;  4RO9 A;  4DY7 C;  2DUT A;  3F5N A;  2R9Y A;  5C98 A;  2BEH L;  2XN6 A;  2HI9 A;  3CVM A;  2ARQ A;  2WY1 A;  4ROB A;  4DTE A;  1BR8 I;  1DZH L;  3DRM A;  9API A;  3KCG I;  2D26 A;  2HIJ I;  2QUG A;  1DB2 A;  1JMJ A;  3DRU A;  4C41 A;  1TB6 I;  2RIW A;  2HIJ L;  2B5T I;  3Q02 A;  2RIV A;  4AQH A;  5CDZ A;  3CWM A;  5CDX A;  3PZF A;  4YIA A;  1ATH A;  2OAY A;  1DVN A;  1QMB A;  3NDA A;  1SR5 A;  5BRR I;  3UT3 A;  2ARR A;  1SNG A;  4Y3K A;  4ZK3 A;  1JMO A;  1HP7 A;  1LQ8 A;  1YXA A;  3F1S A;  2H4P A;  3LE2 A;  1F0C A;  4G8O A;  4G8R A;  1R1L I;  4P0O A;  4GA7 A;  4AJU A;  4AU4 A;  4DY0 A;  1XU8 A;  2ZV6 A;  4AU3 A;  1UHG A;  3OZQ A;  4P0F A;  1JJO C;  3PB1 I;  4R9I A;  1ANT I;  2XN5 A;  1HLE A;  1QLP A;  3CAA A;  1ATT A;  2PEF A;  1E03 I;  1KCT A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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