1SEKA

The structure of active serpin k from manduca sexta and a model for serpin-protease complex formation
Total Genus 112
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
112
sequence length
376
structure length
376
Chain Sequence
GETDLQKILRESNDQFTAQMFSEVVKANPGQNVVLSAFSVLPPLGQLALASVGESHDELLRALALPNDNVTKDVFADLNRGVRAVKGVDLKMASKIYVAKGLELNDDFAAVSRDVFGSEVQNVDFVKSVEAAGAINKWVEDQTNNRIKNLVDPDALDETTRSVLVNAIYFKGSWKDKFNKERTMDRDFHVSKDKTIKVPTMIGKKDVRYADVPELDAKMIEMSYEGDQASMIIILPNQVDGITALEQKLKDPKALSRAEERLYNTEVEIYLPKFKIETTTDLKEVLSNMNIKKLFTPGAARLENLLKTKESLYVDAAIQKAFIEVNEEGAEAAAANAFKITTYSFHFVPKVEINKPFFFSLKYNRNSMFSGVCVQP
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title The structure of active serpin 1K from Manduca sexta.
pubmed doi rcsb
molecule tags Serine protease inhibitor
source organism Manduca sexta
molecule keywords SERPIN K
total genus 112
structure length 376
sequence length 376
ec nomenclature
pdb deposition date 1998-03-06

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00079 Serpin Serpin (serine protease inhibitor)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.30.39.10 Mainly Beta Roll Alpha-1-antitrypsin; domain 1 Alpha-1-antitrypsin, domain 1 1sekA02
3.30.497.10 Alpha Beta 2-Layer Sandwich Antithrombin; Chain I, domain 2 Antithrombin, subunit I, domain 2 1sekA01
1LK6I 4G8OA 3DY0A 1DZHL 2BEHI 3CWMA 1SR5A 3PZFA 4ROAA 1LJ5A 1JJOC 1OYHI 1BY7A 4G8RA 2OAYA 1QMNA 1OVAA 1QMBA 4X30A 3F02A 1OC0A 2ARQA 4P0FA 4AJTA 3PB1I 3EVJI 2ACHA 1XQJA 3FGQA 1D5SA 1AS4A 1R1LI 1UHGA 1QLPA 2VH4A 2ARRA 1MTPA 1HLEA 2XN3A 2ANTI 2OL2A 3Q02A 4IC0A 2BEHL 4YIAA 4P0OA 1EZXA 4AJUA 1DZGL 1JTIA 2ZNHA 2WY0C 1JMOA 2V95A 2WXWA 4Y3KA 1OYHL 3DRUA 3OZQA 2QUGA 1ATHA 3NDFA 1YXAA 1PSIA 1F0CA 1IMVA 3LE2A 3DRMA 3VVJA 3B9FI 2CEOA 3CVMA 9PAIA 2HIJL 1LQ8A 2WXZA 4RSQA 4AU3B 3T1PA 5CDXA 3EOXA 1TB6I 2H4QA 4AFXA 4AU4A 4ZK0A 2DUTA 2PEEA 3NDDA 1B3KA 1C8OA 1JVQI 2VDYA 4DTEA 1M93B 3LW2A 4EB1I 1ANTI 4PYWA 1DVMA 3F5NA 1OO8A 4C41A 4AQHA 4AU3A 4GA7A 1E05I 2XN6A 3NDAA 2B5TI 2WY1A 1ATTA 2RIVA 1A7CA 2WXXA 1HP7A 2XN5A 2HI9A 4BB2A 3DLWA 2B4XI 3UT3A 4DY7C 2PEFA 1BR8I 1ATUA 4ZK3A 1OVAC 4Y40A 2ZV6A 5INWA 4EB1L 8APIA 1SNGA 3CWLA 1AZXI 2H4RA 2VDXA 4DY0A 3NE4A 5HGCA 2WXYC 3STOA 4ROBA 2D26A 1WZ9A 3ZHAA 1DVNA 5IO1A 7APIA 1DZGI 3R4LA 4C49A 2GD4C 1E04I 1KCTA 2RIWA 2B4XL 4AU2A 1T1FA 1K9OI 1XU8A 3H5CA 4KDSA 1DZHI 1DB2A 5CE0A 3F1SA 1OPHA 2XN7A 1NQ9I 2HIJI 3KCGI 2R9YA 1C5GA 1JMJA 1IZ2A 2WXZC 5C98A 1SEKA 2H4PA 3CAAA 3Q03A 4RO9A 5EI0A 1OVAB 9APIA 4IF8A 4CAAA 5CDZA 1XQGA 5BRRI 4R9IA 1E03I 1JRRA
chains in the Genus database with same CATH superfamily
1LK6I 4G8OA 3DY0A 1DZHL 2BEHI 3CWMA 1SR5A 3PZFA 4ROAA 1LJ5A 1JJOC 1OYHI 1BY7A 4G8RA 2OAYA 1QMNA 1OVAA 1QMBA 4X30A 3F02A 1OC0A 2ARQA 4P0FA 4AJTA 3PB1I 3EVJI 2ACHA 1XQJA 3FGQA 1D5SA 1AS4A 1R1LI 1UHGA 1QLPA 2VH4A 2ARRA 1MTPA 1HLEA 2XN3A 2ANTI 2OL2A 3Q02A 4IC0A 2BEHL 4YIAA 4P0OA 1EZXA 4AJUA 1DZGL 1JTIA 2ZNHA 2WY0C 1JMOA 2V95A 2WXWA 4Y3KA 1OYHL 3DRUA 3OZQA 2QUGA 1ATHA 3NDFA 1YXAA 1PSIA 1F0CA 1IMVA 3LE2A 3DRMA 3VVJA 3B9FI 2CEOA 3CVMA 9PAIA 2HIJL 1LQ8A 2WXZA 4RSQA 4AU3B 3T1PA 5CDXA 3EOXA 1TB6I 2H4QA 4AFXA 4AU4A 4ZK0A 2DUTA 2PEEA 3NDDA 1B3KA 1C8OA 1JVQI 2VDYA 4DTEA 1M93B 3LW2A 4EB1I 1ANTI 4PYWA 1DVMA 3F5NA 1OO8A 4C41A 4AQHA 4AU3A 4GA7A 1E05I 2XN6A 3NDAA 2B5TI 2WY1A 1ATTA 2RIVA 1A7CA 2WXXA 1HP7A 2XN5A 2HI9A 4BB2A 3DLWA 2B4XI 3UT3A 4DY7C 2PEFA 1BR8I 1ATUA 4ZK3A 1OVAC 4Y40A 2ZV6A 5INWA 4EB1L 8APIA 1SNGA 3CWLA 1AZXI 2H4RA 2VDXA 4DY0A 3NE4A 5HGCA 2WXYC 3STOA 4ROBA 2D26A 1WZ9A 3ZHAA 1DVNA 5IO1A 7APIA 1DZGI 3R4LA 4C49A 2GD4C 1E04I 1KCTA 2RIWA 2B4XL 4AU2A 1T1FA 1K9OI 1XU8A 3H5CA 4KDSA 1DZHI 1DB2A 5CE0A 3F1SA 1OPHA 2XN7A 1NQ9I 2HIJI 3KCGI 2R9YA 1C5GA 1JMJA 1IZ2A 2WXZC 5C98A 1SEKA 2H4PA 3CAAA 3Q03A 4RO9A 5EI0A 1OVAB 9APIA 4IF8A 4CAAA 5CDZA 1XQGA 5BRRI 4R9IA 1E03I 1JRRA
chains in the Genus database with same CATH topology
1LK6I 4G8OA 3DY0A 1DZHL 2BEHI 3CWMA 1SR5A 3PZFA 4ROAA 1LJ5A 1JJOC 1OYHI 1BY7A 4G8RA 2OAYA 1QMNA 1OVAA 1QMBA 4X30A 3F02A 1OC0A 2ARQA 4P0FA 4AJTA 3PB1I 3EVJI 2ACHA 1XQJA 3FGQA 1D5SA 1AS4A 1R1LI 1UHGA 1QLPA 2VH4A 2ARRA 1MTPA 1HLEA 2XN3A 2ANTI 2OL2A 3Q02A 4IC0A 2BEHL 4YIAA 4P0OA 1EZXA 4AJUA 1DZGL 1JTIA 2ZNHA 2WY0C 1JMOA 2V95A 2WXWA 4Y3KA 1OYHL 3DRUA 3OZQA 2QUGA 1ATHA 3NDFA 1YXAA 1PSIA 1F0CA 1IMVA 3LE2A 3DRMA 3VVJA 3B9FI 2CEOA 3CVMA 9PAIA 2HIJL 1LQ8A 2WXZA 4RSQA 4AU3B 3T1PA 5CDXA 3EOXA 1TB6I 2H4QA 4AFXA 4AU4A 4ZK0A 2DUTA 2PEEA 3NDDA 1B3KA 1C8OA 1JVQI 2VDYA 4DTEA 1M93B 3LW2A 4EB1I 1ANTI 4PYWA 1DVMA 3F5NA 1OO8A 4C41A 4AQHA 4AU3A 4GA7A 1E05I 2XN6A 3NDAA 2B5TI 2WY1A 1ATTA 2RIVA 1A7CA 2WXXA 1HP7A 2XN5A 2HI9A 4BB2A 3DLWA 2B4XI 3UT3A 4DY7C 2PEFA 1BR8I 1ATUA 4ZK3A 1OVAC 4Y40A 2ZV6A 5INWA 4EB1L 8APIA 1SNGA 3CWLA 1AZXI 2H4RA 2VDXA 4DY0A 3NE4A 5HGCA 2WXYC 3STOA 4ROBA 2D26A 1WZ9A 3ZHAA 1DVNA 5IO1A 7APIA 1DZGI 3R4LA 4C49A 2GD4C 1E04I 1KCTA 2RIWA 2B4XL 4AU2A 1T1FA 1K9OI 1XU8A 3H5CA 4KDSA 1DZHI 1DB2A 5CE0A 3F1SA 1OPHA 2XN7A 1NQ9I 2HIJI 3KCGI 2R9YA 1C5GA 1JMJA 1IZ2A 2WXZC 5C98A 1SEKA 2H4PA 3CAAA 3Q03A 4RO9A 5EI0A 1OVAB 9APIA 4IF8A 4CAAA 5CDZA 1XQGA 5BRRI 4R9IA 1E03I 1JRRA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1LK6 I;  4G8O A;  3DY0 A;  1DZH L;  2BEH I;  3CWM A;  1SR5 A;  3PZF A;  4ROA A;  1LJ5 A;  1JJO C;  1OYH I;  1BY7 A;  4G8R A;  2OAY A;  1QMN A;  1OVA A;  1QMB A;  4X30 A;  3F02 A;  1OC0 A;  2ARQ A;  4P0F A;  4AJT A;  3PB1 I;  3EVJ I;  2ACH A;  1XQJ A;  3FGQ A;  1D5S A;  1AS4 A;  1R1L I;  1UHG A;  1QLP A;  2VH4 A;  2ARR A;  1MTP A;  1HLE A;  2XN3 A;  2ANT I;  2OL2 A;  3Q02 A;  4IC0 A;  2BEH L;  4YIA A;  4P0O A;  1EZX A;  4AJU A;  1DZG L;  1JTI A;  2ZNH A;  2WY0 C;  1JMO A;  2V95 A;  2WXW A;  4Y3K A;  1OYH L;  3DRU A;  3OZQ A;  2QUG A;  1ATH A;  3NDF A;  1YXA A;  1PSI A;  1F0C A;  1IMV A;  3LE2 A;  3DRM A;  3VVJ A;  3B9F I;  2CEO A;  3CVM A;  9PAI A;  2HIJ L;  1LQ8 A;  2WXZ A;  4RSQ A;  4AU3 B;  3T1P A;  5CDX A;  3EOX A;  1TB6 I;  2H4Q A;  4AFX A;  4AU4 A;  4ZK0 A;  2DUT A;  2PEE A;  3NDD A;  1B3K A;  1C8O A;  1JVQ I;  2VDY A;  4DTE A;  1M93 B;  3LW2 A;  4EB1 I;  1ANT I;  4PYW A;  1DVM A;  3F5N A;  1OO8 A;  4C41 A;  4AQH A;  4AU3 A;  4GA7 A;  1E05 I;  2XN6 A;  3NDA A;  2B5T I;  2WY1 A;  1ATT A;  2RIV A;  1A7C A;  2WXX A;  1HP7 A;  2XN5 A;  2HI9 A;  4BB2 A;  3DLW A;  2B4X I;  3UT3 A;  4DY7 C;  2PEF A;  1BR8 I;  1ATU A;  4ZK3 A;  1OVA C;  4Y40 A;  2ZV6 A;  5INW A;  4EB1 L;  8API A;  1SNG A;  3CWL A;  1AZX I;  2H4R A;  2VDX A;  4DY0 A;  3NE4 A;  5HGC A;  2WXY C;  3STO A;  4ROB A;  2D26 A;  1WZ9 A;  3ZHA A;  1DVN A;  5IO1 A;  7API A;  1DZG I;  3R4L A;  4C49 A;  2GD4 C;  1E04 I;  1KCT A;  2RIW A;  2B4X L;  4AU2 A;  1T1F A;  1K9O I;  1XU8 A;  3H5C A;  4KDS A;  1DZH I;  1DB2 A;  5CE0 A;  3F1S A;  1OPH A;  2XN7 A;  1NQ9 I;  2HIJ I;  3KCG I;  2R9Y A;  1C5G A;  1JMJ A;  1IZ2 A;  2WXZ C;  5C98 A;  1SEK A;  2H4P A;  3CAA A;  3Q03 A;  4RO9 A;  5EI0 A;  1OVA B;  9API A;  4IF8 A;  4CAA A;  5CDZ A;  1XQG A;  5BRR I;  4R9I A;  1E03 I;  1JRR A; 
#chains in the Genus database with same CATH topology
 1LK6 I;  4G8O A;  3DY0 A;  1DZH L;  2BEH I;  3CWM A;  1SR5 A;  3PZF A;  4ROA A;  1LJ5 A;  1JJO C;  1OYH I;  1BY7 A;  4G8R A;  2OAY A;  1QMN A;  1OVA A;  1QMB A;  4X30 A;  3F02 A;  1OC0 A;  2ARQ A;  4P0F A;  4AJT A;  3PB1 I;  3EVJ I;  2ACH A;  1XQJ A;  3FGQ A;  1D5S A;  1AS4 A;  1R1L I;  1UHG A;  1QLP A;  2VH4 A;  2ARR A;  1MTP A;  1HLE A;  2XN3 A;  2ANT I;  2OL2 A;  3Q02 A;  4IC0 A;  2BEH L;  4YIA A;  4P0O A;  1EZX A;  4AJU A;  1DZG L;  1JTI A;  2ZNH A;  2WY0 C;  1JMO A;  2V95 A;  2WXW A;  4Y3K A;  1OYH L;  3DRU A;  3OZQ A;  2QUG A;  1ATH A;  3NDF A;  1YXA A;  1PSI A;  1F0C A;  1IMV A;  3LE2 A;  3DRM A;  3VVJ A;  3B9F I;  2CEO A;  3CVM A;  9PAI A;  2HIJ L;  1LQ8 A;  2WXZ A;  4RSQ A;  4AU3 B;  3T1P A;  5CDX A;  3EOX A;  1TB6 I;  2H4Q A;  4AFX A;  4AU4 A;  4ZK0 A;  2DUT A;  2PEE A;  3NDD A;  1B3K A;  1C8O A;  1JVQ I;  2VDY A;  4DTE A;  1M93 B;  3LW2 A;  4EB1 I;  1ANT I;  4PYW A;  1DVM A;  3F5N A;  1OO8 A;  4C41 A;  4AQH A;  4AU3 A;  4GA7 A;  1E05 I;  2XN6 A;  3NDA A;  2B5T I;  2WY1 A;  1ATT A;  2RIV A;  1A7C A;  2WXX A;  1HP7 A;  2XN5 A;  2HI9 A;  4BB2 A;  3DLW A;  2B4X I;  3UT3 A;  4DY7 C;  2PEF A;  1BR8 I;  1ATU A;  4ZK3 A;  1OVA C;  4Y40 A;  2ZV6 A;  5INW A;  4EB1 L;  8API A;  1SNG A;  3CWL A;  1AZX I;  2H4R A;  2VDX A;  4DY0 A;  3NE4 A;  5HGC A;  2WXY C;  3STO A;  4ROB A;  2D26 A;  1WZ9 A;  3ZHA A;  1DVN A;  5IO1 A;  7API A;  1DZG I;  3R4L A;  4C49 A;  2GD4 C;  1E04 I;  1KCT A;  2RIW A;  2B4X L;  4AU2 A;  1T1F A;  1K9O I;  1XU8 A;  3H5C A;  4KDS A;  1DZH I;  1DB2 A;  5CE0 A;  3F1S A;  1OPH A;  2XN7 A;  1NQ9 I;  2HIJ I;  3KCG I;  2R9Y A;  1C5G A;  1JMJ A;  1IZ2 A;  2WXZ C;  5C98 A;  1SEK A;  2H4P A;  3CAA A;  3Q03 A;  4RO9 A;  5EI0 A;  1OVA B;  9API A;  4IF8 A;  4CAA A;  5CDZ A;  1XQG A;  5BRR I;  4R9I A;  1E03 I;  1JRR A; 
#chains in the Genus database with same CATH homology
 1LK6 I;  4G8O A;  3DY0 A;  1DZH L;  2BEH I;  3CWM A;  1SR5 A;  3PZF A;  4ROA A;  1LJ5 A;  1JJO C;  1OYH I;  1BY7 A;  4G8R A;  2OAY A;  1QMN A;  1OVA A;  1QMB A;  4X30 A;  3F02 A;  1OC0 A;  2ARQ A;  4P0F A;  4AJT A;  3PB1 I;  3EVJ I;  2ACH A;  1XQJ A;  3FGQ A;  1D5S A;  1AS4 A;  1R1L I;  1UHG A;  1QLP A;  2VH4 A;  2ARR A;  1MTP A;  1HLE A;  2XN3 A;  2ANT I;  2OL2 A;  3Q02 A;  4IC0 A;  2BEH L;  4YIA A;  4P0O A;  1EZX A;  4AJU A;  1DZG L;  1JTI A;  2ZNH A;  2WY0 C;  1JMO A;  2V95 A;  2WXW A;  4Y3K A;  1OYH L;  3DRU A;  3OZQ A;  2QUG A;  1ATH A;  3NDF A;  1YXA A;  1PSI A;  1F0C A;  1IMV A;  3LE2 A;  3DRM A;  3VVJ A;  3B9F I;  2CEO A;  3CVM A;  9PAI A;  2HIJ L;  1LQ8 A;  2WXZ A;  4RSQ A;  4AU3 B;  3T1P A;  5CDX A;  3EOX A;  1TB6 I;  2H4Q A;  4AFX A;  4AU4 A;  4ZK0 A;  2DUT A;  2PEE A;  3NDD A;  1B3K A;  1C8O A;  1JVQ I;  2VDY A;  4DTE A;  1M93 B;  3LW2 A;  4EB1 I;  1ANT I;  4PYW A;  1DVM A;  3F5N A;  1OO8 A;  4C41 A;  4AQH A;  4AU3 A;  4GA7 A;  1E05 I;  2XN6 A;  3NDA A;  2B5T I;  2WY1 A;  1ATT A;  2RIV A;  1A7C A;  2WXX A;  1HP7 A;  2XN5 A;  2HI9 A;  4BB2 A;  3DLW A;  2B4X I;  3UT3 A;  4DY7 C;  2PEF A;  1BR8 I;  1ATU A;  4ZK3 A;  1OVA C;  4Y40 A;  2ZV6 A;  5INW A;  4EB1 L;  8API A;  1SNG A;  3CWL A;  1AZX I;  2H4R A;  2VDX A;  4DY0 A;  3NE4 A;  5HGC A;  2WXY C;  3STO A;  4ROB A;  2D26 A;  1WZ9 A;  3ZHA A;  1DVN A;  5IO1 A;  7API A;  1DZG I;  3R4L A;  4C49 A;  2GD4 C;  1E04 I;  1KCT A;  2RIW A;  2B4X L;  4AU2 A;  1T1F A;  1K9O I;  1XU8 A;  3H5C A;  4KDS A;  1DZH I;  1DB2 A;  5CE0 A;  3F1S A;  1OPH A;  2XN7 A;  1NQ9 I;  2HIJ I;  3KCG I;  2R9Y A;  1C5G A;  1JMJ A;  1IZ2 A;  2WXZ C;  5C98 A;  1SEK A;  2H4P A;  3CAA A;  3Q03 A;  4RO9 A;  5EI0 A;  1OVA B;  9API A;  4IF8 A;  4CAA A;  5CDZ A;  1XQG A;  5BRR I;  4R9I A;  1E03 I;  1JRR A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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