1D5SA

Crystal structure of cleaved antitrypsin polymer
Total Genus 87
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
87
sequence length
334
structure length
334
Chain Sequence
HPTFNKITPNLAEFAFSLYRQLAHQSNSTNIFFSPVSIATAFAMLSLGTKADTHDEILEGLNFNLTEIPEAQIHEGFQELLRTLNQPDSQLQLTTGNGLFLSEGLKLVDKFLEDVKKLYHSEAFTVNFGDTEEAKKQINDYVEKGTQGKIVDLVKELDRDTVFALVNYIFFKGKWERPFEVKDTEEEDFHVDQVTTVKVPMMKRLGMFNIQHCKKLSSWVLLMKYLGNATAIFFLPDEGKLQHLENELTHDIITKFLENEDRRSASLHLPKLSITGTYDLKSVLGQLGITKVFSNGADLSGVTEEAPLKLSKAVHKAVLTIDEKGTEAAGAMFL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Cleaved antitrypsin polymers at atomic resolution.
pubmed rcsb
molecule tags Hydrolase inhibitor
source organism Homo sapiens
molecule keywords P1-ARG ANTITRYPSIN
total genus 87
structure length 334
sequence length 334
ec nomenclature
pdb deposition date 1999-10-11
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.30.39.10 Mainly Beta Roll Alpha-1-antitrypsin; domain 1 Alpha-1-antitrypsin, domain 1 1d5sA01
3.30.497.10 Alpha Beta 2-Layer Sandwich Antithrombin; Chain I, domain 2 Antithrombin, subunit I, domain 2 1d5sA02
2DUTA 3EOXA 4BB2A 1DB2A 2PEEA 2HI9A 2B4XL 4DY0A 8APIA 1DZHL 3LW2A 1E03I 3STOA 1C5GA 1JMJA 3F02A 3Q02A 1JRRA 1HLEA 4AU3A 1F0CA 3B9FI 4P0FA 1OC0A 2ACHA 2WY1A 3PZFA 1DZGL 2XN7A 3PB1I 3EVJI 2WXXA 1EZXA 2GD4C 1M93B 5EI0A 1PSIA 2H4RA 2V95A 2B4XI 2OAYA 1DZHI 2H4QA 3FGQA 7APIA 2XN6A 4AU4A 1E04I 4AU3B 2VDYA 4R9IA 1E05I 1B3KA 1AZXI 1DZGI 5BRRI 4G8OA 3CWLA 1KCTA 4IF8A 2VDXA 2ZNHA 3LE2A 1XU8A 2OL2A 1LK6I 1OPHA 9PAIA 5CE0A 3CAAA 1IMVA 1D5SA 5HGCA 4PYWA 1UHGA 1K9OI 1BY7A 1QLPA 3DRUA 1QMBA 4EB1L 1ANTI 2XN3A 4AJTA 9APIA 3CWMA 3NDAA 1SR5A 4ZK0A 1A7CA 4ROBA 3T1PA 2WY0C 1XQGA 1IZ2A 2CEOA 3DRMA 2BEHI 2ARRA 3NE4A 4G8RA 2PEFA 4AQHA 2HIJL 4EB1I 4X30A 2WXZA 3F5NA 2ZV6A 4YIAA 4DTEA 2RIWA 1ATHA 1TB6I 1JJOC 2XN5A 4KDSA 1HP7A 3DY0A 2BEHL 5CDXA 3UT3A 3R4LA 4AJUA 1YXAA 3NDFA 1NQ9I 2QUGA 1OVAA 1WZ9A 3Q03A 1OYHL 1R1LI 3ZHAA 3KCGI 4ROAA 2H4PA 2HIJI 4Y40A 5IO1A 2ANTI 5CDZA 3OZQA 1JVQI 1OVAC 4Y3KA 1T1FA 2R9YA 1AS4A 2WXWA 3H5CA 1OVAB 3F1SA 1JTIA 4AU2A 1JMOA 1LJ5A 1SNGA 4DY7C 3NDDA 1OYHI 4C49A 5C98A 3CVMA 5INWA 4RO9A 4AFXA 1OO8A 1QMNA 1BR8I 2RIVA 1ATUA 2WXYC 1ATTA 3VVJA 1C8OA 2VH4A 1SEKA 4RSQA 4C41A 3DLWA 4GA7A 1LQ8A 2WXZC 4CAAA 4P0OA 1MTPA 1DVMA 2D26A 1XQJA 1DVNA 4IC0A 4ZK3A 2B5TI 2ARQA
chains in the Genus database with same CATH superfamily
2DUTA 3EOXA 4BB2A 1DB2A 2PEEA 2HI9A 2B4XL 4DY0A 8APIA 1DZHL 3LW2A 1E03I 3STOA 1C5GA 1JMJA 3F02A 3Q02A 1JRRA 1HLEA 4AU3A 1F0CA 3B9FI 4P0FA 1OC0A 2ACHA 2WY1A 3PZFA 1DZGL 2XN7A 3PB1I 3EVJI 2WXXA 1EZXA 2GD4C 1M93B 5EI0A 1PSIA 2H4RA 2V95A 2B4XI 2OAYA 1DZHI 2H4QA 3FGQA 7APIA 2XN6A 4AU4A 1E04I 4AU3B 2VDYA 4R9IA 1E05I 1B3KA 1AZXI 1DZGI 5BRRI 4G8OA 3CWLA 1KCTA 4IF8A 2VDXA 2ZNHA 3LE2A 1XU8A 2OL2A 1LK6I 1OPHA 9PAIA 5CE0A 3CAAA 1IMVA 1D5SA 5HGCA 4PYWA 1UHGA 1K9OI 1BY7A 1QLPA 3DRUA 1QMBA 4EB1L 1ANTI 2XN3A 4AJTA 9APIA 3CWMA 3NDAA 1SR5A 4ZK0A 1A7CA 4ROBA 3T1PA 2WY0C 1XQGA 1IZ2A 2CEOA 3DRMA 2BEHI 2ARRA 3NE4A 4G8RA 2PEFA 4AQHA 2HIJL 4EB1I 4X30A 2WXZA 3F5NA 2ZV6A 4YIAA 4DTEA 2RIWA 1ATHA 1TB6I 1JJOC 2XN5A 4KDSA 1HP7A 3DY0A 2BEHL 5CDXA 3UT3A 3R4LA 4AJUA 1YXAA 3NDFA 1NQ9I 2QUGA 1OVAA 1WZ9A 3Q03A 1OYHL 1R1LI 3ZHAA 3KCGI 4ROAA 2H4PA 2HIJI 4Y40A 5IO1A 2ANTI 5CDZA 3OZQA 1JVQI 1OVAC 4Y3KA 1T1FA 2R9YA 1AS4A 2WXWA 3H5CA 1OVAB 3F1SA 1JTIA 4AU2A 1JMOA 1LJ5A 1SNGA 4DY7C 3NDDA 1OYHI 4C49A 5C98A 3CVMA 5INWA 4RO9A 4AFXA 1OO8A 1QMNA 1BR8I 2RIVA 1ATUA 2WXYC 1ATTA 3VVJA 1C8OA 2VH4A 1SEKA 4RSQA 4C41A 3DLWA 4GA7A 1LQ8A 2WXZC 4CAAA 4P0OA 1MTPA 1DVMA 2D26A 1XQJA 1DVNA 4IC0A 4ZK3A 2B5TI 2ARQA
chains in the Genus database with same CATH topology
2DUTA 3EOXA 4BB2A 1DB2A 2PEEA 2HI9A 2B4XL 4DY0A 8APIA 1DZHL 3LW2A 1E03I 3STOA 1C5GA 1JMJA 3F02A 3Q02A 1JRRA 1HLEA 4AU3A 1F0CA 3B9FI 4P0FA 1OC0A 2ACHA 2WY1A 3PZFA 1DZGL 2XN7A 3PB1I 3EVJI 2WXXA 1EZXA 2GD4C 1M93B 5EI0A 1PSIA 2H4RA 2V95A 2B4XI 2OAYA 1DZHI 2H4QA 3FGQA 7APIA 2XN6A 4AU4A 1E04I 4AU3B 2VDYA 4R9IA 1E05I 1B3KA 1AZXI 1DZGI 5BRRI 4G8OA 3CWLA 1KCTA 4IF8A 2VDXA 2ZNHA 3LE2A 1XU8A 2OL2A 1LK6I 1OPHA 9PAIA 5CE0A 3CAAA 1IMVA 1D5SA 5HGCA 4PYWA 1UHGA 1K9OI 1BY7A 1QLPA 3DRUA 1QMBA 4EB1L 1ANTI 2XN3A 4AJTA 9APIA 3CWMA 3NDAA 1SR5A 4ZK0A 1A7CA 4ROBA 3T1PA 2WY0C 1XQGA 1IZ2A 2CEOA 3DRMA 2BEHI 2ARRA 3NE4A 4G8RA 2PEFA 4AQHA 2HIJL 4EB1I 4X30A 2WXZA 3F5NA 2ZV6A 4YIAA 4DTEA 2RIWA 1ATHA 1TB6I 1JJOC 2XN5A 4KDSA 1HP7A 3DY0A 2BEHL 5CDXA 3UT3A 3R4LA 4AJUA 1YXAA 3NDFA 1NQ9I 2QUGA 1OVAA 1WZ9A 3Q03A 1OYHL 1R1LI 3ZHAA 3KCGI 4ROAA 2H4PA 2HIJI 4Y40A 5IO1A 2ANTI 5CDZA 3OZQA 1JVQI 1OVAC 4Y3KA 1T1FA 2R9YA 1AS4A 2WXWA 3H5CA 1OVAB 3F1SA 1JTIA 4AU2A 1JMOA 1LJ5A 1SNGA 4DY7C 3NDDA 1OYHI 4C49A 5C98A 3CVMA 5INWA 4RO9A 4AFXA 1OO8A 1QMNA 1BR8I 2RIVA 1ATUA 2WXYC 1ATTA 3VVJA 1C8OA 2VH4A 1SEKA 4RSQA 4C41A 3DLWA 4GA7A 1LQ8A 2WXZC 4CAAA 4P0OA 1MTPA 1DVMA 2D26A 1XQJA 1DVNA 4IC0A 4ZK3A 2B5TI 2ARQA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2DUT A;  3EOX A;  4BB2 A;  1DB2 A;  2PEE A;  2HI9 A;  2B4X L;  4DY0 A;  8API A;  1DZH L;  3LW2 A;  1E03 I;  3STO A;  1C5G A;  1JMJ A;  3F02 A;  3Q02 A;  1JRR A;  1HLE A;  4AU3 A;  1F0C A;  3B9F I;  4P0F A;  1OC0 A;  2ACH A;  2WY1 A;  3PZF A;  1DZG L;  2XN7 A;  3PB1 I;  3EVJ I;  2WXX A;  1EZX A;  2GD4 C;  1M93 B;  5EI0 A;  1PSI A;  2H4R A;  2V95 A;  2B4X I;  2OAY A;  1DZH I;  2H4Q A;  3FGQ A;  7API A;  2XN6 A;  4AU4 A;  1E04 I;  4AU3 B;  2VDY A;  4R9I A;  1E05 I;  1B3K A;  1AZX I;  1DZG I;  5BRR I;  4G8O A;  3CWL A;  1KCT A;  4IF8 A;  2VDX A;  2ZNH A;  3LE2 A;  1XU8 A;  2OL2 A;  1LK6 I;  1OPH A;  9PAI A;  5CE0 A;  3CAA A;  1IMV A;  1D5S A;  5HGC A;  4PYW A;  1UHG A;  1K9O I;  1BY7 A;  1QLP A;  3DRU A;  1QMB A;  4EB1 L;  1ANT I;  2XN3 A;  4AJT A;  9API A;  3CWM A;  3NDA A;  1SR5 A;  4ZK0 A;  1A7C A;  4ROB A;  3T1P A;  2WY0 C;  1XQG A;  1IZ2 A;  2CEO A;  3DRM A;  2BEH I;  2ARR A;  3NE4 A;  4G8R A;  2PEF A;  4AQH A;  2HIJ L;  4EB1 I;  4X30 A;  2WXZ A;  3F5N A;  2ZV6 A;  4YIA A;  4DTE A;  2RIW A;  1ATH A;  1TB6 I;  1JJO C;  2XN5 A;  4KDS A;  1HP7 A;  3DY0 A;  2BEH L;  5CDX A;  3UT3 A;  3R4L A;  4AJU A;  1YXA A;  3NDF A;  1NQ9 I;  2QUG A;  1OVA A;  1WZ9 A;  3Q03 A;  1OYH L;  1R1L I;  3ZHA A;  3KCG I;  4ROA A;  2H4P A;  2HIJ I;  4Y40 A;  5IO1 A;  2ANT I;  5CDZ A;  3OZQ A;  1JVQ I;  1OVA C;  4Y3K A;  1T1F A;  2R9Y A;  1AS4 A;  2WXW A;  3H5C A;  1OVA B;  3F1S A;  1JTI A;  4AU2 A;  1JMO A;  1LJ5 A;  1SNG A;  4DY7 C;  3NDD A;  1OYH I;  4C49 A;  5C98 A;  3CVM A;  5INW A;  4RO9 A;  4AFX A;  1OO8 A;  1QMN A;  1BR8 I;  2RIV A;  1ATU A;  2WXY C;  1ATT A;  3VVJ A;  1C8O A;  2VH4 A;  1SEK A;  4RSQ A;  4C41 A;  3DLW A;  4GA7 A;  1LQ8 A;  2WXZ C;  4CAA A;  4P0O A;  1MTP A;  1DVM A;  2D26 A;  1XQJ A;  1DVN A;  4IC0 A;  4ZK3 A;  2B5T I;  2ARQ A; 
#chains in the Genus database with same CATH topology
 2DUT A;  3EOX A;  4BB2 A;  1DB2 A;  2PEE A;  2HI9 A;  2B4X L;  4DY0 A;  8API A;  1DZH L;  3LW2 A;  1E03 I;  3STO A;  1C5G A;  1JMJ A;  3F02 A;  3Q02 A;  1JRR A;  1HLE A;  4AU3 A;  1F0C A;  3B9F I;  4P0F A;  1OC0 A;  2ACH A;  2WY1 A;  3PZF A;  1DZG L;  2XN7 A;  3PB1 I;  3EVJ I;  2WXX A;  1EZX A;  2GD4 C;  1M93 B;  5EI0 A;  1PSI A;  2H4R A;  2V95 A;  2B4X I;  2OAY A;  1DZH I;  2H4Q A;  3FGQ A;  7API A;  2XN6 A;  4AU4 A;  1E04 I;  4AU3 B;  2VDY A;  4R9I A;  1E05 I;  1B3K A;  1AZX I;  1DZG I;  5BRR I;  4G8O A;  3CWL A;  1KCT A;  4IF8 A;  2VDX A;  2ZNH A;  3LE2 A;  1XU8 A;  2OL2 A;  1LK6 I;  1OPH A;  9PAI A;  5CE0 A;  3CAA A;  1IMV A;  1D5S A;  5HGC A;  4PYW A;  1UHG A;  1K9O I;  1BY7 A;  1QLP A;  3DRU A;  1QMB A;  4EB1 L;  1ANT I;  2XN3 A;  4AJT A;  9API A;  3CWM A;  3NDA A;  1SR5 A;  4ZK0 A;  1A7C A;  4ROB A;  3T1P A;  2WY0 C;  1XQG A;  1IZ2 A;  2CEO A;  3DRM A;  2BEH I;  2ARR A;  3NE4 A;  4G8R A;  2PEF A;  4AQH A;  2HIJ L;  4EB1 I;  4X30 A;  2WXZ A;  3F5N A;  2ZV6 A;  4YIA A;  4DTE A;  2RIW A;  1ATH A;  1TB6 I;  1JJO C;  2XN5 A;  4KDS A;  1HP7 A;  3DY0 A;  2BEH L;  5CDX A;  3UT3 A;  3R4L A;  4AJU A;  1YXA A;  3NDF A;  1NQ9 I;  2QUG A;  1OVA A;  1WZ9 A;  3Q03 A;  1OYH L;  1R1L I;  3ZHA A;  3KCG I;  4ROA A;  2H4P A;  2HIJ I;  4Y40 A;  5IO1 A;  2ANT I;  5CDZ A;  3OZQ A;  1JVQ I;  1OVA C;  4Y3K A;  1T1F A;  2R9Y A;  1AS4 A;  2WXW A;  3H5C A;  1OVA B;  3F1S A;  1JTI A;  4AU2 A;  1JMO A;  1LJ5 A;  1SNG A;  4DY7 C;  3NDD A;  1OYH I;  4C49 A;  5C98 A;  3CVM A;  5INW A;  4RO9 A;  4AFX A;  1OO8 A;  1QMN A;  1BR8 I;  2RIV A;  1ATU A;  2WXY C;  1ATT A;  3VVJ A;  1C8O A;  2VH4 A;  1SEK A;  4RSQ A;  4C41 A;  3DLW A;  4GA7 A;  1LQ8 A;  2WXZ C;  4CAA A;  4P0O A;  1MTP A;  1DVM A;  2D26 A;  1XQJ A;  1DVN A;  4IC0 A;  4ZK3 A;  2B5T I;  2ARQ A; 
#chains in the Genus database with same CATH homology
 2DUT A;  3EOX A;  4BB2 A;  1DB2 A;  2PEE A;  2HI9 A;  2B4X L;  4DY0 A;  8API A;  1DZH L;  3LW2 A;  1E03 I;  3STO A;  1C5G A;  1JMJ A;  3F02 A;  3Q02 A;  1JRR A;  1HLE A;  4AU3 A;  1F0C A;  3B9F I;  4P0F A;  1OC0 A;  2ACH A;  2WY1 A;  3PZF A;  1DZG L;  2XN7 A;  3PB1 I;  3EVJ I;  2WXX A;  1EZX A;  2GD4 C;  1M93 B;  5EI0 A;  1PSI A;  2H4R A;  2V95 A;  2B4X I;  2OAY A;  1DZH I;  2H4Q A;  3FGQ A;  7API A;  2XN6 A;  4AU4 A;  1E04 I;  4AU3 B;  2VDY A;  4R9I A;  1E05 I;  1B3K A;  1AZX I;  1DZG I;  5BRR I;  4G8O A;  3CWL A;  1KCT A;  4IF8 A;  2VDX A;  2ZNH A;  3LE2 A;  1XU8 A;  2OL2 A;  1LK6 I;  1OPH A;  9PAI A;  5CE0 A;  3CAA A;  1IMV A;  1D5S A;  5HGC A;  4PYW A;  1UHG A;  1K9O I;  1BY7 A;  1QLP A;  3DRU A;  1QMB A;  4EB1 L;  1ANT I;  2XN3 A;  4AJT A;  9API A;  3CWM A;  3NDA A;  1SR5 A;  4ZK0 A;  1A7C A;  4ROB A;  3T1P A;  2WY0 C;  1XQG A;  1IZ2 A;  2CEO A;  3DRM A;  2BEH I;  2ARR A;  3NE4 A;  4G8R A;  2PEF A;  4AQH A;  2HIJ L;  4EB1 I;  4X30 A;  2WXZ A;  3F5N A;  2ZV6 A;  4YIA A;  4DTE A;  2RIW A;  1ATH A;  1TB6 I;  1JJO C;  2XN5 A;  4KDS A;  1HP7 A;  3DY0 A;  2BEH L;  5CDX A;  3UT3 A;  3R4L A;  4AJU A;  1YXA A;  3NDF A;  1NQ9 I;  2QUG A;  1OVA A;  1WZ9 A;  3Q03 A;  1OYH L;  1R1L I;  3ZHA A;  3KCG I;  4ROA A;  2H4P A;  2HIJ I;  4Y40 A;  5IO1 A;  2ANT I;  5CDZ A;  3OZQ A;  1JVQ I;  1OVA C;  4Y3K A;  1T1F A;  2R9Y A;  1AS4 A;  2WXW A;  3H5C A;  1OVA B;  3F1S A;  1JTI A;  4AU2 A;  1JMO A;  1LJ5 A;  1SNG A;  4DY7 C;  3NDD A;  1OYH I;  4C49 A;  5C98 A;  3CVM A;  5INW A;  4RO9 A;  4AFX A;  1OO8 A;  1QMN A;  1BR8 I;  2RIV A;  1ATU A;  2WXY C;  1ATT A;  3VVJ A;  1C8O A;  2VH4 A;  1SEK A;  4RSQ A;  4C41 A;  3DLW A;  4GA7 A;  1LQ8 A;  2WXZ C;  4CAA A;  4P0O A;  1MTP A;  1DVM A;  2D26 A;  1XQJ A;  1DVN A;  4IC0 A;  4ZK3 A;  2B5T I;  2ARQ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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