1E04I

Plasma beta antithrombin-iii
Total Genus 111
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
111
sequence length
427
structure length
403
Chain Sequence
VDICTAKPRDIPMNPMCRRVWELSKANSRFATTFYQHLADSKNDNDNIFLSPLSISTAFAMTKLGACNDTLQQLMEVFKFDTISEKTSDQIHFFFAKLNCRLYRKANKSSKLVSANRLFGDKSLTFNETYQDISELVYGAKLQPLDFKENAEQSRAAINKWVSNKTEGRITDVIPSEAINELTVLVLVNTIYFKGLWKSKFSPENTRKELFYKADGESCSASMMYQEGKFRYRRVAEGTQVLELPFKGDDITMVLILPKPEKSLAKVEKELTPEVLQEWLDELEEMMLVVHMPRFRIEDGFSLKEQLQDMGLVDLFSPEKSKLPGIVAEGRDDLYVSDAFHKAFLEVNEEGSEAAASTAVVIAGRSLNPNRVTFKANRPFLVFIREVPLNTIIFMGRVANPCV
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structure of Beta-Antithrombin and the Effect of Glycosylation on Antithrombin'S Heparin Affinity and Activity.
pubmed doi rcsb
molecule tags Blood clotting
molecule keywords ANTITHROMBIN-III
total genus 111
structure length 403
sequence length 427
chains with identical sequence L
ec nomenclature
pdb deposition date 2000-03-09

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
I PF00079 Serpin Serpin (serine protease inhibitor)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.30.39.10 Mainly Beta Roll Alpha-1-antitrypsin; domain 1 Alpha-1-antitrypsin, domain 1 1e04I01
3.30.497.10 Alpha Beta 2-Layer Sandwich Antithrombin; Chain I, domain 2 Antithrombin, subunit I, domain 2 1e04I02
7APIA 1JMJA 1DZGI 1SR5A 2VDYA 1E03I 2OAYA 1QLPA 4EB1I 5IO1A 1OPHA 1JTIA 2B5TI 3NDDA 2QUGA 4Y40A 3LW2A 3OZQA 1OVAC 3T1PA 5CDXA 1MTPA 2WXXA 1D5SA 2ACHA 1PSIA 1IZ2A 3F02A 2HI9A 4AU2A 2WY0C 1XU8A 2VDXA 4Y3KA 1C8OA 1YXAA 1OC0A 2D26A 1F0CA 2RIWA 1LK6I 2H4RA 2XN5A 3F1SA 3B9FI 8APIA 1T1FA 3R4LA 3KCGI 4ROBA 3UT3A 2ARQA 1JJOC 1M93B 4G8RA 3Q02A 1C5GA 9PAIA 3DY0A 4AU3A 4DTEA 3DLWA 2XN6A 1DZHL 2WXWA 2B4XL 1BR8I 2OL2A 1ANTI 4RSQA 1DZGL 4EB1L 1E04I 3EVJI 3DRUA 3NDFA 5EI0A 1TB6I 4R9IA 3NDAA 1ATHA 5CDZA 3NE4A 1DB2A 2H4PA 1E05I 2V95A 3CVMA 4ZK0A 5INWA 5BRRI 4X30A 3STOA 2ZNHA 3CWLA 1UHGA 2HIJI 3EOXA 3ZHAA 4P0FA 1XQJA 1WZ9A 1OVAA 2XN7A 3Q03A 1BY7A 2HIJL 4AU4A 5CE0A 1DVNA 1NQ9I 1LJ5A 2WXZA 4C49A 4GA7A 4DY0A 2CEOA 2H4QA 4CAAA 4IF8A 2R9YA 1DVMA 9APIA 2GD4C 2WY1A 3LE2A 4P0OA 1QMBA 1SEKA 4G8OA 4IC0A 1AS4A 2PEFA 3CAAA 4KDSA 1HLEA 2BEHI 1JRRA 4YIAA 2RIVA 1ATUA 1OO8A 5C98A 1B3KA 2DUTA 2BEHL 5HGCA 1R1LI 4DY7C 1JMOA 1K9OI 4AU3B 3PZFA 4RO9A 1AZXI 4AJUA 4ROAA 4AFXA 3F5NA 3H5CA 1OYHI 1XQGA 2WXYC 4AQHA 4ZK3A 1A7CA 1LQ8A 3PB1I 1ATTA 3VVJA 2XN3A 4BB2A 1OYHL 1IMVA 2WXZC 4AJTA 3CWMA 1EZXA 3DRMA 2PEEA 1KCTA 2VH4A 3FGQA 1SNGA 4C41A 1OVAB 4PYWA 2ANTI 1DZHI 2ZV6A 1QMNA 2B4XI 1HP7A 1JVQI 2ARRA
chains in the Genus database with same CATH superfamily
7APIA 1JMJA 1DZGI 1SR5A 2VDYA 1E03I 2OAYA 1QLPA 4EB1I 5IO1A 1OPHA 1JTIA 2B5TI 3NDDA 2QUGA 4Y40A 3LW2A 3OZQA 1OVAC 3T1PA 5CDXA 1MTPA 2WXXA 1D5SA 2ACHA 1PSIA 1IZ2A 3F02A 2HI9A 4AU2A 2WY0C 1XU8A 2VDXA 4Y3KA 1C8OA 1YXAA 1OC0A 2D26A 1F0CA 2RIWA 1LK6I 2H4RA 2XN5A 3F1SA 3B9FI 8APIA 1T1FA 3R4LA 3KCGI 4ROBA 3UT3A 2ARQA 1JJOC 1M93B 4G8RA 3Q02A 1C5GA 9PAIA 3DY0A 4AU3A 4DTEA 3DLWA 2XN6A 1DZHL 2WXWA 2B4XL 1BR8I 2OL2A 1ANTI 4RSQA 1DZGL 4EB1L 1E04I 3EVJI 3DRUA 3NDFA 5EI0A 1TB6I 4R9IA 3NDAA 1ATHA 5CDZA 3NE4A 1DB2A 2H4PA 1E05I 2V95A 3CVMA 4ZK0A 5INWA 5BRRI 4X30A 3STOA 2ZNHA 3CWLA 1UHGA 2HIJI 3EOXA 3ZHAA 4P0FA 1XQJA 1WZ9A 1OVAA 2XN7A 3Q03A 1BY7A 2HIJL 4AU4A 5CE0A 1DVNA 1NQ9I 1LJ5A 2WXZA 4C49A 4GA7A 4DY0A 2CEOA 2H4QA 4CAAA 4IF8A 2R9YA 1DVMA 9APIA 2GD4C 2WY1A 3LE2A 4P0OA 1QMBA 1SEKA 4G8OA 4IC0A 1AS4A 2PEFA 3CAAA 4KDSA 1HLEA 2BEHI 1JRRA 4YIAA 2RIVA 1ATUA 1OO8A 5C98A 1B3KA 2DUTA 2BEHL 5HGCA 1R1LI 4DY7C 1JMOA 1K9OI 4AU3B 3PZFA 4RO9A 1AZXI 4AJUA 4ROAA 4AFXA 3F5NA 3H5CA 1OYHI 1XQGA 2WXYC 4AQHA 4ZK3A 1A7CA 1LQ8A 3PB1I 1ATTA 3VVJA 2XN3A 4BB2A 1OYHL 1IMVA 2WXZC 4AJTA 3CWMA 1EZXA 3DRMA 2PEEA 1KCTA 2VH4A 3FGQA 1SNGA 4C41A 1OVAB 4PYWA 2ANTI 1DZHI 2ZV6A 1QMNA 2B4XI 1HP7A 1JVQI 2ARRA
chains in the Genus database with same CATH topology
7APIA 1JMJA 1DZGI 1SR5A 2VDYA 1E03I 2OAYA 1QLPA 4EB1I 5IO1A 1OPHA 1JTIA 2B5TI 3NDDA 2QUGA 4Y40A 3LW2A 3OZQA 1OVAC 3T1PA 5CDXA 1MTPA 2WXXA 1D5SA 2ACHA 1PSIA 1IZ2A 3F02A 2HI9A 4AU2A 2WY0C 1XU8A 2VDXA 4Y3KA 1C8OA 1YXAA 1OC0A 2D26A 1F0CA 2RIWA 1LK6I 2H4RA 2XN5A 3F1SA 3B9FI 8APIA 1T1FA 3R4LA 3KCGI 4ROBA 3UT3A 2ARQA 1JJOC 1M93B 4G8RA 3Q02A 1C5GA 9PAIA 3DY0A 4AU3A 4DTEA 3DLWA 2XN6A 1DZHL 2WXWA 2B4XL 1BR8I 2OL2A 1ANTI 4RSQA 1DZGL 4EB1L 1E04I 3EVJI 3DRUA 3NDFA 5EI0A 1TB6I 4R9IA 3NDAA 1ATHA 5CDZA 3NE4A 1DB2A 2H4PA 1E05I 2V95A 3CVMA 4ZK0A 5INWA 5BRRI 4X30A 3STOA 2ZNHA 3CWLA 1UHGA 2HIJI 3EOXA 3ZHAA 4P0FA 1XQJA 1WZ9A 1OVAA 2XN7A 3Q03A 1BY7A 2HIJL 4AU4A 5CE0A 1DVNA 1NQ9I 1LJ5A 2WXZA 4C49A 4GA7A 4DY0A 2CEOA 2H4QA 4CAAA 4IF8A 2R9YA 1DVMA 9APIA 2GD4C 2WY1A 3LE2A 4P0OA 1QMBA 1SEKA 4G8OA 4IC0A 1AS4A 2PEFA 3CAAA 4KDSA 1HLEA 2BEHI 1JRRA 4YIAA 2RIVA 1ATUA 1OO8A 5C98A 1B3KA 2DUTA 2BEHL 5HGCA 1R1LI 4DY7C 1JMOA 1K9OI 4AU3B 3PZFA 4RO9A 1AZXI 4AJUA 4ROAA 4AFXA 3F5NA 3H5CA 1OYHI 1XQGA 2WXYC 4AQHA 4ZK3A 1A7CA 1LQ8A 3PB1I 1ATTA 3VVJA 2XN3A 4BB2A 1OYHL 1IMVA 2WXZC 4AJTA 3CWMA 1EZXA 3DRMA 2PEEA 1KCTA 2VH4A 3FGQA 1SNGA 4C41A 1OVAB 4PYWA 2ANTI 1DZHI 2ZV6A 1QMNA 2B4XI 1HP7A 1JVQI 2ARRA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 7API A;  1JMJ A;  1DZG I;  1SR5 A;  2VDY A;  1E03 I;  2OAY A;  1QLP A;  4EB1 I;  5IO1 A;  1OPH A;  1JTI A;  2B5T I;  3NDD A;  2QUG A;  4Y40 A;  3LW2 A;  3OZQ A;  1OVA C;  3T1P A;  5CDX A;  1MTP A;  2WXX A;  1D5S A;  2ACH A;  1PSI A;  1IZ2 A;  3F02 A;  2HI9 A;  4AU2 A;  2WY0 C;  1XU8 A;  2VDX A;  4Y3K A;  1C8O A;  1YXA A;  1OC0 A;  2D26 A;  1F0C A;  2RIW A;  1LK6 I;  2H4R A;  2XN5 A;  3F1S A;  3B9F I;  8API A;  1T1F A;  3R4L A;  3KCG I;  4ROB A;  3UT3 A;  2ARQ A;  1JJO C;  1M93 B;  4G8R A;  3Q02 A;  1C5G A;  9PAI A;  3DY0 A;  4AU3 A;  4DTE A;  3DLW A;  2XN6 A;  1DZH L;  2WXW A;  2B4X L;  1BR8 I;  2OL2 A;  1ANT I;  4RSQ A;  1DZG L;  4EB1 L;  1E04 I;  3EVJ I;  3DRU A;  3NDF A;  5EI0 A;  1TB6 I;  4R9I A;  3NDA A;  1ATH A;  5CDZ A;  3NE4 A;  1DB2 A;  2H4P A;  1E05 I;  2V95 A;  3CVM A;  4ZK0 A;  5INW A;  5BRR I;  4X30 A;  3STO A;  2ZNH A;  3CWL A;  1UHG A;  2HIJ I;  3EOX A;  3ZHA A;  4P0F A;  1XQJ A;  1WZ9 A;  1OVA A;  2XN7 A;  3Q03 A;  1BY7 A;  2HIJ L;  4AU4 A;  5CE0 A;  1DVN A;  1NQ9 I;  1LJ5 A;  2WXZ A;  4C49 A;  4GA7 A;  4DY0 A;  2CEO A;  2H4Q A;  4CAA A;  4IF8 A;  2R9Y A;  1DVM A;  9API A;  2GD4 C;  2WY1 A;  3LE2 A;  4P0O A;  1QMB A;  1SEK A;  4G8O A;  4IC0 A;  1AS4 A;  2PEF A;  3CAA A;  4KDS A;  1HLE A;  2BEH I;  1JRR A;  4YIA A;  2RIV A;  1ATU A;  1OO8 A;  5C98 A;  1B3K A;  2DUT A;  2BEH L;  5HGC A;  1R1L I;  4DY7 C;  1JMO A;  1K9O I;  4AU3 B;  3PZF A;  4RO9 A;  1AZX I;  4AJU A;  4ROA A;  4AFX A;  3F5N A;  3H5C A;  1OYH I;  1XQG A;  2WXY C;  4AQH A;  4ZK3 A;  1A7C A;  1LQ8 A;  3PB1 I;  1ATT A;  3VVJ A;  2XN3 A;  4BB2 A;  1OYH L;  1IMV A;  2WXZ C;  4AJT A;  3CWM A;  1EZX A;  3DRM A;  2PEE A;  1KCT A;  2VH4 A;  3FGQ A;  1SNG A;  4C41 A;  1OVA B;  4PYW A;  2ANT I;  1DZH I;  2ZV6 A;  1QMN A;  2B4X I;  1HP7 A;  1JVQ I;  2ARR A; 
#chains in the Genus database with same CATH topology
 7API A;  1JMJ A;  1DZG I;  1SR5 A;  2VDY A;  1E03 I;  2OAY A;  1QLP A;  4EB1 I;  5IO1 A;  1OPH A;  1JTI A;  2B5T I;  3NDD A;  2QUG A;  4Y40 A;  3LW2 A;  3OZQ A;  1OVA C;  3T1P A;  5CDX A;  1MTP A;  2WXX A;  1D5S A;  2ACH A;  1PSI A;  1IZ2 A;  3F02 A;  2HI9 A;  4AU2 A;  2WY0 C;  1XU8 A;  2VDX A;  4Y3K A;  1C8O A;  1YXA A;  1OC0 A;  2D26 A;  1F0C A;  2RIW A;  1LK6 I;  2H4R A;  2XN5 A;  3F1S A;  3B9F I;  8API A;  1T1F A;  3R4L A;  3KCG I;  4ROB A;  3UT3 A;  2ARQ A;  1JJO C;  1M93 B;  4G8R A;  3Q02 A;  1C5G A;  9PAI A;  3DY0 A;  4AU3 A;  4DTE A;  3DLW A;  2XN6 A;  1DZH L;  2WXW A;  2B4X L;  1BR8 I;  2OL2 A;  1ANT I;  4RSQ A;  1DZG L;  4EB1 L;  1E04 I;  3EVJ I;  3DRU A;  3NDF A;  5EI0 A;  1TB6 I;  4R9I A;  3NDA A;  1ATH A;  5CDZ A;  3NE4 A;  1DB2 A;  2H4P A;  1E05 I;  2V95 A;  3CVM A;  4ZK0 A;  5INW A;  5BRR I;  4X30 A;  3STO A;  2ZNH A;  3CWL A;  1UHG A;  2HIJ I;  3EOX A;  3ZHA A;  4P0F A;  1XQJ A;  1WZ9 A;  1OVA A;  2XN7 A;  3Q03 A;  1BY7 A;  2HIJ L;  4AU4 A;  5CE0 A;  1DVN A;  1NQ9 I;  1LJ5 A;  2WXZ A;  4C49 A;  4GA7 A;  4DY0 A;  2CEO A;  2H4Q A;  4CAA A;  4IF8 A;  2R9Y A;  1DVM A;  9API A;  2GD4 C;  2WY1 A;  3LE2 A;  4P0O A;  1QMB A;  1SEK A;  4G8O A;  4IC0 A;  1AS4 A;  2PEF A;  3CAA A;  4KDS A;  1HLE A;  2BEH I;  1JRR A;  4YIA A;  2RIV A;  1ATU A;  1OO8 A;  5C98 A;  1B3K A;  2DUT A;  2BEH L;  5HGC A;  1R1L I;  4DY7 C;  1JMO A;  1K9O I;  4AU3 B;  3PZF A;  4RO9 A;  1AZX I;  4AJU A;  4ROA A;  4AFX A;  3F5N A;  3H5C A;  1OYH I;  1XQG A;  2WXY C;  4AQH A;  4ZK3 A;  1A7C A;  1LQ8 A;  3PB1 I;  1ATT A;  3VVJ A;  2XN3 A;  4BB2 A;  1OYH L;  1IMV A;  2WXZ C;  4AJT A;  3CWM A;  1EZX A;  3DRM A;  2PEE A;  1KCT A;  2VH4 A;  3FGQ A;  1SNG A;  4C41 A;  1OVA B;  4PYW A;  2ANT I;  1DZH I;  2ZV6 A;  1QMN A;  2B4X I;  1HP7 A;  1JVQ I;  2ARR A; 
#chains in the Genus database with same CATH homology
 7API A;  1JMJ A;  1DZG I;  1SR5 A;  2VDY A;  1E03 I;  2OAY A;  1QLP A;  4EB1 I;  5IO1 A;  1OPH A;  1JTI A;  2B5T I;  3NDD A;  2QUG A;  4Y40 A;  3LW2 A;  3OZQ A;  1OVA C;  3T1P A;  5CDX A;  1MTP A;  2WXX A;  1D5S A;  2ACH A;  1PSI A;  1IZ2 A;  3F02 A;  2HI9 A;  4AU2 A;  2WY0 C;  1XU8 A;  2VDX A;  4Y3K A;  1C8O A;  1YXA A;  1OC0 A;  2D26 A;  1F0C A;  2RIW A;  1LK6 I;  2H4R A;  2XN5 A;  3F1S A;  3B9F I;  8API A;  1T1F A;  3R4L A;  3KCG I;  4ROB A;  3UT3 A;  2ARQ A;  1JJO C;  1M93 B;  4G8R A;  3Q02 A;  1C5G A;  9PAI A;  3DY0 A;  4AU3 A;  4DTE A;  3DLW A;  2XN6 A;  1DZH L;  2WXW A;  2B4X L;  1BR8 I;  2OL2 A;  1ANT I;  4RSQ A;  1DZG L;  4EB1 L;  1E04 I;  3EVJ I;  3DRU A;  3NDF A;  5EI0 A;  1TB6 I;  4R9I A;  3NDA A;  1ATH A;  5CDZ A;  3NE4 A;  1DB2 A;  2H4P A;  1E05 I;  2V95 A;  3CVM A;  4ZK0 A;  5INW A;  5BRR I;  4X30 A;  3STO A;  2ZNH A;  3CWL A;  1UHG A;  2HIJ I;  3EOX A;  3ZHA A;  4P0F A;  1XQJ A;  1WZ9 A;  1OVA A;  2XN7 A;  3Q03 A;  1BY7 A;  2HIJ L;  4AU4 A;  5CE0 A;  1DVN A;  1NQ9 I;  1LJ5 A;  2WXZ A;  4C49 A;  4GA7 A;  4DY0 A;  2CEO A;  2H4Q A;  4CAA A;  4IF8 A;  2R9Y A;  1DVM A;  9API A;  2GD4 C;  2WY1 A;  3LE2 A;  4P0O A;  1QMB A;  1SEK A;  4G8O A;  4IC0 A;  1AS4 A;  2PEF A;  3CAA A;  4KDS A;  1HLE A;  2BEH I;  1JRR A;  4YIA A;  2RIV A;  1ATU A;  1OO8 A;  5C98 A;  1B3K A;  2DUT A;  2BEH L;  5HGC A;  1R1L I;  4DY7 C;  1JMO A;  1K9O I;  4AU3 B;  3PZF A;  4RO9 A;  1AZX I;  4AJU A;  4ROA A;  4AFX A;  3F5N A;  3H5C A;  1OYH I;  1XQG A;  2WXY C;  4AQH A;  4ZK3 A;  1A7C A;  1LQ8 A;  3PB1 I;  1ATT A;  3VVJ A;  2XN3 A;  4BB2 A;  1OYH L;  1IMV A;  2WXZ C;  4AJT A;  3CWM A;  1EZX A;  3DRM A;  2PEE A;  1KCT A;  2VH4 A;  3FGQ A;  1SNG A;  4C41 A;  1OVA B;  4PYW A;  2ANT I;  1DZH I;  2ZV6 A;  1QMN A;  2B4X I;  1HP7 A;  1JVQ I;  2ARR A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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