1SEKA

The structure of active serpin k from manduca sexta and a model for serpin-protease complex formation
Total Genus 112
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
112
sequence length
376
structure length
376
Chain Sequence
GETDLQKILRESNDQFTAQMFSEVVKANPGQNVVLSAFSVLPPLGQLALASVGESHDELLRALALPNDNVTKDVFADLNRGVRAVKGVDLKMASKIYVAKGLELNDDFAAVSRDVFGSEVQNVDFVKSVEAAGAINKWVEDQTNNRIKNLVDPDALDETTRSVLVNAIYFKGSWKDKFNKERTMDRDFHVSKDKTIKVPTMIGKKDVRYADVPELDAKMIEMSYEGDQASMIIILPNQVDGITALEQKLKDPKALSRAEERLYNTEVEIYLPKFKIETTTDLKEVLSNMNIKKLFTPGAARLENLLKTKESLYVDAAIQKAFIEVNEEGAEAAAANAFKITTYSFHFVPKVEINKPFFFSLKYNRNSMFSGVCVQP
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title The structure of active serpin 1K from Manduca sexta.
pubmed doi rcsb
molecule tags Serine protease inhibitor
source organism Manduca sexta
molecule keywords SERPIN K
total genus 112
structure length 376
sequence length 376
ec nomenclature
pdb deposition date 1998-03-06

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00079 Serpin Serpin (serine protease inhibitor)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.30.39.10 Mainly Beta Roll Alpha-1-antitrypsin; domain 1 Alpha-1-antitrypsin, domain 1 1sekA02
3.30.497.10 Alpha Beta 2-Layer Sandwich Antithrombin; Chain I, domain 2 Antithrombin, subunit I, domain 2 1sekA01
2V95A 4CAAA 1OVAA 1SEKA 2PEFA 2RIVA 1DVMA 2GD4C 2OAYA 5CDZA 9APIA 1DVNA 1OVAB 2D26A 1PSIA 4AFXA 4AU2A 1QMNA 3F02A 2XN3A 1LQ8A 1F0CA 3FGQA 1LK6I 1OYHL 3LE2A 4DTEA 4EB1L 1JMOA 5CE0A 1ATHA 2HI9A 4R9IA 1HLEA 1JJOC 2HIJL 3OZQA 3Q03A 4ROAA 1C5GA 1DZHL 2WXXA 3Q02A 2RIWA 3DRUA 4EB1I 1M93B 1OPHA 4C49A 2WXZC 4AU4A 2H4PA 1R1LI 2WXWA 2ANTI 2HIJI 3DLWA 1JMJA 1LJ5A 3KCGI 1IMVA 4C41A 2DUTA 3EVJI 3NE4A 1D5SA 3CWLA 2B5TI 4AJUA 1DZGL 4GA7A 4AQHA 4Y40A 2BEHL 4DY7C 1K9OI 2WXZA 4AJTA 2ZV6A 3CAAA 2WY0C 2WY1A 2B4XL 1SR5A 1KCTA 8APIA 1XU8A 9PAIA 1B3KA 1JRRA 2R9YA 2QUGA 1DZGI 5INWA 1SNGA 1OYHI 3R4LA 3UT3A 4PYWA 4ZK3A 1ATUA 1XQGA 2ZNHA 4AU3A 1E04I 2H4RA 3F5NA 3F1SA 2B4XI 3LW2A 1JVQI 3NDAA 5C98A 3PB1I 3CVMA 1ATTA 1DZHI 1AZXI 4AU3B 3DY0A 3CWMA 1E05I 4KDSA 4IC0A 1XQJA 1QLPA 1NQ9I 1T1FA 4Y3KA 4ROBA 5CDXA 3DRMA 1IZ2A 1BY7A 2H4QA 4P0FA 1QMBA 1BR8I 2VDYA 5HGCA 1ANTI 2CEOA 1YXAA 4YIAA 1HP7A 4IF8A 4BB2A 4X30A 4DY0A 3T1PA 4ZK0A 2PEEA 2XN6A 2ARRA 1TB6I 1E03I 2BEHI 1AS4A 3PZFA 1OO8A 3B9FI 2VH4A 4P0OA 4G8RA 2XN7A 3VVJA 1A7CA 1UHGA 2WXYC 1JTIA 4G8OA 1MTPA 3ZHAA 2ARQA 3NDDA 1C8OA 2XN5A 1DB2A 1OVAC 5BRRI 2VDXA 7APIA 1WZ9A 5EI0A 3STOA 1OC0A 2ACHA 3EOXA 4RO9A 5IO1A 3NDFA 4RSQA 2OL2A 1EZXA 3H5CA
chains in the Genus database with same CATH superfamily
2V95A 4CAAA 1OVAA 1SEKA 2PEFA 2RIVA 1DVMA 2GD4C 2OAYA 5CDZA 9APIA 1DVNA 1OVAB 2D26A 1PSIA 4AFXA 4AU2A 1QMNA 3F02A 2XN3A 1LQ8A 1F0CA 3FGQA 1LK6I 1OYHL 3LE2A 4DTEA 4EB1L 1JMOA 5CE0A 1ATHA 2HI9A 4R9IA 1HLEA 1JJOC 2HIJL 3OZQA 3Q03A 4ROAA 1C5GA 1DZHL 2WXXA 3Q02A 2RIWA 3DRUA 4EB1I 1M93B 1OPHA 4C49A 2WXZC 4AU4A 2H4PA 1R1LI 2WXWA 2ANTI 2HIJI 3DLWA 1JMJA 1LJ5A 3KCGI 1IMVA 4C41A 2DUTA 3EVJI 3NE4A 1D5SA 3CWLA 2B5TI 4AJUA 1DZGL 4GA7A 4AQHA 4Y40A 2BEHL 4DY7C 1K9OI 2WXZA 4AJTA 2ZV6A 3CAAA 2WY0C 2WY1A 2B4XL 1SR5A 1KCTA 8APIA 1XU8A 9PAIA 1B3KA 1JRRA 2R9YA 2QUGA 1DZGI 5INWA 1SNGA 1OYHI 3R4LA 3UT3A 4PYWA 4ZK3A 1ATUA 1XQGA 2ZNHA 4AU3A 1E04I 2H4RA 3F5NA 3F1SA 2B4XI 3LW2A 1JVQI 3NDAA 5C98A 3PB1I 3CVMA 1ATTA 1DZHI 1AZXI 4AU3B 3DY0A 3CWMA 1E05I 4KDSA 4IC0A 1XQJA 1QLPA 1NQ9I 1T1FA 4Y3KA 4ROBA 5CDXA 3DRMA 1IZ2A 1BY7A 2H4QA 4P0FA 1QMBA 1BR8I 2VDYA 5HGCA 1ANTI 2CEOA 1YXAA 4YIAA 1HP7A 4IF8A 4BB2A 4X30A 4DY0A 3T1PA 4ZK0A 2PEEA 2XN6A 2ARRA 1TB6I 1E03I 2BEHI 1AS4A 3PZFA 1OO8A 3B9FI 2VH4A 4P0OA 4G8RA 2XN7A 3VVJA 1A7CA 1UHGA 2WXYC 1JTIA 4G8OA 1MTPA 3ZHAA 2ARQA 3NDDA 1C8OA 2XN5A 1DB2A 1OVAC 5BRRI 2VDXA 7APIA 1WZ9A 5EI0A 3STOA 1OC0A 2ACHA 3EOXA 4RO9A 5IO1A 3NDFA 4RSQA 2OL2A 1EZXA 3H5CA
chains in the Genus database with same CATH topology
2V95A 4CAAA 1OVAA 1SEKA 2PEFA 2RIVA 1DVMA 2GD4C 2OAYA 5CDZA 9APIA 1DVNA 1OVAB 2D26A 1PSIA 4AFXA 4AU2A 1QMNA 3F02A 2XN3A 1LQ8A 1F0CA 3FGQA 1LK6I 1OYHL 3LE2A 4DTEA 4EB1L 1JMOA 5CE0A 1ATHA 2HI9A 4R9IA 1HLEA 1JJOC 2HIJL 3OZQA 3Q03A 4ROAA 1C5GA 1DZHL 2WXXA 3Q02A 2RIWA 3DRUA 4EB1I 1M93B 1OPHA 4C49A 2WXZC 4AU4A 2H4PA 1R1LI 2WXWA 2ANTI 2HIJI 3DLWA 1JMJA 1LJ5A 3KCGI 1IMVA 4C41A 2DUTA 3EVJI 3NE4A 1D5SA 3CWLA 2B5TI 4AJUA 1DZGL 4GA7A 4AQHA 4Y40A 2BEHL 4DY7C 1K9OI 2WXZA 4AJTA 2ZV6A 3CAAA 2WY0C 2WY1A 2B4XL 1SR5A 1KCTA 8APIA 1XU8A 9PAIA 1B3KA 1JRRA 2R9YA 2QUGA 1DZGI 5INWA 1SNGA 1OYHI 3R4LA 3UT3A 4PYWA 4ZK3A 1ATUA 1XQGA 2ZNHA 4AU3A 1E04I 2H4RA 3F5NA 3F1SA 2B4XI 3LW2A 1JVQI 3NDAA 5C98A 3PB1I 3CVMA 1ATTA 1DZHI 1AZXI 4AU3B 3DY0A 3CWMA 1E05I 4KDSA 4IC0A 1XQJA 1QLPA 1NQ9I 1T1FA 4Y3KA 4ROBA 5CDXA 3DRMA 1IZ2A 1BY7A 2H4QA 4P0FA 1QMBA 1BR8I 2VDYA 5HGCA 1ANTI 2CEOA 1YXAA 4YIAA 1HP7A 4IF8A 4BB2A 4X30A 4DY0A 3T1PA 4ZK0A 2PEEA 2XN6A 2ARRA 1TB6I 1E03I 2BEHI 1AS4A 3PZFA 1OO8A 3B9FI 2VH4A 4P0OA 4G8RA 2XN7A 3VVJA 1A7CA 1UHGA 2WXYC 1JTIA 4G8OA 1MTPA 3ZHAA 2ARQA 3NDDA 1C8OA 2XN5A 1DB2A 1OVAC 5BRRI 2VDXA 7APIA 1WZ9A 5EI0A 3STOA 1OC0A 2ACHA 3EOXA 4RO9A 5IO1A 3NDFA 4RSQA 2OL2A 1EZXA 3H5CA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2V95 A;  4CAA A;  1OVA A;  1SEK A;  2PEF A;  2RIV A;  1DVM A;  2GD4 C;  2OAY A;  5CDZ A;  9API A;  1DVN A;  1OVA B;  2D26 A;  1PSI A;  4AFX A;  4AU2 A;  1QMN A;  3F02 A;  2XN3 A;  1LQ8 A;  1F0C A;  3FGQ A;  1LK6 I;  1OYH L;  3LE2 A;  4DTE A;  4EB1 L;  1JMO A;  5CE0 A;  1ATH A;  2HI9 A;  4R9I A;  1HLE A;  1JJO C;  2HIJ L;  3OZQ A;  3Q03 A;  4ROA A;  1C5G A;  1DZH L;  2WXX A;  3Q02 A;  2RIW A;  3DRU A;  4EB1 I;  1M93 B;  1OPH A;  4C49 A;  2WXZ C;  4AU4 A;  2H4P A;  1R1L I;  2WXW A;  2ANT I;  2HIJ I;  3DLW A;  1JMJ A;  1LJ5 A;  3KCG I;  1IMV A;  4C41 A;  2DUT A;  3EVJ I;  3NE4 A;  1D5S A;  3CWL A;  2B5T I;  4AJU A;  1DZG L;  4GA7 A;  4AQH A;  4Y40 A;  2BEH L;  4DY7 C;  1K9O I;  2WXZ A;  4AJT A;  2ZV6 A;  3CAA A;  2WY0 C;  2WY1 A;  2B4X L;  1SR5 A;  1KCT A;  8API A;  1XU8 A;  9PAI A;  1B3K A;  1JRR A;  2R9Y A;  2QUG A;  1DZG I;  5INW A;  1SNG A;  1OYH I;  3R4L A;  3UT3 A;  4PYW A;  4ZK3 A;  1ATU A;  1XQG A;  2ZNH A;  4AU3 A;  1E04 I;  2H4R A;  3F5N A;  3F1S A;  2B4X I;  3LW2 A;  1JVQ I;  3NDA A;  5C98 A;  3PB1 I;  3CVM A;  1ATT A;  1DZH I;  1AZX I;  4AU3 B;  3DY0 A;  3CWM A;  1E05 I;  4KDS A;  4IC0 A;  1XQJ A;  1QLP A;  1NQ9 I;  1T1F A;  4Y3K A;  4ROB A;  5CDX A;  3DRM A;  1IZ2 A;  1BY7 A;  2H4Q A;  4P0F A;  1QMB A;  1BR8 I;  2VDY A;  5HGC A;  1ANT I;  2CEO A;  1YXA A;  4YIA A;  1HP7 A;  4IF8 A;  4BB2 A;  4X30 A;  4DY0 A;  3T1P A;  4ZK0 A;  2PEE A;  2XN6 A;  2ARR A;  1TB6 I;  1E03 I;  2BEH I;  1AS4 A;  3PZF A;  1OO8 A;  3B9F I;  2VH4 A;  4P0O A;  4G8R A;  2XN7 A;  3VVJ A;  1A7C A;  1UHG A;  2WXY C;  1JTI A;  4G8O A;  1MTP A;  3ZHA A;  2ARQ A;  3NDD A;  1C8O A;  2XN5 A;  1DB2 A;  1OVA C;  5BRR I;  2VDX A;  7API A;  1WZ9 A;  5EI0 A;  3STO A;  1OC0 A;  2ACH A;  3EOX A;  4RO9 A;  5IO1 A;  3NDF A;  4RSQ A;  2OL2 A;  1EZX A;  3H5C A; 
#chains in the Genus database with same CATH topology
 2V95 A;  4CAA A;  1OVA A;  1SEK A;  2PEF A;  2RIV A;  1DVM A;  2GD4 C;  2OAY A;  5CDZ A;  9API A;  1DVN A;  1OVA B;  2D26 A;  1PSI A;  4AFX A;  4AU2 A;  1QMN A;  3F02 A;  2XN3 A;  1LQ8 A;  1F0C A;  3FGQ A;  1LK6 I;  1OYH L;  3LE2 A;  4DTE A;  4EB1 L;  1JMO A;  5CE0 A;  1ATH A;  2HI9 A;  4R9I A;  1HLE A;  1JJO C;  2HIJ L;  3OZQ A;  3Q03 A;  4ROA A;  1C5G A;  1DZH L;  2WXX A;  3Q02 A;  2RIW A;  3DRU A;  4EB1 I;  1M93 B;  1OPH A;  4C49 A;  2WXZ C;  4AU4 A;  2H4P A;  1R1L I;  2WXW A;  2ANT I;  2HIJ I;  3DLW A;  1JMJ A;  1LJ5 A;  3KCG I;  1IMV A;  4C41 A;  2DUT A;  3EVJ I;  3NE4 A;  1D5S A;  3CWL A;  2B5T I;  4AJU A;  1DZG L;  4GA7 A;  4AQH A;  4Y40 A;  2BEH L;  4DY7 C;  1K9O I;  2WXZ A;  4AJT A;  2ZV6 A;  3CAA A;  2WY0 C;  2WY1 A;  2B4X L;  1SR5 A;  1KCT A;  8API A;  1XU8 A;  9PAI A;  1B3K A;  1JRR A;  2R9Y A;  2QUG A;  1DZG I;  5INW A;  1SNG A;  1OYH I;  3R4L A;  3UT3 A;  4PYW A;  4ZK3 A;  1ATU A;  1XQG A;  2ZNH A;  4AU3 A;  1E04 I;  2H4R A;  3F5N A;  3F1S A;  2B4X I;  3LW2 A;  1JVQ I;  3NDA A;  5C98 A;  3PB1 I;  3CVM A;  1ATT A;  1DZH I;  1AZX I;  4AU3 B;  3DY0 A;  3CWM A;  1E05 I;  4KDS A;  4IC0 A;  1XQJ A;  1QLP A;  1NQ9 I;  1T1F A;  4Y3K A;  4ROB A;  5CDX A;  3DRM A;  1IZ2 A;  1BY7 A;  2H4Q A;  4P0F A;  1QMB A;  1BR8 I;  2VDY A;  5HGC A;  1ANT I;  2CEO A;  1YXA A;  4YIA A;  1HP7 A;  4IF8 A;  4BB2 A;  4X30 A;  4DY0 A;  3T1P A;  4ZK0 A;  2PEE A;  2XN6 A;  2ARR A;  1TB6 I;  1E03 I;  2BEH I;  1AS4 A;  3PZF A;  1OO8 A;  3B9F I;  2VH4 A;  4P0O A;  4G8R A;  2XN7 A;  3VVJ A;  1A7C A;  1UHG A;  2WXY C;  1JTI A;  4G8O A;  1MTP A;  3ZHA A;  2ARQ A;  3NDD A;  1C8O A;  2XN5 A;  1DB2 A;  1OVA C;  5BRR I;  2VDX A;  7API A;  1WZ9 A;  5EI0 A;  3STO A;  1OC0 A;  2ACH A;  3EOX A;  4RO9 A;  5IO1 A;  3NDF A;  4RSQ A;  2OL2 A;  1EZX A;  3H5C A; 
#chains in the Genus database with same CATH homology
 2V95 A;  4CAA A;  1OVA A;  1SEK A;  2PEF A;  2RIV A;  1DVM A;  2GD4 C;  2OAY A;  5CDZ A;  9API A;  1DVN A;  1OVA B;  2D26 A;  1PSI A;  4AFX A;  4AU2 A;  1QMN A;  3F02 A;  2XN3 A;  1LQ8 A;  1F0C A;  3FGQ A;  1LK6 I;  1OYH L;  3LE2 A;  4DTE A;  4EB1 L;  1JMO A;  5CE0 A;  1ATH A;  2HI9 A;  4R9I A;  1HLE A;  1JJO C;  2HIJ L;  3OZQ A;  3Q03 A;  4ROA A;  1C5G A;  1DZH L;  2WXX A;  3Q02 A;  2RIW A;  3DRU A;  4EB1 I;  1M93 B;  1OPH A;  4C49 A;  2WXZ C;  4AU4 A;  2H4P A;  1R1L I;  2WXW A;  2ANT I;  2HIJ I;  3DLW A;  1JMJ A;  1LJ5 A;  3KCG I;  1IMV A;  4C41 A;  2DUT A;  3EVJ I;  3NE4 A;  1D5S A;  3CWL A;  2B5T I;  4AJU A;  1DZG L;  4GA7 A;  4AQH A;  4Y40 A;  2BEH L;  4DY7 C;  1K9O I;  2WXZ A;  4AJT A;  2ZV6 A;  3CAA A;  2WY0 C;  2WY1 A;  2B4X L;  1SR5 A;  1KCT A;  8API A;  1XU8 A;  9PAI A;  1B3K A;  1JRR A;  2R9Y A;  2QUG A;  1DZG I;  5INW A;  1SNG A;  1OYH I;  3R4L A;  3UT3 A;  4PYW A;  4ZK3 A;  1ATU A;  1XQG A;  2ZNH A;  4AU3 A;  1E04 I;  2H4R A;  3F5N A;  3F1S A;  2B4X I;  3LW2 A;  1JVQ I;  3NDA A;  5C98 A;  3PB1 I;  3CVM A;  1ATT A;  1DZH I;  1AZX I;  4AU3 B;  3DY0 A;  3CWM A;  1E05 I;  4KDS A;  4IC0 A;  1XQJ A;  1QLP A;  1NQ9 I;  1T1F A;  4Y3K A;  4ROB A;  5CDX A;  3DRM A;  1IZ2 A;  1BY7 A;  2H4Q A;  4P0F A;  1QMB A;  1BR8 I;  2VDY A;  5HGC A;  1ANT I;  2CEO A;  1YXA A;  4YIA A;  1HP7 A;  4IF8 A;  4BB2 A;  4X30 A;  4DY0 A;  3T1P A;  4ZK0 A;  2PEE A;  2XN6 A;  2ARR A;  1TB6 I;  1E03 I;  2BEH I;  1AS4 A;  3PZF A;  1OO8 A;  3B9F I;  2VH4 A;  4P0O A;  4G8R A;  2XN7 A;  3VVJ A;  1A7C A;  1UHG A;  2WXY C;  1JTI A;  4G8O A;  1MTP A;  3ZHA A;  2ARQ A;  3NDD A;  1C8O A;  2XN5 A;  1DB2 A;  1OVA C;  5BRR I;  2VDX A;  7API A;  1WZ9 A;  5EI0 A;  3STO A;  1OC0 A;  2ACH A;  3EOX A;  4RO9 A;  5IO1 A;  3NDF A;  4RSQ A;  2OL2 A;  1EZX A;  3H5C A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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