2HI9A

Crystal structure of human native protein c inhibitor
Total Genus 107
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
107
sequence length
363
structure length
356
Chain Sequence
SRRDFTFDLYRALASAAPSQNIFFSPVSISMSLAMLSLGAGSSTKMQILEGLGLNLQKSSEKELHRGFQQLLQELNQPRDGFQLSLGNALFTDLVVDLQDTFVSAMKTLYLADTFPTNFRDSAGAMKQINDYVAKQTKGKIVDLLKNLDSNAVVIMVNYIFFKAKWETSFNHKGTQEQDFYVTSETVVRVPMMSREDQYHYLLDRNLSCRVVGVPYQGNATALFILPSEGKMQQVENGLSEKTLRKWLKMFKKRQLELYLPKFSIEGSYQLEKVLPSLGISNVFTSHADLSGISNHSNIQVSEMVHKAVVEVDESGTRAAAATGTIFTSQRLVFNRPFLMFIVDNNILFLGKVNRP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structure of native protein C inhibitor provides insight into its multiple functions.
pubmed doi rcsb
molecule tags Hydrolase inhibitor
source organism Homo sapiens
molecule keywords Plasma serine protease inhibitor
total genus 107
structure length 356
sequence length 363
chains with identical sequence B, C
ec nomenclature
pdb deposition date 2006-06-29
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.30.39.10 Mainly Beta Roll Alpha-1-antitrypsin; domain 1 Alpha-1-antitrypsin, domain 1 2hi9A02
3.30.497.10 Alpha Beta 2-Layer Sandwich Antithrombin; Chain I, domain 2 Antithrombin, subunit I, domain 2 2hi9A01
4Y40A 3ZHAA 3NDAA 3Q02A 1ANTI 2RIWA 3DRUA 3OZQA 2WXYC 3UT3A 4AU4A 1JVQI 4G8RA 1QMNA 3H5CA 2OL2A 4KDSA 1F0CA 2D26A 3DRMA 1DZGI 3STOA 1PSIA 4RO9A 4YIAA 1C8OA 4GA7A 2B4XI 1B3KA 1OYHL 3CWLA 3T1PA 1DVMA 4ROBA 4AQHA 1ATUA 1XU8A 3NDDA 2GD4C 1WZ9A 1XQJA 1C5GA 3KCGI 4AJTA 3VVJA 3F5NA 2XN5A 3CWMA 3CAAA 3EVJI 2OAYA 2XN3A 3EOXA 2WXZC 2QUGA 1BR8I 1KCTA 3PZFA 1DZHI 3CVMA 2ACHA 8APIA 1ATHA 2BEHI 2VDXA 4IF8A 1A7CA 4BB2A 4R9IA 1JMOA 1SNGA 1SR5A 1QLPA 2PEFA 4DY0A 1DZGL 5CE0A 1LQ8A 2B5TI 5CDXA 1OO8A 4DTEA 1ATTA 2B4XL 1BY7A 2ANTI 2H4RA 3F1SA 1TB6I 1AZXI 4AU3B 1JTIA 1QMBA 3NDFA 3Q03A 4IC0A 4EB1I 4AJUA 1NQ9I 1E04I 1K9OI 2H4PA 2HI9A 4AFXA 4AU3A 9PAIA 1OVAB 3B9FI 2H4QA 1E05I 7APIA 2HIJI 5IO1A 1OC0A 1OPHA 1JJOC 2RIVA 3LW2A 1HP7A 2ARRA 1T1FA 1DZHL 2WY0C 2WXWA 2WXXA 1JMJA 2XN6A 5EI0A 1XQGA 3FGQA 2BEHL 1OVAA 3DLWA 1LJ5A 4G8OA 1EZXA 1E03I 4P0FA 4X30A 1IMVA 2V95A 4AU2A 9APIA 1OVAC 1AS4A 1M93B 1D5SA 2R9YA 2PEEA 1SEKA 4ROAA 4C41A 2WY1A 3PB1I 4ZK0A 1YXAA 1DB2A 2VH4A 2ZV6A 3R4LA 4P0OA 5BRRI 1OYHI 2CEOA 1DVNA 1R1LI 2ZNHA 4EB1L 4CAAA 2XN7A 2VDYA 1HLEA 4RSQA 4C49A 4DY7C 5HGCA 3F02A 2DUTA 5CDZA 1IZ2A 4ZK3A 4PYWA 2HIJL 3DY0A 5INWA 3NE4A 1JRRA 1LK6I 1MTPA 2ARQA 2WXZA 4Y3KA 3LE2A 1UHGA 5C98A
chains in the Genus database with same CATH superfamily
4Y40A 3ZHAA 3NDAA 3Q02A 1ANTI 2RIWA 3DRUA 3OZQA 2WXYC 3UT3A 4AU4A 1JVQI 4G8RA 1QMNA 3H5CA 2OL2A 4KDSA 1F0CA 2D26A 3DRMA 1DZGI 3STOA 1PSIA 4RO9A 4YIAA 1C8OA 4GA7A 2B4XI 1B3KA 1OYHL 3CWLA 3T1PA 1DVMA 4ROBA 4AQHA 1ATUA 1XU8A 3NDDA 2GD4C 1WZ9A 1XQJA 1C5GA 3KCGI 4AJTA 3VVJA 3F5NA 2XN5A 3CWMA 3CAAA 3EVJI 2OAYA 2XN3A 3EOXA 2WXZC 2QUGA 1BR8I 1KCTA 3PZFA 1DZHI 3CVMA 2ACHA 8APIA 1ATHA 2BEHI 2VDXA 4IF8A 1A7CA 4BB2A 4R9IA 1JMOA 1SNGA 1SR5A 1QLPA 2PEFA 4DY0A 1DZGL 5CE0A 1LQ8A 2B5TI 5CDXA 1OO8A 4DTEA 1ATTA 2B4XL 1BY7A 2ANTI 2H4RA 3F1SA 1TB6I 1AZXI 4AU3B 1JTIA 1QMBA 3NDFA 3Q03A 4IC0A 4EB1I 4AJUA 1NQ9I 1E04I 1K9OI 2H4PA 2HI9A 4AFXA 4AU3A 9PAIA 1OVAB 3B9FI 2H4QA 1E05I 7APIA 2HIJI 5IO1A 1OC0A 1OPHA 1JJOC 2RIVA 3LW2A 1HP7A 2ARRA 1T1FA 1DZHL 2WY0C 2WXWA 2WXXA 1JMJA 2XN6A 5EI0A 1XQGA 3FGQA 2BEHL 1OVAA 3DLWA 1LJ5A 4G8OA 1EZXA 1E03I 4P0FA 4X30A 1IMVA 2V95A 4AU2A 9APIA 1OVAC 1AS4A 1M93B 1D5SA 2R9YA 2PEEA 1SEKA 4ROAA 4C41A 2WY1A 3PB1I 4ZK0A 1YXAA 1DB2A 2VH4A 2ZV6A 3R4LA 4P0OA 5BRRI 1OYHI 2CEOA 1DVNA 1R1LI 2ZNHA 4EB1L 4CAAA 2XN7A 2VDYA 1HLEA 4RSQA 4C49A 4DY7C 5HGCA 3F02A 2DUTA 5CDZA 1IZ2A 4ZK3A 4PYWA 2HIJL 3DY0A 5INWA 3NE4A 1JRRA 1LK6I 1MTPA 2ARQA 2WXZA 4Y3KA 3LE2A 1UHGA 5C98A
chains in the Genus database with same CATH topology
4Y40A 3ZHAA 3NDAA 3Q02A 1ANTI 2RIWA 3DRUA 3OZQA 2WXYC 3UT3A 4AU4A 1JVQI 4G8RA 1QMNA 3H5CA 2OL2A 4KDSA 1F0CA 2D26A 3DRMA 1DZGI 3STOA 1PSIA 4RO9A 4YIAA 1C8OA 4GA7A 2B4XI 1B3KA 1OYHL 3CWLA 3T1PA 1DVMA 4ROBA 4AQHA 1ATUA 1XU8A 3NDDA 2GD4C 1WZ9A 1XQJA 1C5GA 3KCGI 4AJTA 3VVJA 3F5NA 2XN5A 3CWMA 3CAAA 3EVJI 2OAYA 2XN3A 3EOXA 2WXZC 2QUGA 1BR8I 1KCTA 3PZFA 1DZHI 3CVMA 2ACHA 8APIA 1ATHA 2BEHI 2VDXA 4IF8A 1A7CA 4BB2A 4R9IA 1JMOA 1SNGA 1SR5A 1QLPA 2PEFA 4DY0A 1DZGL 5CE0A 1LQ8A 2B5TI 5CDXA 1OO8A 4DTEA 1ATTA 2B4XL 1BY7A 2ANTI 2H4RA 3F1SA 1TB6I 1AZXI 4AU3B 1JTIA 1QMBA 3NDFA 3Q03A 4IC0A 4EB1I 4AJUA 1NQ9I 1E04I 1K9OI 2H4PA 2HI9A 4AFXA 4AU3A 9PAIA 1OVAB 3B9FI 2H4QA 1E05I 7APIA 2HIJI 5IO1A 1OC0A 1OPHA 1JJOC 2RIVA 3LW2A 1HP7A 2ARRA 1T1FA 1DZHL 2WY0C 2WXWA 2WXXA 1JMJA 2XN6A 5EI0A 1XQGA 3FGQA 2BEHL 1OVAA 3DLWA 1LJ5A 4G8OA 1EZXA 1E03I 4P0FA 4X30A 1IMVA 2V95A 4AU2A 9APIA 1OVAC 1AS4A 1M93B 1D5SA 2R9YA 2PEEA 1SEKA 4ROAA 4C41A 2WY1A 3PB1I 4ZK0A 1YXAA 1DB2A 2VH4A 2ZV6A 3R4LA 4P0OA 5BRRI 1OYHI 2CEOA 1DVNA 1R1LI 2ZNHA 4EB1L 4CAAA 2XN7A 2VDYA 1HLEA 4RSQA 4C49A 4DY7C 5HGCA 3F02A 2DUTA 5CDZA 1IZ2A 4ZK3A 4PYWA 2HIJL 3DY0A 5INWA 3NE4A 1JRRA 1LK6I 1MTPA 2ARQA 2WXZA 4Y3KA 3LE2A 1UHGA 5C98A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4Y40 A;  3ZHA A;  3NDA A;  3Q02 A;  1ANT I;  2RIW A;  3DRU A;  3OZQ A;  2WXY C;  3UT3 A;  4AU4 A;  1JVQ I;  4G8R A;  1QMN A;  3H5C A;  2OL2 A;  4KDS A;  1F0C A;  2D26 A;  3DRM A;  1DZG I;  3STO A;  1PSI A;  4RO9 A;  4YIA A;  1C8O A;  4GA7 A;  2B4X I;  1B3K A;  1OYH L;  3CWL A;  3T1P A;  1DVM A;  4ROB A;  4AQH A;  1ATU A;  1XU8 A;  3NDD A;  2GD4 C;  1WZ9 A;  1XQJ A;  1C5G A;  3KCG I;  4AJT A;  3VVJ A;  3F5N A;  2XN5 A;  3CWM A;  3CAA A;  3EVJ I;  2OAY A;  2XN3 A;  3EOX A;  2WXZ C;  2QUG A;  1BR8 I;  1KCT A;  3PZF A;  1DZH I;  3CVM A;  2ACH A;  8API A;  1ATH A;  2BEH I;  2VDX A;  4IF8 A;  1A7C A;  4BB2 A;  4R9I A;  1JMO A;  1SNG A;  1SR5 A;  1QLP A;  2PEF A;  4DY0 A;  1DZG L;  5CE0 A;  1LQ8 A;  2B5T I;  5CDX A;  1OO8 A;  4DTE A;  1ATT A;  2B4X L;  1BY7 A;  2ANT I;  2H4R A;  3F1S A;  1TB6 I;  1AZX I;  4AU3 B;  1JTI A;  1QMB A;  3NDF A;  3Q03 A;  4IC0 A;  4EB1 I;  4AJU A;  1NQ9 I;  1E04 I;  1K9O I;  2H4P A;  2HI9 A;  4AFX A;  4AU3 A;  9PAI A;  1OVA B;  3B9F I;  2H4Q A;  1E05 I;  7API A;  2HIJ I;  5IO1 A;  1OC0 A;  1OPH A;  1JJO C;  2RIV A;  3LW2 A;  1HP7 A;  2ARR A;  1T1F A;  1DZH L;  2WY0 C;  2WXW A;  2WXX A;  1JMJ A;  2XN6 A;  5EI0 A;  1XQG A;  3FGQ A;  2BEH L;  1OVA A;  3DLW A;  1LJ5 A;  4G8O A;  1EZX A;  1E03 I;  4P0F A;  4X30 A;  1IMV A;  2V95 A;  4AU2 A;  9API A;  1OVA C;  1AS4 A;  1M93 B;  1D5S A;  2R9Y A;  2PEE A;  1SEK A;  4ROA A;  4C41 A;  2WY1 A;  3PB1 I;  4ZK0 A;  1YXA A;  1DB2 A;  2VH4 A;  2ZV6 A;  3R4L A;  4P0O A;  5BRR I;  1OYH I;  2CEO A;  1DVN A;  1R1L I;  2ZNH A;  4EB1 L;  4CAA A;  2XN7 A;  2VDY A;  1HLE A;  4RSQ A;  4C49 A;  4DY7 C;  5HGC A;  3F02 A;  2DUT A;  5CDZ A;  1IZ2 A;  4ZK3 A;  4PYW A;  2HIJ L;  3DY0 A;  5INW A;  3NE4 A;  1JRR A;  1LK6 I;  1MTP A;  2ARQ A;  2WXZ A;  4Y3K A;  3LE2 A;  1UHG A;  5C98 A; 
#chains in the Genus database with same CATH topology
 4Y40 A;  3ZHA A;  3NDA A;  3Q02 A;  1ANT I;  2RIW A;  3DRU A;  3OZQ A;  2WXY C;  3UT3 A;  4AU4 A;  1JVQ I;  4G8R A;  1QMN A;  3H5C A;  2OL2 A;  4KDS A;  1F0C A;  2D26 A;  3DRM A;  1DZG I;  3STO A;  1PSI A;  4RO9 A;  4YIA A;  1C8O A;  4GA7 A;  2B4X I;  1B3K A;  1OYH L;  3CWL A;  3T1P A;  1DVM A;  4ROB A;  4AQH A;  1ATU A;  1XU8 A;  3NDD A;  2GD4 C;  1WZ9 A;  1XQJ A;  1C5G A;  3KCG I;  4AJT A;  3VVJ A;  3F5N A;  2XN5 A;  3CWM A;  3CAA A;  3EVJ I;  2OAY A;  2XN3 A;  3EOX A;  2WXZ C;  2QUG A;  1BR8 I;  1KCT A;  3PZF A;  1DZH I;  3CVM A;  2ACH A;  8API A;  1ATH A;  2BEH I;  2VDX A;  4IF8 A;  1A7C A;  4BB2 A;  4R9I A;  1JMO A;  1SNG A;  1SR5 A;  1QLP A;  2PEF A;  4DY0 A;  1DZG L;  5CE0 A;  1LQ8 A;  2B5T I;  5CDX A;  1OO8 A;  4DTE A;  1ATT A;  2B4X L;  1BY7 A;  2ANT I;  2H4R A;  3F1S A;  1TB6 I;  1AZX I;  4AU3 B;  1JTI A;  1QMB A;  3NDF A;  3Q03 A;  4IC0 A;  4EB1 I;  4AJU A;  1NQ9 I;  1E04 I;  1K9O I;  2H4P A;  2HI9 A;  4AFX A;  4AU3 A;  9PAI A;  1OVA B;  3B9F I;  2H4Q A;  1E05 I;  7API A;  2HIJ I;  5IO1 A;  1OC0 A;  1OPH A;  1JJO C;  2RIV A;  3LW2 A;  1HP7 A;  2ARR A;  1T1F A;  1DZH L;  2WY0 C;  2WXW A;  2WXX A;  1JMJ A;  2XN6 A;  5EI0 A;  1XQG A;  3FGQ A;  2BEH L;  1OVA A;  3DLW A;  1LJ5 A;  4G8O A;  1EZX A;  1E03 I;  4P0F A;  4X30 A;  1IMV A;  2V95 A;  4AU2 A;  9API A;  1OVA C;  1AS4 A;  1M93 B;  1D5S A;  2R9Y A;  2PEE A;  1SEK A;  4ROA A;  4C41 A;  2WY1 A;  3PB1 I;  4ZK0 A;  1YXA A;  1DB2 A;  2VH4 A;  2ZV6 A;  3R4L A;  4P0O A;  5BRR I;  1OYH I;  2CEO A;  1DVN A;  1R1L I;  2ZNH A;  4EB1 L;  4CAA A;  2XN7 A;  2VDY A;  1HLE A;  4RSQ A;  4C49 A;  4DY7 C;  5HGC A;  3F02 A;  2DUT A;  5CDZ A;  1IZ2 A;  4ZK3 A;  4PYW A;  2HIJ L;  3DY0 A;  5INW A;  3NE4 A;  1JRR A;  1LK6 I;  1MTP A;  2ARQ A;  2WXZ A;  4Y3K A;  3LE2 A;  1UHG A;  5C98 A; 
#chains in the Genus database with same CATH homology
 4Y40 A;  3ZHA A;  3NDA A;  3Q02 A;  1ANT I;  2RIW A;  3DRU A;  3OZQ A;  2WXY C;  3UT3 A;  4AU4 A;  1JVQ I;  4G8R A;  1QMN A;  3H5C A;  2OL2 A;  4KDS A;  1F0C A;  2D26 A;  3DRM A;  1DZG I;  3STO A;  1PSI A;  4RO9 A;  4YIA A;  1C8O A;  4GA7 A;  2B4X I;  1B3K A;  1OYH L;  3CWL A;  3T1P A;  1DVM A;  4ROB A;  4AQH A;  1ATU A;  1XU8 A;  3NDD A;  2GD4 C;  1WZ9 A;  1XQJ A;  1C5G A;  3KCG I;  4AJT A;  3VVJ A;  3F5N A;  2XN5 A;  3CWM A;  3CAA A;  3EVJ I;  2OAY A;  2XN3 A;  3EOX A;  2WXZ C;  2QUG A;  1BR8 I;  1KCT A;  3PZF A;  1DZH I;  3CVM A;  2ACH A;  8API A;  1ATH A;  2BEH I;  2VDX A;  4IF8 A;  1A7C A;  4BB2 A;  4R9I A;  1JMO A;  1SNG A;  1SR5 A;  1QLP A;  2PEF A;  4DY0 A;  1DZG L;  5CE0 A;  1LQ8 A;  2B5T I;  5CDX A;  1OO8 A;  4DTE A;  1ATT A;  2B4X L;  1BY7 A;  2ANT I;  2H4R A;  3F1S A;  1TB6 I;  1AZX I;  4AU3 B;  1JTI A;  1QMB A;  3NDF A;  3Q03 A;  4IC0 A;  4EB1 I;  4AJU A;  1NQ9 I;  1E04 I;  1K9O I;  2H4P A;  2HI9 A;  4AFX A;  4AU3 A;  9PAI A;  1OVA B;  3B9F I;  2H4Q A;  1E05 I;  7API A;  2HIJ I;  5IO1 A;  1OC0 A;  1OPH A;  1JJO C;  2RIV A;  3LW2 A;  1HP7 A;  2ARR A;  1T1F A;  1DZH L;  2WY0 C;  2WXW A;  2WXX A;  1JMJ A;  2XN6 A;  5EI0 A;  1XQG A;  3FGQ A;  2BEH L;  1OVA A;  3DLW A;  1LJ5 A;  4G8O A;  1EZX A;  1E03 I;  4P0F A;  4X30 A;  1IMV A;  2V95 A;  4AU2 A;  9API A;  1OVA C;  1AS4 A;  1M93 B;  1D5S A;  2R9Y A;  2PEE A;  1SEK A;  4ROA A;  4C41 A;  2WY1 A;  3PB1 I;  4ZK0 A;  1YXA A;  1DB2 A;  2VH4 A;  2ZV6 A;  3R4L A;  4P0O A;  5BRR I;  1OYH I;  2CEO A;  1DVN A;  1R1L I;  2ZNH A;  4EB1 L;  4CAA A;  2XN7 A;  2VDY A;  1HLE A;  4RSQ A;  4C49 A;  4DY7 C;  5HGC A;  3F02 A;  2DUT A;  5CDZ A;  1IZ2 A;  4ZK3 A;  4PYW A;  2HIJ L;  3DY0 A;  5INW A;  3NE4 A;  1JRR A;  1LK6 I;  1MTP A;  2ARQ A;  2WXZ A;  4Y3K A;  3LE2 A;  1UHG A;  5C98 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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