2HIJI

Crystal structure of p14 alanine variant of antithrombin
Total Genus 112
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
112
sequence length
427
structure length
411
Chain Sequence
VDICTAKPRDIPMNPMCIYRSPEKTNRRVWELSKANSRFATTFYQHLADSKNDNDNIFLSPLSISTAFAMTKLGACNDTLQQLMEVFKFDTISEKTSDQIHFFFAKLNCRLYRKAAKSSKLVSANRLFGDKSLTFNETYQDISELVYGAKLQPLDFKENAEQSRAAINKWVSNKTEGRITDVIPSAINELTVLVLVNTIYFKGLWKSKFSPENTRKELFYKADGESCSASMMYQEGKFRYRRVAEGTQVLELPFKGDDITMVLILPKPEKSLAKVEKELTPEVLQEWLDELEEMMLVVHMPRFRIEDGFSLKEQLQDMGLVDLFSPEKSKLPGIVAEGRDDLYVSDAFHKAFLEVNEEGAEAAASTAVVIAGRSLNPNRVTFKANRPFLVFIREVPLNTIIFMGRVANPCV
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal Structure of P14 Alanine Variant of Antithrombin
rcsb
molecule tags Blood clotting/ hydrolase inhibitor
source organism Homo sapiens
molecule keywords Antithrombin-III
total genus 112
structure length 411
sequence length 427
ec nomenclature
pdb deposition date 2006-06-29

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
I PF00079 Serpin Serpin (serine protease inhibitor)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.30.39.10 Mainly Beta Roll Alpha-1-antitrypsin; domain 1 Alpha-1-antitrypsin, domain 1 2hijI02
3.30.497.10 Alpha Beta 2-Layer Sandwich Antithrombin; Chain I, domain 2 Antithrombin, subunit I, domain 2 2hijI01
4PYWA 3F02A 3Q02A 3NE4A 2XN7A 2WXWA 4Y40A 4AJTA 1K9OI 1E04I 3NDDA 1A7CA 2XN6A 4YIAA 3F5NA 1OYHI 7APIA 4C49A 1QMBA 1OC0A 1D5SA 2WY0C 4RO9A 1AZXI 2OL2A 3CVMA 2HIJI 9PAIA 1QMNA 2ARQA 1EZXA 9APIA 1OPHA 3VVJA 2B4XI 2ANTI 2CEOA 4AU3A 1KCTA 3B9FI 1F0CA 3EVJI 1HP7A 4AFXA 1M93B 1SEKA 3R4LA 1AS4A 4C41A 8APIA 1IMVA 3OZQA 1LJ5A 1OYHL 1C5GA 1BY7A 3NDFA 2RIVA 3FGQA 4DY7C 2XN3A 3DRUA 2ZV6A 2HIJL 2H4PA 3PZFA 1T1FA 3PB1I 3Q03A 4IF8A 2B5TI 4G8OA 2B4XL 2WXZA 1HLEA 2VDYA 2OAYA 4P0FA 4EB1I 1JTIA 1XQGA 2WXYC 5IO1A 1YXAA 3DY0A 2VDXA 1ATTA 4RSQA 2H4QA 3LW2A 2GD4C 1JJOC 1NQ9I 5EI0A 2V95A 4CAAA 5CDXA 1E03I 4ZK3A 3H5CA 5BRRI 2HI9A 1PSIA 2ZNHA 1JMOA 3F1SA 4EB1L 4X30A 4ZK0A 1TB6I 1ANTI 5HGCA 5CE0A 1JMJA 1LK6I 2WXZC 4AJUA 1BR8I 4R9IA 4KDSA 4Y3KA 1SNGA 3ZHAA 3CWLA 3CWMA 1OO8A 4DY0A 1R1LI 4AQHA 1WZ9A 2ARRA 5CDZA 1E05I 2PEFA 1C8OA 1JRRA 3KCGI 2QUGA 1LQ8A 3NDAA 3T1PA 2BEHI 1DZGI 2RIWA 4BB2A 2DUTA 2VH4A 2XN5A 4ROAA 1IZ2A 1DZHI 2D26A 3LE2A 1XU8A 3EOXA 2WXXA 2WY1A 1SR5A 1QLPA 3UT3A 1JVQI 3DLWA 3CAAA 5C98A 1DVNA 2R9YA 1OVAC 4P0OA 1MTPA 3STOA 4AU3B 1OVAB 1DB2A 2BEHL 1B3KA 4DTEA 4AU2A 1DZGL 1XQJA 1OVAA 1ATHA 1UHGA 5INWA 1DZHL 4GA7A 2ACHA 2PEEA 4G8RA 2H4RA 1ATUA 4AU4A 1DVMA 4IC0A 3DRMA 4ROBA
chains in the Genus database with same CATH superfamily
4PYWA 3F02A 3Q02A 3NE4A 2XN7A 2WXWA 4Y40A 4AJTA 1K9OI 1E04I 3NDDA 1A7CA 2XN6A 4YIAA 3F5NA 1OYHI 7APIA 4C49A 1QMBA 1OC0A 1D5SA 2WY0C 4RO9A 1AZXI 2OL2A 3CVMA 2HIJI 9PAIA 1QMNA 2ARQA 1EZXA 9APIA 1OPHA 3VVJA 2B4XI 2ANTI 2CEOA 4AU3A 1KCTA 3B9FI 1F0CA 3EVJI 1HP7A 4AFXA 1M93B 1SEKA 3R4LA 1AS4A 4C41A 8APIA 1IMVA 3OZQA 1LJ5A 1OYHL 1C5GA 1BY7A 3NDFA 2RIVA 3FGQA 4DY7C 2XN3A 3DRUA 2ZV6A 2HIJL 2H4PA 3PZFA 1T1FA 3PB1I 3Q03A 4IF8A 2B5TI 4G8OA 2B4XL 2WXZA 1HLEA 2VDYA 2OAYA 4P0FA 4EB1I 1JTIA 1XQGA 2WXYC 5IO1A 1YXAA 3DY0A 2VDXA 1ATTA 4RSQA 2H4QA 3LW2A 2GD4C 1JJOC 1NQ9I 5EI0A 2V95A 4CAAA 5CDXA 1E03I 4ZK3A 3H5CA 5BRRI 2HI9A 1PSIA 2ZNHA 1JMOA 3F1SA 4EB1L 4X30A 4ZK0A 1TB6I 1ANTI 5HGCA 5CE0A 1JMJA 1LK6I 2WXZC 4AJUA 1BR8I 4R9IA 4KDSA 4Y3KA 1SNGA 3ZHAA 3CWLA 3CWMA 1OO8A 4DY0A 1R1LI 4AQHA 1WZ9A 2ARRA 5CDZA 1E05I 2PEFA 1C8OA 1JRRA 3KCGI 2QUGA 1LQ8A 3NDAA 3T1PA 2BEHI 1DZGI 2RIWA 4BB2A 2DUTA 2VH4A 2XN5A 4ROAA 1IZ2A 1DZHI 2D26A 3LE2A 1XU8A 3EOXA 2WXXA 2WY1A 1SR5A 1QLPA 3UT3A 1JVQI 3DLWA 3CAAA 5C98A 1DVNA 2R9YA 1OVAC 4P0OA 1MTPA 3STOA 4AU3B 1OVAB 1DB2A 2BEHL 1B3KA 4DTEA 4AU2A 1DZGL 1XQJA 1OVAA 1ATHA 1UHGA 5INWA 1DZHL 4GA7A 2ACHA 2PEEA 4G8RA 2H4RA 1ATUA 4AU4A 1DVMA 4IC0A 3DRMA 4ROBA
chains in the Genus database with same CATH topology
4PYWA 3F02A 3Q02A 3NE4A 2XN7A 2WXWA 4Y40A 4AJTA 1K9OI 1E04I 3NDDA 1A7CA 2XN6A 4YIAA 3F5NA 1OYHI 7APIA 4C49A 1QMBA 1OC0A 1D5SA 2WY0C 4RO9A 1AZXI 2OL2A 3CVMA 2HIJI 9PAIA 1QMNA 2ARQA 1EZXA 9APIA 1OPHA 3VVJA 2B4XI 2ANTI 2CEOA 4AU3A 1KCTA 3B9FI 1F0CA 3EVJI 1HP7A 4AFXA 1M93B 1SEKA 3R4LA 1AS4A 4C41A 8APIA 1IMVA 3OZQA 1LJ5A 1OYHL 1C5GA 1BY7A 3NDFA 2RIVA 3FGQA 4DY7C 2XN3A 3DRUA 2ZV6A 2HIJL 2H4PA 3PZFA 1T1FA 3PB1I 3Q03A 4IF8A 2B5TI 4G8OA 2B4XL 2WXZA 1HLEA 2VDYA 2OAYA 4P0FA 4EB1I 1JTIA 1XQGA 2WXYC 5IO1A 1YXAA 3DY0A 2VDXA 1ATTA 4RSQA 2H4QA 3LW2A 2GD4C 1JJOC 1NQ9I 5EI0A 2V95A 4CAAA 5CDXA 1E03I 4ZK3A 3H5CA 5BRRI 2HI9A 1PSIA 2ZNHA 1JMOA 3F1SA 4EB1L 4X30A 4ZK0A 1TB6I 1ANTI 5HGCA 5CE0A 1JMJA 1LK6I 2WXZC 4AJUA 1BR8I 4R9IA 4KDSA 4Y3KA 1SNGA 3ZHAA 3CWLA 3CWMA 1OO8A 4DY0A 1R1LI 4AQHA 1WZ9A 2ARRA 5CDZA 1E05I 2PEFA 1C8OA 1JRRA 3KCGI 2QUGA 1LQ8A 3NDAA 3T1PA 2BEHI 1DZGI 2RIWA 4BB2A 2DUTA 2VH4A 2XN5A 4ROAA 1IZ2A 1DZHI 2D26A 3LE2A 1XU8A 3EOXA 2WXXA 2WY1A 1SR5A 1QLPA 3UT3A 1JVQI 3DLWA 3CAAA 5C98A 1DVNA 2R9YA 1OVAC 4P0OA 1MTPA 3STOA 4AU3B 1OVAB 1DB2A 2BEHL 1B3KA 4DTEA 4AU2A 1DZGL 1XQJA 1OVAA 1ATHA 1UHGA 5INWA 1DZHL 4GA7A 2ACHA 2PEEA 4G8RA 2H4RA 1ATUA 4AU4A 1DVMA 4IC0A 3DRMA 4ROBA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4PYW A;  3F02 A;  3Q02 A;  3NE4 A;  2XN7 A;  2WXW A;  4Y40 A;  4AJT A;  1K9O I;  1E04 I;  3NDD A;  1A7C A;  2XN6 A;  4YIA A;  3F5N A;  1OYH I;  7API A;  4C49 A;  1QMB A;  1OC0 A;  1D5S A;  2WY0 C;  4RO9 A;  1AZX I;  2OL2 A;  3CVM A;  2HIJ I;  9PAI A;  1QMN A;  2ARQ A;  1EZX A;  9API A;  1OPH A;  3VVJ A;  2B4X I;  2ANT I;  2CEO A;  4AU3 A;  1KCT A;  3B9F I;  1F0C A;  3EVJ I;  1HP7 A;  4AFX A;  1M93 B;  1SEK A;  3R4L A;  1AS4 A;  4C41 A;  8API A;  1IMV A;  3OZQ A;  1LJ5 A;  1OYH L;  1C5G A;  1BY7 A;  3NDF A;  2RIV A;  3FGQ A;  4DY7 C;  2XN3 A;  3DRU A;  2ZV6 A;  2HIJ L;  2H4P A;  3PZF A;  1T1F A;  3PB1 I;  3Q03 A;  4IF8 A;  2B5T I;  4G8O A;  2B4X L;  2WXZ A;  1HLE A;  2VDY A;  2OAY A;  4P0F A;  4EB1 I;  1JTI A;  1XQG A;  2WXY C;  5IO1 A;  1YXA A;  3DY0 A;  2VDX A;  1ATT A;  4RSQ A;  2H4Q A;  3LW2 A;  2GD4 C;  1JJO C;  1NQ9 I;  5EI0 A;  2V95 A;  4CAA A;  5CDX A;  1E03 I;  4ZK3 A;  3H5C A;  5BRR I;  2HI9 A;  1PSI A;  2ZNH A;  1JMO A;  3F1S A;  4EB1 L;  4X30 A;  4ZK0 A;  1TB6 I;  1ANT I;  5HGC A;  5CE0 A;  1JMJ A;  1LK6 I;  2WXZ C;  4AJU A;  1BR8 I;  4R9I A;  4KDS A;  4Y3K A;  1SNG A;  3ZHA A;  3CWL A;  3CWM A;  1OO8 A;  4DY0 A;  1R1L I;  4AQH A;  1WZ9 A;  2ARR A;  5CDZ A;  1E05 I;  2PEF A;  1C8O A;  1JRR A;  3KCG I;  2QUG A;  1LQ8 A;  3NDA A;  3T1P A;  2BEH I;  1DZG I;  2RIW A;  4BB2 A;  2DUT A;  2VH4 A;  2XN5 A;  4ROA A;  1IZ2 A;  1DZH I;  2D26 A;  3LE2 A;  1XU8 A;  3EOX A;  2WXX A;  2WY1 A;  1SR5 A;  1QLP A;  3UT3 A;  1JVQ I;  3DLW A;  3CAA A;  5C98 A;  1DVN A;  2R9Y A;  1OVA C;  4P0O A;  1MTP A;  3STO A;  4AU3 B;  1OVA B;  1DB2 A;  2BEH L;  1B3K A;  4DTE A;  4AU2 A;  1DZG L;  1XQJ A;  1OVA A;  1ATH A;  1UHG A;  5INW A;  1DZH L;  4GA7 A;  2ACH A;  2PEE A;  4G8R A;  2H4R A;  1ATU A;  4AU4 A;  1DVM A;  4IC0 A;  3DRM A;  4ROB A; 
#chains in the Genus database with same CATH topology
 4PYW A;  3F02 A;  3Q02 A;  3NE4 A;  2XN7 A;  2WXW A;  4Y40 A;  4AJT A;  1K9O I;  1E04 I;  3NDD A;  1A7C A;  2XN6 A;  4YIA A;  3F5N A;  1OYH I;  7API A;  4C49 A;  1QMB A;  1OC0 A;  1D5S A;  2WY0 C;  4RO9 A;  1AZX I;  2OL2 A;  3CVM A;  2HIJ I;  9PAI A;  1QMN A;  2ARQ A;  1EZX A;  9API A;  1OPH A;  3VVJ A;  2B4X I;  2ANT I;  2CEO A;  4AU3 A;  1KCT A;  3B9F I;  1F0C A;  3EVJ I;  1HP7 A;  4AFX A;  1M93 B;  1SEK A;  3R4L A;  1AS4 A;  4C41 A;  8API A;  1IMV A;  3OZQ A;  1LJ5 A;  1OYH L;  1C5G A;  1BY7 A;  3NDF A;  2RIV A;  3FGQ A;  4DY7 C;  2XN3 A;  3DRU A;  2ZV6 A;  2HIJ L;  2H4P A;  3PZF A;  1T1F A;  3PB1 I;  3Q03 A;  4IF8 A;  2B5T I;  4G8O A;  2B4X L;  2WXZ A;  1HLE A;  2VDY A;  2OAY A;  4P0F A;  4EB1 I;  1JTI A;  1XQG A;  2WXY C;  5IO1 A;  1YXA A;  3DY0 A;  2VDX A;  1ATT A;  4RSQ A;  2H4Q A;  3LW2 A;  2GD4 C;  1JJO C;  1NQ9 I;  5EI0 A;  2V95 A;  4CAA A;  5CDX A;  1E03 I;  4ZK3 A;  3H5C A;  5BRR I;  2HI9 A;  1PSI A;  2ZNH A;  1JMO A;  3F1S A;  4EB1 L;  4X30 A;  4ZK0 A;  1TB6 I;  1ANT I;  5HGC A;  5CE0 A;  1JMJ A;  1LK6 I;  2WXZ C;  4AJU A;  1BR8 I;  4R9I A;  4KDS A;  4Y3K A;  1SNG A;  3ZHA A;  3CWL A;  3CWM A;  1OO8 A;  4DY0 A;  1R1L I;  4AQH A;  1WZ9 A;  2ARR A;  5CDZ A;  1E05 I;  2PEF A;  1C8O A;  1JRR A;  3KCG I;  2QUG A;  1LQ8 A;  3NDA A;  3T1P A;  2BEH I;  1DZG I;  2RIW A;  4BB2 A;  2DUT A;  2VH4 A;  2XN5 A;  4ROA A;  1IZ2 A;  1DZH I;  2D26 A;  3LE2 A;  1XU8 A;  3EOX A;  2WXX A;  2WY1 A;  1SR5 A;  1QLP A;  3UT3 A;  1JVQ I;  3DLW A;  3CAA A;  5C98 A;  1DVN A;  2R9Y A;  1OVA C;  4P0O A;  1MTP A;  3STO A;  4AU3 B;  1OVA B;  1DB2 A;  2BEH L;  1B3K A;  4DTE A;  4AU2 A;  1DZG L;  1XQJ A;  1OVA A;  1ATH A;  1UHG A;  5INW A;  1DZH L;  4GA7 A;  2ACH A;  2PEE A;  4G8R A;  2H4R A;  1ATU A;  4AU4 A;  1DVM A;  4IC0 A;  3DRM A;  4ROB A; 
#chains in the Genus database with same CATH homology
 4PYW A;  3F02 A;  3Q02 A;  3NE4 A;  2XN7 A;  2WXW A;  4Y40 A;  4AJT A;  1K9O I;  1E04 I;  3NDD A;  1A7C A;  2XN6 A;  4YIA A;  3F5N A;  1OYH I;  7API A;  4C49 A;  1QMB A;  1OC0 A;  1D5S A;  2WY0 C;  4RO9 A;  1AZX I;  2OL2 A;  3CVM A;  2HIJ I;  9PAI A;  1QMN A;  2ARQ A;  1EZX A;  9API A;  1OPH A;  3VVJ A;  2B4X I;  2ANT I;  2CEO A;  4AU3 A;  1KCT A;  3B9F I;  1F0C A;  3EVJ I;  1HP7 A;  4AFX A;  1M93 B;  1SEK A;  3R4L A;  1AS4 A;  4C41 A;  8API A;  1IMV A;  3OZQ A;  1LJ5 A;  1OYH L;  1C5G A;  1BY7 A;  3NDF A;  2RIV A;  3FGQ A;  4DY7 C;  2XN3 A;  3DRU A;  2ZV6 A;  2HIJ L;  2H4P A;  3PZF A;  1T1F A;  3PB1 I;  3Q03 A;  4IF8 A;  2B5T I;  4G8O A;  2B4X L;  2WXZ A;  1HLE A;  2VDY A;  2OAY A;  4P0F A;  4EB1 I;  1JTI A;  1XQG A;  2WXY C;  5IO1 A;  1YXA A;  3DY0 A;  2VDX A;  1ATT A;  4RSQ A;  2H4Q A;  3LW2 A;  2GD4 C;  1JJO C;  1NQ9 I;  5EI0 A;  2V95 A;  4CAA A;  5CDX A;  1E03 I;  4ZK3 A;  3H5C A;  5BRR I;  2HI9 A;  1PSI A;  2ZNH A;  1JMO A;  3F1S A;  4EB1 L;  4X30 A;  4ZK0 A;  1TB6 I;  1ANT I;  5HGC A;  5CE0 A;  1JMJ A;  1LK6 I;  2WXZ C;  4AJU A;  1BR8 I;  4R9I A;  4KDS A;  4Y3K A;  1SNG A;  3ZHA A;  3CWL A;  3CWM A;  1OO8 A;  4DY0 A;  1R1L I;  4AQH A;  1WZ9 A;  2ARR A;  5CDZ A;  1E05 I;  2PEF A;  1C8O A;  1JRR A;  3KCG I;  2QUG A;  1LQ8 A;  3NDA A;  3T1P A;  2BEH I;  1DZG I;  2RIW A;  4BB2 A;  2DUT A;  2VH4 A;  2XN5 A;  4ROA A;  1IZ2 A;  1DZH I;  2D26 A;  3LE2 A;  1XU8 A;  3EOX A;  2WXX A;  2WY1 A;  1SR5 A;  1QLP A;  3UT3 A;  1JVQ I;  3DLW A;  3CAA A;  5C98 A;  1DVN A;  2R9Y A;  1OVA C;  4P0O A;  1MTP A;  3STO A;  4AU3 B;  1OVA B;  1DB2 A;  2BEH L;  1B3K A;  4DTE A;  4AU2 A;  1DZG L;  1XQJ A;  1OVA A;  1ATH A;  1UHG A;  5INW A;  1DZH L;  4GA7 A;  2ACH A;  2PEE A;  4G8R A;  2H4R A;  1ATU A;  4AU4 A;  1DVM A;  4IC0 A;  3DRM A;  4ROB A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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