2VDYA

Crystal structure of the reactive loop cleaved corticosteroid binding globulin complexed with cortisol
Total Genus 118
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
118
sequence length
368
structure length
361
Chain Sequence
GLASANVDFAFSLYKHLVALSPKKNIFISPVSISMALAMLSLGTCGHTRAQLLQGLGFNLSETEIHQGFQHLHQLFAKSDTSLEMTMGNALFLDGSLELLESFSADIKHYYESEVLAMNFQDWATASRQINSYVKNKTQGKIVDLFDSPAILVLVNYIFFKGTWTQPFDLASTREENFYVDETTVVKVPMMLQSSTISYLHDSELPCQLVQMNYVGNGTVFFILPDKGKMNTVIAALSRDTINRWSAGLTSSQVDLYIPKVTISGVYDLGDVLEEMGIADLFTTQANFSRITQDAQLKSSKVVHKAVLQLNEEGTEAAGAMFLEAIPRKPIILRFNQPFIIMIFDHFTWSSLFLARVMNPV
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title The S-to-R Transition of Corticosteroid-Binding Globulin and the Mechanism of Hormone Release.
pubmed doi rcsb
molecule tags Transport protein
source organism Homo sapiens
molecule keywords CORTICOSTEROID-BINDING GLOBULIN
total genus 118
structure length 361
sequence length 368
chains with identical sequence B
ec nomenclature
pdb deposition date 2007-10-13

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00079 Serpin Serpin (serine protease inhibitor)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.30.39.10 Mainly Beta Roll Alpha-1-antitrypsin; domain 1 Alpha-1-antitrypsin, domain 1 2vdyA02
3.30.497.10 Alpha Beta 2-Layer Sandwich Antithrombin; Chain I, domain 2 Antithrombin, subunit I, domain 2 2vdyA01
1DZHL 4CAAA 1JMOA 3EVJI 1XQJA 1MTPA 2WXWA 3EOXA 5CDXA 1QLPA 1QMBA 1OYHI 4ZK0A 4AFXA 1JJOC 3CAAA 1OVAA 1OYHL 1NQ9I 3OZQA 1LQ8A 4C41A 5C98A 4IF8A 4Y40A 1IZ2A 1B3KA 2HI9A 1XU8A 1DVNA 5EI0A 3NDAA 2QUGA 5IO1A 4X30A 5CDZA 3ZHAA 2VDYA 1JRRA 1SR5A 4G8OA 4GA7A 2VH4A 3NDDA 4G8RA 4AU3A 1E03I 4AU4A 1OVAC 3F5NA 1EZXA 1SEKA 1XQGA 2OL2A 2XN3A 2XN5A 1BY7A 1R1LI 4Y3KA 4P0FA 3R4LA 5HGCA 1BR8I 3DY0A 1E05I 3Q03A 1HLEA 4DY7C 2WY0C 5INWA 3F02A 4AJUA 2PEEA 5CE0A 1DZGI 1TB6I 3UT3A 1DZGL 3B9FI 4AQHA 1YXAA 3KCGI 5BRRI 9APIA 2ARRA 4R9IA 9PAIA 4ROAA 4RO9A 2WXZA 3DRMA 1WZ9A 1DB2A 1KCTA 3Q02A 4PYWA 4AU2A 2H4QA 3DRUA 1F0CA 1OVAB 2H4PA 1C5GA 3DLWA 4BB2A 1LJ5A 4C49A 3F1SA 1QMNA 4YIAA 1LK6I 1UHGA 1AS4A 2CEOA 2V95A 1M93B 3CWMA 1K9OI 4AJTA 1DVMA 3FGQA 2WXYC 2ZNHA 3T1PA 4DTEA 4DY0A 4ZK3A 1ATTA 3NE4A 1JMJA 2D26A 2DUTA 2RIWA 2ARQA 4AU3B 3CWLA 1T1FA 2B4XL 3NDFA 1OC0A 3LW2A 1SNGA 2ANTI 1ATUA 3CVMA 1JVQI 1A7CA 2GD4C 2RIVA 2XN6A 2R9YA 2ZV6A 4ROBA 2WY1A 4EB1I 7APIA 2HIJI 3H5CA 3PB1I 1AZXI 3PZFA 4EB1L 1D5SA 2HIJL 1OO8A 2B5TI 2ACHA 4KDSA 1IMVA 2BEHI 1PSIA 3STOA 4RSQA 2PEFA 1E04I 2OAYA 3LE2A 2BEHL 3VVJA 8APIA 2VDXA 1HP7A 4IC0A 2WXZC 1ANTI 1C8OA 4P0OA 2XN7A 2B4XI 2H4RA 1OPHA 1JTIA 1ATHA 2WXXA 1DZHI
chains in the Genus database with same CATH superfamily
1DZHL 4CAAA 1JMOA 3EVJI 1XQJA 1MTPA 2WXWA 3EOXA 5CDXA 1QLPA 1QMBA 1OYHI 4ZK0A 4AFXA 1JJOC 3CAAA 1OVAA 1OYHL 1NQ9I 3OZQA 1LQ8A 4C41A 5C98A 4IF8A 4Y40A 1IZ2A 1B3KA 2HI9A 1XU8A 1DVNA 5EI0A 3NDAA 2QUGA 5IO1A 4X30A 5CDZA 3ZHAA 2VDYA 1JRRA 1SR5A 4G8OA 4GA7A 2VH4A 3NDDA 4G8RA 4AU3A 1E03I 4AU4A 1OVAC 3F5NA 1EZXA 1SEKA 1XQGA 2OL2A 2XN3A 2XN5A 1BY7A 1R1LI 4Y3KA 4P0FA 3R4LA 5HGCA 1BR8I 3DY0A 1E05I 3Q03A 1HLEA 4DY7C 2WY0C 5INWA 3F02A 4AJUA 2PEEA 5CE0A 1DZGI 1TB6I 3UT3A 1DZGL 3B9FI 4AQHA 1YXAA 3KCGI 5BRRI 9APIA 2ARRA 4R9IA 9PAIA 4ROAA 4RO9A 2WXZA 3DRMA 1WZ9A 1DB2A 1KCTA 3Q02A 4PYWA 4AU2A 2H4QA 3DRUA 1F0CA 1OVAB 2H4PA 1C5GA 3DLWA 4BB2A 1LJ5A 4C49A 3F1SA 1QMNA 4YIAA 1LK6I 1UHGA 1AS4A 2CEOA 2V95A 1M93B 3CWMA 1K9OI 4AJTA 1DVMA 3FGQA 2WXYC 2ZNHA 3T1PA 4DTEA 4DY0A 4ZK3A 1ATTA 3NE4A 1JMJA 2D26A 2DUTA 2RIWA 2ARQA 4AU3B 3CWLA 1T1FA 2B4XL 3NDFA 1OC0A 3LW2A 1SNGA 2ANTI 1ATUA 3CVMA 1JVQI 1A7CA 2GD4C 2RIVA 2XN6A 2R9YA 2ZV6A 4ROBA 2WY1A 4EB1I 7APIA 2HIJI 3H5CA 3PB1I 1AZXI 3PZFA 4EB1L 1D5SA 2HIJL 1OO8A 2B5TI 2ACHA 4KDSA 1IMVA 2BEHI 1PSIA 3STOA 4RSQA 2PEFA 1E04I 2OAYA 3LE2A 2BEHL 3VVJA 8APIA 2VDXA 1HP7A 4IC0A 2WXZC 1ANTI 1C8OA 4P0OA 2XN7A 2B4XI 2H4RA 1OPHA 1JTIA 1ATHA 2WXXA 1DZHI
chains in the Genus database with same CATH topology
1DZHL 4CAAA 1JMOA 3EVJI 1XQJA 1MTPA 2WXWA 3EOXA 5CDXA 1QLPA 1QMBA 1OYHI 4ZK0A 4AFXA 1JJOC 3CAAA 1OVAA 1OYHL 1NQ9I 3OZQA 1LQ8A 4C41A 5C98A 4IF8A 4Y40A 1IZ2A 1B3KA 2HI9A 1XU8A 1DVNA 5EI0A 3NDAA 2QUGA 5IO1A 4X30A 5CDZA 3ZHAA 2VDYA 1JRRA 1SR5A 4G8OA 4GA7A 2VH4A 3NDDA 4G8RA 4AU3A 1E03I 4AU4A 1OVAC 3F5NA 1EZXA 1SEKA 1XQGA 2OL2A 2XN3A 2XN5A 1BY7A 1R1LI 4Y3KA 4P0FA 3R4LA 5HGCA 1BR8I 3DY0A 1E05I 3Q03A 1HLEA 4DY7C 2WY0C 5INWA 3F02A 4AJUA 2PEEA 5CE0A 1DZGI 1TB6I 3UT3A 1DZGL 3B9FI 4AQHA 1YXAA 3KCGI 5BRRI 9APIA 2ARRA 4R9IA 9PAIA 4ROAA 4RO9A 2WXZA 3DRMA 1WZ9A 1DB2A 1KCTA 3Q02A 4PYWA 4AU2A 2H4QA 3DRUA 1F0CA 1OVAB 2H4PA 1C5GA 3DLWA 4BB2A 1LJ5A 4C49A 3F1SA 1QMNA 4YIAA 1LK6I 1UHGA 1AS4A 2CEOA 2V95A 1M93B 3CWMA 1K9OI 4AJTA 1DVMA 3FGQA 2WXYC 2ZNHA 3T1PA 4DTEA 4DY0A 4ZK3A 1ATTA 3NE4A 1JMJA 2D26A 2DUTA 2RIWA 2ARQA 4AU3B 3CWLA 1T1FA 2B4XL 3NDFA 1OC0A 3LW2A 1SNGA 2ANTI 1ATUA 3CVMA 1JVQI 1A7CA 2GD4C 2RIVA 2XN6A 2R9YA 2ZV6A 4ROBA 2WY1A 4EB1I 7APIA 2HIJI 3H5CA 3PB1I 1AZXI 3PZFA 4EB1L 1D5SA 2HIJL 1OO8A 2B5TI 2ACHA 4KDSA 1IMVA 2BEHI 1PSIA 3STOA 4RSQA 2PEFA 1E04I 2OAYA 3LE2A 2BEHL 3VVJA 8APIA 2VDXA 1HP7A 4IC0A 2WXZC 1ANTI 1C8OA 4P0OA 2XN7A 2B4XI 2H4RA 1OPHA 1JTIA 1ATHA 2WXXA 1DZHI
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1DZH L;  4CAA A;  1JMO A;  3EVJ I;  1XQJ A;  1MTP A;  2WXW A;  3EOX A;  5CDX A;  1QLP A;  1QMB A;  1OYH I;  4ZK0 A;  4AFX A;  1JJO C;  3CAA A;  1OVA A;  1OYH L;  1NQ9 I;  3OZQ A;  1LQ8 A;  4C41 A;  5C98 A;  4IF8 A;  4Y40 A;  1IZ2 A;  1B3K A;  2HI9 A;  1XU8 A;  1DVN A;  5EI0 A;  3NDA A;  2QUG A;  5IO1 A;  4X30 A;  5CDZ A;  3ZHA A;  2VDY A;  1JRR A;  1SR5 A;  4G8O A;  4GA7 A;  2VH4 A;  3NDD A;  4G8R A;  4AU3 A;  1E03 I;  4AU4 A;  1OVA C;  3F5N A;  1EZX A;  1SEK A;  1XQG A;  2OL2 A;  2XN3 A;  2XN5 A;  1BY7 A;  1R1L I;  4Y3K A;  4P0F A;  3R4L A;  5HGC A;  1BR8 I;  3DY0 A;  1E05 I;  3Q03 A;  1HLE A;  4DY7 C;  2WY0 C;  5INW A;  3F02 A;  4AJU A;  2PEE A;  5CE0 A;  1DZG I;  1TB6 I;  3UT3 A;  1DZG L;  3B9F I;  4AQH A;  1YXA A;  3KCG I;  5BRR I;  9API A;  2ARR A;  4R9I A;  9PAI A;  4ROA A;  4RO9 A;  2WXZ A;  3DRM A;  1WZ9 A;  1DB2 A;  1KCT A;  3Q02 A;  4PYW A;  4AU2 A;  2H4Q A;  3DRU A;  1F0C A;  1OVA B;  2H4P A;  1C5G A;  3DLW A;  4BB2 A;  1LJ5 A;  4C49 A;  3F1S A;  1QMN A;  4YIA A;  1LK6 I;  1UHG A;  1AS4 A;  2CEO A;  2V95 A;  1M93 B;  3CWM A;  1K9O I;  4AJT A;  1DVM A;  3FGQ A;  2WXY C;  2ZNH A;  3T1P A;  4DTE A;  4DY0 A;  4ZK3 A;  1ATT A;  3NE4 A;  1JMJ A;  2D26 A;  2DUT A;  2RIW A;  2ARQ A;  4AU3 B;  3CWL A;  1T1F A;  2B4X L;  3NDF A;  1OC0 A;  3LW2 A;  1SNG A;  2ANT I;  1ATU A;  3CVM A;  1JVQ I;  1A7C A;  2GD4 C;  2RIV A;  2XN6 A;  2R9Y A;  2ZV6 A;  4ROB A;  2WY1 A;  4EB1 I;  7API A;  2HIJ I;  3H5C A;  3PB1 I;  1AZX I;  3PZF A;  4EB1 L;  1D5S A;  2HIJ L;  1OO8 A;  2B5T I;  2ACH A;  4KDS A;  1IMV A;  2BEH I;  1PSI A;  3STO A;  4RSQ A;  2PEF A;  1E04 I;  2OAY A;  3LE2 A;  2BEH L;  3VVJ A;  8API A;  2VDX A;  1HP7 A;  4IC0 A;  2WXZ C;  1ANT I;  1C8O A;  4P0O A;  2XN7 A;  2B4X I;  2H4R A;  1OPH A;  1JTI A;  1ATH A;  2WXX A;  1DZH I; 
#chains in the Genus database with same CATH topology
 1DZH L;  4CAA A;  1JMO A;  3EVJ I;  1XQJ A;  1MTP A;  2WXW A;  3EOX A;  5CDX A;  1QLP A;  1QMB A;  1OYH I;  4ZK0 A;  4AFX A;  1JJO C;  3CAA A;  1OVA A;  1OYH L;  1NQ9 I;  3OZQ A;  1LQ8 A;  4C41 A;  5C98 A;  4IF8 A;  4Y40 A;  1IZ2 A;  1B3K A;  2HI9 A;  1XU8 A;  1DVN A;  5EI0 A;  3NDA A;  2QUG A;  5IO1 A;  4X30 A;  5CDZ A;  3ZHA A;  2VDY A;  1JRR A;  1SR5 A;  4G8O A;  4GA7 A;  2VH4 A;  3NDD A;  4G8R A;  4AU3 A;  1E03 I;  4AU4 A;  1OVA C;  3F5N A;  1EZX A;  1SEK A;  1XQG A;  2OL2 A;  2XN3 A;  2XN5 A;  1BY7 A;  1R1L I;  4Y3K A;  4P0F A;  3R4L A;  5HGC A;  1BR8 I;  3DY0 A;  1E05 I;  3Q03 A;  1HLE A;  4DY7 C;  2WY0 C;  5INW A;  3F02 A;  4AJU A;  2PEE A;  5CE0 A;  1DZG I;  1TB6 I;  3UT3 A;  1DZG L;  3B9F I;  4AQH A;  1YXA A;  3KCG I;  5BRR I;  9API A;  2ARR A;  4R9I A;  9PAI A;  4ROA A;  4RO9 A;  2WXZ A;  3DRM A;  1WZ9 A;  1DB2 A;  1KCT A;  3Q02 A;  4PYW A;  4AU2 A;  2H4Q A;  3DRU A;  1F0C A;  1OVA B;  2H4P A;  1C5G A;  3DLW A;  4BB2 A;  1LJ5 A;  4C49 A;  3F1S A;  1QMN A;  4YIA A;  1LK6 I;  1UHG A;  1AS4 A;  2CEO A;  2V95 A;  1M93 B;  3CWM A;  1K9O I;  4AJT A;  1DVM A;  3FGQ A;  2WXY C;  2ZNH A;  3T1P A;  4DTE A;  4DY0 A;  4ZK3 A;  1ATT A;  3NE4 A;  1JMJ A;  2D26 A;  2DUT A;  2RIW A;  2ARQ A;  4AU3 B;  3CWL A;  1T1F A;  2B4X L;  3NDF A;  1OC0 A;  3LW2 A;  1SNG A;  2ANT I;  1ATU A;  3CVM A;  1JVQ I;  1A7C A;  2GD4 C;  2RIV A;  2XN6 A;  2R9Y A;  2ZV6 A;  4ROB A;  2WY1 A;  4EB1 I;  7API A;  2HIJ I;  3H5C A;  3PB1 I;  1AZX I;  3PZF A;  4EB1 L;  1D5S A;  2HIJ L;  1OO8 A;  2B5T I;  2ACH A;  4KDS A;  1IMV A;  2BEH I;  1PSI A;  3STO A;  4RSQ A;  2PEF A;  1E04 I;  2OAY A;  3LE2 A;  2BEH L;  3VVJ A;  8API A;  2VDX A;  1HP7 A;  4IC0 A;  2WXZ C;  1ANT I;  1C8O A;  4P0O A;  2XN7 A;  2B4X I;  2H4R A;  1OPH A;  1JTI A;  1ATH A;  2WXX A;  1DZH I; 
#chains in the Genus database with same CATH homology
 1DZH L;  4CAA A;  1JMO A;  3EVJ I;  1XQJ A;  1MTP A;  2WXW A;  3EOX A;  5CDX A;  1QLP A;  1QMB A;  1OYH I;  4ZK0 A;  4AFX A;  1JJO C;  3CAA A;  1OVA A;  1OYH L;  1NQ9 I;  3OZQ A;  1LQ8 A;  4C41 A;  5C98 A;  4IF8 A;  4Y40 A;  1IZ2 A;  1B3K A;  2HI9 A;  1XU8 A;  1DVN A;  5EI0 A;  3NDA A;  2QUG A;  5IO1 A;  4X30 A;  5CDZ A;  3ZHA A;  2VDY A;  1JRR A;  1SR5 A;  4G8O A;  4GA7 A;  2VH4 A;  3NDD A;  4G8R A;  4AU3 A;  1E03 I;  4AU4 A;  1OVA C;  3F5N A;  1EZX A;  1SEK A;  1XQG A;  2OL2 A;  2XN3 A;  2XN5 A;  1BY7 A;  1R1L I;  4Y3K A;  4P0F A;  3R4L A;  5HGC A;  1BR8 I;  3DY0 A;  1E05 I;  3Q03 A;  1HLE A;  4DY7 C;  2WY0 C;  5INW A;  3F02 A;  4AJU A;  2PEE A;  5CE0 A;  1DZG I;  1TB6 I;  3UT3 A;  1DZG L;  3B9F I;  4AQH A;  1YXA A;  3KCG I;  5BRR I;  9API A;  2ARR A;  4R9I A;  9PAI A;  4ROA A;  4RO9 A;  2WXZ A;  3DRM A;  1WZ9 A;  1DB2 A;  1KCT A;  3Q02 A;  4PYW A;  4AU2 A;  2H4Q A;  3DRU A;  1F0C A;  1OVA B;  2H4P A;  1C5G A;  3DLW A;  4BB2 A;  1LJ5 A;  4C49 A;  3F1S A;  1QMN A;  4YIA A;  1LK6 I;  1UHG A;  1AS4 A;  2CEO A;  2V95 A;  1M93 B;  3CWM A;  1K9O I;  4AJT A;  1DVM A;  3FGQ A;  2WXY C;  2ZNH A;  3T1P A;  4DTE A;  4DY0 A;  4ZK3 A;  1ATT A;  3NE4 A;  1JMJ A;  2D26 A;  2DUT A;  2RIW A;  2ARQ A;  4AU3 B;  3CWL A;  1T1F A;  2B4X L;  3NDF A;  1OC0 A;  3LW2 A;  1SNG A;  2ANT I;  1ATU A;  3CVM A;  1JVQ I;  1A7C A;  2GD4 C;  2RIV A;  2XN6 A;  2R9Y A;  2ZV6 A;  4ROB A;  2WY1 A;  4EB1 I;  7API A;  2HIJ I;  3H5C A;  3PB1 I;  1AZX I;  3PZF A;  4EB1 L;  1D5S A;  2HIJ L;  1OO8 A;  2B5T I;  2ACH A;  4KDS A;  1IMV A;  2BEH I;  1PSI A;  3STO A;  4RSQ A;  2PEF A;  1E04 I;  2OAY A;  3LE2 A;  2BEH L;  3VVJ A;  8API A;  2VDX A;  1HP7 A;  4IC0 A;  2WXZ C;  1ANT I;  1C8O A;  4P0O A;  2XN7 A;  2B4X I;  2H4R A;  1OPH A;  1JTI A;  1ATH A;  2WXX A;  1DZH I; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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