2HI9A

Crystal structure of human native protein c inhibitor
Total Genus 107
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
107
sequence length
363
structure length
356
Chain Sequence
SRRDFTFDLYRALASAAPSQNIFFSPVSISMSLAMLSLGAGSSTKMQILEGLGLNLQKSSEKELHRGFQQLLQELNQPRDGFQLSLGNALFTDLVVDLQDTFVSAMKTLYLADTFPTNFRDSAGAMKQINDYVAKQTKGKIVDLLKNLDSNAVVIMVNYIFFKAKWETSFNHKGTQEQDFYVTSETVVRVPMMSREDQYHYLLDRNLSCRVVGVPYQGNATALFILPSEGKMQQVENGLSEKTLRKWLKMFKKRQLELYLPKFSIEGSYQLEKVLPSLGISNVFTSHADLSGISNHSNIQVSEMVHKAVVEVDESGTRAAAATGTIFTSQRLVFNRPFLMFIVDNNILFLGKVNRP
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
publication title Structure of native protein C inhibitor provides insight into its multiple functions.
pubmed doi rcsb
molecule tags Hydrolase inhibitor
source organism Homo sapiens
molecule keywords Plasma serine protease inhibitor
total genus 107
structure length 356
sequence length 363
chains with identical sequence B, C
ec nomenclature
pdb deposition date 2006-06-29
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.30.39.10 Mainly Beta Roll Alpha-1-antitrypsin; domain 1 Alpha-1-antitrypsin, domain 1 2hi9A02
3.30.497.10 Alpha Beta 2-Layer Sandwich Antithrombin; Chain I, domain 2 Antithrombin, subunit I, domain 2 2hi9A01
4P0FA 4AFXA 4PYWA 1DZHI 1NQ9I 4AU4A 1XU8A 1OVAA 1DZGI 1SNGA 5BRRI 4X30A 2VDXA 4YIAA 2ZNHA 2ZV6A 3NDDA 1ATHA 4KDSA 4Y40A 1LQ8A 5INWA 4AJUA 1OO8A 1T1FA 3OZQA 4IF8A 2VH4A 4G8OA 4ROBA 1DVNA 1OYHL 5C98A 1K9OI 1QMNA 1B3KA 3ZHAA 3DLWA 1QLPA 1OPHA 4DY7C 1F0CA 2OL2A 3F02A 1DB2A 2GD4C 2WY1A 1ATUA 1XQJA 1A7CA 3F1SA 5CDXA 1OYHI 3CWLA 1SEKA 4R9IA 4RSQA 1BY7A 3Q02A 2BEHL 2WY0C 2XN7A 1UHGA 4BB2A 1JVQI 1TB6I 1HP7A 2WXYC 1XQGA 3DRUA 4C49A 3STOA 1LJ5A 1AZXI 2OAYA 4DTEA 2B4XL 1OC0A 1ANTI 2ARQA 4EB1L 4AU3A 3B9FI 3UT3A 3FGQA 2R9YA 4AU2A 2WXZC 2BEHI 3F5NA 1EZXA 1AS4A 5EI0A 1M93B 1R1LI 1OVAB 1YXAA 2WXXA 3DRMA 3CWMA 4P0OA 4AQHA 3NDAA 1IMVA 2B4XI 2DUTA 2WXZA 3CVMA 4DY0A 4C41A 3NE4A 2QUGA 4EB1I 3PB1I 5HGCA 8APIA 1E04I 3R4LA 1JTIA 1QMBA 2WXWA 4AU3B 1IZ2A 1BR8I 3LW2A 5CDZA 3Q03A 4RO9A 3EVJI 3T1PA 4IC0A 1PSIA 1E05I 2ACHA 3DY0A 2H4QA 2D26A 2PEEA 3KCGI 2XN5A 3CAAA 3VVJA 3LE2A 5IO1A 4ROAA 1E03I 2CEOA 3PZFA 7APIA 2VDYA 1LK6I 2B5TI 3H5CA 9APIA 2V95A 4ZK0A 1JMJA 1HLEA 1JMOA 5CE0A 2HI9A 4AJTA 9PAIA 1C5GA 2H4PA 2RIWA 2HIJL 1MTPA 2XN3A 2ARRA 1D5SA 1C8OA 4G8RA 3NDFA 1DZHL 4Y3KA 2RIVA 1DZGL 1WZ9A 3EOXA 1DVMA 2H4RA 2PEFA 2XN6A 1JRRA 2ANTI 1OVAC 4ZK3A 2HIJI 1JJOC 1SR5A 1ATTA 4CAAA 4GA7A 1KCTA
chains in the Genus database with same CATH superfamily
4P0FA 4AFXA 4PYWA 1DZHI 1NQ9I 4AU4A 1XU8A 1OVAA 1DZGI 1SNGA 5BRRI 4X30A 2VDXA 4YIAA 2ZNHA 2ZV6A 3NDDA 1ATHA 4KDSA 4Y40A 1LQ8A 5INWA 4AJUA 1OO8A 1T1FA 3OZQA 4IF8A 2VH4A 4G8OA 4ROBA 1DVNA 1OYHL 5C98A 1K9OI 1QMNA 1B3KA 3ZHAA 3DLWA 1QLPA 1OPHA 4DY7C 1F0CA 2OL2A 3F02A 1DB2A 2GD4C 2WY1A 1ATUA 1XQJA 1A7CA 3F1SA 5CDXA 1OYHI 3CWLA 1SEKA 4R9IA 4RSQA 1BY7A 3Q02A 2BEHL 2WY0C 2XN7A 1UHGA 4BB2A 1JVQI 1TB6I 1HP7A 2WXYC 1XQGA 3DRUA 4C49A 3STOA 1LJ5A 1AZXI 2OAYA 4DTEA 2B4XL 1OC0A 1ANTI 2ARQA 4EB1L 4AU3A 3B9FI 3UT3A 3FGQA 2R9YA 4AU2A 2WXZC 2BEHI 3F5NA 1EZXA 1AS4A 5EI0A 1M93B 1R1LI 1OVAB 1YXAA 2WXXA 3DRMA 3CWMA 4P0OA 4AQHA 3NDAA 1IMVA 2B4XI 2DUTA 2WXZA 3CVMA 4DY0A 4C41A 3NE4A 2QUGA 4EB1I 3PB1I 5HGCA 8APIA 1E04I 3R4LA 1JTIA 1QMBA 2WXWA 4AU3B 1IZ2A 1BR8I 3LW2A 5CDZA 3Q03A 4RO9A 3EVJI 3T1PA 4IC0A 1PSIA 1E05I 2ACHA 3DY0A 2H4QA 2D26A 2PEEA 3KCGI 2XN5A 3CAAA 3VVJA 3LE2A 5IO1A 4ROAA 1E03I 2CEOA 3PZFA 7APIA 2VDYA 1LK6I 2B5TI 3H5CA 9APIA 2V95A 4ZK0A 1JMJA 1HLEA 1JMOA 5CE0A 2HI9A 4AJTA 9PAIA 1C5GA 2H4PA 2RIWA 2HIJL 1MTPA 2XN3A 2ARRA 1D5SA 1C8OA 4G8RA 3NDFA 1DZHL 4Y3KA 2RIVA 1DZGL 1WZ9A 3EOXA 1DVMA 2H4RA 2PEFA 2XN6A 1JRRA 2ANTI 1OVAC 4ZK3A 2HIJI 1JJOC 1SR5A 1ATTA 4CAAA 4GA7A 1KCTA
chains in the Genus database with same CATH topology
4P0FA 4AFXA 4PYWA 1DZHI 1NQ9I 4AU4A 1XU8A 1OVAA 1DZGI 1SNGA 5BRRI 4X30A 2VDXA 4YIAA 2ZNHA 2ZV6A 3NDDA 1ATHA 4KDSA 4Y40A 1LQ8A 5INWA 4AJUA 1OO8A 1T1FA 3OZQA 4IF8A 2VH4A 4G8OA 4ROBA 1DVNA 1OYHL 5C98A 1K9OI 1QMNA 1B3KA 3ZHAA 3DLWA 1QLPA 1OPHA 4DY7C 1F0CA 2OL2A 3F02A 1DB2A 2GD4C 2WY1A 1ATUA 1XQJA 1A7CA 3F1SA 5CDXA 1OYHI 3CWLA 1SEKA 4R9IA 4RSQA 1BY7A 3Q02A 2BEHL 2WY0C 2XN7A 1UHGA 4BB2A 1JVQI 1TB6I 1HP7A 2WXYC 1XQGA 3DRUA 4C49A 3STOA 1LJ5A 1AZXI 2OAYA 4DTEA 2B4XL 1OC0A 1ANTI 2ARQA 4EB1L 4AU3A 3B9FI 3UT3A 3FGQA 2R9YA 4AU2A 2WXZC 2BEHI 3F5NA 1EZXA 1AS4A 5EI0A 1M93B 1R1LI 1OVAB 1YXAA 2WXXA 3DRMA 3CWMA 4P0OA 4AQHA 3NDAA 1IMVA 2B4XI 2DUTA 2WXZA 3CVMA 4DY0A 4C41A 3NE4A 2QUGA 4EB1I 3PB1I 5HGCA 8APIA 1E04I 3R4LA 1JTIA 1QMBA 2WXWA 4AU3B 1IZ2A 1BR8I 3LW2A 5CDZA 3Q03A 4RO9A 3EVJI 3T1PA 4IC0A 1PSIA 1E05I 2ACHA 3DY0A 2H4QA 2D26A 2PEEA 3KCGI 2XN5A 3CAAA 3VVJA 3LE2A 5IO1A 4ROAA 1E03I 2CEOA 3PZFA 7APIA 2VDYA 1LK6I 2B5TI 3H5CA 9APIA 2V95A 4ZK0A 1JMJA 1HLEA 1JMOA 5CE0A 2HI9A 4AJTA 9PAIA 1C5GA 2H4PA 2RIWA 2HIJL 1MTPA 2XN3A 2ARRA 1D5SA 1C8OA 4G8RA 3NDFA 1DZHL 4Y3KA 2RIVA 1DZGL 1WZ9A 3EOXA 1DVMA 2H4RA 2PEFA 2XN6A 1JRRA 2ANTI 1OVAC 4ZK3A 2HIJI 1JJOC 1SR5A 1ATTA 4CAAA 4GA7A 1KCTA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4P0F A;  4AFX A;  4PYW A;  1DZH I;  1NQ9 I;  4AU4 A;  1XU8 A;  1OVA A;  1DZG I;  1SNG A;  5BRR I;  4X30 A;  2VDX A;  4YIA A;  2ZNH A;  2ZV6 A;  3NDD A;  1ATH A;  4KDS A;  4Y40 A;  1LQ8 A;  5INW A;  4AJU A;  1OO8 A;  1T1F A;  3OZQ A;  4IF8 A;  2VH4 A;  4G8O A;  4ROB A;  1DVN A;  1OYH L;  5C98 A;  1K9O I;  1QMN A;  1B3K A;  3ZHA A;  3DLW A;  1QLP A;  1OPH A;  4DY7 C;  1F0C A;  2OL2 A;  3F02 A;  1DB2 A;  2GD4 C;  2WY1 A;  1ATU A;  1XQJ A;  1A7C A;  3F1S A;  5CDX A;  1OYH I;  3CWL A;  1SEK A;  4R9I A;  4RSQ A;  1BY7 A;  3Q02 A;  2BEH L;  2WY0 C;  2XN7 A;  1UHG A;  4BB2 A;  1JVQ I;  1TB6 I;  1HP7 A;  2WXY C;  1XQG A;  3DRU A;  4C49 A;  3STO A;  1LJ5 A;  1AZX I;  2OAY A;  4DTE A;  2B4X L;  1OC0 A;  1ANT I;  2ARQ A;  4EB1 L;  4AU3 A;  3B9F I;  3UT3 A;  3FGQ A;  2R9Y A;  4AU2 A;  2WXZ C;  2BEH I;  3F5N A;  1EZX A;  1AS4 A;  5EI0 A;  1M93 B;  1R1L I;  1OVA B;  1YXA A;  2WXX A;  3DRM A;  3CWM A;  4P0O A;  4AQH A;  3NDA A;  1IMV A;  2B4X I;  2DUT A;  2WXZ A;  3CVM A;  4DY0 A;  4C41 A;  3NE4 A;  2QUG A;  4EB1 I;  3PB1 I;  5HGC A;  8API A;  1E04 I;  3R4L A;  1JTI A;  1QMB A;  2WXW A;  4AU3 B;  1IZ2 A;  1BR8 I;  3LW2 A;  5CDZ A;  3Q03 A;  4RO9 A;  3EVJ I;  3T1P A;  4IC0 A;  1PSI A;  1E05 I;  2ACH A;  3DY0 A;  2H4Q A;  2D26 A;  2PEE A;  3KCG I;  2XN5 A;  3CAA A;  3VVJ A;  3LE2 A;  5IO1 A;  4ROA A;  1E03 I;  2CEO A;  3PZF A;  7API A;  2VDY A;  1LK6 I;  2B5T I;  3H5C A;  9API A;  2V95 A;  4ZK0 A;  1JMJ A;  1HLE A;  1JMO A;  5CE0 A;  2HI9 A;  4AJT A;  9PAI A;  1C5G A;  2H4P A;  2RIW A;  2HIJ L;  1MTP A;  2XN3 A;  2ARR A;  1D5S A;  1C8O A;  4G8R A;  3NDF A;  1DZH L;  4Y3K A;  2RIV A;  1DZG L;  1WZ9 A;  3EOX A;  1DVM A;  2H4R A;  2PEF A;  2XN6 A;  1JRR A;  2ANT I;  1OVA C;  4ZK3 A;  2HIJ I;  1JJO C;  1SR5 A;  1ATT A;  4CAA A;  4GA7 A;  1KCT A; 
#chains in the Genus database with same CATH topology
 4P0F A;  4AFX A;  4PYW A;  1DZH I;  1NQ9 I;  4AU4 A;  1XU8 A;  1OVA A;  1DZG I;  1SNG A;  5BRR I;  4X30 A;  2VDX A;  4YIA A;  2ZNH A;  2ZV6 A;  3NDD A;  1ATH A;  4KDS A;  4Y40 A;  1LQ8 A;  5INW A;  4AJU A;  1OO8 A;  1T1F A;  3OZQ A;  4IF8 A;  2VH4 A;  4G8O A;  4ROB A;  1DVN A;  1OYH L;  5C98 A;  1K9O I;  1QMN A;  1B3K A;  3ZHA A;  3DLW A;  1QLP A;  1OPH A;  4DY7 C;  1F0C A;  2OL2 A;  3F02 A;  1DB2 A;  2GD4 C;  2WY1 A;  1ATU A;  1XQJ A;  1A7C A;  3F1S A;  5CDX A;  1OYH I;  3CWL A;  1SEK A;  4R9I A;  4RSQ A;  1BY7 A;  3Q02 A;  2BEH L;  2WY0 C;  2XN7 A;  1UHG A;  4BB2 A;  1JVQ I;  1TB6 I;  1HP7 A;  2WXY C;  1XQG A;  3DRU A;  4C49 A;  3STO A;  1LJ5 A;  1AZX I;  2OAY A;  4DTE A;  2B4X L;  1OC0 A;  1ANT I;  2ARQ A;  4EB1 L;  4AU3 A;  3B9F I;  3UT3 A;  3FGQ A;  2R9Y A;  4AU2 A;  2WXZ C;  2BEH I;  3F5N A;  1EZX A;  1AS4 A;  5EI0 A;  1M93 B;  1R1L I;  1OVA B;  1YXA A;  2WXX A;  3DRM A;  3CWM A;  4P0O A;  4AQH A;  3NDA A;  1IMV A;  2B4X I;  2DUT A;  2WXZ A;  3CVM A;  4DY0 A;  4C41 A;  3NE4 A;  2QUG A;  4EB1 I;  3PB1 I;  5HGC A;  8API A;  1E04 I;  3R4L A;  1JTI A;  1QMB A;  2WXW A;  4AU3 B;  1IZ2 A;  1BR8 I;  3LW2 A;  5CDZ A;  3Q03 A;  4RO9 A;  3EVJ I;  3T1P A;  4IC0 A;  1PSI A;  1E05 I;  2ACH A;  3DY0 A;  2H4Q A;  2D26 A;  2PEE A;  3KCG I;  2XN5 A;  3CAA A;  3VVJ A;  3LE2 A;  5IO1 A;  4ROA A;  1E03 I;  2CEO A;  3PZF A;  7API A;  2VDY A;  1LK6 I;  2B5T I;  3H5C A;  9API A;  2V95 A;  4ZK0 A;  1JMJ A;  1HLE A;  1JMO A;  5CE0 A;  2HI9 A;  4AJT A;  9PAI A;  1C5G A;  2H4P A;  2RIW A;  2HIJ L;  1MTP A;  2XN3 A;  2ARR A;  1D5S A;  1C8O A;  4G8R A;  3NDF A;  1DZH L;  4Y3K A;  2RIV A;  1DZG L;  1WZ9 A;  3EOX A;  1DVM A;  2H4R A;  2PEF A;  2XN6 A;  1JRR A;  2ANT I;  1OVA C;  4ZK3 A;  2HIJ I;  1JJO C;  1SR5 A;  1ATT A;  4CAA A;  4GA7 A;  1KCT A; 
#chains in the Genus database with same CATH homology
 4P0F A;  4AFX A;  4PYW A;  1DZH I;  1NQ9 I;  4AU4 A;  1XU8 A;  1OVA A;  1DZG I;  1SNG A;  5BRR I;  4X30 A;  2VDX A;  4YIA A;  2ZNH A;  2ZV6 A;  3NDD A;  1ATH A;  4KDS A;  4Y40 A;  1LQ8 A;  5INW A;  4AJU A;  1OO8 A;  1T1F A;  3OZQ A;  4IF8 A;  2VH4 A;  4G8O A;  4ROB A;  1DVN A;  1OYH L;  5C98 A;  1K9O I;  1QMN A;  1B3K A;  3ZHA A;  3DLW A;  1QLP A;  1OPH A;  4DY7 C;  1F0C A;  2OL2 A;  3F02 A;  1DB2 A;  2GD4 C;  2WY1 A;  1ATU A;  1XQJ A;  1A7C A;  3F1S A;  5CDX A;  1OYH I;  3CWL A;  1SEK A;  4R9I A;  4RSQ A;  1BY7 A;  3Q02 A;  2BEH L;  2WY0 C;  2XN7 A;  1UHG A;  4BB2 A;  1JVQ I;  1TB6 I;  1HP7 A;  2WXY C;  1XQG A;  3DRU A;  4C49 A;  3STO A;  1LJ5 A;  1AZX I;  2OAY A;  4DTE A;  2B4X L;  1OC0 A;  1ANT I;  2ARQ A;  4EB1 L;  4AU3 A;  3B9F I;  3UT3 A;  3FGQ A;  2R9Y A;  4AU2 A;  2WXZ C;  2BEH I;  3F5N A;  1EZX A;  1AS4 A;  5EI0 A;  1M93 B;  1R1L I;  1OVA B;  1YXA A;  2WXX A;  3DRM A;  3CWM A;  4P0O A;  4AQH A;  3NDA A;  1IMV A;  2B4X I;  2DUT A;  2WXZ A;  3CVM A;  4DY0 A;  4C41 A;  3NE4 A;  2QUG A;  4EB1 I;  3PB1 I;  5HGC A;  8API A;  1E04 I;  3R4L A;  1JTI A;  1QMB A;  2WXW A;  4AU3 B;  1IZ2 A;  1BR8 I;  3LW2 A;  5CDZ A;  3Q03 A;  4RO9 A;  3EVJ I;  3T1P A;  4IC0 A;  1PSI A;  1E05 I;  2ACH A;  3DY0 A;  2H4Q A;  2D26 A;  2PEE A;  3KCG I;  2XN5 A;  3CAA A;  3VVJ A;  3LE2 A;  5IO1 A;  4ROA A;  1E03 I;  2CEO A;  3PZF A;  7API A;  2VDY A;  1LK6 I;  2B5T I;  3H5C A;  9API A;  2V95 A;  4ZK0 A;  1JMJ A;  1HLE A;  1JMO A;  5CE0 A;  2HI9 A;  4AJT A;  9PAI A;  1C5G A;  2H4P A;  2RIW A;  2HIJ L;  1MTP A;  2XN3 A;  2ARR A;  1D5S A;  1C8O A;  4G8R A;  3NDF A;  1DZH L;  4Y3K A;  2RIV A;  1DZG L;  1WZ9 A;  3EOX A;  1DVM A;  2H4R A;  2PEF A;  2XN6 A;  1JRR A;  2ANT I;  1OVA C;  4ZK3 A;  2HIJ I;  1JJO C;  1SR5 A;  1ATT A;  4CAA A;  4GA7 A;  1KCT A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...