2HIJI

Crystal structure of p14 alanine variant of antithrombin
Total Genus 112
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
112
sequence length
427
structure length
411
Chain Sequence
VDICTAKPRDIPMNPMCIYRSPEKTNRRVWELSKANSRFATTFYQHLADSKNDNDNIFLSPLSISTAFAMTKLGACNDTLQQLMEVFKFDTISEKTSDQIHFFFAKLNCRLYRKAAKSSKLVSANRLFGDKSLTFNETYQDISELVYGAKLQPLDFKENAEQSRAAINKWVSNKTEGRITDVIPSAINELTVLVLVNTIYFKGLWKSKFSPENTRKELFYKADGESCSASMMYQEGKFRYRRVAEGTQVLELPFKGDDITMVLILPKPEKSLAKVEKELTPEVLQEWLDELEEMMLVVHMPRFRIEDGFSLKEQLQDMGLVDLFSPEKSKLPGIVAEGRDDLYVSDAFHKAFLEVNEEGAEAAASTAVVIAGRSLNPNRVTFKANRPFLVFIREVPLNTIIFMGRVANPCV
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal Structure of P14 Alanine Variant of Antithrombin
rcsb
molecule tags Blood clotting/ hydrolase inhibitor
source organism Homo sapiens
molecule keywords Antithrombin-III
total genus 112
structure length 411
sequence length 427
ec nomenclature
pdb deposition date 2006-06-29

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
I PF00079 Serpin Serpin (serine protease inhibitor)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.30.39.10 Mainly Beta Roll Alpha-1-antitrypsin; domain 1 Alpha-1-antitrypsin, domain 1 2hijI02
3.30.497.10 Alpha Beta 2-Layer Sandwich Antithrombin; Chain I, domain 2 Antithrombin, subunit I, domain 2 2hijI01
3EOXA 1HLEA 3DRMA 3B9FI 4ZK0A 2WXZC 1ATUA 2ANTI 3CVMA 4Y40A 1DZGL 4AU4A 9PAIA 3STOA 3R4LA 1E04I 2BEHI 1JMJA 1NQ9I 2XN7A 4RSQA 1A7CA 1T1FA 1AS4A 1QMNA 3DLWA 1YXAA 3Q02A 4AQHA 2H4QA 2RIWA 1BR8I 4AFXA 1OYHI 4ROBA 2B4XI 2ZV6A 4P0FA 4AJTA 2PEFA 1ATHA 4IC0A 4CAAA 5C98A 4EB1I 5CDXA 1MTPA 1M93B 3DRUA 1JMOA 1DVMA 1R1LI 5CDZA 4ZK3A 1BY7A 2XN5A 3PZFA 5EI0A 4P0OA 2D26A 4PYWA 3NDDA 4AU3B 4AU3A 4YIAA 4DY7C 1DVNA 1K9OI 1JJOC 4C49A 3CWLA 1E05I 4EB1L 1OO8A 1DZHI 2GD4C 9APIA 8APIA 3OZQA 5IO1A 1C8OA 1B3KA 1SEKA 4X30A 3NDFA 1IZ2A 2HIJI 2WXYC 3ZHAA 3F1SA 3F5NA 4BB2A 2H4RA 2VDYA 3LW2A 1F0CA 1UHGA 4RO9A 3VVJA 4DY0A 3T1PA 2BEHL 2ZNHA 1TB6I 2QUGA 1ATTA 1XU8A 2PEEA 3EVJI 3Q03A 1DB2A 2OAYA 1LQ8A 2WXWA 1OYHL 4R9IA 2B4XL 1DZGI 1OVAB 2HIJL 2V95A 2ACHA 2ARQA 1XQGA 1OVAA 1HP7A 1AZXI 5CE0A 1ANTI 4IF8A 2XN3A 1SR5A 1OPHA 1QLPA 2HI9A 3NE4A 2VDXA 2CEOA 7APIA 1EZXA 5BRRI 2WY1A 1LK6I 4GA7A 1PSIA 3FGQA 2DUTA 4ROAA 2R9YA 2WXZA 1JVQI 2RIVA 1WZ9A 2XN6A 1KCTA 4Y3KA 3F02A 4C41A 1OC0A 2OL2A 1DZHL 3NDAA 1LJ5A 4DTEA 2H4PA 3KCGI 5HGCA 2WXXA 1D5SA 1E03I 4G8OA 1C5GA 1JTIA 3LE2A 1OVAC 3PB1I 4KDSA 1XQJA 1IMVA 5INWA 4G8RA 3H5CA 4AJUA 3DY0A 2WY0C 4AU2A 3UT3A 2B5TI 1JRRA 1SNGA 2ARRA 3CWMA 2VH4A 1QMBA 3CAAA
chains in the Genus database with same CATH superfamily
3EOXA 1HLEA 3DRMA 3B9FI 4ZK0A 2WXZC 1ATUA 2ANTI 3CVMA 4Y40A 1DZGL 4AU4A 9PAIA 3STOA 3R4LA 1E04I 2BEHI 1JMJA 1NQ9I 2XN7A 4RSQA 1A7CA 1T1FA 1AS4A 1QMNA 3DLWA 1YXAA 3Q02A 4AQHA 2H4QA 2RIWA 1BR8I 4AFXA 1OYHI 4ROBA 2B4XI 2ZV6A 4P0FA 4AJTA 2PEFA 1ATHA 4IC0A 4CAAA 5C98A 4EB1I 5CDXA 1MTPA 1M93B 3DRUA 1JMOA 1DVMA 1R1LI 5CDZA 4ZK3A 1BY7A 2XN5A 3PZFA 5EI0A 4P0OA 2D26A 4PYWA 3NDDA 4AU3B 4AU3A 4YIAA 4DY7C 1DVNA 1K9OI 1JJOC 4C49A 3CWLA 1E05I 4EB1L 1OO8A 1DZHI 2GD4C 9APIA 8APIA 3OZQA 5IO1A 1C8OA 1B3KA 1SEKA 4X30A 3NDFA 1IZ2A 2HIJI 2WXYC 3ZHAA 3F1SA 3F5NA 4BB2A 2H4RA 2VDYA 3LW2A 1F0CA 1UHGA 4RO9A 3VVJA 4DY0A 3T1PA 2BEHL 2ZNHA 1TB6I 2QUGA 1ATTA 1XU8A 2PEEA 3EVJI 3Q03A 1DB2A 2OAYA 1LQ8A 2WXWA 1OYHL 4R9IA 2B4XL 1DZGI 1OVAB 2HIJL 2V95A 2ACHA 2ARQA 1XQGA 1OVAA 1HP7A 1AZXI 5CE0A 1ANTI 4IF8A 2XN3A 1SR5A 1OPHA 1QLPA 2HI9A 3NE4A 2VDXA 2CEOA 7APIA 1EZXA 5BRRI 2WY1A 1LK6I 4GA7A 1PSIA 3FGQA 2DUTA 4ROAA 2R9YA 2WXZA 1JVQI 2RIVA 1WZ9A 2XN6A 1KCTA 4Y3KA 3F02A 4C41A 1OC0A 2OL2A 1DZHL 3NDAA 1LJ5A 4DTEA 2H4PA 3KCGI 5HGCA 2WXXA 1D5SA 1E03I 4G8OA 1C5GA 1JTIA 3LE2A 1OVAC 3PB1I 4KDSA 1XQJA 1IMVA 5INWA 4G8RA 3H5CA 4AJUA 3DY0A 2WY0C 4AU2A 3UT3A 2B5TI 1JRRA 1SNGA 2ARRA 3CWMA 2VH4A 1QMBA 3CAAA
chains in the Genus database with same CATH topology
3EOXA 1HLEA 3DRMA 3B9FI 4ZK0A 2WXZC 1ATUA 2ANTI 3CVMA 4Y40A 1DZGL 4AU4A 9PAIA 3STOA 3R4LA 1E04I 2BEHI 1JMJA 1NQ9I 2XN7A 4RSQA 1A7CA 1T1FA 1AS4A 1QMNA 3DLWA 1YXAA 3Q02A 4AQHA 2H4QA 2RIWA 1BR8I 4AFXA 1OYHI 4ROBA 2B4XI 2ZV6A 4P0FA 4AJTA 2PEFA 1ATHA 4IC0A 4CAAA 5C98A 4EB1I 5CDXA 1MTPA 1M93B 3DRUA 1JMOA 1DVMA 1R1LI 5CDZA 4ZK3A 1BY7A 2XN5A 3PZFA 5EI0A 4P0OA 2D26A 4PYWA 3NDDA 4AU3B 4AU3A 4YIAA 4DY7C 1DVNA 1K9OI 1JJOC 4C49A 3CWLA 1E05I 4EB1L 1OO8A 1DZHI 2GD4C 9APIA 8APIA 3OZQA 5IO1A 1C8OA 1B3KA 1SEKA 4X30A 3NDFA 1IZ2A 2HIJI 2WXYC 3ZHAA 3F1SA 3F5NA 4BB2A 2H4RA 2VDYA 3LW2A 1F0CA 1UHGA 4RO9A 3VVJA 4DY0A 3T1PA 2BEHL 2ZNHA 1TB6I 2QUGA 1ATTA 1XU8A 2PEEA 3EVJI 3Q03A 1DB2A 2OAYA 1LQ8A 2WXWA 1OYHL 4R9IA 2B4XL 1DZGI 1OVAB 2HIJL 2V95A 2ACHA 2ARQA 1XQGA 1OVAA 1HP7A 1AZXI 5CE0A 1ANTI 4IF8A 2XN3A 1SR5A 1OPHA 1QLPA 2HI9A 3NE4A 2VDXA 2CEOA 7APIA 1EZXA 5BRRI 2WY1A 1LK6I 4GA7A 1PSIA 3FGQA 2DUTA 4ROAA 2R9YA 2WXZA 1JVQI 2RIVA 1WZ9A 2XN6A 1KCTA 4Y3KA 3F02A 4C41A 1OC0A 2OL2A 1DZHL 3NDAA 1LJ5A 4DTEA 2H4PA 3KCGI 5HGCA 2WXXA 1D5SA 1E03I 4G8OA 1C5GA 1JTIA 3LE2A 1OVAC 3PB1I 4KDSA 1XQJA 1IMVA 5INWA 4G8RA 3H5CA 4AJUA 3DY0A 2WY0C 4AU2A 3UT3A 2B5TI 1JRRA 1SNGA 2ARRA 3CWMA 2VH4A 1QMBA 3CAAA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3EOX A;  1HLE A;  3DRM A;  3B9F I;  4ZK0 A;  2WXZ C;  1ATU A;  2ANT I;  3CVM A;  4Y40 A;  1DZG L;  4AU4 A;  9PAI A;  3STO A;  3R4L A;  1E04 I;  2BEH I;  1JMJ A;  1NQ9 I;  2XN7 A;  4RSQ A;  1A7C A;  1T1F A;  1AS4 A;  1QMN A;  3DLW A;  1YXA A;  3Q02 A;  4AQH A;  2H4Q A;  2RIW A;  1BR8 I;  4AFX A;  1OYH I;  4ROB A;  2B4X I;  2ZV6 A;  4P0F A;  4AJT A;  2PEF A;  1ATH A;  4IC0 A;  4CAA A;  5C98 A;  4EB1 I;  5CDX A;  1MTP A;  1M93 B;  3DRU A;  1JMO A;  1DVM A;  1R1L I;  5CDZ A;  4ZK3 A;  1BY7 A;  2XN5 A;  3PZF A;  5EI0 A;  4P0O A;  2D26 A;  4PYW A;  3NDD A;  4AU3 B;  4AU3 A;  4YIA A;  4DY7 C;  1DVN A;  1K9O I;  1JJO C;  4C49 A;  3CWL A;  1E05 I;  4EB1 L;  1OO8 A;  1DZH I;  2GD4 C;  9API A;  8API A;  3OZQ A;  5IO1 A;  1C8O A;  1B3K A;  1SEK A;  4X30 A;  3NDF A;  1IZ2 A;  2HIJ I;  2WXY C;  3ZHA A;  3F1S A;  3F5N A;  4BB2 A;  2H4R A;  2VDY A;  3LW2 A;  1F0C A;  1UHG A;  4RO9 A;  3VVJ A;  4DY0 A;  3T1P A;  2BEH L;  2ZNH A;  1TB6 I;  2QUG A;  1ATT A;  1XU8 A;  2PEE A;  3EVJ I;  3Q03 A;  1DB2 A;  2OAY A;  1LQ8 A;  2WXW A;  1OYH L;  4R9I A;  2B4X L;  1DZG I;  1OVA B;  2HIJ L;  2V95 A;  2ACH A;  2ARQ A;  1XQG A;  1OVA A;  1HP7 A;  1AZX I;  5CE0 A;  1ANT I;  4IF8 A;  2XN3 A;  1SR5 A;  1OPH A;  1QLP A;  2HI9 A;  3NE4 A;  2VDX A;  2CEO A;  7API A;  1EZX A;  5BRR I;  2WY1 A;  1LK6 I;  4GA7 A;  1PSI A;  3FGQ A;  2DUT A;  4ROA A;  2R9Y A;  2WXZ A;  1JVQ I;  2RIV A;  1WZ9 A;  2XN6 A;  1KCT A;  4Y3K A;  3F02 A;  4C41 A;  1OC0 A;  2OL2 A;  1DZH L;  3NDA A;  1LJ5 A;  4DTE A;  2H4P A;  3KCG I;  5HGC A;  2WXX A;  1D5S A;  1E03 I;  4G8O A;  1C5G A;  1JTI A;  3LE2 A;  1OVA C;  3PB1 I;  4KDS A;  1XQJ A;  1IMV A;  5INW A;  4G8R A;  3H5C A;  4AJU A;  3DY0 A;  2WY0 C;  4AU2 A;  3UT3 A;  2B5T I;  1JRR A;  1SNG A;  2ARR A;  3CWM A;  2VH4 A;  1QMB A;  3CAA A; 
#chains in the Genus database with same CATH topology
 3EOX A;  1HLE A;  3DRM A;  3B9F I;  4ZK0 A;  2WXZ C;  1ATU A;  2ANT I;  3CVM A;  4Y40 A;  1DZG L;  4AU4 A;  9PAI A;  3STO A;  3R4L A;  1E04 I;  2BEH I;  1JMJ A;  1NQ9 I;  2XN7 A;  4RSQ A;  1A7C A;  1T1F A;  1AS4 A;  1QMN A;  3DLW A;  1YXA A;  3Q02 A;  4AQH A;  2H4Q A;  2RIW A;  1BR8 I;  4AFX A;  1OYH I;  4ROB A;  2B4X I;  2ZV6 A;  4P0F A;  4AJT A;  2PEF A;  1ATH A;  4IC0 A;  4CAA A;  5C98 A;  4EB1 I;  5CDX A;  1MTP A;  1M93 B;  3DRU A;  1JMO A;  1DVM A;  1R1L I;  5CDZ A;  4ZK3 A;  1BY7 A;  2XN5 A;  3PZF A;  5EI0 A;  4P0O A;  2D26 A;  4PYW A;  3NDD A;  4AU3 B;  4AU3 A;  4YIA A;  4DY7 C;  1DVN A;  1K9O I;  1JJO C;  4C49 A;  3CWL A;  1E05 I;  4EB1 L;  1OO8 A;  1DZH I;  2GD4 C;  9API A;  8API A;  3OZQ A;  5IO1 A;  1C8O A;  1B3K A;  1SEK A;  4X30 A;  3NDF A;  1IZ2 A;  2HIJ I;  2WXY C;  3ZHA A;  3F1S A;  3F5N A;  4BB2 A;  2H4R A;  2VDY A;  3LW2 A;  1F0C A;  1UHG A;  4RO9 A;  3VVJ A;  4DY0 A;  3T1P A;  2BEH L;  2ZNH A;  1TB6 I;  2QUG A;  1ATT A;  1XU8 A;  2PEE A;  3EVJ I;  3Q03 A;  1DB2 A;  2OAY A;  1LQ8 A;  2WXW A;  1OYH L;  4R9I A;  2B4X L;  1DZG I;  1OVA B;  2HIJ L;  2V95 A;  2ACH A;  2ARQ A;  1XQG A;  1OVA A;  1HP7 A;  1AZX I;  5CE0 A;  1ANT I;  4IF8 A;  2XN3 A;  1SR5 A;  1OPH A;  1QLP A;  2HI9 A;  3NE4 A;  2VDX A;  2CEO A;  7API A;  1EZX A;  5BRR I;  2WY1 A;  1LK6 I;  4GA7 A;  1PSI A;  3FGQ A;  2DUT A;  4ROA A;  2R9Y A;  2WXZ A;  1JVQ I;  2RIV A;  1WZ9 A;  2XN6 A;  1KCT A;  4Y3K A;  3F02 A;  4C41 A;  1OC0 A;  2OL2 A;  1DZH L;  3NDA A;  1LJ5 A;  4DTE A;  2H4P A;  3KCG I;  5HGC A;  2WXX A;  1D5S A;  1E03 I;  4G8O A;  1C5G A;  1JTI A;  3LE2 A;  1OVA C;  3PB1 I;  4KDS A;  1XQJ A;  1IMV A;  5INW A;  4G8R A;  3H5C A;  4AJU A;  3DY0 A;  2WY0 C;  4AU2 A;  3UT3 A;  2B5T I;  1JRR A;  1SNG A;  2ARR A;  3CWM A;  2VH4 A;  1QMB A;  3CAA A; 
#chains in the Genus database with same CATH homology
 3EOX A;  1HLE A;  3DRM A;  3B9F I;  4ZK0 A;  2WXZ C;  1ATU A;  2ANT I;  3CVM A;  4Y40 A;  1DZG L;  4AU4 A;  9PAI A;  3STO A;  3R4L A;  1E04 I;  2BEH I;  1JMJ A;  1NQ9 I;  2XN7 A;  4RSQ A;  1A7C A;  1T1F A;  1AS4 A;  1QMN A;  3DLW A;  1YXA A;  3Q02 A;  4AQH A;  2H4Q A;  2RIW A;  1BR8 I;  4AFX A;  1OYH I;  4ROB A;  2B4X I;  2ZV6 A;  4P0F A;  4AJT A;  2PEF A;  1ATH A;  4IC0 A;  4CAA A;  5C98 A;  4EB1 I;  5CDX A;  1MTP A;  1M93 B;  3DRU A;  1JMO A;  1DVM A;  1R1L I;  5CDZ A;  4ZK3 A;  1BY7 A;  2XN5 A;  3PZF A;  5EI0 A;  4P0O A;  2D26 A;  4PYW A;  3NDD A;  4AU3 B;  4AU3 A;  4YIA A;  4DY7 C;  1DVN A;  1K9O I;  1JJO C;  4C49 A;  3CWL A;  1E05 I;  4EB1 L;  1OO8 A;  1DZH I;  2GD4 C;  9API A;  8API A;  3OZQ A;  5IO1 A;  1C8O A;  1B3K A;  1SEK A;  4X30 A;  3NDF A;  1IZ2 A;  2HIJ I;  2WXY C;  3ZHA A;  3F1S A;  3F5N A;  4BB2 A;  2H4R A;  2VDY A;  3LW2 A;  1F0C A;  1UHG A;  4RO9 A;  3VVJ A;  4DY0 A;  3T1P A;  2BEH L;  2ZNH A;  1TB6 I;  2QUG A;  1ATT A;  1XU8 A;  2PEE A;  3EVJ I;  3Q03 A;  1DB2 A;  2OAY A;  1LQ8 A;  2WXW A;  1OYH L;  4R9I A;  2B4X L;  1DZG I;  1OVA B;  2HIJ L;  2V95 A;  2ACH A;  2ARQ A;  1XQG A;  1OVA A;  1HP7 A;  1AZX I;  5CE0 A;  1ANT I;  4IF8 A;  2XN3 A;  1SR5 A;  1OPH A;  1QLP A;  2HI9 A;  3NE4 A;  2VDX A;  2CEO A;  7API A;  1EZX A;  5BRR I;  2WY1 A;  1LK6 I;  4GA7 A;  1PSI A;  3FGQ A;  2DUT A;  4ROA A;  2R9Y A;  2WXZ A;  1JVQ I;  2RIV A;  1WZ9 A;  2XN6 A;  1KCT A;  4Y3K A;  3F02 A;  4C41 A;  1OC0 A;  2OL2 A;  1DZH L;  3NDA A;  1LJ5 A;  4DTE A;  2H4P A;  3KCG I;  5HGC A;  2WXX A;  1D5S A;  1E03 I;  4G8O A;  1C5G A;  1JTI A;  3LE2 A;  1OVA C;  3PB1 I;  4KDS A;  1XQJ A;  1IMV A;  5INW A;  4G8R A;  3H5C A;  4AJU A;  3DY0 A;  2WY0 C;  4AU2 A;  3UT3 A;  2B5T I;  1JRR A;  1SNG A;  2ARR A;  3CWM A;  2VH4 A;  1QMB A;  3CAA A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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