2HIJL

Crystal structure of p14 alanine variant of antithrombin
Total Genus 111
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
111
sequence length
426
structure length
409
Chain Sequence
VDICTAKPRDIPMNPMCIYRSPATNRRVWELSKANSRFATTFYQHLADSKNDNDNIFLSPLSISTAFAMTKLGACNDTLQQLMEVFKFDTISEKTSDQIHFFFAKLNCRLYRKANKSSKLVSANRLFGDKSLTFNETYQDISELVYGAKLQPLDFKENAEQSRAAINKWVSNKTEGRITDVIPSEAINELTVLVLVNTIYFKGLWKSKFSPENTRKELFYKADGESCSASMMYQEGKFRYRRVAEGTQVLELPFKGDDITMVLILPKPEKSLAKVEKELTPEVLQEWLDELEEMMLVVHMPRFRIEDGFSLKEQLQDMGLVDLFSPEKSKLPGIVAEGRDDLYVSDAFHKAFLEVNEEGSEAAASTAVVIAGRSLNPNRVTKANRPFLVFIREVPLNTIIFMGRVANPC
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal Structure of P14 Alanine Variant of Antithrombin
rcsb
molecule tags Blood clotting/ hydrolase inhibitor
source organism Homo sapiens
molecule keywords Antithrombin-III
total genus 111
structure length 409
sequence length 426
ec nomenclature
pdb deposition date 2006-06-29

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
L PF00079 Serpin Serpin (serine protease inhibitor)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.30.39.10 Mainly Beta Roll Alpha-1-antitrypsin; domain 1 Alpha-1-antitrypsin, domain 1 2hijL02
3.30.497.10 Alpha Beta 2-Layer Sandwich Antithrombin; Chain I, domain 2 Antithrombin, subunit I, domain 2 2hijL01
1M93B 2HI9A 3VVJA 1XQGA 2XN7A 2OAYA 1E05I 3OZQA 5INWA 4Y3KA 1C5GA 1JJOC 2ANTI 4G8OA 4AFXA 2HIJL 5IO1A 1BY7A 1QMNA 1JVQI 3NDFA 4KDSA 4GA7A 2CEOA 1K9OI 3FGQA 2XN3A 4IF8A 4EB1I 3PB1I 1XU8A 2QUGA 1LJ5A 4C49A 2WXZA 1SEKA 2RIWA 1QMBA 4AU3A 4AJUA 1MTPA 2DUTA 2WXYC 3T1PA 4RO9A 2VDYA 1DZHI 1QLPA 3PZFA 4DY7C 2BEHI 1PSIA 2H4PA 2ARQA 1T1FA 1JMJA 3UT3A 1OO8A 5HGCA 3B9FI 1E04I 2H4QA 1SR5A 4DY0A 5C98A 1F0CA 1R1LI 2PEFA 4PYWA 5CDZA 2D26A 4G8RA 1DZHL 1OVAA 2H4RA 1E03I 3DLWA 3ZHAA 3CWMA 3NDAA 1OYHI 1LK6I 3R4LA 4ROAA 1B3KA 1DZGI 5EI0A 2B4XI 4C41A 3F1SA 4AJTA 3CVMA 1UHGA 1OC0A 3DRMA 3NDDA 4CAAA 7APIA 2WXZC 4R9IA 4BB2A 4EB1L 2ARRA 4AU2A 3DY0A 3Q03A 3CAAA 2ZNHA 3LE2A 2WY1A 2WXXA 1DVNA 1SNGA 4IC0A 1EZXA 2WXWA 1ATTA 2B5TI 1XQJA 9APIA 1A7CA 4AQHA 5CE0A 2ZV6A 4RSQA 3NE4A 1TB6I 2XN5A 5BRRI 1YXAA 3STOA 2GD4C 4DTEA 1BR8I 1AZXI 2HIJI 1ATUA 2BEHL 1JMOA 3LW2A 4AU3B 4P0FA 4ROBA 3EOXA 1IZ2A 3F02A 2R9YA 2VH4A 4ZK3A 1OVAC 2RIVA 3KCGI 1DVMA 1NQ9I 2XN6A 1C8OA 2ACHA 8APIA 3H5CA 1WZ9A 1OYHL 2WY0C 1ATHA 1JTIA 4P0OA 1DB2A 3DRUA 2PEEA 4YIAA 1KCTA 1DZGL 3EVJI 2V95A 4X30A 1D5SA 1HLEA 4Y40A 1LQ8A 2B4XL 1OVAB 1HP7A 1IMVA 3CWLA 3Q02A 1JRRA 2VDXA 4ZK0A 4AU4A 5CDXA 1AS4A 3F5NA 1OPHA 2OL2A 1ANTI 9PAIA
chains in the Genus database with same CATH superfamily
1M93B 2HI9A 3VVJA 1XQGA 2XN7A 2OAYA 1E05I 3OZQA 5INWA 4Y3KA 1C5GA 1JJOC 2ANTI 4G8OA 4AFXA 2HIJL 5IO1A 1BY7A 1QMNA 1JVQI 3NDFA 4KDSA 4GA7A 2CEOA 1K9OI 3FGQA 2XN3A 4IF8A 4EB1I 3PB1I 1XU8A 2QUGA 1LJ5A 4C49A 2WXZA 1SEKA 2RIWA 1QMBA 4AU3A 4AJUA 1MTPA 2DUTA 2WXYC 3T1PA 4RO9A 2VDYA 1DZHI 1QLPA 3PZFA 4DY7C 2BEHI 1PSIA 2H4PA 2ARQA 1T1FA 1JMJA 3UT3A 1OO8A 5HGCA 3B9FI 1E04I 2H4QA 1SR5A 4DY0A 5C98A 1F0CA 1R1LI 2PEFA 4PYWA 5CDZA 2D26A 4G8RA 1DZHL 1OVAA 2H4RA 1E03I 3DLWA 3ZHAA 3CWMA 3NDAA 1OYHI 1LK6I 3R4LA 4ROAA 1B3KA 1DZGI 5EI0A 2B4XI 4C41A 3F1SA 4AJTA 3CVMA 1UHGA 1OC0A 3DRMA 3NDDA 4CAAA 7APIA 2WXZC 4R9IA 4BB2A 4EB1L 2ARRA 4AU2A 3DY0A 3Q03A 3CAAA 2ZNHA 3LE2A 2WY1A 2WXXA 1DVNA 1SNGA 4IC0A 1EZXA 2WXWA 1ATTA 2B5TI 1XQJA 9APIA 1A7CA 4AQHA 5CE0A 2ZV6A 4RSQA 3NE4A 1TB6I 2XN5A 5BRRI 1YXAA 3STOA 2GD4C 4DTEA 1BR8I 1AZXI 2HIJI 1ATUA 2BEHL 1JMOA 3LW2A 4AU3B 4P0FA 4ROBA 3EOXA 1IZ2A 3F02A 2R9YA 2VH4A 4ZK3A 1OVAC 2RIVA 3KCGI 1DVMA 1NQ9I 2XN6A 1C8OA 2ACHA 8APIA 3H5CA 1WZ9A 1OYHL 2WY0C 1ATHA 1JTIA 4P0OA 1DB2A 3DRUA 2PEEA 4YIAA 1KCTA 1DZGL 3EVJI 2V95A 4X30A 1D5SA 1HLEA 4Y40A 1LQ8A 2B4XL 1OVAB 1HP7A 1IMVA 3CWLA 3Q02A 1JRRA 2VDXA 4ZK0A 4AU4A 5CDXA 1AS4A 3F5NA 1OPHA 2OL2A 1ANTI 9PAIA
chains in the Genus database with same CATH topology
1M93B 2HI9A 3VVJA 1XQGA 2XN7A 2OAYA 1E05I 3OZQA 5INWA 4Y3KA 1C5GA 1JJOC 2ANTI 4G8OA 4AFXA 2HIJL 5IO1A 1BY7A 1QMNA 1JVQI 3NDFA 4KDSA 4GA7A 2CEOA 1K9OI 3FGQA 2XN3A 4IF8A 4EB1I 3PB1I 1XU8A 2QUGA 1LJ5A 4C49A 2WXZA 1SEKA 2RIWA 1QMBA 4AU3A 4AJUA 1MTPA 2DUTA 2WXYC 3T1PA 4RO9A 2VDYA 1DZHI 1QLPA 3PZFA 4DY7C 2BEHI 1PSIA 2H4PA 2ARQA 1T1FA 1JMJA 3UT3A 1OO8A 5HGCA 3B9FI 1E04I 2H4QA 1SR5A 4DY0A 5C98A 1F0CA 1R1LI 2PEFA 4PYWA 5CDZA 2D26A 4G8RA 1DZHL 1OVAA 2H4RA 1E03I 3DLWA 3ZHAA 3CWMA 3NDAA 1OYHI 1LK6I 3R4LA 4ROAA 1B3KA 1DZGI 5EI0A 2B4XI 4C41A 3F1SA 4AJTA 3CVMA 1UHGA 1OC0A 3DRMA 3NDDA 4CAAA 7APIA 2WXZC 4R9IA 4BB2A 4EB1L 2ARRA 4AU2A 3DY0A 3Q03A 3CAAA 2ZNHA 3LE2A 2WY1A 2WXXA 1DVNA 1SNGA 4IC0A 1EZXA 2WXWA 1ATTA 2B5TI 1XQJA 9APIA 1A7CA 4AQHA 5CE0A 2ZV6A 4RSQA 3NE4A 1TB6I 2XN5A 5BRRI 1YXAA 3STOA 2GD4C 4DTEA 1BR8I 1AZXI 2HIJI 1ATUA 2BEHL 1JMOA 3LW2A 4AU3B 4P0FA 4ROBA 3EOXA 1IZ2A 3F02A 2R9YA 2VH4A 4ZK3A 1OVAC 2RIVA 3KCGI 1DVMA 1NQ9I 2XN6A 1C8OA 2ACHA 8APIA 3H5CA 1WZ9A 1OYHL 2WY0C 1ATHA 1JTIA 4P0OA 1DB2A 3DRUA 2PEEA 4YIAA 1KCTA 1DZGL 3EVJI 2V95A 4X30A 1D5SA 1HLEA 4Y40A 1LQ8A 2B4XL 1OVAB 1HP7A 1IMVA 3CWLA 3Q02A 1JRRA 2VDXA 4ZK0A 4AU4A 5CDXA 1AS4A 3F5NA 1OPHA 2OL2A 1ANTI 9PAIA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1M93 B;  2HI9 A;  3VVJ A;  1XQG A;  2XN7 A;  2OAY A;  1E05 I;  3OZQ A;  5INW A;  4Y3K A;  1C5G A;  1JJO C;  2ANT I;  4G8O A;  4AFX A;  2HIJ L;  5IO1 A;  1BY7 A;  1QMN A;  1JVQ I;  3NDF A;  4KDS A;  4GA7 A;  2CEO A;  1K9O I;  3FGQ A;  2XN3 A;  4IF8 A;  4EB1 I;  3PB1 I;  1XU8 A;  2QUG A;  1LJ5 A;  4C49 A;  2WXZ A;  1SEK A;  2RIW A;  1QMB A;  4AU3 A;  4AJU A;  1MTP A;  2DUT A;  2WXY C;  3T1P A;  4RO9 A;  2VDY A;  1DZH I;  1QLP A;  3PZF A;  4DY7 C;  2BEH I;  1PSI A;  2H4P A;  2ARQ A;  1T1F A;  1JMJ A;  3UT3 A;  1OO8 A;  5HGC A;  3B9F I;  1E04 I;  2H4Q A;  1SR5 A;  4DY0 A;  5C98 A;  1F0C A;  1R1L I;  2PEF A;  4PYW A;  5CDZ A;  2D26 A;  4G8R A;  1DZH L;  1OVA A;  2H4R A;  1E03 I;  3DLW A;  3ZHA A;  3CWM A;  3NDA A;  1OYH I;  1LK6 I;  3R4L A;  4ROA A;  1B3K A;  1DZG I;  5EI0 A;  2B4X I;  4C41 A;  3F1S A;  4AJT A;  3CVM A;  1UHG A;  1OC0 A;  3DRM A;  3NDD A;  4CAA A;  7API A;  2WXZ C;  4R9I A;  4BB2 A;  4EB1 L;  2ARR A;  4AU2 A;  3DY0 A;  3Q03 A;  3CAA A;  2ZNH A;  3LE2 A;  2WY1 A;  2WXX A;  1DVN A;  1SNG A;  4IC0 A;  1EZX A;  2WXW A;  1ATT A;  2B5T I;  1XQJ A;  9API A;  1A7C A;  4AQH A;  5CE0 A;  2ZV6 A;  4RSQ A;  3NE4 A;  1TB6 I;  2XN5 A;  5BRR I;  1YXA A;  3STO A;  2GD4 C;  4DTE A;  1BR8 I;  1AZX I;  2HIJ I;  1ATU A;  2BEH L;  1JMO A;  3LW2 A;  4AU3 B;  4P0F A;  4ROB A;  3EOX A;  1IZ2 A;  3F02 A;  2R9Y A;  2VH4 A;  4ZK3 A;  1OVA C;  2RIV A;  3KCG I;  1DVM A;  1NQ9 I;  2XN6 A;  1C8O A;  2ACH A;  8API A;  3H5C A;  1WZ9 A;  1OYH L;  2WY0 C;  1ATH A;  1JTI A;  4P0O A;  1DB2 A;  3DRU A;  2PEE A;  4YIA A;  1KCT A;  1DZG L;  3EVJ I;  2V95 A;  4X30 A;  1D5S A;  1HLE A;  4Y40 A;  1LQ8 A;  2B4X L;  1OVA B;  1HP7 A;  1IMV A;  3CWL A;  3Q02 A;  1JRR A;  2VDX A;  4ZK0 A;  4AU4 A;  5CDX A;  1AS4 A;  3F5N A;  1OPH A;  2OL2 A;  1ANT I;  9PAI A; 
#chains in the Genus database with same CATH topology
 1M93 B;  2HI9 A;  3VVJ A;  1XQG A;  2XN7 A;  2OAY A;  1E05 I;  3OZQ A;  5INW A;  4Y3K A;  1C5G A;  1JJO C;  2ANT I;  4G8O A;  4AFX A;  2HIJ L;  5IO1 A;  1BY7 A;  1QMN A;  1JVQ I;  3NDF A;  4KDS A;  4GA7 A;  2CEO A;  1K9O I;  3FGQ A;  2XN3 A;  4IF8 A;  4EB1 I;  3PB1 I;  1XU8 A;  2QUG A;  1LJ5 A;  4C49 A;  2WXZ A;  1SEK A;  2RIW A;  1QMB A;  4AU3 A;  4AJU A;  1MTP A;  2DUT A;  2WXY C;  3T1P A;  4RO9 A;  2VDY A;  1DZH I;  1QLP A;  3PZF A;  4DY7 C;  2BEH I;  1PSI A;  2H4P A;  2ARQ A;  1T1F A;  1JMJ A;  3UT3 A;  1OO8 A;  5HGC A;  3B9F I;  1E04 I;  2H4Q A;  1SR5 A;  4DY0 A;  5C98 A;  1F0C A;  1R1L I;  2PEF A;  4PYW A;  5CDZ A;  2D26 A;  4G8R A;  1DZH L;  1OVA A;  2H4R A;  1E03 I;  3DLW A;  3ZHA A;  3CWM A;  3NDA A;  1OYH I;  1LK6 I;  3R4L A;  4ROA A;  1B3K A;  1DZG I;  5EI0 A;  2B4X I;  4C41 A;  3F1S A;  4AJT A;  3CVM A;  1UHG A;  1OC0 A;  3DRM A;  3NDD A;  4CAA A;  7API A;  2WXZ C;  4R9I A;  4BB2 A;  4EB1 L;  2ARR A;  4AU2 A;  3DY0 A;  3Q03 A;  3CAA A;  2ZNH A;  3LE2 A;  2WY1 A;  2WXX A;  1DVN A;  1SNG A;  4IC0 A;  1EZX A;  2WXW A;  1ATT A;  2B5T I;  1XQJ A;  9API A;  1A7C A;  4AQH A;  5CE0 A;  2ZV6 A;  4RSQ A;  3NE4 A;  1TB6 I;  2XN5 A;  5BRR I;  1YXA A;  3STO A;  2GD4 C;  4DTE A;  1BR8 I;  1AZX I;  2HIJ I;  1ATU A;  2BEH L;  1JMO A;  3LW2 A;  4AU3 B;  4P0F A;  4ROB A;  3EOX A;  1IZ2 A;  3F02 A;  2R9Y A;  2VH4 A;  4ZK3 A;  1OVA C;  2RIV A;  3KCG I;  1DVM A;  1NQ9 I;  2XN6 A;  1C8O A;  2ACH A;  8API A;  3H5C A;  1WZ9 A;  1OYH L;  2WY0 C;  1ATH A;  1JTI A;  4P0O A;  1DB2 A;  3DRU A;  2PEE A;  4YIA A;  1KCT A;  1DZG L;  3EVJ I;  2V95 A;  4X30 A;  1D5S A;  1HLE A;  4Y40 A;  1LQ8 A;  2B4X L;  1OVA B;  1HP7 A;  1IMV A;  3CWL A;  3Q02 A;  1JRR A;  2VDX A;  4ZK0 A;  4AU4 A;  5CDX A;  1AS4 A;  3F5N A;  1OPH A;  2OL2 A;  1ANT I;  9PAI A; 
#chains in the Genus database with same CATH homology
 1M93 B;  2HI9 A;  3VVJ A;  1XQG A;  2XN7 A;  2OAY A;  1E05 I;  3OZQ A;  5INW A;  4Y3K A;  1C5G A;  1JJO C;  2ANT I;  4G8O A;  4AFX A;  2HIJ L;  5IO1 A;  1BY7 A;  1QMN A;  1JVQ I;  3NDF A;  4KDS A;  4GA7 A;  2CEO A;  1K9O I;  3FGQ A;  2XN3 A;  4IF8 A;  4EB1 I;  3PB1 I;  1XU8 A;  2QUG A;  1LJ5 A;  4C49 A;  2WXZ A;  1SEK A;  2RIW A;  1QMB A;  4AU3 A;  4AJU A;  1MTP A;  2DUT A;  2WXY C;  3T1P A;  4RO9 A;  2VDY A;  1DZH I;  1QLP A;  3PZF A;  4DY7 C;  2BEH I;  1PSI A;  2H4P A;  2ARQ A;  1T1F A;  1JMJ A;  3UT3 A;  1OO8 A;  5HGC A;  3B9F I;  1E04 I;  2H4Q A;  1SR5 A;  4DY0 A;  5C98 A;  1F0C A;  1R1L I;  2PEF A;  4PYW A;  5CDZ A;  2D26 A;  4G8R A;  1DZH L;  1OVA A;  2H4R A;  1E03 I;  3DLW A;  3ZHA A;  3CWM A;  3NDA A;  1OYH I;  1LK6 I;  3R4L A;  4ROA A;  1B3K A;  1DZG I;  5EI0 A;  2B4X I;  4C41 A;  3F1S A;  4AJT A;  3CVM A;  1UHG A;  1OC0 A;  3DRM A;  3NDD A;  4CAA A;  7API A;  2WXZ C;  4R9I A;  4BB2 A;  4EB1 L;  2ARR A;  4AU2 A;  3DY0 A;  3Q03 A;  3CAA A;  2ZNH A;  3LE2 A;  2WY1 A;  2WXX A;  1DVN A;  1SNG A;  4IC0 A;  1EZX A;  2WXW A;  1ATT A;  2B5T I;  1XQJ A;  9API A;  1A7C A;  4AQH A;  5CE0 A;  2ZV6 A;  4RSQ A;  3NE4 A;  1TB6 I;  2XN5 A;  5BRR I;  1YXA A;  3STO A;  2GD4 C;  4DTE A;  1BR8 I;  1AZX I;  2HIJ I;  1ATU A;  2BEH L;  1JMO A;  3LW2 A;  4AU3 B;  4P0F A;  4ROB A;  3EOX A;  1IZ2 A;  3F02 A;  2R9Y A;  2VH4 A;  4ZK3 A;  1OVA C;  2RIV A;  3KCG I;  1DVM A;  1NQ9 I;  2XN6 A;  1C8O A;  2ACH A;  8API A;  3H5C A;  1WZ9 A;  1OYH L;  2WY0 C;  1ATH A;  1JTI A;  4P0O A;  1DB2 A;  3DRU A;  2PEE A;  4YIA A;  1KCT A;  1DZG L;  3EVJ I;  2V95 A;  4X30 A;  1D5S A;  1HLE A;  4Y40 A;  1LQ8 A;  2B4X L;  1OVA B;  1HP7 A;  1IMV A;  3CWL A;  3Q02 A;  1JRR A;  2VDX A;  4ZK0 A;  4AU4 A;  5CDX A;  1AS4 A;  3F5N A;  1OPH A;  2OL2 A;  1ANT I;  9PAI A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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