2PEFA

Crystal structure of a thermophilic serpin, tengpin, in the latent state
Total Genus 111
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
111
sequence length
373
structure length
366
Chain Sequence
MEKNIDEKFIYNTADFSIELFKNSIDDKENSLISPLSAMLALAMTANGADNETLAQMEKALGKDISIEDLNKYLYTYMKKLPNEEKSKLTIANSIWFKENDFMPSKDFLQIIADYYKADIFKAAFDSSTVSDINNWVKSKTNGMIDKILNKIDPEDVMYLINAVAFDAEWETVYEKASVHEDIFTDVYGNRQKVEFMNSEENLYIEEENAVGFVKPYAKNHYSFVAILPDENISVNEYIKTLTGQKFIDLIKNAKITLVRASLPKFKYEYTIKMNETLESLGMTDAFLPDKADFSKLGKSDIGNLYISEVLHKTFISVDELGTKAGAVTSVDITFKTVKLNRPFIFAIIDNSTNLPIFIGTVLSLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title The N terminus of the serpin, tengpin, functions to trap the metastable native state.
pubmed doi rcsb
molecule tags Protease inhibitor
source organism Thermoanaerobacter tengcongensis
molecule keywords Serine protease inhibitor
total genus 111
structure length 366
sequence length 373
ec nomenclature
pdb deposition date 2007-04-03

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00079 Serpin Serpin (serine protease inhibitor)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.30.39.10 Mainly Beta Roll Alpha-1-antitrypsin; domain 1 Alpha-1-antitrypsin, domain 1 2pefA02
3.30.497.10 Alpha Beta 2-Layer Sandwich Antithrombin; Chain I, domain 2 Antithrombin, subunit I, domain 2 2pefA01
2RIWA 1IZ2A 3CVMA 4DY7C 2VDXA 3LW2A 2V95A 4GA7A 3EVJI 1JMOA 2ANTI 1KCTA 3NDFA 2H4QA 3F5NA 3DY0A 4ROBA 8APIA 1XU8A 2XN7A 1BR8I 2VDYA 1OVAB 3CAAA 4IF8A 1EZXA 1R1LI 1C8OA 2H4RA 3B9FI 1SEKA 3STOA 1LQ8A 1OO8A 2VH4A 1ATTA 1JMJA 3PB1I 3R4LA 2WXZA 4AU2A 5CDZA 5CDXA 4Y3KA 5CE0A 2HI9A 1WZ9A 2ARQA 1XQGA 5INWA 1E05I 4RO9A 2DUTA 3T1PA 2OL2A 3FGQA 5IO1A 2HIJI 1ATUA 1OYHI 1TB6I 1LJ5A 3F02A 3VVJA 3CWMA 4R9IA 2XN5A 3Q02A 1DZHI 4EB1I 2HIJL 5EI0A 3H5CA 1PSIA 5BRRI 1OPHA 4KDSA 3NDDA 1JRRA 1JTIA 1MTPA 2XN6A 2CEOA 1DZHL 1ATHA 4EB1L 2OAYA 1HP7A 4CAAA 4ZK0A 5C98A 1B3KA 3KCGI 1D5SA 1BY7A 1DB2A 9PAIA 4C41A 2XN3A 3OZQA 3Q03A 1UHGA 4RSQA 4ZK3A 1OVAC 3ZHAA 1T1FA 1AS4A 1LK6I 2B4XI 2ARRA 1JJOC 4AQHA 4YIAA 9APIA 4PYWA 4ROAA 3CWLA 1E04I 2WXZC 2WXYC 4Y40A 2WXXA 2B4XL 1QLPA 3F1SA 1F0CA 1NQ9I 2PEFA 4C49A 1DVMA 1OYHL 1E03I 2PEEA 2ZV6A 3NE4A 3LE2A 3UT3A 4AJTA 2B5TI 2D26A 2ZNHA 1HLEA 4BB2A 2BEHI 1AZXI 1DVNA 2ACHA 3NDAA 2QUGA 2H4PA 1XQJA 1C5GA 4X30A 2BEHL 1DZGI 3DLWA 2WXWA 4AU3A 4AU3B 3DRMA 4IC0A 4DY0A 1DZGL 2WY0C 3EOXA 1M93B 4G8RA 1JVQI 1IMVA 1OVAA 1SR5A 1A7CA 1K9OI 1YXAA 2WY1A 2RIVA 4DTEA 3PZFA 1OC0A 3DRUA 2GD4C 1QMBA 1SNGA 1QMNA 4G8OA 4P0FA 4AJUA 5HGCA 4AU4A 2R9YA 7APIA 1ANTI 4AFXA 4P0OA
chains in the Genus database with same CATH superfamily
2RIWA 1IZ2A 3CVMA 4DY7C 2VDXA 3LW2A 2V95A 4GA7A 3EVJI 1JMOA 2ANTI 1KCTA 3NDFA 2H4QA 3F5NA 3DY0A 4ROBA 8APIA 1XU8A 2XN7A 1BR8I 2VDYA 1OVAB 3CAAA 4IF8A 1EZXA 1R1LI 1C8OA 2H4RA 3B9FI 1SEKA 3STOA 1LQ8A 1OO8A 2VH4A 1ATTA 1JMJA 3PB1I 3R4LA 2WXZA 4AU2A 5CDZA 5CDXA 4Y3KA 5CE0A 2HI9A 1WZ9A 2ARQA 1XQGA 5INWA 1E05I 4RO9A 2DUTA 3T1PA 2OL2A 3FGQA 5IO1A 2HIJI 1ATUA 1OYHI 1TB6I 1LJ5A 3F02A 3VVJA 3CWMA 4R9IA 2XN5A 3Q02A 1DZHI 4EB1I 2HIJL 5EI0A 3H5CA 1PSIA 5BRRI 1OPHA 4KDSA 3NDDA 1JRRA 1JTIA 1MTPA 2XN6A 2CEOA 1DZHL 1ATHA 4EB1L 2OAYA 1HP7A 4CAAA 4ZK0A 5C98A 1B3KA 3KCGI 1D5SA 1BY7A 1DB2A 9PAIA 4C41A 2XN3A 3OZQA 3Q03A 1UHGA 4RSQA 4ZK3A 1OVAC 3ZHAA 1T1FA 1AS4A 1LK6I 2B4XI 2ARRA 1JJOC 4AQHA 4YIAA 9APIA 4PYWA 4ROAA 3CWLA 1E04I 2WXZC 2WXYC 4Y40A 2WXXA 2B4XL 1QLPA 3F1SA 1F0CA 1NQ9I 2PEFA 4C49A 1DVMA 1OYHL 1E03I 2PEEA 2ZV6A 3NE4A 3LE2A 3UT3A 4AJTA 2B5TI 2D26A 2ZNHA 1HLEA 4BB2A 2BEHI 1AZXI 1DVNA 2ACHA 3NDAA 2QUGA 2H4PA 1XQJA 1C5GA 4X30A 2BEHL 1DZGI 3DLWA 2WXWA 4AU3A 4AU3B 3DRMA 4IC0A 4DY0A 1DZGL 2WY0C 3EOXA 1M93B 4G8RA 1JVQI 1IMVA 1OVAA 1SR5A 1A7CA 1K9OI 1YXAA 2WY1A 2RIVA 4DTEA 3PZFA 1OC0A 3DRUA 2GD4C 1QMBA 1SNGA 1QMNA 4G8OA 4P0FA 4AJUA 5HGCA 4AU4A 2R9YA 7APIA 1ANTI 4AFXA 4P0OA
chains in the Genus database with same CATH topology
2RIWA 1IZ2A 3CVMA 4DY7C 2VDXA 3LW2A 2V95A 4GA7A 3EVJI 1JMOA 2ANTI 1KCTA 3NDFA 2H4QA 3F5NA 3DY0A 4ROBA 8APIA 1XU8A 2XN7A 1BR8I 2VDYA 1OVAB 3CAAA 4IF8A 1EZXA 1R1LI 1C8OA 2H4RA 3B9FI 1SEKA 3STOA 1LQ8A 1OO8A 2VH4A 1ATTA 1JMJA 3PB1I 3R4LA 2WXZA 4AU2A 5CDZA 5CDXA 4Y3KA 5CE0A 2HI9A 1WZ9A 2ARQA 1XQGA 5INWA 1E05I 4RO9A 2DUTA 3T1PA 2OL2A 3FGQA 5IO1A 2HIJI 1ATUA 1OYHI 1TB6I 1LJ5A 3F02A 3VVJA 3CWMA 4R9IA 2XN5A 3Q02A 1DZHI 4EB1I 2HIJL 5EI0A 3H5CA 1PSIA 5BRRI 1OPHA 4KDSA 3NDDA 1JRRA 1JTIA 1MTPA 2XN6A 2CEOA 1DZHL 1ATHA 4EB1L 2OAYA 1HP7A 4CAAA 4ZK0A 5C98A 1B3KA 3KCGI 1D5SA 1BY7A 1DB2A 9PAIA 4C41A 2XN3A 3OZQA 3Q03A 1UHGA 4RSQA 4ZK3A 1OVAC 3ZHAA 1T1FA 1AS4A 1LK6I 2B4XI 2ARRA 1JJOC 4AQHA 4YIAA 9APIA 4PYWA 4ROAA 3CWLA 1E04I 2WXZC 2WXYC 4Y40A 2WXXA 2B4XL 1QLPA 3F1SA 1F0CA 1NQ9I 2PEFA 4C49A 1DVMA 1OYHL 1E03I 2PEEA 2ZV6A 3NE4A 3LE2A 3UT3A 4AJTA 2B5TI 2D26A 2ZNHA 1HLEA 4BB2A 2BEHI 1AZXI 1DVNA 2ACHA 3NDAA 2QUGA 2H4PA 1XQJA 1C5GA 4X30A 2BEHL 1DZGI 3DLWA 2WXWA 4AU3A 4AU3B 3DRMA 4IC0A 4DY0A 1DZGL 2WY0C 3EOXA 1M93B 4G8RA 1JVQI 1IMVA 1OVAA 1SR5A 1A7CA 1K9OI 1YXAA 2WY1A 2RIVA 4DTEA 3PZFA 1OC0A 3DRUA 2GD4C 1QMBA 1SNGA 1QMNA 4G8OA 4P0FA 4AJUA 5HGCA 4AU4A 2R9YA 7APIA 1ANTI 4AFXA 4P0OA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2RIW A;  1IZ2 A;  3CVM A;  4DY7 C;  2VDX A;  3LW2 A;  2V95 A;  4GA7 A;  3EVJ I;  1JMO A;  2ANT I;  1KCT A;  3NDF A;  2H4Q A;  3F5N A;  3DY0 A;  4ROB A;  8API A;  1XU8 A;  2XN7 A;  1BR8 I;  2VDY A;  1OVA B;  3CAA A;  4IF8 A;  1EZX A;  1R1L I;  1C8O A;  2H4R A;  3B9F I;  1SEK A;  3STO A;  1LQ8 A;  1OO8 A;  2VH4 A;  1ATT A;  1JMJ A;  3PB1 I;  3R4L A;  2WXZ A;  4AU2 A;  5CDZ A;  5CDX A;  4Y3K A;  5CE0 A;  2HI9 A;  1WZ9 A;  2ARQ A;  1XQG A;  5INW A;  1E05 I;  4RO9 A;  2DUT A;  3T1P A;  2OL2 A;  3FGQ A;  5IO1 A;  2HIJ I;  1ATU A;  1OYH I;  1TB6 I;  1LJ5 A;  3F02 A;  3VVJ A;  3CWM A;  4R9I A;  2XN5 A;  3Q02 A;  1DZH I;  4EB1 I;  2HIJ L;  5EI0 A;  3H5C A;  1PSI A;  5BRR I;  1OPH A;  4KDS A;  3NDD A;  1JRR A;  1JTI A;  1MTP A;  2XN6 A;  2CEO A;  1DZH L;  1ATH A;  4EB1 L;  2OAY A;  1HP7 A;  4CAA A;  4ZK0 A;  5C98 A;  1B3K A;  3KCG I;  1D5S A;  1BY7 A;  1DB2 A;  9PAI A;  4C41 A;  2XN3 A;  3OZQ A;  3Q03 A;  1UHG A;  4RSQ A;  4ZK3 A;  1OVA C;  3ZHA A;  1T1F A;  1AS4 A;  1LK6 I;  2B4X I;  2ARR A;  1JJO C;  4AQH A;  4YIA A;  9API A;  4PYW A;  4ROA A;  3CWL A;  1E04 I;  2WXZ C;  2WXY C;  4Y40 A;  2WXX A;  2B4X L;  1QLP A;  3F1S A;  1F0C A;  1NQ9 I;  2PEF A;  4C49 A;  1DVM A;  1OYH L;  1E03 I;  2PEE A;  2ZV6 A;  3NE4 A;  3LE2 A;  3UT3 A;  4AJT A;  2B5T I;  2D26 A;  2ZNH A;  1HLE A;  4BB2 A;  2BEH I;  1AZX I;  1DVN A;  2ACH A;  3NDA A;  2QUG A;  2H4P A;  1XQJ A;  1C5G A;  4X30 A;  2BEH L;  1DZG I;  3DLW A;  2WXW A;  4AU3 A;  4AU3 B;  3DRM A;  4IC0 A;  4DY0 A;  1DZG L;  2WY0 C;  3EOX A;  1M93 B;  4G8R A;  1JVQ I;  1IMV A;  1OVA A;  1SR5 A;  1A7C A;  1K9O I;  1YXA A;  2WY1 A;  2RIV A;  4DTE A;  3PZF A;  1OC0 A;  3DRU A;  2GD4 C;  1QMB A;  1SNG A;  1QMN A;  4G8O A;  4P0F A;  4AJU A;  5HGC A;  4AU4 A;  2R9Y A;  7API A;  1ANT I;  4AFX A;  4P0O A; 
#chains in the Genus database with same CATH topology
 2RIW A;  1IZ2 A;  3CVM A;  4DY7 C;  2VDX A;  3LW2 A;  2V95 A;  4GA7 A;  3EVJ I;  1JMO A;  2ANT I;  1KCT A;  3NDF A;  2H4Q A;  3F5N A;  3DY0 A;  4ROB A;  8API A;  1XU8 A;  2XN7 A;  1BR8 I;  2VDY A;  1OVA B;  3CAA A;  4IF8 A;  1EZX A;  1R1L I;  1C8O A;  2H4R A;  3B9F I;  1SEK A;  3STO A;  1LQ8 A;  1OO8 A;  2VH4 A;  1ATT A;  1JMJ A;  3PB1 I;  3R4L A;  2WXZ A;  4AU2 A;  5CDZ A;  5CDX A;  4Y3K A;  5CE0 A;  2HI9 A;  1WZ9 A;  2ARQ A;  1XQG A;  5INW A;  1E05 I;  4RO9 A;  2DUT A;  3T1P A;  2OL2 A;  3FGQ A;  5IO1 A;  2HIJ I;  1ATU A;  1OYH I;  1TB6 I;  1LJ5 A;  3F02 A;  3VVJ A;  3CWM A;  4R9I A;  2XN5 A;  3Q02 A;  1DZH I;  4EB1 I;  2HIJ L;  5EI0 A;  3H5C A;  1PSI A;  5BRR I;  1OPH A;  4KDS A;  3NDD A;  1JRR A;  1JTI A;  1MTP A;  2XN6 A;  2CEO A;  1DZH L;  1ATH A;  4EB1 L;  2OAY A;  1HP7 A;  4CAA A;  4ZK0 A;  5C98 A;  1B3K A;  3KCG I;  1D5S A;  1BY7 A;  1DB2 A;  9PAI A;  4C41 A;  2XN3 A;  3OZQ A;  3Q03 A;  1UHG A;  4RSQ A;  4ZK3 A;  1OVA C;  3ZHA A;  1T1F A;  1AS4 A;  1LK6 I;  2B4X I;  2ARR A;  1JJO C;  4AQH A;  4YIA A;  9API A;  4PYW A;  4ROA A;  3CWL A;  1E04 I;  2WXZ C;  2WXY C;  4Y40 A;  2WXX A;  2B4X L;  1QLP A;  3F1S A;  1F0C A;  1NQ9 I;  2PEF A;  4C49 A;  1DVM A;  1OYH L;  1E03 I;  2PEE A;  2ZV6 A;  3NE4 A;  3LE2 A;  3UT3 A;  4AJT A;  2B5T I;  2D26 A;  2ZNH A;  1HLE A;  4BB2 A;  2BEH I;  1AZX I;  1DVN A;  2ACH A;  3NDA A;  2QUG A;  2H4P A;  1XQJ A;  1C5G A;  4X30 A;  2BEH L;  1DZG I;  3DLW A;  2WXW A;  4AU3 A;  4AU3 B;  3DRM A;  4IC0 A;  4DY0 A;  1DZG L;  2WY0 C;  3EOX A;  1M93 B;  4G8R A;  1JVQ I;  1IMV A;  1OVA A;  1SR5 A;  1A7C A;  1K9O I;  1YXA A;  2WY1 A;  2RIV A;  4DTE A;  3PZF A;  1OC0 A;  3DRU A;  2GD4 C;  1QMB A;  1SNG A;  1QMN A;  4G8O A;  4P0F A;  4AJU A;  5HGC A;  4AU4 A;  2R9Y A;  7API A;  1ANT I;  4AFX A;  4P0O A; 
#chains in the Genus database with same CATH homology
 2RIW A;  1IZ2 A;  3CVM A;  4DY7 C;  2VDX A;  3LW2 A;  2V95 A;  4GA7 A;  3EVJ I;  1JMO A;  2ANT I;  1KCT A;  3NDF A;  2H4Q A;  3F5N A;  3DY0 A;  4ROB A;  8API A;  1XU8 A;  2XN7 A;  1BR8 I;  2VDY A;  1OVA B;  3CAA A;  4IF8 A;  1EZX A;  1R1L I;  1C8O A;  2H4R A;  3B9F I;  1SEK A;  3STO A;  1LQ8 A;  1OO8 A;  2VH4 A;  1ATT A;  1JMJ A;  3PB1 I;  3R4L A;  2WXZ A;  4AU2 A;  5CDZ A;  5CDX A;  4Y3K A;  5CE0 A;  2HI9 A;  1WZ9 A;  2ARQ A;  1XQG A;  5INW A;  1E05 I;  4RO9 A;  2DUT A;  3T1P A;  2OL2 A;  3FGQ A;  5IO1 A;  2HIJ I;  1ATU A;  1OYH I;  1TB6 I;  1LJ5 A;  3F02 A;  3VVJ A;  3CWM A;  4R9I A;  2XN5 A;  3Q02 A;  1DZH I;  4EB1 I;  2HIJ L;  5EI0 A;  3H5C A;  1PSI A;  5BRR I;  1OPH A;  4KDS A;  3NDD A;  1JRR A;  1JTI A;  1MTP A;  2XN6 A;  2CEO A;  1DZH L;  1ATH A;  4EB1 L;  2OAY A;  1HP7 A;  4CAA A;  4ZK0 A;  5C98 A;  1B3K A;  3KCG I;  1D5S A;  1BY7 A;  1DB2 A;  9PAI A;  4C41 A;  2XN3 A;  3OZQ A;  3Q03 A;  1UHG A;  4RSQ A;  4ZK3 A;  1OVA C;  3ZHA A;  1T1F A;  1AS4 A;  1LK6 I;  2B4X I;  2ARR A;  1JJO C;  4AQH A;  4YIA A;  9API A;  4PYW A;  4ROA A;  3CWL A;  1E04 I;  2WXZ C;  2WXY C;  4Y40 A;  2WXX A;  2B4X L;  1QLP A;  3F1S A;  1F0C A;  1NQ9 I;  2PEF A;  4C49 A;  1DVM A;  1OYH L;  1E03 I;  2PEE A;  2ZV6 A;  3NE4 A;  3LE2 A;  3UT3 A;  4AJT A;  2B5T I;  2D26 A;  2ZNH A;  1HLE A;  4BB2 A;  2BEH I;  1AZX I;  1DVN A;  2ACH A;  3NDA A;  2QUG A;  2H4P A;  1XQJ A;  1C5G A;  4X30 A;  2BEH L;  1DZG I;  3DLW A;  2WXW A;  4AU3 A;  4AU3 B;  3DRM A;  4IC0 A;  4DY0 A;  1DZG L;  2WY0 C;  3EOX A;  1M93 B;  4G8R A;  1JVQ I;  1IMV A;  1OVA A;  1SR5 A;  1A7C A;  1K9O I;  1YXA A;  2WY1 A;  2RIV A;  4DTE A;  3PZF A;  1OC0 A;  3DRU A;  2GD4 C;  1QMB A;  1SNG A;  1QMN A;  4G8O A;  4P0F A;  4AJU A;  5HGC A;  4AU4 A;  2R9Y A;  7API A;  1ANT I;  4AFX A;  4P0O A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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