2WXWA

Crystal structure of human angiotensinogen
Total Genus 99
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
99
sequence length
450
structure length
438
Chain Sequence
SDRVYIHPFHLVIHNESTCEQLAKANAGKPKDPTFIPAPIQAKTSPVDEKALQDQLVLVAAKLDTEDKLRAAMVGMLANFLGFRIYGMHSELWGVVHGATVLSPTAVFGTLASLYLGALDHTADRLQAILGVPWKDKNCTSRLDAHKVLSALQAVQGLLVAQGRADSQAQLLLSTVVGVFTAPGLHLKQPFVQGLALYTPVVLPRSLDFTELDVAAEKIDRFMQAVTGWKTGCSLMGASVDSTLAFNTYVHFQGKMKGFSLLAEPQEFWVDNSTSVSVPMLSGMGTFQHWSDIQDNFSVTQVPFTESACLLLIQPHYASDLDKVEGLTFQQNSLNWMKKLSPRTIHLTMPQLVLQGSYDLQDLLAQAELPAILHTELNLQKLSNDRIRVGEVLNSIFFELEADEPEVLEVTLNRPFLFAVYDQSATALHFLGRVANPL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title A Redox Switch in Angiotensinogen Modulates Angiotensin Release.
pubmed doi rcsb
molecule tags Hormone
source organism Homo sapiens
molecule keywords ANGIOTENSINOGEN
total genus 99
structure length 438
sequence length 450
ec nomenclature
pdb deposition date 2009-11-11

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00079 Serpin Serpin (serine protease inhibitor)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.30.39.10 Mainly Beta Roll Alpha-1-antitrypsin; domain 1 Alpha-1-antitrypsin, domain 1 2wxwA01
3.30.497.10 Alpha Beta 2-Layer Sandwich Antithrombin; Chain I, domain 2 Antithrombin, subunit I, domain 2 2wxwA02
3DRUA 4X30A 4IC0A 4ZK0A 1D5SA 1AZXI 2ANTI 2H4PA 3CVMA 5C98A 1JJOC 3Q02A 1JRRA 4BB2A 2OL2A 3KCGI 1OVAB 1T1FA 4AJTA 1UHGA 1HLEA 7APIA 1F0CA 1SR5A 1WZ9A 1DVMA 1XU8A 8APIA 1E05I 2XN6A 1XQJA 2ZNHA 4EB1L 4Y3KA 4DY7C 1AS4A 1MTPA 1OYHL 1HP7A 2WXZC 4Y40A 5EI0A 1IMVA 1DZHL 2B4XI 3OZQA 2D26A 4PYWA 3FGQA 3UT3A 4C41A 3DY0A 4DY0A 3F02A 4G8RA 2HIJI 5CE0A 3PZFA 3EOXA 1XQGA 2GD4C 2BEHL 1ATUA 2WY0C 2RIWA 4AU3B 3NDFA 5CDZA 1OC0A 2HI9A 1LJ5A 4AU3A 1ATHA 9APIA 4CAAA 2WXYC 1OPHA 4ROAA 1PSIA 4G8OA 2H4QA 3LW2A 2WXWA 4KDSA 3B9FI 4IF8A 3STOA 3NDDA 4ROBA 3NE4A 1R1LI 1OYHI 3Q03A 4R9IA 1DZGI 3T1PA 4DTEA 4C49A 2WY1A 1DZHI 3PB1I 1SEKA 1M93B 1A7CA 3LE2A 1ANTI 2WXXA 5INWA 4AFXA 4AJUA 2RIVA 1OVAC 3F5NA 2ARQA 2XN5A 2QUGA 4RO9A 1DB2A 3CAAA 4ZK3A 4AQHA 4P0OA 1E03I 1B3KA 2CEOA 3DRMA 4YIAA 1NQ9I 1LQ8A 2B4XL 3EVJI 2VDXA 4RSQA 1QMBA 1QLPA 2VDYA 1JMJA 4P0FA 2OAYA 1EZXA 3H5CA 9PAIA 4EB1I 1JVQI 1JTIA 2HIJL 1JMOA 1E04I 3F1SA 5CDXA 2XN3A 1SNGA 1KCTA 1YXAA 2V95A 2ACHA 1TB6I 2WXZA 1BY7A 4AU4A 2H4RA 2PEFA 5BRRI 1IZ2A 3CWLA 3R4LA 2BEHI 1C8OA 1LK6I 2VH4A 1BR8I 2ARRA 1OVAA 2R9YA 1C5GA 1ATTA 3NDAA 3VVJA 2XN7A 4GA7A 3CWMA 1QMNA 3DLWA 1DVNA 2B5TI 5HGCA 1DZGL 2DUTA 3ZHAA 2ZV6A 1OO8A 1K9OI 5IO1A 4AU2A 2PEEA
chains in the Genus database with same CATH superfamily
3DRUA 4X30A 4IC0A 4ZK0A 1D5SA 1AZXI 2ANTI 2H4PA 3CVMA 5C98A 1JJOC 3Q02A 1JRRA 4BB2A 2OL2A 3KCGI 1OVAB 1T1FA 4AJTA 1UHGA 1HLEA 7APIA 1F0CA 1SR5A 1WZ9A 1DVMA 1XU8A 8APIA 1E05I 2XN6A 1XQJA 2ZNHA 4EB1L 4Y3KA 4DY7C 1AS4A 1MTPA 1OYHL 1HP7A 2WXZC 4Y40A 5EI0A 1IMVA 1DZHL 2B4XI 3OZQA 2D26A 4PYWA 3FGQA 3UT3A 4C41A 3DY0A 4DY0A 3F02A 4G8RA 2HIJI 5CE0A 3PZFA 3EOXA 1XQGA 2GD4C 2BEHL 1ATUA 2WY0C 2RIWA 4AU3B 3NDFA 5CDZA 1OC0A 2HI9A 1LJ5A 4AU3A 1ATHA 9APIA 4CAAA 2WXYC 1OPHA 4ROAA 1PSIA 4G8OA 2H4QA 3LW2A 2WXWA 4KDSA 3B9FI 4IF8A 3STOA 3NDDA 4ROBA 3NE4A 1R1LI 1OYHI 3Q03A 4R9IA 1DZGI 3T1PA 4DTEA 4C49A 2WY1A 1DZHI 3PB1I 1SEKA 1M93B 1A7CA 3LE2A 1ANTI 2WXXA 5INWA 4AFXA 4AJUA 2RIVA 1OVAC 3F5NA 2ARQA 2XN5A 2QUGA 4RO9A 1DB2A 3CAAA 4ZK3A 4AQHA 4P0OA 1E03I 1B3KA 2CEOA 3DRMA 4YIAA 1NQ9I 1LQ8A 2B4XL 3EVJI 2VDXA 4RSQA 1QMBA 1QLPA 2VDYA 1JMJA 4P0FA 2OAYA 1EZXA 3H5CA 9PAIA 4EB1I 1JVQI 1JTIA 2HIJL 1JMOA 1E04I 3F1SA 5CDXA 2XN3A 1SNGA 1KCTA 1YXAA 2V95A 2ACHA 1TB6I 2WXZA 1BY7A 4AU4A 2H4RA 2PEFA 5BRRI 1IZ2A 3CWLA 3R4LA 2BEHI 1C8OA 1LK6I 2VH4A 1BR8I 2ARRA 1OVAA 2R9YA 1C5GA 1ATTA 3NDAA 3VVJA 2XN7A 4GA7A 3CWMA 1QMNA 3DLWA 1DVNA 2B5TI 5HGCA 1DZGL 2DUTA 3ZHAA 2ZV6A 1OO8A 1K9OI 5IO1A 4AU2A 2PEEA
chains in the Genus database with same CATH topology
3DRUA 4X30A 4IC0A 4ZK0A 1D5SA 1AZXI 2ANTI 2H4PA 3CVMA 5C98A 1JJOC 3Q02A 1JRRA 4BB2A 2OL2A 3KCGI 1OVAB 1T1FA 4AJTA 1UHGA 1HLEA 7APIA 1F0CA 1SR5A 1WZ9A 1DVMA 1XU8A 8APIA 1E05I 2XN6A 1XQJA 2ZNHA 4EB1L 4Y3KA 4DY7C 1AS4A 1MTPA 1OYHL 1HP7A 2WXZC 4Y40A 5EI0A 1IMVA 1DZHL 2B4XI 3OZQA 2D26A 4PYWA 3FGQA 3UT3A 4C41A 3DY0A 4DY0A 3F02A 4G8RA 2HIJI 5CE0A 3PZFA 3EOXA 1XQGA 2GD4C 2BEHL 1ATUA 2WY0C 2RIWA 4AU3B 3NDFA 5CDZA 1OC0A 2HI9A 1LJ5A 4AU3A 1ATHA 9APIA 4CAAA 2WXYC 1OPHA 4ROAA 1PSIA 4G8OA 2H4QA 3LW2A 2WXWA 4KDSA 3B9FI 4IF8A 3STOA 3NDDA 4ROBA 3NE4A 1R1LI 1OYHI 3Q03A 4R9IA 1DZGI 3T1PA 4DTEA 4C49A 2WY1A 1DZHI 3PB1I 1SEKA 1M93B 1A7CA 3LE2A 1ANTI 2WXXA 5INWA 4AFXA 4AJUA 2RIVA 1OVAC 3F5NA 2ARQA 2XN5A 2QUGA 4RO9A 1DB2A 3CAAA 4ZK3A 4AQHA 4P0OA 1E03I 1B3KA 2CEOA 3DRMA 4YIAA 1NQ9I 1LQ8A 2B4XL 3EVJI 2VDXA 4RSQA 1QMBA 1QLPA 2VDYA 1JMJA 4P0FA 2OAYA 1EZXA 3H5CA 9PAIA 4EB1I 1JVQI 1JTIA 2HIJL 1JMOA 1E04I 3F1SA 5CDXA 2XN3A 1SNGA 1KCTA 1YXAA 2V95A 2ACHA 1TB6I 2WXZA 1BY7A 4AU4A 2H4RA 2PEFA 5BRRI 1IZ2A 3CWLA 3R4LA 2BEHI 1C8OA 1LK6I 2VH4A 1BR8I 2ARRA 1OVAA 2R9YA 1C5GA 1ATTA 3NDAA 3VVJA 2XN7A 4GA7A 3CWMA 1QMNA 3DLWA 1DVNA 2B5TI 5HGCA 1DZGL 2DUTA 3ZHAA 2ZV6A 1OO8A 1K9OI 5IO1A 4AU2A 2PEEA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3DRU A;  4X30 A;  4IC0 A;  4ZK0 A;  1D5S A;  1AZX I;  2ANT I;  2H4P A;  3CVM A;  5C98 A;  1JJO C;  3Q02 A;  1JRR A;  4BB2 A;  2OL2 A;  3KCG I;  1OVA B;  1T1F A;  4AJT A;  1UHG A;  1HLE A;  7API A;  1F0C A;  1SR5 A;  1WZ9 A;  1DVM A;  1XU8 A;  8API A;  1E05 I;  2XN6 A;  1XQJ A;  2ZNH A;  4EB1 L;  4Y3K A;  4DY7 C;  1AS4 A;  1MTP A;  1OYH L;  1HP7 A;  2WXZ C;  4Y40 A;  5EI0 A;  1IMV A;  1DZH L;  2B4X I;  3OZQ A;  2D26 A;  4PYW A;  3FGQ A;  3UT3 A;  4C41 A;  3DY0 A;  4DY0 A;  3F02 A;  4G8R A;  2HIJ I;  5CE0 A;  3PZF A;  3EOX A;  1XQG A;  2GD4 C;  2BEH L;  1ATU A;  2WY0 C;  2RIW A;  4AU3 B;  3NDF A;  5CDZ A;  1OC0 A;  2HI9 A;  1LJ5 A;  4AU3 A;  1ATH A;  9API A;  4CAA A;  2WXY C;  1OPH A;  4ROA A;  1PSI A;  4G8O A;  2H4Q A;  3LW2 A;  2WXW A;  4KDS A;  3B9F I;  4IF8 A;  3STO A;  3NDD A;  4ROB A;  3NE4 A;  1R1L I;  1OYH I;  3Q03 A;  4R9I A;  1DZG I;  3T1P A;  4DTE A;  4C49 A;  2WY1 A;  1DZH I;  3PB1 I;  1SEK A;  1M93 B;  1A7C A;  3LE2 A;  1ANT I;  2WXX A;  5INW A;  4AFX A;  4AJU A;  2RIV A;  1OVA C;  3F5N A;  2ARQ A;  2XN5 A;  2QUG A;  4RO9 A;  1DB2 A;  3CAA A;  4ZK3 A;  4AQH A;  4P0O A;  1E03 I;  1B3K A;  2CEO A;  3DRM A;  4YIA A;  1NQ9 I;  1LQ8 A;  2B4X L;  3EVJ I;  2VDX A;  4RSQ A;  1QMB A;  1QLP A;  2VDY A;  1JMJ A;  4P0F A;  2OAY A;  1EZX A;  3H5C A;  9PAI A;  4EB1 I;  1JVQ I;  1JTI A;  2HIJ L;  1JMO A;  1E04 I;  3F1S A;  5CDX A;  2XN3 A;  1SNG A;  1KCT A;  1YXA A;  2V95 A;  2ACH A;  1TB6 I;  2WXZ A;  1BY7 A;  4AU4 A;  2H4R A;  2PEF A;  5BRR I;  1IZ2 A;  3CWL A;  3R4L A;  2BEH I;  1C8O A;  1LK6 I;  2VH4 A;  1BR8 I;  2ARR A;  1OVA A;  2R9Y A;  1C5G A;  1ATT A;  3NDA A;  3VVJ A;  2XN7 A;  4GA7 A;  3CWM A;  1QMN A;  3DLW A;  1DVN A;  2B5T I;  5HGC A;  1DZG L;  2DUT A;  3ZHA A;  2ZV6 A;  1OO8 A;  1K9O I;  5IO1 A;  4AU2 A;  2PEE A; 
#chains in the Genus database with same CATH topology
 3DRU A;  4X30 A;  4IC0 A;  4ZK0 A;  1D5S A;  1AZX I;  2ANT I;  2H4P A;  3CVM A;  5C98 A;  1JJO C;  3Q02 A;  1JRR A;  4BB2 A;  2OL2 A;  3KCG I;  1OVA B;  1T1F A;  4AJT A;  1UHG A;  1HLE A;  7API A;  1F0C A;  1SR5 A;  1WZ9 A;  1DVM A;  1XU8 A;  8API A;  1E05 I;  2XN6 A;  1XQJ A;  2ZNH A;  4EB1 L;  4Y3K A;  4DY7 C;  1AS4 A;  1MTP A;  1OYH L;  1HP7 A;  2WXZ C;  4Y40 A;  5EI0 A;  1IMV A;  1DZH L;  2B4X I;  3OZQ A;  2D26 A;  4PYW A;  3FGQ A;  3UT3 A;  4C41 A;  3DY0 A;  4DY0 A;  3F02 A;  4G8R A;  2HIJ I;  5CE0 A;  3PZF A;  3EOX A;  1XQG A;  2GD4 C;  2BEH L;  1ATU A;  2WY0 C;  2RIW A;  4AU3 B;  3NDF A;  5CDZ A;  1OC0 A;  2HI9 A;  1LJ5 A;  4AU3 A;  1ATH A;  9API A;  4CAA A;  2WXY C;  1OPH A;  4ROA A;  1PSI A;  4G8O A;  2H4Q A;  3LW2 A;  2WXW A;  4KDS A;  3B9F I;  4IF8 A;  3STO A;  3NDD A;  4ROB A;  3NE4 A;  1R1L I;  1OYH I;  3Q03 A;  4R9I A;  1DZG I;  3T1P A;  4DTE A;  4C49 A;  2WY1 A;  1DZH I;  3PB1 I;  1SEK A;  1M93 B;  1A7C A;  3LE2 A;  1ANT I;  2WXX A;  5INW A;  4AFX A;  4AJU A;  2RIV A;  1OVA C;  3F5N A;  2ARQ A;  2XN5 A;  2QUG A;  4RO9 A;  1DB2 A;  3CAA A;  4ZK3 A;  4AQH A;  4P0O A;  1E03 I;  1B3K A;  2CEO A;  3DRM A;  4YIA A;  1NQ9 I;  1LQ8 A;  2B4X L;  3EVJ I;  2VDX A;  4RSQ A;  1QMB A;  1QLP A;  2VDY A;  1JMJ A;  4P0F A;  2OAY A;  1EZX A;  3H5C A;  9PAI A;  4EB1 I;  1JVQ I;  1JTI A;  2HIJ L;  1JMO A;  1E04 I;  3F1S A;  5CDX A;  2XN3 A;  1SNG A;  1KCT A;  1YXA A;  2V95 A;  2ACH A;  1TB6 I;  2WXZ A;  1BY7 A;  4AU4 A;  2H4R A;  2PEF A;  5BRR I;  1IZ2 A;  3CWL A;  3R4L A;  2BEH I;  1C8O A;  1LK6 I;  2VH4 A;  1BR8 I;  2ARR A;  1OVA A;  2R9Y A;  1C5G A;  1ATT A;  3NDA A;  3VVJ A;  2XN7 A;  4GA7 A;  3CWM A;  1QMN A;  3DLW A;  1DVN A;  2B5T I;  5HGC A;  1DZG L;  2DUT A;  3ZHA A;  2ZV6 A;  1OO8 A;  1K9O I;  5IO1 A;  4AU2 A;  2PEE A; 
#chains in the Genus database with same CATH homology
 3DRU A;  4X30 A;  4IC0 A;  4ZK0 A;  1D5S A;  1AZX I;  2ANT I;  2H4P A;  3CVM A;  5C98 A;  1JJO C;  3Q02 A;  1JRR A;  4BB2 A;  2OL2 A;  3KCG I;  1OVA B;  1T1F A;  4AJT A;  1UHG A;  1HLE A;  7API A;  1F0C A;  1SR5 A;  1WZ9 A;  1DVM A;  1XU8 A;  8API A;  1E05 I;  2XN6 A;  1XQJ A;  2ZNH A;  4EB1 L;  4Y3K A;  4DY7 C;  1AS4 A;  1MTP A;  1OYH L;  1HP7 A;  2WXZ C;  4Y40 A;  5EI0 A;  1IMV A;  1DZH L;  2B4X I;  3OZQ A;  2D26 A;  4PYW A;  3FGQ A;  3UT3 A;  4C41 A;  3DY0 A;  4DY0 A;  3F02 A;  4G8R A;  2HIJ I;  5CE0 A;  3PZF A;  3EOX A;  1XQG A;  2GD4 C;  2BEH L;  1ATU A;  2WY0 C;  2RIW A;  4AU3 B;  3NDF A;  5CDZ A;  1OC0 A;  2HI9 A;  1LJ5 A;  4AU3 A;  1ATH A;  9API A;  4CAA A;  2WXY C;  1OPH A;  4ROA A;  1PSI A;  4G8O A;  2H4Q A;  3LW2 A;  2WXW A;  4KDS A;  3B9F I;  4IF8 A;  3STO A;  3NDD A;  4ROB A;  3NE4 A;  1R1L I;  1OYH I;  3Q03 A;  4R9I A;  1DZG I;  3T1P A;  4DTE A;  4C49 A;  2WY1 A;  1DZH I;  3PB1 I;  1SEK A;  1M93 B;  1A7C A;  3LE2 A;  1ANT I;  2WXX A;  5INW A;  4AFX A;  4AJU A;  2RIV A;  1OVA C;  3F5N A;  2ARQ A;  2XN5 A;  2QUG A;  4RO9 A;  1DB2 A;  3CAA A;  4ZK3 A;  4AQH A;  4P0O A;  1E03 I;  1B3K A;  2CEO A;  3DRM A;  4YIA A;  1NQ9 I;  1LQ8 A;  2B4X L;  3EVJ I;  2VDX A;  4RSQ A;  1QMB A;  1QLP A;  2VDY A;  1JMJ A;  4P0F A;  2OAY A;  1EZX A;  3H5C A;  9PAI A;  4EB1 I;  1JVQ I;  1JTI A;  2HIJ L;  1JMO A;  1E04 I;  3F1S A;  5CDX A;  2XN3 A;  1SNG A;  1KCT A;  1YXA A;  2V95 A;  2ACH A;  1TB6 I;  2WXZ A;  1BY7 A;  4AU4 A;  2H4R A;  2PEF A;  5BRR I;  1IZ2 A;  3CWL A;  3R4L A;  2BEH I;  1C8O A;  1LK6 I;  2VH4 A;  1BR8 I;  2ARR A;  1OVA A;  2R9Y A;  1C5G A;  1ATT A;  3NDA A;  3VVJ A;  2XN7 A;  4GA7 A;  3CWM A;  1QMN A;  3DLW A;  1DVN A;  2B5T I;  5HGC A;  1DZG L;  2DUT A;  3ZHA A;  2ZV6 A;  1OO8 A;  1K9O I;  5IO1 A;  4AU2 A;  2PEE A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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