3T1PA

Crystal structure of an alpha-1-antitrypsin trimer
Total Genus 77
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
77
sequence length
371
structure length
371
Chain Sequence
NKITPNLAEFAFSLYRQLAHQSNSTNIFFSPVSIATAFAMLSLGTKADTHDEILEGLNFNLTEIPEAQIHEGFQELLRTLNQPDSQLQLTTGNGLFLSEGLKLVDKFLEDVKKLYHSEAFTVNFGDTEEAKKQINDYVEKGTQGKIVDLVKELDRDTVFALVNYIFFKGKWERPFEVKDTEEEDFHVDQVTTVKVPMMKRLGMFNIQHSKKLSSWVLLMKYLGNATAIFFLPDEGKLQHLENELTHDIITKFLENEDRRSASLHLPKLCITGTYDLKSVLGQLGITKVFSNGADLSGVTEEAPLKLSKAVHKAVLCIDEKGTEAAGAMFLEAIPRSIPPEVKFNKPFVFLMIEQNTKSPLFMGKVVNPTQK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase inhibitor
molecule keywords Alpha-1-antitrypsin
publication title Molecular basis of alpha 1-antitrypsin deficiency revealed by the structure of a domain-swapped trimer.
pubmed doi rcsb
source organism Homo sapiens
total genus 77
structure length 371
sequence length 371
ec nomenclature
pdb deposition date 2011-07-22

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00079 Serpin Serpin (serine protease inhibitor)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.30.39.10 Mainly Beta Roll Alpha-1-antitrypsin; domain 1 Alpha-1-antitrypsin, domain 1 3t1pA02
3.30.497.10 Alpha Beta 2-Layer Sandwich Antithrombin; Chain I, domain 2 Antithrombin, subunit I, domain 2 3t1pA01
4BB2A 4IC0A 2XN3A 2QUGA 1DVMA 4KDSA 2H4QA 1OO8A 3PZFA 1HLEA 1OVAC 2WY0C 1ANTI 1JVQI 3STOA 4AU3A 1JMOA 3DLWA 4DTEA 2DUTA 9PAIA 1ATTA 2XN7A 2VDYA 1JMJA 2WXZA 3PB1I 3CAAA 4P0FA 2HIJI 1MTPA 1IZ2A 4AU4A 3OZQA 5CDZA 1JTIA 3EVJI 4EB1I 2D26A 1OPHA 3EOXA 5INWA 1NQ9I 4Y40A 3Q02A 4AU2A 4AU3B 3UT3A 1D5SA 1BR8I 2CEOA 1OYHL 2H4RA 3T1PA 2WXWA 1E03I 1SR5A 1QMNA 3DRUA 3NDAA 5C98A 1SNGA 1XU8A 1JJOC 5CE0A 4YIAA 2ZNHA 4CAAA 2WY1A 1ATUA 1E05I 4ZK3A 2VDXA 3Q03A 3LW2A 4GA7A 1OVAA 1YXAA 1LK6I 4C41A 1UHGA 1DZHL 2B5TI 2HI9A 4AQHA 1LQ8A 3B9FI 1T1FA 1DZGL 2XN6A 3ZHAA 7APIA 4Y3KA 1F0CA 2H4PA 2R9YA 1R1LI 2BEHL 1LJ5A 2XN5A 4DY7C 3H5CA 1E04I 1A7CA 1OVAB 3DRMA 3VVJA 1BY7A 1QLPA 2ACHA 4AJUA 4PYWA 4IF8A 1AZXI 4DY0A 2PEFA 1AS4A 1OC0A 3NDFA 1EZXA 1XQGA 1XQJA 2WXXA 1KCTA 3CWLA 4C49A 1C5GA 4ROAA 8APIA 4G8RA 4RSQA 2HIJL 3KCGI 3F5NA 5BRRI 4AFXA 1M93B 3NDDA 2OL2A 1B3KA 3F02A 1K9OI 1WZ9A 2B4XL 1OYHI 1HP7A 2ARQA 1TB6I 3CWMA 2RIVA 3DY0A 3F1SA 4RO9A 4X30A 4AJTA 1PSIA 2WXYC 3CVMA 1SEKA 3R4LA 2WXZC 2ANTI 9APIA 5HGCA 5IO1A 3LE2A 2PEEA 1C8OA 1DZHI 1ATHA 2VH4A 2OAYA 4R9IA 4G8OA 4ROBA 1DZGI 5CDXA 2GD4C 4ZK0A 1DB2A 2V95A 2RIWA 2ARRA 3NE4A 1IMVA 4P0OA 2B4XI 2BEHI 4EB1L 1JRRA 1QMBA 1DVNA 5EI0A 2ZV6A 3FGQA
chains in the Genus database with same CATH superfamily
4BB2A 4IC0A 2XN3A 2QUGA 1DVMA 4KDSA 2H4QA 1OO8A 3PZFA 1HLEA 1OVAC 2WY0C 1ANTI 1JVQI 3STOA 4AU3A 1JMOA 3DLWA 4DTEA 2DUTA 9PAIA 1ATTA 2XN7A 2VDYA 1JMJA 2WXZA 3PB1I 3CAAA 4P0FA 2HIJI 1MTPA 1IZ2A 4AU4A 3OZQA 5CDZA 1JTIA 3EVJI 4EB1I 2D26A 1OPHA 3EOXA 5INWA 1NQ9I 4Y40A 3Q02A 4AU2A 4AU3B 3UT3A 1D5SA 1BR8I 2CEOA 1OYHL 2H4RA 3T1PA 2WXWA 1E03I 1SR5A 1QMNA 3DRUA 3NDAA 5C98A 1SNGA 1XU8A 1JJOC 5CE0A 4YIAA 2ZNHA 4CAAA 2WY1A 1ATUA 1E05I 4ZK3A 2VDXA 3Q03A 3LW2A 4GA7A 1OVAA 1YXAA 1LK6I 4C41A 1UHGA 1DZHL 2B5TI 2HI9A 4AQHA 1LQ8A 3B9FI 1T1FA 1DZGL 2XN6A 3ZHAA 7APIA 4Y3KA 1F0CA 2H4PA 2R9YA 1R1LI 2BEHL 1LJ5A 2XN5A 4DY7C 3H5CA 1E04I 1A7CA 1OVAB 3DRMA 3VVJA 1BY7A 1QLPA 2ACHA 4AJUA 4PYWA 4IF8A 1AZXI 4DY0A 2PEFA 1AS4A 1OC0A 3NDFA 1EZXA 1XQGA 1XQJA 2WXXA 1KCTA 3CWLA 4C49A 1C5GA 4ROAA 8APIA 4G8RA 4RSQA 2HIJL 3KCGI 3F5NA 5BRRI 4AFXA 1M93B 3NDDA 2OL2A 1B3KA 3F02A 1K9OI 1WZ9A 2B4XL 1OYHI 1HP7A 2ARQA 1TB6I 3CWMA 2RIVA 3DY0A 3F1SA 4RO9A 4X30A 4AJTA 1PSIA 2WXYC 3CVMA 1SEKA 3R4LA 2WXZC 2ANTI 9APIA 5HGCA 5IO1A 3LE2A 2PEEA 1C8OA 1DZHI 1ATHA 2VH4A 2OAYA 4R9IA 4G8OA 4ROBA 1DZGI 5CDXA 2GD4C 4ZK0A 1DB2A 2V95A 2RIWA 2ARRA 3NE4A 1IMVA 4P0OA 2B4XI 2BEHI 4EB1L 1JRRA 1QMBA 1DVNA 5EI0A 2ZV6A 3FGQA
chains in the Genus database with same CATH topology
4BB2A 4IC0A 2XN3A 2QUGA 1DVMA 4KDSA 2H4QA 1OO8A 3PZFA 1HLEA 1OVAC 2WY0C 1ANTI 1JVQI 3STOA 4AU3A 1JMOA 3DLWA 4DTEA 2DUTA 9PAIA 1ATTA 2XN7A 2VDYA 1JMJA 2WXZA 3PB1I 3CAAA 4P0FA 2HIJI 1MTPA 1IZ2A 4AU4A 3OZQA 5CDZA 1JTIA 3EVJI 4EB1I 2D26A 1OPHA 3EOXA 5INWA 1NQ9I 4Y40A 3Q02A 4AU2A 4AU3B 3UT3A 1D5SA 1BR8I 2CEOA 1OYHL 2H4RA 3T1PA 2WXWA 1E03I 1SR5A 1QMNA 3DRUA 3NDAA 5C98A 1SNGA 1XU8A 1JJOC 5CE0A 4YIAA 2ZNHA 4CAAA 2WY1A 1ATUA 1E05I 4ZK3A 2VDXA 3Q03A 3LW2A 4GA7A 1OVAA 1YXAA 1LK6I 4C41A 1UHGA 1DZHL 2B5TI 2HI9A 4AQHA 1LQ8A 3B9FI 1T1FA 1DZGL 2XN6A 3ZHAA 7APIA 4Y3KA 1F0CA 2H4PA 2R9YA 1R1LI 2BEHL 1LJ5A 2XN5A 4DY7C 3H5CA 1E04I 1A7CA 1OVAB 3DRMA 3VVJA 1BY7A 1QLPA 2ACHA 4AJUA 4PYWA 4IF8A 1AZXI 4DY0A 2PEFA 1AS4A 1OC0A 3NDFA 1EZXA 1XQGA 1XQJA 2WXXA 1KCTA 3CWLA 4C49A 1C5GA 4ROAA 8APIA 4G8RA 4RSQA 2HIJL 3KCGI 3F5NA 5BRRI 4AFXA 1M93B 3NDDA 2OL2A 1B3KA 3F02A 1K9OI 1WZ9A 2B4XL 1OYHI 1HP7A 2ARQA 1TB6I 3CWMA 2RIVA 3DY0A 3F1SA 4RO9A 4X30A 4AJTA 1PSIA 2WXYC 3CVMA 1SEKA 3R4LA 2WXZC 2ANTI 9APIA 5HGCA 5IO1A 3LE2A 2PEEA 1C8OA 1DZHI 1ATHA 2VH4A 2OAYA 4R9IA 4G8OA 4ROBA 1DZGI 5CDXA 2GD4C 4ZK0A 1DB2A 2V95A 2RIWA 2ARRA 3NE4A 1IMVA 4P0OA 2B4XI 2BEHI 4EB1L 1JRRA 1QMBA 1DVNA 5EI0A 2ZV6A 3FGQA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4BB2 A;  4IC0 A;  2XN3 A;  2QUG A;  1DVM A;  4KDS A;  2H4Q A;  1OO8 A;  3PZF A;  1HLE A;  1OVA C;  2WY0 C;  1ANT I;  1JVQ I;  3STO A;  4AU3 A;  1JMO A;  3DLW A;  4DTE A;  2DUT A;  9PAI A;  1ATT A;  2XN7 A;  2VDY A;  1JMJ A;  2WXZ A;  3PB1 I;  3CAA A;  4P0F A;  2HIJ I;  1MTP A;  1IZ2 A;  4AU4 A;  3OZQ A;  5CDZ A;  1JTI A;  3EVJ I;  4EB1 I;  2D26 A;  1OPH A;  3EOX A;  5INW A;  1NQ9 I;  4Y40 A;  3Q02 A;  4AU2 A;  4AU3 B;  3UT3 A;  1D5S A;  1BR8 I;  2CEO A;  1OYH L;  2H4R A;  3T1P A;  2WXW A;  1E03 I;  1SR5 A;  1QMN A;  3DRU A;  3NDA A;  5C98 A;  1SNG A;  1XU8 A;  1JJO C;  5CE0 A;  4YIA A;  2ZNH A;  4CAA A;  2WY1 A;  1ATU A;  1E05 I;  4ZK3 A;  2VDX A;  3Q03 A;  3LW2 A;  4GA7 A;  1OVA A;  1YXA A;  1LK6 I;  4C41 A;  1UHG A;  1DZH L;  2B5T I;  2HI9 A;  4AQH A;  1LQ8 A;  3B9F I;  1T1F A;  1DZG L;  2XN6 A;  3ZHA A;  7API A;  4Y3K A;  1F0C A;  2H4P A;  2R9Y A;  1R1L I;  2BEH L;  1LJ5 A;  2XN5 A;  4DY7 C;  3H5C A;  1E04 I;  1A7C A;  1OVA B;  3DRM A;  3VVJ A;  1BY7 A;  1QLP A;  2ACH A;  4AJU A;  4PYW A;  4IF8 A;  1AZX I;  4DY0 A;  2PEF A;  1AS4 A;  1OC0 A;  3NDF A;  1EZX A;  1XQG A;  1XQJ A;  2WXX A;  1KCT A;  3CWL A;  4C49 A;  1C5G A;  4ROA A;  8API A;  4G8R A;  4RSQ A;  2HIJ L;  3KCG I;  3F5N A;  5BRR I;  4AFX A;  1M93 B;  3NDD A;  2OL2 A;  1B3K A;  3F02 A;  1K9O I;  1WZ9 A;  2B4X L;  1OYH I;  1HP7 A;  2ARQ A;  1TB6 I;  3CWM A;  2RIV A;  3DY0 A;  3F1S A;  4RO9 A;  4X30 A;  4AJT A;  1PSI A;  2WXY C;  3CVM A;  1SEK A;  3R4L A;  2WXZ C;  2ANT I;  9API A;  5HGC A;  5IO1 A;  3LE2 A;  2PEE A;  1C8O A;  1DZH I;  1ATH A;  2VH4 A;  2OAY A;  4R9I A;  4G8O A;  4ROB A;  1DZG I;  5CDX A;  2GD4 C;  4ZK0 A;  1DB2 A;  2V95 A;  2RIW A;  2ARR A;  3NE4 A;  1IMV A;  4P0O A;  2B4X I;  2BEH I;  4EB1 L;  1JRR A;  1QMB A;  1DVN A;  5EI0 A;  2ZV6 A;  3FGQ A; 
#chains in the Genus database with same CATH topology
 4BB2 A;  4IC0 A;  2XN3 A;  2QUG A;  1DVM A;  4KDS A;  2H4Q A;  1OO8 A;  3PZF A;  1HLE A;  1OVA C;  2WY0 C;  1ANT I;  1JVQ I;  3STO A;  4AU3 A;  1JMO A;  3DLW A;  4DTE A;  2DUT A;  9PAI A;  1ATT A;  2XN7 A;  2VDY A;  1JMJ A;  2WXZ A;  3PB1 I;  3CAA A;  4P0F A;  2HIJ I;  1MTP A;  1IZ2 A;  4AU4 A;  3OZQ A;  5CDZ A;  1JTI A;  3EVJ I;  4EB1 I;  2D26 A;  1OPH A;  3EOX A;  5INW A;  1NQ9 I;  4Y40 A;  3Q02 A;  4AU2 A;  4AU3 B;  3UT3 A;  1D5S A;  1BR8 I;  2CEO A;  1OYH L;  2H4R A;  3T1P A;  2WXW A;  1E03 I;  1SR5 A;  1QMN A;  3DRU A;  3NDA A;  5C98 A;  1SNG A;  1XU8 A;  1JJO C;  5CE0 A;  4YIA A;  2ZNH A;  4CAA A;  2WY1 A;  1ATU A;  1E05 I;  4ZK3 A;  2VDX A;  3Q03 A;  3LW2 A;  4GA7 A;  1OVA A;  1YXA A;  1LK6 I;  4C41 A;  1UHG A;  1DZH L;  2B5T I;  2HI9 A;  4AQH A;  1LQ8 A;  3B9F I;  1T1F A;  1DZG L;  2XN6 A;  3ZHA A;  7API A;  4Y3K A;  1F0C A;  2H4P A;  2R9Y A;  1R1L I;  2BEH L;  1LJ5 A;  2XN5 A;  4DY7 C;  3H5C A;  1E04 I;  1A7C A;  1OVA B;  3DRM A;  3VVJ A;  1BY7 A;  1QLP A;  2ACH A;  4AJU A;  4PYW A;  4IF8 A;  1AZX I;  4DY0 A;  2PEF A;  1AS4 A;  1OC0 A;  3NDF A;  1EZX A;  1XQG A;  1XQJ A;  2WXX A;  1KCT A;  3CWL A;  4C49 A;  1C5G A;  4ROA A;  8API A;  4G8R A;  4RSQ A;  2HIJ L;  3KCG I;  3F5N A;  5BRR I;  4AFX A;  1M93 B;  3NDD A;  2OL2 A;  1B3K A;  3F02 A;  1K9O I;  1WZ9 A;  2B4X L;  1OYH I;  1HP7 A;  2ARQ A;  1TB6 I;  3CWM A;  2RIV A;  3DY0 A;  3F1S A;  4RO9 A;  4X30 A;  4AJT A;  1PSI A;  2WXY C;  3CVM A;  1SEK A;  3R4L A;  2WXZ C;  2ANT I;  9API A;  5HGC A;  5IO1 A;  3LE2 A;  2PEE A;  1C8O A;  1DZH I;  1ATH A;  2VH4 A;  2OAY A;  4R9I A;  4G8O A;  4ROB A;  1DZG I;  5CDX A;  2GD4 C;  4ZK0 A;  1DB2 A;  2V95 A;  2RIW A;  2ARR A;  3NE4 A;  1IMV A;  4P0O A;  2B4X I;  2BEH I;  4EB1 L;  1JRR A;  1QMB A;  1DVN A;  5EI0 A;  2ZV6 A;  3FGQ A; 
#chains in the Genus database with same CATH homology
 4BB2 A;  4IC0 A;  2XN3 A;  2QUG A;  1DVM A;  4KDS A;  2H4Q A;  1OO8 A;  3PZF A;  1HLE A;  1OVA C;  2WY0 C;  1ANT I;  1JVQ I;  3STO A;  4AU3 A;  1JMO A;  3DLW A;  4DTE A;  2DUT A;  9PAI A;  1ATT A;  2XN7 A;  2VDY A;  1JMJ A;  2WXZ A;  3PB1 I;  3CAA A;  4P0F A;  2HIJ I;  1MTP A;  1IZ2 A;  4AU4 A;  3OZQ A;  5CDZ A;  1JTI A;  3EVJ I;  4EB1 I;  2D26 A;  1OPH A;  3EOX A;  5INW A;  1NQ9 I;  4Y40 A;  3Q02 A;  4AU2 A;  4AU3 B;  3UT3 A;  1D5S A;  1BR8 I;  2CEO A;  1OYH L;  2H4R A;  3T1P A;  2WXW A;  1E03 I;  1SR5 A;  1QMN A;  3DRU A;  3NDA A;  5C98 A;  1SNG A;  1XU8 A;  1JJO C;  5CE0 A;  4YIA A;  2ZNH A;  4CAA A;  2WY1 A;  1ATU A;  1E05 I;  4ZK3 A;  2VDX A;  3Q03 A;  3LW2 A;  4GA7 A;  1OVA A;  1YXA A;  1LK6 I;  4C41 A;  1UHG A;  1DZH L;  2B5T I;  2HI9 A;  4AQH A;  1LQ8 A;  3B9F I;  1T1F A;  1DZG L;  2XN6 A;  3ZHA A;  7API A;  4Y3K A;  1F0C A;  2H4P A;  2R9Y A;  1R1L I;  2BEH L;  1LJ5 A;  2XN5 A;  4DY7 C;  3H5C A;  1E04 I;  1A7C A;  1OVA B;  3DRM A;  3VVJ A;  1BY7 A;  1QLP A;  2ACH A;  4AJU A;  4PYW A;  4IF8 A;  1AZX I;  4DY0 A;  2PEF A;  1AS4 A;  1OC0 A;  3NDF A;  1EZX A;  1XQG A;  1XQJ A;  2WXX A;  1KCT A;  3CWL A;  4C49 A;  1C5G A;  4ROA A;  8API A;  4G8R A;  4RSQ A;  2HIJ L;  3KCG I;  3F5N A;  5BRR I;  4AFX A;  1M93 B;  3NDD A;  2OL2 A;  1B3K A;  3F02 A;  1K9O I;  1WZ9 A;  2B4X L;  1OYH I;  1HP7 A;  2ARQ A;  1TB6 I;  3CWM A;  2RIV A;  3DY0 A;  3F1S A;  4RO9 A;  4X30 A;  4AJT A;  1PSI A;  2WXY C;  3CVM A;  1SEK A;  3R4L A;  2WXZ C;  2ANT I;  9API A;  5HGC A;  5IO1 A;  3LE2 A;  2PEE A;  1C8O A;  1DZH I;  1ATH A;  2VH4 A;  2OAY A;  4R9I A;  4G8O A;  4ROB A;  1DZG I;  5CDX A;  2GD4 C;  4ZK0 A;  1DB2 A;  2V95 A;  2RIW A;  2ARR A;  3NE4 A;  1IMV A;  4P0O A;  2B4X I;  2BEH I;  4EB1 L;  1JRR A;  1QMB A;  1DVN A;  5EI0 A;  2ZV6 A;  3FGQ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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