3UT3A

A novel pai-i inhibitor and its structural mechanism
Total Genus 108
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
108
sequence length
373
structure length
367
Chain Sequence
YVAHLASDFGVRVFQQVAQASKDRNVVFSPYGVASVLAMLQLTTGGETQQQIQAAMGFKIDDKGMAPALRHLYKELMGPWNKDEISTTDAIFVQRDLKLVQGFMPHFFRLFRSTVKQVDFSEVERARFIINDWVKTHTKGMISHLLGTGAVDQLTRLVLVNALYFNGQWKTPFPDSSTHRRLFHKSDGSTVSVPMMAQTNKFNYTEFTTPDGHYYDILELPYHGDTLSMFIAAPYEKEVPLSALTNILSAQLISHWKGNMTRLPRLLVLPKFSLETEVDLRKPLENLGMTDMFRQFQADFTSLSDQEPLHVALALQKVKIEVNESGTAVIVSARMAPEEIIIDRPFLFVVRHNPTGTVLFMGQVMEP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase inhibitor
molecule keywords Plasminogen activator inhibitor 1
publication title A novel PAI-I inhibitor and its structural mechanism
rcsb
source organism Homo sapiens
total genus 108
structure length 367
sequence length 373
chains with identical sequence B, C, D
ec nomenclature
pdb deposition date 2011-11-25

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00079 Serpin Serpin (serine protease inhibitor)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.30.39.10 Mainly Beta Roll Alpha-1-antitrypsin; domain 1 Alpha-1-antitrypsin, domain 1 3ut3A02
3.30.497.10 Alpha Beta 2-Layer Sandwich Antithrombin; Chain I, domain 2 Antithrombin, subunit I, domain 2 3ut3A01
4IC0A 4BB2A 1IMVA 4DY7C 3PZFA 2XN7A 1MTPA 2R9YA 2VH4A 1E05I 1K9OI 1YXAA 4X30A 3VVJA 2V95A 3CAAA 2OAYA 2WXZC 1OVAA 9APIA 4C49A 4Y40A 3CWMA 1OYHL 1JVQI 2B5TI 2WXWA 2RIWA 3ZHAA 4C41A 1LK6I 1E04I 2RIVA 1A7CA 4AQHA 2WXYC 2ZV6A 4AU3B 3PB1I 1ATTA 4IF8A 4ZK3A 2QUGA 2BEHL 1QMBA 1OVAC 5C98A 1ATHA 3DY0A 1OPHA 5BRRI 1WZ9A 1JTIA 1NQ9I 1OC0A 1AZXI 1HLEA 2H4RA 2XN5A 1ANTI 4EB1L 1DB2A 3DRMA 4AU3A 2WY1A 1XQJA 2ZNHA 1DVMA 4RO9A 1JMOA 1DZHL 1KCTA 2OL2A 1SNGA 1DZGI 4GA7A 4AJUA 3F5NA 2CEOA 2ARRA 2HI9A 3LE2A 4PYWA 5CDZA 4RSQA 2VDYA 2PEEA 5INWA 5EI0A 9PAIA 7APIA 4AU4A 5CDXA 1T1FA 3LW2A 1R1LI 1DVNA 1C8OA 4G8RA 4KDSA 1JJOC 1LJ5A 2ANTI 2DUTA 3NDDA 1UHGA 3DLWA 2HIJI 4AFXA 1M93B 1IZ2A 3OZQA 1AS4A 1XU8A 3NDFA 2B4XL 3FGQA 2PEFA 5HGCA 2ACHA 1SEKA 2GD4C 2WXZA 1QLPA 4R9IA 2WY0C 3B9FI 2XN3A 1D5SA 3F02A 4AU2A 4CAAA 2XN6A 1OYHI 4ROAA 1TB6I 5IO1A 3UT3A 5CE0A 1JRRA 1BY7A 2ARQA 3T1PA 4ROBA 4ZK0A 1XQGA 4Y3KA 8APIA 4P0FA 1JMJA 1DZGL 1ATUA 4G8OA 1SR5A 1B3KA 1F0CA 2VDXA 2WXXA 2BEHI 1PSIA 1OO8A 1EZXA 3Q03A 4P0OA 4YIAA 4DY0A 1LQ8A 3CWLA 3R4LA 1QMNA 3KCGI 2H4QA 1HP7A 3Q02A 4DTEA 2D26A 1E03I 1OVAB 3EVJI 3H5CA 3NDAA 1C5GA 3STOA 2B4XI 3EOXA 4EB1I 1BR8I 1DZHI 3NE4A 2HIJL 3DRUA 3F1SA 2H4PA 4AJTA 3CVMA
chains in the Genus database with same CATH superfamily
4IC0A 4BB2A 1IMVA 4DY7C 3PZFA 2XN7A 1MTPA 2R9YA 2VH4A 1E05I 1K9OI 1YXAA 4X30A 3VVJA 2V95A 3CAAA 2OAYA 2WXZC 1OVAA 9APIA 4C49A 4Y40A 3CWMA 1OYHL 1JVQI 2B5TI 2WXWA 2RIWA 3ZHAA 4C41A 1LK6I 1E04I 2RIVA 1A7CA 4AQHA 2WXYC 2ZV6A 4AU3B 3PB1I 1ATTA 4IF8A 4ZK3A 2QUGA 2BEHL 1QMBA 1OVAC 5C98A 1ATHA 3DY0A 1OPHA 5BRRI 1WZ9A 1JTIA 1NQ9I 1OC0A 1AZXI 1HLEA 2H4RA 2XN5A 1ANTI 4EB1L 1DB2A 3DRMA 4AU3A 2WY1A 1XQJA 2ZNHA 1DVMA 4RO9A 1JMOA 1DZHL 1KCTA 2OL2A 1SNGA 1DZGI 4GA7A 4AJUA 3F5NA 2CEOA 2ARRA 2HI9A 3LE2A 4PYWA 5CDZA 4RSQA 2VDYA 2PEEA 5INWA 5EI0A 9PAIA 7APIA 4AU4A 5CDXA 1T1FA 3LW2A 1R1LI 1DVNA 1C8OA 4G8RA 4KDSA 1JJOC 1LJ5A 2ANTI 2DUTA 3NDDA 1UHGA 3DLWA 2HIJI 4AFXA 1M93B 1IZ2A 3OZQA 1AS4A 1XU8A 3NDFA 2B4XL 3FGQA 2PEFA 5HGCA 2ACHA 1SEKA 2GD4C 2WXZA 1QLPA 4R9IA 2WY0C 3B9FI 2XN3A 1D5SA 3F02A 4AU2A 4CAAA 2XN6A 1OYHI 4ROAA 1TB6I 5IO1A 3UT3A 5CE0A 1JRRA 1BY7A 2ARQA 3T1PA 4ROBA 4ZK0A 1XQGA 4Y3KA 8APIA 4P0FA 1JMJA 1DZGL 1ATUA 4G8OA 1SR5A 1B3KA 1F0CA 2VDXA 2WXXA 2BEHI 1PSIA 1OO8A 1EZXA 3Q03A 4P0OA 4YIAA 4DY0A 1LQ8A 3CWLA 3R4LA 1QMNA 3KCGI 2H4QA 1HP7A 3Q02A 4DTEA 2D26A 1E03I 1OVAB 3EVJI 3H5CA 3NDAA 1C5GA 3STOA 2B4XI 3EOXA 4EB1I 1BR8I 1DZHI 3NE4A 2HIJL 3DRUA 3F1SA 2H4PA 4AJTA 3CVMA
chains in the Genus database with same CATH topology
4IC0A 4BB2A 1IMVA 4DY7C 3PZFA 2XN7A 1MTPA 2R9YA 2VH4A 1E05I 1K9OI 1YXAA 4X30A 3VVJA 2V95A 3CAAA 2OAYA 2WXZC 1OVAA 9APIA 4C49A 4Y40A 3CWMA 1OYHL 1JVQI 2B5TI 2WXWA 2RIWA 3ZHAA 4C41A 1LK6I 1E04I 2RIVA 1A7CA 4AQHA 2WXYC 2ZV6A 4AU3B 3PB1I 1ATTA 4IF8A 4ZK3A 2QUGA 2BEHL 1QMBA 1OVAC 5C98A 1ATHA 3DY0A 1OPHA 5BRRI 1WZ9A 1JTIA 1NQ9I 1OC0A 1AZXI 1HLEA 2H4RA 2XN5A 1ANTI 4EB1L 1DB2A 3DRMA 4AU3A 2WY1A 1XQJA 2ZNHA 1DVMA 4RO9A 1JMOA 1DZHL 1KCTA 2OL2A 1SNGA 1DZGI 4GA7A 4AJUA 3F5NA 2CEOA 2ARRA 2HI9A 3LE2A 4PYWA 5CDZA 4RSQA 2VDYA 2PEEA 5INWA 5EI0A 9PAIA 7APIA 4AU4A 5CDXA 1T1FA 3LW2A 1R1LI 1DVNA 1C8OA 4G8RA 4KDSA 1JJOC 1LJ5A 2ANTI 2DUTA 3NDDA 1UHGA 3DLWA 2HIJI 4AFXA 1M93B 1IZ2A 3OZQA 1AS4A 1XU8A 3NDFA 2B4XL 3FGQA 2PEFA 5HGCA 2ACHA 1SEKA 2GD4C 2WXZA 1QLPA 4R9IA 2WY0C 3B9FI 2XN3A 1D5SA 3F02A 4AU2A 4CAAA 2XN6A 1OYHI 4ROAA 1TB6I 5IO1A 3UT3A 5CE0A 1JRRA 1BY7A 2ARQA 3T1PA 4ROBA 4ZK0A 1XQGA 4Y3KA 8APIA 4P0FA 1JMJA 1DZGL 1ATUA 4G8OA 1SR5A 1B3KA 1F0CA 2VDXA 2WXXA 2BEHI 1PSIA 1OO8A 1EZXA 3Q03A 4P0OA 4YIAA 4DY0A 1LQ8A 3CWLA 3R4LA 1QMNA 3KCGI 2H4QA 1HP7A 3Q02A 4DTEA 2D26A 1E03I 1OVAB 3EVJI 3H5CA 3NDAA 1C5GA 3STOA 2B4XI 3EOXA 4EB1I 1BR8I 1DZHI 3NE4A 2HIJL 3DRUA 3F1SA 2H4PA 4AJTA 3CVMA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4IC0 A;  4BB2 A;  1IMV A;  4DY7 C;  3PZF A;  2XN7 A;  1MTP A;  2R9Y A;  2VH4 A;  1E05 I;  1K9O I;  1YXA A;  4X30 A;  3VVJ A;  2V95 A;  3CAA A;  2OAY A;  2WXZ C;  1OVA A;  9API A;  4C49 A;  4Y40 A;  3CWM A;  1OYH L;  1JVQ I;  2B5T I;  2WXW A;  2RIW A;  3ZHA A;  4C41 A;  1LK6 I;  1E04 I;  2RIV A;  1A7C A;  4AQH A;  2WXY C;  2ZV6 A;  4AU3 B;  3PB1 I;  1ATT A;  4IF8 A;  4ZK3 A;  2QUG A;  2BEH L;  1QMB A;  1OVA C;  5C98 A;  1ATH A;  3DY0 A;  1OPH A;  5BRR I;  1WZ9 A;  1JTI A;  1NQ9 I;  1OC0 A;  1AZX I;  1HLE A;  2H4R A;  2XN5 A;  1ANT I;  4EB1 L;  1DB2 A;  3DRM A;  4AU3 A;  2WY1 A;  1XQJ A;  2ZNH A;  1DVM A;  4RO9 A;  1JMO A;  1DZH L;  1KCT A;  2OL2 A;  1SNG A;  1DZG I;  4GA7 A;  4AJU A;  3F5N A;  2CEO A;  2ARR A;  2HI9 A;  3LE2 A;  4PYW A;  5CDZ A;  4RSQ A;  2VDY A;  2PEE A;  5INW A;  5EI0 A;  9PAI A;  7API A;  4AU4 A;  5CDX A;  1T1F A;  3LW2 A;  1R1L I;  1DVN A;  1C8O A;  4G8R A;  4KDS A;  1JJO C;  1LJ5 A;  2ANT I;  2DUT A;  3NDD A;  1UHG A;  3DLW A;  2HIJ I;  4AFX A;  1M93 B;  1IZ2 A;  3OZQ A;  1AS4 A;  1XU8 A;  3NDF A;  2B4X L;  3FGQ A;  2PEF A;  5HGC A;  2ACH A;  1SEK A;  2GD4 C;  2WXZ A;  1QLP A;  4R9I A;  2WY0 C;  3B9F I;  2XN3 A;  1D5S A;  3F02 A;  4AU2 A;  4CAA A;  2XN6 A;  1OYH I;  4ROA A;  1TB6 I;  5IO1 A;  3UT3 A;  5CE0 A;  1JRR A;  1BY7 A;  2ARQ A;  3T1P A;  4ROB A;  4ZK0 A;  1XQG A;  4Y3K A;  8API A;  4P0F A;  1JMJ A;  1DZG L;  1ATU A;  4G8O A;  1SR5 A;  1B3K A;  1F0C A;  2VDX A;  2WXX A;  2BEH I;  1PSI A;  1OO8 A;  1EZX A;  3Q03 A;  4P0O A;  4YIA A;  4DY0 A;  1LQ8 A;  3CWL A;  3R4L A;  1QMN A;  3KCG I;  2H4Q A;  1HP7 A;  3Q02 A;  4DTE A;  2D26 A;  1E03 I;  1OVA B;  3EVJ I;  3H5C A;  3NDA A;  1C5G A;  3STO A;  2B4X I;  3EOX A;  4EB1 I;  1BR8 I;  1DZH I;  3NE4 A;  2HIJ L;  3DRU A;  3F1S A;  2H4P A;  4AJT A;  3CVM A; 
#chains in the Genus database with same CATH topology
 4IC0 A;  4BB2 A;  1IMV A;  4DY7 C;  3PZF A;  2XN7 A;  1MTP A;  2R9Y A;  2VH4 A;  1E05 I;  1K9O I;  1YXA A;  4X30 A;  3VVJ A;  2V95 A;  3CAA A;  2OAY A;  2WXZ C;  1OVA A;  9API A;  4C49 A;  4Y40 A;  3CWM A;  1OYH L;  1JVQ I;  2B5T I;  2WXW A;  2RIW A;  3ZHA A;  4C41 A;  1LK6 I;  1E04 I;  2RIV A;  1A7C A;  4AQH A;  2WXY C;  2ZV6 A;  4AU3 B;  3PB1 I;  1ATT A;  4IF8 A;  4ZK3 A;  2QUG A;  2BEH L;  1QMB A;  1OVA C;  5C98 A;  1ATH A;  3DY0 A;  1OPH A;  5BRR I;  1WZ9 A;  1JTI A;  1NQ9 I;  1OC0 A;  1AZX I;  1HLE A;  2H4R A;  2XN5 A;  1ANT I;  4EB1 L;  1DB2 A;  3DRM A;  4AU3 A;  2WY1 A;  1XQJ A;  2ZNH A;  1DVM A;  4RO9 A;  1JMO A;  1DZH L;  1KCT A;  2OL2 A;  1SNG A;  1DZG I;  4GA7 A;  4AJU A;  3F5N A;  2CEO A;  2ARR A;  2HI9 A;  3LE2 A;  4PYW A;  5CDZ A;  4RSQ A;  2VDY A;  2PEE A;  5INW A;  5EI0 A;  9PAI A;  7API A;  4AU4 A;  5CDX A;  1T1F A;  3LW2 A;  1R1L I;  1DVN A;  1C8O A;  4G8R A;  4KDS A;  1JJO C;  1LJ5 A;  2ANT I;  2DUT A;  3NDD A;  1UHG A;  3DLW A;  2HIJ I;  4AFX A;  1M93 B;  1IZ2 A;  3OZQ A;  1AS4 A;  1XU8 A;  3NDF A;  2B4X L;  3FGQ A;  2PEF A;  5HGC A;  2ACH A;  1SEK A;  2GD4 C;  2WXZ A;  1QLP A;  4R9I A;  2WY0 C;  3B9F I;  2XN3 A;  1D5S A;  3F02 A;  4AU2 A;  4CAA A;  2XN6 A;  1OYH I;  4ROA A;  1TB6 I;  5IO1 A;  3UT3 A;  5CE0 A;  1JRR A;  1BY7 A;  2ARQ A;  3T1P A;  4ROB A;  4ZK0 A;  1XQG A;  4Y3K A;  8API A;  4P0F A;  1JMJ A;  1DZG L;  1ATU A;  4G8O A;  1SR5 A;  1B3K A;  1F0C A;  2VDX A;  2WXX A;  2BEH I;  1PSI A;  1OO8 A;  1EZX A;  3Q03 A;  4P0O A;  4YIA A;  4DY0 A;  1LQ8 A;  3CWL A;  3R4L A;  1QMN A;  3KCG I;  2H4Q A;  1HP7 A;  3Q02 A;  4DTE A;  2D26 A;  1E03 I;  1OVA B;  3EVJ I;  3H5C A;  3NDA A;  1C5G A;  3STO A;  2B4X I;  3EOX A;  4EB1 I;  1BR8 I;  1DZH I;  3NE4 A;  2HIJ L;  3DRU A;  3F1S A;  2H4P A;  4AJT A;  3CVM A; 
#chains in the Genus database with same CATH homology
 4IC0 A;  4BB2 A;  1IMV A;  4DY7 C;  3PZF A;  2XN7 A;  1MTP A;  2R9Y A;  2VH4 A;  1E05 I;  1K9O I;  1YXA A;  4X30 A;  3VVJ A;  2V95 A;  3CAA A;  2OAY A;  2WXZ C;  1OVA A;  9API A;  4C49 A;  4Y40 A;  3CWM A;  1OYH L;  1JVQ I;  2B5T I;  2WXW A;  2RIW A;  3ZHA A;  4C41 A;  1LK6 I;  1E04 I;  2RIV A;  1A7C A;  4AQH A;  2WXY C;  2ZV6 A;  4AU3 B;  3PB1 I;  1ATT A;  4IF8 A;  4ZK3 A;  2QUG A;  2BEH L;  1QMB A;  1OVA C;  5C98 A;  1ATH A;  3DY0 A;  1OPH A;  5BRR I;  1WZ9 A;  1JTI A;  1NQ9 I;  1OC0 A;  1AZX I;  1HLE A;  2H4R A;  2XN5 A;  1ANT I;  4EB1 L;  1DB2 A;  3DRM A;  4AU3 A;  2WY1 A;  1XQJ A;  2ZNH A;  1DVM A;  4RO9 A;  1JMO A;  1DZH L;  1KCT A;  2OL2 A;  1SNG A;  1DZG I;  4GA7 A;  4AJU A;  3F5N A;  2CEO A;  2ARR A;  2HI9 A;  3LE2 A;  4PYW A;  5CDZ A;  4RSQ A;  2VDY A;  2PEE A;  5INW A;  5EI0 A;  9PAI A;  7API A;  4AU4 A;  5CDX A;  1T1F A;  3LW2 A;  1R1L I;  1DVN A;  1C8O A;  4G8R A;  4KDS A;  1JJO C;  1LJ5 A;  2ANT I;  2DUT A;  3NDD A;  1UHG A;  3DLW A;  2HIJ I;  4AFX A;  1M93 B;  1IZ2 A;  3OZQ A;  1AS4 A;  1XU8 A;  3NDF A;  2B4X L;  3FGQ A;  2PEF A;  5HGC A;  2ACH A;  1SEK A;  2GD4 C;  2WXZ A;  1QLP A;  4R9I A;  2WY0 C;  3B9F I;  2XN3 A;  1D5S A;  3F02 A;  4AU2 A;  4CAA A;  2XN6 A;  1OYH I;  4ROA A;  1TB6 I;  5IO1 A;  3UT3 A;  5CE0 A;  1JRR A;  1BY7 A;  2ARQ A;  3T1P A;  4ROB A;  4ZK0 A;  1XQG A;  4Y3K A;  8API A;  4P0F A;  1JMJ A;  1DZG L;  1ATU A;  4G8O A;  1SR5 A;  1B3K A;  1F0C A;  2VDX A;  2WXX A;  2BEH I;  1PSI A;  1OO8 A;  1EZX A;  3Q03 A;  4P0O A;  4YIA A;  4DY0 A;  1LQ8 A;  3CWL A;  3R4L A;  1QMN A;  3KCG I;  2H4Q A;  1HP7 A;  3Q02 A;  4DTE A;  2D26 A;  1E03 I;  1OVA B;  3EVJ I;  3H5C A;  3NDA A;  1C5G A;  3STO A;  2B4X I;  3EOX A;  4EB1 I;  1BR8 I;  1DZH I;  3NE4 A;  2HIJ L;  3DRU A;  3F1S A;  2H4P A;  4AJT A;  3CVM A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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