3ZHAA

Molecular basis for the action of the collagen-specific chaperone hsp47 serpinh1 and its structure-specific client recognition.
Total Genus 115
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
115
sequence length
386
structure length
380
Chain Sequence
MLSPKAATLAERSAGLAFSLYQAMAKDQAVENILLSPVVVASSLGLVSLGGKATTASQAKAVLSAEQLRDEEVHAGLGELLRSLSVTWKLGSRLYGPSSVSFAEDFVRSSKQHYNCEHSKINFRDKRSALQSINEWAAQTTDGKLPEVTKDVERTDGALLVNAMFFKPHWDEKFHHKMVDNRGFMVTRSYTVGVTMMHRTGLYNYYDDEKEKLQIVEMPLAHKLSSLIILMPHHVEPLERLEKLLTKEQLKIWMGKMQKKAVAISLPKGVVEVTHDLQKHLAGLGLTEAIDKNKADLSRMSGKKDLYLASVFHATAFEWDTEGNPFDQDIYGREELRSPKLFYADHPFIFLVRDTQSGSLLFIGRLVRPKGDKMRDELLE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Chaperone
molecule keywords HSP47
publication title Molecular Basis for the Action of the Collagen-Specific Chaperone Hsp47/Serpinh1 and its Structure-Specific Client Recognition.
pubmed doi rcsb
source organism Canis lupus familiaris
total genus 115
structure length 380
sequence length 386
chains with identical sequence B, C, D, K, L, P, Q
ec nomenclature
pdb deposition date 2012-12-20

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00079 Serpin Serpin (serine protease inhibitor)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.30.39.10 Mainly Beta Roll Alpha-1-antitrypsin; domain 1 Alpha-1-antitrypsin, domain 1 3zhaA02
3.30.497.10 Alpha Beta 2-Layer Sandwich Antithrombin; Chain I, domain 2 Antithrombin, subunit I, domain 2 3zhaA01
2V95A 2H4QA 5CE0A 1DZGL 2HIJL 2WY0C 1MTPA 1C8OA 3DLWA 4IC0A 9PAIA 4AFXA 1HLEA 4ZK0A 1ANTI 2RIWA 4AU4A 2WY1A 2D26A 4G8RA 9APIA 1IZ2A 3EVJI 4EB1I 1DZGI 2HIJI 1AS4A 3F1SA 2ZV6A 3CAAA 1SEKA 2ARRA 1HP7A 2PEEA 2VDXA 1OYHL 1JMOA 1OC0A 1F0CA 2B4XL 1DVMA 5CDXA 4AJUA 2H4PA 1LQ8A 1KCTA 1PSIA 1ATHA 3NDAA 2XN7A 1T1FA 1OPHA 8APIA 1DVNA 1E04I 1OVAA 1JVQI 1DZHL 3KCGI 4Y3KA 3NDDA 1D5SA 1C5GA 2ZNHA 1LK6I 1SR5A 4ZK3A 2ARQA 2GD4C 1WZ9A 4DY7C 1TB6I 3F5NA 4GA7A 3T1PA 4X30A 4Y40A 2XN3A 2WXZC 1QLPA 1ATUA 2WXXA 2OAYA 1AZXI 2ACHA 2QUGA 4R9IA 1JJOC 1UHGA 3B9FI 4CAAA 1JRRA 4RSQA 5INWA 1BY7A 4C49A 2XN6A 3CWMA 2BEHL 4AU2A 1XQJA 2WXYC 3F02A 5HGCA 5BRRI 1E03I 2CEOA 2H4RA 3R4LA 1NQ9I 1DB2A 1OYHI 4P0FA 1QMNA 2B4XI 2VH4A 1LJ5A 2RIVA 1XU8A 1BR8I 1IMVA 2DUTA 2PEFA 1SNGA 3LW2A 3CWLA 3STOA 4AU3B 3DY0A 7APIA 3PB1I 2ANTI 4P0OA 4DY0A 3FGQA 2WXWA 1DZHI 3UT3A 4YIAA 5EI0A 1YXAA 5CDZA 3Q02A 4EB1L 2OL2A 1K9OI 3NDFA 1QMBA 3ZHAA 2R9YA 2XN5A 4DTEA 1JTIA 3NE4A 4IF8A 4KDSA 4PYWA 4RO9A 4BB2A 5IO1A 3DRUA 3LE2A 4G8OA 4ROBA 4AU3A 2WXZA 1ATTA 1M93B 3OZQA 2VDYA 1EZXA 4AJTA 3Q03A 3VVJA 1B3KA 1R1LI 3H5CA 1JMJA 3DRMA 2HI9A 4ROAA 3EOXA 3PZFA 4AQHA 1A7CA 1OVAB 4C41A 1OO8A 1XQGA 2BEHI 1OVAC 5C98A 3CVMA 2B5TI 1E05I
chains in the Genus database with same CATH superfamily
2V95A 2H4QA 5CE0A 1DZGL 2HIJL 2WY0C 1MTPA 1C8OA 3DLWA 4IC0A 9PAIA 4AFXA 1HLEA 4ZK0A 1ANTI 2RIWA 4AU4A 2WY1A 2D26A 4G8RA 9APIA 1IZ2A 3EVJI 4EB1I 1DZGI 2HIJI 1AS4A 3F1SA 2ZV6A 3CAAA 1SEKA 2ARRA 1HP7A 2PEEA 2VDXA 1OYHL 1JMOA 1OC0A 1F0CA 2B4XL 1DVMA 5CDXA 4AJUA 2H4PA 1LQ8A 1KCTA 1PSIA 1ATHA 3NDAA 2XN7A 1T1FA 1OPHA 8APIA 1DVNA 1E04I 1OVAA 1JVQI 1DZHL 3KCGI 4Y3KA 3NDDA 1D5SA 1C5GA 2ZNHA 1LK6I 1SR5A 4ZK3A 2ARQA 2GD4C 1WZ9A 4DY7C 1TB6I 3F5NA 4GA7A 3T1PA 4X30A 4Y40A 2XN3A 2WXZC 1QLPA 1ATUA 2WXXA 2OAYA 1AZXI 2ACHA 2QUGA 4R9IA 1JJOC 1UHGA 3B9FI 4CAAA 1JRRA 4RSQA 5INWA 1BY7A 4C49A 2XN6A 3CWMA 2BEHL 4AU2A 1XQJA 2WXYC 3F02A 5HGCA 5BRRI 1E03I 2CEOA 2H4RA 3R4LA 1NQ9I 1DB2A 1OYHI 4P0FA 1QMNA 2B4XI 2VH4A 1LJ5A 2RIVA 1XU8A 1BR8I 1IMVA 2DUTA 2PEFA 1SNGA 3LW2A 3CWLA 3STOA 4AU3B 3DY0A 7APIA 3PB1I 2ANTI 4P0OA 4DY0A 3FGQA 2WXWA 1DZHI 3UT3A 4YIAA 5EI0A 1YXAA 5CDZA 3Q02A 4EB1L 2OL2A 1K9OI 3NDFA 1QMBA 3ZHAA 2R9YA 2XN5A 4DTEA 1JTIA 3NE4A 4IF8A 4KDSA 4PYWA 4RO9A 4BB2A 5IO1A 3DRUA 3LE2A 4G8OA 4ROBA 4AU3A 2WXZA 1ATTA 1M93B 3OZQA 2VDYA 1EZXA 4AJTA 3Q03A 3VVJA 1B3KA 1R1LI 3H5CA 1JMJA 3DRMA 2HI9A 4ROAA 3EOXA 3PZFA 4AQHA 1A7CA 1OVAB 4C41A 1OO8A 1XQGA 2BEHI 1OVAC 5C98A 3CVMA 2B5TI 1E05I
chains in the Genus database with same CATH topology
2V95A 2H4QA 5CE0A 1DZGL 2HIJL 2WY0C 1MTPA 1C8OA 3DLWA 4IC0A 9PAIA 4AFXA 1HLEA 4ZK0A 1ANTI 2RIWA 4AU4A 2WY1A 2D26A 4G8RA 9APIA 1IZ2A 3EVJI 4EB1I 1DZGI 2HIJI 1AS4A 3F1SA 2ZV6A 3CAAA 1SEKA 2ARRA 1HP7A 2PEEA 2VDXA 1OYHL 1JMOA 1OC0A 1F0CA 2B4XL 1DVMA 5CDXA 4AJUA 2H4PA 1LQ8A 1KCTA 1PSIA 1ATHA 3NDAA 2XN7A 1T1FA 1OPHA 8APIA 1DVNA 1E04I 1OVAA 1JVQI 1DZHL 3KCGI 4Y3KA 3NDDA 1D5SA 1C5GA 2ZNHA 1LK6I 1SR5A 4ZK3A 2ARQA 2GD4C 1WZ9A 4DY7C 1TB6I 3F5NA 4GA7A 3T1PA 4X30A 4Y40A 2XN3A 2WXZC 1QLPA 1ATUA 2WXXA 2OAYA 1AZXI 2ACHA 2QUGA 4R9IA 1JJOC 1UHGA 3B9FI 4CAAA 1JRRA 4RSQA 5INWA 1BY7A 4C49A 2XN6A 3CWMA 2BEHL 4AU2A 1XQJA 2WXYC 3F02A 5HGCA 5BRRI 1E03I 2CEOA 2H4RA 3R4LA 1NQ9I 1DB2A 1OYHI 4P0FA 1QMNA 2B4XI 2VH4A 1LJ5A 2RIVA 1XU8A 1BR8I 1IMVA 2DUTA 2PEFA 1SNGA 3LW2A 3CWLA 3STOA 4AU3B 3DY0A 7APIA 3PB1I 2ANTI 4P0OA 4DY0A 3FGQA 2WXWA 1DZHI 3UT3A 4YIAA 5EI0A 1YXAA 5CDZA 3Q02A 4EB1L 2OL2A 1K9OI 3NDFA 1QMBA 3ZHAA 2R9YA 2XN5A 4DTEA 1JTIA 3NE4A 4IF8A 4KDSA 4PYWA 4RO9A 4BB2A 5IO1A 3DRUA 3LE2A 4G8OA 4ROBA 4AU3A 2WXZA 1ATTA 1M93B 3OZQA 2VDYA 1EZXA 4AJTA 3Q03A 3VVJA 1B3KA 1R1LI 3H5CA 1JMJA 3DRMA 2HI9A 4ROAA 3EOXA 3PZFA 4AQHA 1A7CA 1OVAB 4C41A 1OO8A 1XQGA 2BEHI 1OVAC 5C98A 3CVMA 2B5TI 1E05I
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2V95 A;  2H4Q A;  5CE0 A;  1DZG L;  2HIJ L;  2WY0 C;  1MTP A;  1C8O A;  3DLW A;  4IC0 A;  9PAI A;  4AFX A;  1HLE A;  4ZK0 A;  1ANT I;  2RIW A;  4AU4 A;  2WY1 A;  2D26 A;  4G8R A;  9API A;  1IZ2 A;  3EVJ I;  4EB1 I;  1DZG I;  2HIJ I;  1AS4 A;  3F1S A;  2ZV6 A;  3CAA A;  1SEK A;  2ARR A;  1HP7 A;  2PEE A;  2VDX A;  1OYH L;  1JMO A;  1OC0 A;  1F0C A;  2B4X L;  1DVM A;  5CDX A;  4AJU A;  2H4P A;  1LQ8 A;  1KCT A;  1PSI A;  1ATH A;  3NDA A;  2XN7 A;  1T1F A;  1OPH A;  8API A;  1DVN A;  1E04 I;  1OVA A;  1JVQ I;  1DZH L;  3KCG I;  4Y3K A;  3NDD A;  1D5S A;  1C5G A;  2ZNH A;  1LK6 I;  1SR5 A;  4ZK3 A;  2ARQ A;  2GD4 C;  1WZ9 A;  4DY7 C;  1TB6 I;  3F5N A;  4GA7 A;  3T1P A;  4X30 A;  4Y40 A;  2XN3 A;  2WXZ C;  1QLP A;  1ATU A;  2WXX A;  2OAY A;  1AZX I;  2ACH A;  2QUG A;  4R9I A;  1JJO C;  1UHG A;  3B9F I;  4CAA A;  1JRR A;  4RSQ A;  5INW A;  1BY7 A;  4C49 A;  2XN6 A;  3CWM A;  2BEH L;  4AU2 A;  1XQJ A;  2WXY C;  3F02 A;  5HGC A;  5BRR I;  1E03 I;  2CEO A;  2H4R A;  3R4L A;  1NQ9 I;  1DB2 A;  1OYH I;  4P0F A;  1QMN A;  2B4X I;  2VH4 A;  1LJ5 A;  2RIV A;  1XU8 A;  1BR8 I;  1IMV A;  2DUT A;  2PEF A;  1SNG A;  3LW2 A;  3CWL A;  3STO A;  4AU3 B;  3DY0 A;  7API A;  3PB1 I;  2ANT I;  4P0O A;  4DY0 A;  3FGQ A;  2WXW A;  1DZH I;  3UT3 A;  4YIA A;  5EI0 A;  1YXA A;  5CDZ A;  3Q02 A;  4EB1 L;  2OL2 A;  1K9O I;  3NDF A;  1QMB A;  3ZHA A;  2R9Y A;  2XN5 A;  4DTE A;  1JTI A;  3NE4 A;  4IF8 A;  4KDS A;  4PYW A;  4RO9 A;  4BB2 A;  5IO1 A;  3DRU A;  3LE2 A;  4G8O A;  4ROB A;  4AU3 A;  2WXZ A;  1ATT A;  1M93 B;  3OZQ A;  2VDY A;  1EZX A;  4AJT A;  3Q03 A;  3VVJ A;  1B3K A;  1R1L I;  3H5C A;  1JMJ A;  3DRM A;  2HI9 A;  4ROA A;  3EOX A;  3PZF A;  4AQH A;  1A7C A;  1OVA B;  4C41 A;  1OO8 A;  1XQG A;  2BEH I;  1OVA C;  5C98 A;  3CVM A;  2B5T I;  1E05 I; 
#chains in the Genus database with same CATH topology
 2V95 A;  2H4Q A;  5CE0 A;  1DZG L;  2HIJ L;  2WY0 C;  1MTP A;  1C8O A;  3DLW A;  4IC0 A;  9PAI A;  4AFX A;  1HLE A;  4ZK0 A;  1ANT I;  2RIW A;  4AU4 A;  2WY1 A;  2D26 A;  4G8R A;  9API A;  1IZ2 A;  3EVJ I;  4EB1 I;  1DZG I;  2HIJ I;  1AS4 A;  3F1S A;  2ZV6 A;  3CAA A;  1SEK A;  2ARR A;  1HP7 A;  2PEE A;  2VDX A;  1OYH L;  1JMO A;  1OC0 A;  1F0C A;  2B4X L;  1DVM A;  5CDX A;  4AJU A;  2H4P A;  1LQ8 A;  1KCT A;  1PSI A;  1ATH A;  3NDA A;  2XN7 A;  1T1F A;  1OPH A;  8API A;  1DVN A;  1E04 I;  1OVA A;  1JVQ I;  1DZH L;  3KCG I;  4Y3K A;  3NDD A;  1D5S A;  1C5G A;  2ZNH A;  1LK6 I;  1SR5 A;  4ZK3 A;  2ARQ A;  2GD4 C;  1WZ9 A;  4DY7 C;  1TB6 I;  3F5N A;  4GA7 A;  3T1P A;  4X30 A;  4Y40 A;  2XN3 A;  2WXZ C;  1QLP A;  1ATU A;  2WXX A;  2OAY A;  1AZX I;  2ACH A;  2QUG A;  4R9I A;  1JJO C;  1UHG A;  3B9F I;  4CAA A;  1JRR A;  4RSQ A;  5INW A;  1BY7 A;  4C49 A;  2XN6 A;  3CWM A;  2BEH L;  4AU2 A;  1XQJ A;  2WXY C;  3F02 A;  5HGC A;  5BRR I;  1E03 I;  2CEO A;  2H4R A;  3R4L A;  1NQ9 I;  1DB2 A;  1OYH I;  4P0F A;  1QMN A;  2B4X I;  2VH4 A;  1LJ5 A;  2RIV A;  1XU8 A;  1BR8 I;  1IMV A;  2DUT A;  2PEF A;  1SNG A;  3LW2 A;  3CWL A;  3STO A;  4AU3 B;  3DY0 A;  7API A;  3PB1 I;  2ANT I;  4P0O A;  4DY0 A;  3FGQ A;  2WXW A;  1DZH I;  3UT3 A;  4YIA A;  5EI0 A;  1YXA A;  5CDZ A;  3Q02 A;  4EB1 L;  2OL2 A;  1K9O I;  3NDF A;  1QMB A;  3ZHA A;  2R9Y A;  2XN5 A;  4DTE A;  1JTI A;  3NE4 A;  4IF8 A;  4KDS A;  4PYW A;  4RO9 A;  4BB2 A;  5IO1 A;  3DRU A;  3LE2 A;  4G8O A;  4ROB A;  4AU3 A;  2WXZ A;  1ATT A;  1M93 B;  3OZQ A;  2VDY A;  1EZX A;  4AJT A;  3Q03 A;  3VVJ A;  1B3K A;  1R1L I;  3H5C A;  1JMJ A;  3DRM A;  2HI9 A;  4ROA A;  3EOX A;  3PZF A;  4AQH A;  1A7C A;  1OVA B;  4C41 A;  1OO8 A;  1XQG A;  2BEH I;  1OVA C;  5C98 A;  3CVM A;  2B5T I;  1E05 I; 
#chains in the Genus database with same CATH homology
 2V95 A;  2H4Q A;  5CE0 A;  1DZG L;  2HIJ L;  2WY0 C;  1MTP A;  1C8O A;  3DLW A;  4IC0 A;  9PAI A;  4AFX A;  1HLE A;  4ZK0 A;  1ANT I;  2RIW A;  4AU4 A;  2WY1 A;  2D26 A;  4G8R A;  9API A;  1IZ2 A;  3EVJ I;  4EB1 I;  1DZG I;  2HIJ I;  1AS4 A;  3F1S A;  2ZV6 A;  3CAA A;  1SEK A;  2ARR A;  1HP7 A;  2PEE A;  2VDX A;  1OYH L;  1JMO A;  1OC0 A;  1F0C A;  2B4X L;  1DVM A;  5CDX A;  4AJU A;  2H4P A;  1LQ8 A;  1KCT A;  1PSI A;  1ATH A;  3NDA A;  2XN7 A;  1T1F A;  1OPH A;  8API A;  1DVN A;  1E04 I;  1OVA A;  1JVQ I;  1DZH L;  3KCG I;  4Y3K A;  3NDD A;  1D5S A;  1C5G A;  2ZNH A;  1LK6 I;  1SR5 A;  4ZK3 A;  2ARQ A;  2GD4 C;  1WZ9 A;  4DY7 C;  1TB6 I;  3F5N A;  4GA7 A;  3T1P A;  4X30 A;  4Y40 A;  2XN3 A;  2WXZ C;  1QLP A;  1ATU A;  2WXX A;  2OAY A;  1AZX I;  2ACH A;  2QUG A;  4R9I A;  1JJO C;  1UHG A;  3B9F I;  4CAA A;  1JRR A;  4RSQ A;  5INW A;  1BY7 A;  4C49 A;  2XN6 A;  3CWM A;  2BEH L;  4AU2 A;  1XQJ A;  2WXY C;  3F02 A;  5HGC A;  5BRR I;  1E03 I;  2CEO A;  2H4R A;  3R4L A;  1NQ9 I;  1DB2 A;  1OYH I;  4P0F A;  1QMN A;  2B4X I;  2VH4 A;  1LJ5 A;  2RIV A;  1XU8 A;  1BR8 I;  1IMV A;  2DUT A;  2PEF A;  1SNG A;  3LW2 A;  3CWL A;  3STO A;  4AU3 B;  3DY0 A;  7API A;  3PB1 I;  2ANT I;  4P0O A;  4DY0 A;  3FGQ A;  2WXW A;  1DZH I;  3UT3 A;  4YIA A;  5EI0 A;  1YXA A;  5CDZ A;  3Q02 A;  4EB1 L;  2OL2 A;  1K9O I;  3NDF A;  1QMB A;  3ZHA A;  2R9Y A;  2XN5 A;  4DTE A;  1JTI A;  3NE4 A;  4IF8 A;  4KDS A;  4PYW A;  4RO9 A;  4BB2 A;  5IO1 A;  3DRU A;  3LE2 A;  4G8O A;  4ROB A;  4AU3 A;  2WXZ A;  1ATT A;  1M93 B;  3OZQ A;  2VDY A;  1EZX A;  4AJT A;  3Q03 A;  3VVJ A;  1B3K A;  1R1L I;  3H5C A;  1JMJ A;  3DRM A;  2HI9 A;  4ROA A;  3EOX A;  3PZF A;  4AQH A;  1A7C A;  1OVA B;  4C41 A;  1OO8 A;  1XQG A;  2BEH I;  1OVA C;  5C98 A;  3CVM A;  2B5T I;  1E05 I; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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