4AFXA

Crystal structure of the reactive loop cleaved zpi in i2 space group
Total Genus 93
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
93
sequence length
347
structure length
347
Chain Sequence
SEEEKAWLMASRQQLAKETSNFGFSLLRKISMRHDGNMVFSPFGMSLAMTGLMLGATGPTETQIKRGLHLQALKPTKPGLLPSLFKGLRETLSRNLELGLTQGSFAFIHKDFDVKETFFNLSKRYFDTECVPMNFRNASQAKRLMNHYINKETRGKIPKLFDEINPETKLILVDYILFKGKWLTPFDPVFTEVDTFHLDKYKTIKVPMMYGAGKFASTFDKNFRCHVLKLPYQGNATMLVVLMEKMGDHLALEDYLTTDLVETWLRNMKTRNMEVFFPKFKLDQKYEMHELLRQMGIRRIFSPFADLSELSATGRNLQVSRVLQRTVIEVDERGTEAVAGILSEITA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural Basis for Catalytic Activation of Protein Z-Dependent Protease Inhibitor (Zpi) by Protein Z.
pubmed doi rcsb
molecule tags Hydrolase inhibitor
source organism Homo sapiens
molecule keywords PROTEIN Z DEPENDENT PROTEASE INHIBITOR
total genus 93
structure length 347
sequence length 347
ec nomenclature
pdb deposition date 2012-01-23
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.30.39.10 Mainly Beta Roll Alpha-1-antitrypsin; domain 1 Alpha-1-antitrypsin, domain 1 4afxA02
3.30.497.10 Alpha Beta 2-Layer Sandwich Antithrombin; Chain I, domain 2 Antithrombin, subunit I, domain 2 4afxA01
4AQHA 2XN5A 1SNGA 2B4XL 4AU3A 2WXWA 4PYWA 1OVAA 1WZ9A 1XU8A 2DUTA 4ZK0A 3H5CA 2ARQA 1JRRA 4BB2A 3Q02A 2CEOA 3DLWA 1JMOA 2HI9A 2XN6A 1PSIA 2WXZC 1E04I 2VDXA 2ANTI 2PEFA 1YXAA 1XQJA 1HLEA 3DRUA 1E03I 1SR5A 1R1LI 1JJOC 1QMNA 1DZHL 4KDSA 4AU4A 4AJTA 2OL2A 2OAYA 4C41A 4YIAA 5EI0A 2PEEA 9PAIA 1IZ2A 3ZHAA 5C98A 2WY1A 3NDFA 1A7CA 2BEHL 1JMJA 3PB1I 1C8OA 3PZFA 2VH4A 4X30A 1LJ5A 2XN7A 5HGCA 1OC0A 7APIA 2GD4C 4EB1L 4DY0A 2H4PA 1IMVA 3KCGI 4IC0A 3DRMA 2HIJL 4DTEA 3VVJA 3NDDA 2H4RA 1B3KA 2ACHA 1ATHA 4AU3B 1E05I 1EZXA 1OVAB 2B4XI 2WY0C 4G8RA 4G8OA 1HP7A 4ROAA 4P0OA 2WXZA 3T1PA 1AZXI 3F02A 2WXXA 1ATTA 4AFXA 1OYHL 1BY7A 5IO1A 4DY7C 4C49A 2R9YA 3CAAA 2V95A 2HIJI 3Q03A 1LK6I 4ZK3A 4GA7A 1DVNA 2RIWA 2H4QA 3CWLA 3F1SA 4R9IA 5INWA 8APIA 3F5NA 1OPHA 1ATUA 1TB6I 1AS4A 1DB2A 2QUGA 1DZHI 2ZV6A 1T1FA 4Y3KA 3LE2A 5CDZA 3EOXA 1M93B 2WXYC 1OVAC 1DZGL 3STOA 2D26A 3DY0A 2ARRA 4CAAA 1K9OI 2BEHI 1C5GA 4Y40A 3UT3A 2B5TI 3NE4A 1OO8A 1DVMA 4RSQA 2VDYA 3LW2A 3EVJI 1F0CA 4EB1I 4P0FA 1JTIA 5CDXA 4AU2A 1SEKA 5BRRI 9APIA 1NQ9I 1JVQI 1QLPA 4RO9A 3CWMA 3R4LA 1DZGI 1D5SA 3NDAA 1QMBA 1UHGA 2XN3A 4ROBA 1MTPA 4AJUA 1ANTI 3CVMA 1XQGA 2ZNHA 4IF8A 2RIVA 5CE0A 1KCTA 3B9FI 3OZQA 3FGQA 1LQ8A 1OYHI 1BR8I
chains in the Genus database with same CATH superfamily
4AQHA 2XN5A 1SNGA 2B4XL 4AU3A 2WXWA 4PYWA 1OVAA 1WZ9A 1XU8A 2DUTA 4ZK0A 3H5CA 2ARQA 1JRRA 4BB2A 3Q02A 2CEOA 3DLWA 1JMOA 2HI9A 2XN6A 1PSIA 2WXZC 1E04I 2VDXA 2ANTI 2PEFA 1YXAA 1XQJA 1HLEA 3DRUA 1E03I 1SR5A 1R1LI 1JJOC 1QMNA 1DZHL 4KDSA 4AU4A 4AJTA 2OL2A 2OAYA 4C41A 4YIAA 5EI0A 2PEEA 9PAIA 1IZ2A 3ZHAA 5C98A 2WY1A 3NDFA 1A7CA 2BEHL 1JMJA 3PB1I 1C8OA 3PZFA 2VH4A 4X30A 1LJ5A 2XN7A 5HGCA 1OC0A 7APIA 2GD4C 4EB1L 4DY0A 2H4PA 1IMVA 3KCGI 4IC0A 3DRMA 2HIJL 4DTEA 3VVJA 3NDDA 2H4RA 1B3KA 2ACHA 1ATHA 4AU3B 1E05I 1EZXA 1OVAB 2B4XI 2WY0C 4G8RA 4G8OA 1HP7A 4ROAA 4P0OA 2WXZA 3T1PA 1AZXI 3F02A 2WXXA 1ATTA 4AFXA 1OYHL 1BY7A 5IO1A 4DY7C 4C49A 2R9YA 3CAAA 2V95A 2HIJI 3Q03A 1LK6I 4ZK3A 4GA7A 1DVNA 2RIWA 2H4QA 3CWLA 3F1SA 4R9IA 5INWA 8APIA 3F5NA 1OPHA 1ATUA 1TB6I 1AS4A 1DB2A 2QUGA 1DZHI 2ZV6A 1T1FA 4Y3KA 3LE2A 5CDZA 3EOXA 1M93B 2WXYC 1OVAC 1DZGL 3STOA 2D26A 3DY0A 2ARRA 4CAAA 1K9OI 2BEHI 1C5GA 4Y40A 3UT3A 2B5TI 3NE4A 1OO8A 1DVMA 4RSQA 2VDYA 3LW2A 3EVJI 1F0CA 4EB1I 4P0FA 1JTIA 5CDXA 4AU2A 1SEKA 5BRRI 9APIA 1NQ9I 1JVQI 1QLPA 4RO9A 3CWMA 3R4LA 1DZGI 1D5SA 3NDAA 1QMBA 1UHGA 2XN3A 4ROBA 1MTPA 4AJUA 1ANTI 3CVMA 1XQGA 2ZNHA 4IF8A 2RIVA 5CE0A 1KCTA 3B9FI 3OZQA 3FGQA 1LQ8A 1OYHI 1BR8I
chains in the Genus database with same CATH topology
4AQHA 2XN5A 1SNGA 2B4XL 4AU3A 2WXWA 4PYWA 1OVAA 1WZ9A 1XU8A 2DUTA 4ZK0A 3H5CA 2ARQA 1JRRA 4BB2A 3Q02A 2CEOA 3DLWA 1JMOA 2HI9A 2XN6A 1PSIA 2WXZC 1E04I 2VDXA 2ANTI 2PEFA 1YXAA 1XQJA 1HLEA 3DRUA 1E03I 1SR5A 1R1LI 1JJOC 1QMNA 1DZHL 4KDSA 4AU4A 4AJTA 2OL2A 2OAYA 4C41A 4YIAA 5EI0A 2PEEA 9PAIA 1IZ2A 3ZHAA 5C98A 2WY1A 3NDFA 1A7CA 2BEHL 1JMJA 3PB1I 1C8OA 3PZFA 2VH4A 4X30A 1LJ5A 2XN7A 5HGCA 1OC0A 7APIA 2GD4C 4EB1L 4DY0A 2H4PA 1IMVA 3KCGI 4IC0A 3DRMA 2HIJL 4DTEA 3VVJA 3NDDA 2H4RA 1B3KA 2ACHA 1ATHA 4AU3B 1E05I 1EZXA 1OVAB 2B4XI 2WY0C 4G8RA 4G8OA 1HP7A 4ROAA 4P0OA 2WXZA 3T1PA 1AZXI 3F02A 2WXXA 1ATTA 4AFXA 1OYHL 1BY7A 5IO1A 4DY7C 4C49A 2R9YA 3CAAA 2V95A 2HIJI 3Q03A 1LK6I 4ZK3A 4GA7A 1DVNA 2RIWA 2H4QA 3CWLA 3F1SA 4R9IA 5INWA 8APIA 3F5NA 1OPHA 1ATUA 1TB6I 1AS4A 1DB2A 2QUGA 1DZHI 2ZV6A 1T1FA 4Y3KA 3LE2A 5CDZA 3EOXA 1M93B 2WXYC 1OVAC 1DZGL 3STOA 2D26A 3DY0A 2ARRA 4CAAA 1K9OI 2BEHI 1C5GA 4Y40A 3UT3A 2B5TI 3NE4A 1OO8A 1DVMA 4RSQA 2VDYA 3LW2A 3EVJI 1F0CA 4EB1I 4P0FA 1JTIA 5CDXA 4AU2A 1SEKA 5BRRI 9APIA 1NQ9I 1JVQI 1QLPA 4RO9A 3CWMA 3R4LA 1DZGI 1D5SA 3NDAA 1QMBA 1UHGA 2XN3A 4ROBA 1MTPA 4AJUA 1ANTI 3CVMA 1XQGA 2ZNHA 4IF8A 2RIVA 5CE0A 1KCTA 3B9FI 3OZQA 3FGQA 1LQ8A 1OYHI 1BR8I
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4AQH A;  2XN5 A;  1SNG A;  2B4X L;  4AU3 A;  2WXW A;  4PYW A;  1OVA A;  1WZ9 A;  1XU8 A;  2DUT A;  4ZK0 A;  3H5C A;  2ARQ A;  1JRR A;  4BB2 A;  3Q02 A;  2CEO A;  3DLW A;  1JMO A;  2HI9 A;  2XN6 A;  1PSI A;  2WXZ C;  1E04 I;  2VDX A;  2ANT I;  2PEF A;  1YXA A;  1XQJ A;  1HLE A;  3DRU A;  1E03 I;  1SR5 A;  1R1L I;  1JJO C;  1QMN A;  1DZH L;  4KDS A;  4AU4 A;  4AJT A;  2OL2 A;  2OAY A;  4C41 A;  4YIA A;  5EI0 A;  2PEE A;  9PAI A;  1IZ2 A;  3ZHA A;  5C98 A;  2WY1 A;  3NDF A;  1A7C A;  2BEH L;  1JMJ A;  3PB1 I;  1C8O A;  3PZF A;  2VH4 A;  4X30 A;  1LJ5 A;  2XN7 A;  5HGC A;  1OC0 A;  7API A;  2GD4 C;  4EB1 L;  4DY0 A;  2H4P A;  1IMV A;  3KCG I;  4IC0 A;  3DRM A;  2HIJ L;  4DTE A;  3VVJ A;  3NDD A;  2H4R A;  1B3K A;  2ACH A;  1ATH A;  4AU3 B;  1E05 I;  1EZX A;  1OVA B;  2B4X I;  2WY0 C;  4G8R A;  4G8O A;  1HP7 A;  4ROA A;  4P0O A;  2WXZ A;  3T1P A;  1AZX I;  3F02 A;  2WXX A;  1ATT A;  4AFX A;  1OYH L;  1BY7 A;  5IO1 A;  4DY7 C;  4C49 A;  2R9Y A;  3CAA A;  2V95 A;  2HIJ I;  3Q03 A;  1LK6 I;  4ZK3 A;  4GA7 A;  1DVN A;  2RIW A;  2H4Q A;  3CWL A;  3F1S A;  4R9I A;  5INW A;  8API A;  3F5N A;  1OPH A;  1ATU A;  1TB6 I;  1AS4 A;  1DB2 A;  2QUG A;  1DZH I;  2ZV6 A;  1T1F A;  4Y3K A;  3LE2 A;  5CDZ A;  3EOX A;  1M93 B;  2WXY C;  1OVA C;  1DZG L;  3STO A;  2D26 A;  3DY0 A;  2ARR A;  4CAA A;  1K9O I;  2BEH I;  1C5G A;  4Y40 A;  3UT3 A;  2B5T I;  3NE4 A;  1OO8 A;  1DVM A;  4RSQ A;  2VDY A;  3LW2 A;  3EVJ I;  1F0C A;  4EB1 I;  4P0F A;  1JTI A;  5CDX A;  4AU2 A;  1SEK A;  5BRR I;  9API A;  1NQ9 I;  1JVQ I;  1QLP A;  4RO9 A;  3CWM A;  3R4L A;  1DZG I;  1D5S A;  3NDA A;  1QMB A;  1UHG A;  2XN3 A;  4ROB A;  1MTP A;  4AJU A;  1ANT I;  3CVM A;  1XQG A;  2ZNH A;  4IF8 A;  2RIV A;  5CE0 A;  1KCT A;  3B9F I;  3OZQ A;  3FGQ A;  1LQ8 A;  1OYH I;  1BR8 I; 
#chains in the Genus database with same CATH topology
 4AQH A;  2XN5 A;  1SNG A;  2B4X L;  4AU3 A;  2WXW A;  4PYW A;  1OVA A;  1WZ9 A;  1XU8 A;  2DUT A;  4ZK0 A;  3H5C A;  2ARQ A;  1JRR A;  4BB2 A;  3Q02 A;  2CEO A;  3DLW A;  1JMO A;  2HI9 A;  2XN6 A;  1PSI A;  2WXZ C;  1E04 I;  2VDX A;  2ANT I;  2PEF A;  1YXA A;  1XQJ A;  1HLE A;  3DRU A;  1E03 I;  1SR5 A;  1R1L I;  1JJO C;  1QMN A;  1DZH L;  4KDS A;  4AU4 A;  4AJT A;  2OL2 A;  2OAY A;  4C41 A;  4YIA A;  5EI0 A;  2PEE A;  9PAI A;  1IZ2 A;  3ZHA A;  5C98 A;  2WY1 A;  3NDF A;  1A7C A;  2BEH L;  1JMJ A;  3PB1 I;  1C8O A;  3PZF A;  2VH4 A;  4X30 A;  1LJ5 A;  2XN7 A;  5HGC A;  1OC0 A;  7API A;  2GD4 C;  4EB1 L;  4DY0 A;  2H4P A;  1IMV A;  3KCG I;  4IC0 A;  3DRM A;  2HIJ L;  4DTE A;  3VVJ A;  3NDD A;  2H4R A;  1B3K A;  2ACH A;  1ATH A;  4AU3 B;  1E05 I;  1EZX A;  1OVA B;  2B4X I;  2WY0 C;  4G8R A;  4G8O A;  1HP7 A;  4ROA A;  4P0O A;  2WXZ A;  3T1P A;  1AZX I;  3F02 A;  2WXX A;  1ATT A;  4AFX A;  1OYH L;  1BY7 A;  5IO1 A;  4DY7 C;  4C49 A;  2R9Y A;  3CAA A;  2V95 A;  2HIJ I;  3Q03 A;  1LK6 I;  4ZK3 A;  4GA7 A;  1DVN A;  2RIW A;  2H4Q A;  3CWL A;  3F1S A;  4R9I A;  5INW A;  8API A;  3F5N A;  1OPH A;  1ATU A;  1TB6 I;  1AS4 A;  1DB2 A;  2QUG A;  1DZH I;  2ZV6 A;  1T1F A;  4Y3K A;  3LE2 A;  5CDZ A;  3EOX A;  1M93 B;  2WXY C;  1OVA C;  1DZG L;  3STO A;  2D26 A;  3DY0 A;  2ARR A;  4CAA A;  1K9O I;  2BEH I;  1C5G A;  4Y40 A;  3UT3 A;  2B5T I;  3NE4 A;  1OO8 A;  1DVM A;  4RSQ A;  2VDY A;  3LW2 A;  3EVJ I;  1F0C A;  4EB1 I;  4P0F A;  1JTI A;  5CDX A;  4AU2 A;  1SEK A;  5BRR I;  9API A;  1NQ9 I;  1JVQ I;  1QLP A;  4RO9 A;  3CWM A;  3R4L A;  1DZG I;  1D5S A;  3NDA A;  1QMB A;  1UHG A;  2XN3 A;  4ROB A;  1MTP A;  4AJU A;  1ANT I;  3CVM A;  1XQG A;  2ZNH A;  4IF8 A;  2RIV A;  5CE0 A;  1KCT A;  3B9F I;  3OZQ A;  3FGQ A;  1LQ8 A;  1OYH I;  1BR8 I; 
#chains in the Genus database with same CATH homology
 4AQH A;  2XN5 A;  1SNG A;  2B4X L;  4AU3 A;  2WXW A;  4PYW A;  1OVA A;  1WZ9 A;  1XU8 A;  2DUT A;  4ZK0 A;  3H5C A;  2ARQ A;  1JRR A;  4BB2 A;  3Q02 A;  2CEO A;  3DLW A;  1JMO A;  2HI9 A;  2XN6 A;  1PSI A;  2WXZ C;  1E04 I;  2VDX A;  2ANT I;  2PEF A;  1YXA A;  1XQJ A;  1HLE A;  3DRU A;  1E03 I;  1SR5 A;  1R1L I;  1JJO C;  1QMN A;  1DZH L;  4KDS A;  4AU4 A;  4AJT A;  2OL2 A;  2OAY A;  4C41 A;  4YIA A;  5EI0 A;  2PEE A;  9PAI A;  1IZ2 A;  3ZHA A;  5C98 A;  2WY1 A;  3NDF A;  1A7C A;  2BEH L;  1JMJ A;  3PB1 I;  1C8O A;  3PZF A;  2VH4 A;  4X30 A;  1LJ5 A;  2XN7 A;  5HGC A;  1OC0 A;  7API A;  2GD4 C;  4EB1 L;  4DY0 A;  2H4P A;  1IMV A;  3KCG I;  4IC0 A;  3DRM A;  2HIJ L;  4DTE A;  3VVJ A;  3NDD A;  2H4R A;  1B3K A;  2ACH A;  1ATH A;  4AU3 B;  1E05 I;  1EZX A;  1OVA B;  2B4X I;  2WY0 C;  4G8R A;  4G8O A;  1HP7 A;  4ROA A;  4P0O A;  2WXZ A;  3T1P A;  1AZX I;  3F02 A;  2WXX A;  1ATT A;  4AFX A;  1OYH L;  1BY7 A;  5IO1 A;  4DY7 C;  4C49 A;  2R9Y A;  3CAA A;  2V95 A;  2HIJ I;  3Q03 A;  1LK6 I;  4ZK3 A;  4GA7 A;  1DVN A;  2RIW A;  2H4Q A;  3CWL A;  3F1S A;  4R9I A;  5INW A;  8API A;  3F5N A;  1OPH A;  1ATU A;  1TB6 I;  1AS4 A;  1DB2 A;  2QUG A;  1DZH I;  2ZV6 A;  1T1F A;  4Y3K A;  3LE2 A;  5CDZ A;  3EOX A;  1M93 B;  2WXY C;  1OVA C;  1DZG L;  3STO A;  2D26 A;  3DY0 A;  2ARR A;  4CAA A;  1K9O I;  2BEH I;  1C5G A;  4Y40 A;  3UT3 A;  2B5T I;  3NE4 A;  1OO8 A;  1DVM A;  4RSQ A;  2VDY A;  3LW2 A;  3EVJ I;  1F0C A;  4EB1 I;  4P0F A;  1JTI A;  5CDX A;  4AU2 A;  1SEK A;  5BRR I;  9API A;  1NQ9 I;  1JVQ I;  1QLP A;  4RO9 A;  3CWM A;  3R4L A;  1DZG I;  1D5S A;  3NDA A;  1QMB A;  1UHG A;  2XN3 A;  4ROB A;  1MTP A;  4AJU A;  1ANT I;  3CVM A;  1XQG A;  2ZNH A;  4IF8 A;  2RIV A;  5CE0 A;  1KCT A;  3B9F I;  3OZQ A;  3FGQ A;  1LQ8 A;  1OYH I;  1BR8 I; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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