4AJTA

The crystal structure of mouse protein-z dependent protease inhibitor(mzpi)
Total Genus 116
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
116
sequence length
379
structure length
372
Chain Sequence
DEEYWLRASQQLSNETSSFGFNLLRKISMRHDGNVIFSPFGLSVAMVNLMLGTKGETKVQIENGLNLQALSQAGPLILPALFKKVKETFSSNRDLGLSQGSFAFIHKDFDIKETYFNLSKKYFDIEYVSINFQNSSQARGLINHCIVKETEGKIPKLFDEINPETKLILVDYVLFKGKWLTPFDPSFTEADTFHLDKYRAIKVPMMYREGNFTSTFDKKFRCHILKLPYQGNATMLVVLMEKTGDYLALEDYLTVDLVETWLQNMKTRKMEVFFPKFKLNQRYEMHELLKQMGIRRLFSTSADLSELSAMARNLQVSRVLQQSVLEVDERGTEEIIAYSMPPAIKVNRPFHFIIYEEMSRMLLFLGRVVNPT
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural Basis for Catalytic Activation of Protein Z-Dependent Protease Inhibitor (Zpi) by Protein Z.
pubmed doi rcsb
molecule tags Blood clotting
source organism Mus musculus
molecule keywords PROTEIN Z-DEPENDENT PROTEASE INHIBITOR
total genus 116
structure length 372
sequence length 379
ec nomenclature
pdb deposition date 2012-02-19

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00079 Serpin Serpin (serine protease inhibitor)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.30.39.10 Mainly Beta Roll Alpha-1-antitrypsin; domain 1 Alpha-1-antitrypsin, domain 1 4ajtA02
3.30.497.10 Alpha Beta 2-Layer Sandwich Antithrombin; Chain I, domain 2 Antithrombin, subunit I, domain 2 4ajtA01
4CAAA 2GD4C 1OPHA 2VDYA 4AFXA 4AU3B 1DZGI 4DY7C 2PEFA 4X30A 2B4XI 4DY0A 2WXXA 3NE4A 3DRUA 3T1PA 4P0OA 1E03I 3FGQA 2BEHL 1SEKA 2QUGA 1UHGA 3VVJA 4Y40A 2VH4A 1OO8A 1SNGA 1JMOA 9PAIA 1ATHA 2ACHA 4AJUA 1YXAA 1DB2A 1OYHI 1E05I 1QMNA 2D26A 4AJTA 1DZHL 3NDAA 4R9IA 4AQHA 1JMJA 3Q03A 3R4LA 5HGCA 4ROAA 4ROBA 1QMBA 3B9FI 2ARRA 2CEOA 1A7CA 4P0FA 1JTIA 1ATUA 3CAAA 1DVMA 2VDXA 4AU4A 2OL2A 1DZGL 1JVQI 1OVAB 4G8OA 2B4XL 2DUTA 3NDDA 1KCTA 4EB1I 1ATTA 2PEEA 3EOXA 5CE0A 2V95A 1LJ5A 2OAYA 1EZXA 2XN6A 1JRRA 3F5NA 2H4PA 3F1SA 4YIAA 1SR5A 8APIA 1M93B 3LE2A 1T1FA 1OYHL 1C5GA 2ANTI 1HLEA 4C49A 1LK6I 3KCGI 2RIVA 2XN5A 4AU2A 2WXZC 3PZFA 4RSQA 3DRMA 4C41A 2HIJI 2B5TI 2ARQA 3NDFA 2WY1A 1AS4A 1TB6I 2H4QA 1IZ2A 1F0CA 4EB1L 2WXYC 1E04I 3EVJI 3STOA 3ZHAA 3PB1I 1B3KA 1DZHI 3CWMA 4AU3A 1XU8A 1IMVA 1XQJA 1D5SA 2WXWA 2ZV6A 3DY0A 5EI0A 2XN7A 2XN3A 3CWLA 5INWA 1QLPA 4IF8A 1WZ9A 2R9YA 1DVNA 1HP7A 3H5CA 9APIA 4GA7A 4IC0A 4G8RA 1JJOC 3UT3A 1AZXI 2BEHI 3CVMA 1K9OI 2HI9A 2WXZA 4RO9A 2HIJL 3F02A 4DTEA 4BB2A 4ZK0A 2H4RA 4Y3KA 1BY7A 1NQ9I 1XQGA 2RIWA 1OVAC 3Q02A 1C8OA 1BR8I 1LQ8A 5IO1A 5C98A 1R1LI 4ZK3A 3LW2A 1OVAA 4PYWA 1MTPA 1OC0A 5BRRI 2ZNHA 1ANTI 7APIA 1PSIA 3DLWA 3OZQA 4KDSA 5CDXA 5CDZA 2WY0C
chains in the Genus database with same CATH superfamily
4CAAA 2GD4C 1OPHA 2VDYA 4AFXA 4AU3B 1DZGI 4DY7C 2PEFA 4X30A 2B4XI 4DY0A 2WXXA 3NE4A 3DRUA 3T1PA 4P0OA 1E03I 3FGQA 2BEHL 1SEKA 2QUGA 1UHGA 3VVJA 4Y40A 2VH4A 1OO8A 1SNGA 1JMOA 9PAIA 1ATHA 2ACHA 4AJUA 1YXAA 1DB2A 1OYHI 1E05I 1QMNA 2D26A 4AJTA 1DZHL 3NDAA 4R9IA 4AQHA 1JMJA 3Q03A 3R4LA 5HGCA 4ROAA 4ROBA 1QMBA 3B9FI 2ARRA 2CEOA 1A7CA 4P0FA 1JTIA 1ATUA 3CAAA 1DVMA 2VDXA 4AU4A 2OL2A 1DZGL 1JVQI 1OVAB 4G8OA 2B4XL 2DUTA 3NDDA 1KCTA 4EB1I 1ATTA 2PEEA 3EOXA 5CE0A 2V95A 1LJ5A 2OAYA 1EZXA 2XN6A 1JRRA 3F5NA 2H4PA 3F1SA 4YIAA 1SR5A 8APIA 1M93B 3LE2A 1T1FA 1OYHL 1C5GA 2ANTI 1HLEA 4C49A 1LK6I 3KCGI 2RIVA 2XN5A 4AU2A 2WXZC 3PZFA 4RSQA 3DRMA 4C41A 2HIJI 2B5TI 2ARQA 3NDFA 2WY1A 1AS4A 1TB6I 2H4QA 1IZ2A 1F0CA 4EB1L 2WXYC 1E04I 3EVJI 3STOA 3ZHAA 3PB1I 1B3KA 1DZHI 3CWMA 4AU3A 1XU8A 1IMVA 1XQJA 1D5SA 2WXWA 2ZV6A 3DY0A 5EI0A 2XN7A 2XN3A 3CWLA 5INWA 1QLPA 4IF8A 1WZ9A 2R9YA 1DVNA 1HP7A 3H5CA 9APIA 4GA7A 4IC0A 4G8RA 1JJOC 3UT3A 1AZXI 2BEHI 3CVMA 1K9OI 2HI9A 2WXZA 4RO9A 2HIJL 3F02A 4DTEA 4BB2A 4ZK0A 2H4RA 4Y3KA 1BY7A 1NQ9I 1XQGA 2RIWA 1OVAC 3Q02A 1C8OA 1BR8I 1LQ8A 5IO1A 5C98A 1R1LI 4ZK3A 3LW2A 1OVAA 4PYWA 1MTPA 1OC0A 5BRRI 2ZNHA 1ANTI 7APIA 1PSIA 3DLWA 3OZQA 4KDSA 5CDXA 5CDZA 2WY0C
chains in the Genus database with same CATH topology
4CAAA 2GD4C 1OPHA 2VDYA 4AFXA 4AU3B 1DZGI 4DY7C 2PEFA 4X30A 2B4XI 4DY0A 2WXXA 3NE4A 3DRUA 3T1PA 4P0OA 1E03I 3FGQA 2BEHL 1SEKA 2QUGA 1UHGA 3VVJA 4Y40A 2VH4A 1OO8A 1SNGA 1JMOA 9PAIA 1ATHA 2ACHA 4AJUA 1YXAA 1DB2A 1OYHI 1E05I 1QMNA 2D26A 4AJTA 1DZHL 3NDAA 4R9IA 4AQHA 1JMJA 3Q03A 3R4LA 5HGCA 4ROAA 4ROBA 1QMBA 3B9FI 2ARRA 2CEOA 1A7CA 4P0FA 1JTIA 1ATUA 3CAAA 1DVMA 2VDXA 4AU4A 2OL2A 1DZGL 1JVQI 1OVAB 4G8OA 2B4XL 2DUTA 3NDDA 1KCTA 4EB1I 1ATTA 2PEEA 3EOXA 5CE0A 2V95A 1LJ5A 2OAYA 1EZXA 2XN6A 1JRRA 3F5NA 2H4PA 3F1SA 4YIAA 1SR5A 8APIA 1M93B 3LE2A 1T1FA 1OYHL 1C5GA 2ANTI 1HLEA 4C49A 1LK6I 3KCGI 2RIVA 2XN5A 4AU2A 2WXZC 3PZFA 4RSQA 3DRMA 4C41A 2HIJI 2B5TI 2ARQA 3NDFA 2WY1A 1AS4A 1TB6I 2H4QA 1IZ2A 1F0CA 4EB1L 2WXYC 1E04I 3EVJI 3STOA 3ZHAA 3PB1I 1B3KA 1DZHI 3CWMA 4AU3A 1XU8A 1IMVA 1XQJA 1D5SA 2WXWA 2ZV6A 3DY0A 5EI0A 2XN7A 2XN3A 3CWLA 5INWA 1QLPA 4IF8A 1WZ9A 2R9YA 1DVNA 1HP7A 3H5CA 9APIA 4GA7A 4IC0A 4G8RA 1JJOC 3UT3A 1AZXI 2BEHI 3CVMA 1K9OI 2HI9A 2WXZA 4RO9A 2HIJL 3F02A 4DTEA 4BB2A 4ZK0A 2H4RA 4Y3KA 1BY7A 1NQ9I 1XQGA 2RIWA 1OVAC 3Q02A 1C8OA 1BR8I 1LQ8A 5IO1A 5C98A 1R1LI 4ZK3A 3LW2A 1OVAA 4PYWA 1MTPA 1OC0A 5BRRI 2ZNHA 1ANTI 7APIA 1PSIA 3DLWA 3OZQA 4KDSA 5CDXA 5CDZA 2WY0C
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4CAA A;  2GD4 C;  1OPH A;  2VDY A;  4AFX A;  4AU3 B;  1DZG I;  4DY7 C;  2PEF A;  4X30 A;  2B4X I;  4DY0 A;  2WXX A;  3NE4 A;  3DRU A;  3T1P A;  4P0O A;  1E03 I;  3FGQ A;  2BEH L;  1SEK A;  2QUG A;  1UHG A;  3VVJ A;  4Y40 A;  2VH4 A;  1OO8 A;  1SNG A;  1JMO A;  9PAI A;  1ATH A;  2ACH A;  4AJU A;  1YXA A;  1DB2 A;  1OYH I;  1E05 I;  1QMN A;  2D26 A;  4AJT A;  1DZH L;  3NDA A;  4R9I A;  4AQH A;  1JMJ A;  3Q03 A;  3R4L A;  5HGC A;  4ROA A;  4ROB A;  1QMB A;  3B9F I;  2ARR A;  2CEO A;  1A7C A;  4P0F A;  1JTI A;  1ATU A;  3CAA A;  1DVM A;  2VDX A;  4AU4 A;  2OL2 A;  1DZG L;  1JVQ I;  1OVA B;  4G8O A;  2B4X L;  2DUT A;  3NDD A;  1KCT A;  4EB1 I;  1ATT A;  2PEE A;  3EOX A;  5CE0 A;  2V95 A;  1LJ5 A;  2OAY A;  1EZX A;  2XN6 A;  1JRR A;  3F5N A;  2H4P A;  3F1S A;  4YIA A;  1SR5 A;  8API A;  1M93 B;  3LE2 A;  1T1F A;  1OYH L;  1C5G A;  2ANT I;  1HLE A;  4C49 A;  1LK6 I;  3KCG I;  2RIV A;  2XN5 A;  4AU2 A;  2WXZ C;  3PZF A;  4RSQ A;  3DRM A;  4C41 A;  2HIJ I;  2B5T I;  2ARQ A;  3NDF A;  2WY1 A;  1AS4 A;  1TB6 I;  2H4Q A;  1IZ2 A;  1F0C A;  4EB1 L;  2WXY C;  1E04 I;  3EVJ I;  3STO A;  3ZHA A;  3PB1 I;  1B3K A;  1DZH I;  3CWM A;  4AU3 A;  1XU8 A;  1IMV A;  1XQJ A;  1D5S A;  2WXW A;  2ZV6 A;  3DY0 A;  5EI0 A;  2XN7 A;  2XN3 A;  3CWL A;  5INW A;  1QLP A;  4IF8 A;  1WZ9 A;  2R9Y A;  1DVN A;  1HP7 A;  3H5C A;  9API A;  4GA7 A;  4IC0 A;  4G8R A;  1JJO C;  3UT3 A;  1AZX I;  2BEH I;  3CVM A;  1K9O I;  2HI9 A;  2WXZ A;  4RO9 A;  2HIJ L;  3F02 A;  4DTE A;  4BB2 A;  4ZK0 A;  2H4R A;  4Y3K A;  1BY7 A;  1NQ9 I;  1XQG A;  2RIW A;  1OVA C;  3Q02 A;  1C8O A;  1BR8 I;  1LQ8 A;  5IO1 A;  5C98 A;  1R1L I;  4ZK3 A;  3LW2 A;  1OVA A;  4PYW A;  1MTP A;  1OC0 A;  5BRR I;  2ZNH A;  1ANT I;  7API A;  1PSI A;  3DLW A;  3OZQ A;  4KDS A;  5CDX A;  5CDZ A;  2WY0 C; 
#chains in the Genus database with same CATH topology
 4CAA A;  2GD4 C;  1OPH A;  2VDY A;  4AFX A;  4AU3 B;  1DZG I;  4DY7 C;  2PEF A;  4X30 A;  2B4X I;  4DY0 A;  2WXX A;  3NE4 A;  3DRU A;  3T1P A;  4P0O A;  1E03 I;  3FGQ A;  2BEH L;  1SEK A;  2QUG A;  1UHG A;  3VVJ A;  4Y40 A;  2VH4 A;  1OO8 A;  1SNG A;  1JMO A;  9PAI A;  1ATH A;  2ACH A;  4AJU A;  1YXA A;  1DB2 A;  1OYH I;  1E05 I;  1QMN A;  2D26 A;  4AJT A;  1DZH L;  3NDA A;  4R9I A;  4AQH A;  1JMJ A;  3Q03 A;  3R4L A;  5HGC A;  4ROA A;  4ROB A;  1QMB A;  3B9F I;  2ARR A;  2CEO A;  1A7C A;  4P0F A;  1JTI A;  1ATU A;  3CAA A;  1DVM A;  2VDX A;  4AU4 A;  2OL2 A;  1DZG L;  1JVQ I;  1OVA B;  4G8O A;  2B4X L;  2DUT A;  3NDD A;  1KCT A;  4EB1 I;  1ATT A;  2PEE A;  3EOX A;  5CE0 A;  2V95 A;  1LJ5 A;  2OAY A;  1EZX A;  2XN6 A;  1JRR A;  3F5N A;  2H4P A;  3F1S A;  4YIA A;  1SR5 A;  8API A;  1M93 B;  3LE2 A;  1T1F A;  1OYH L;  1C5G A;  2ANT I;  1HLE A;  4C49 A;  1LK6 I;  3KCG I;  2RIV A;  2XN5 A;  4AU2 A;  2WXZ C;  3PZF A;  4RSQ A;  3DRM A;  4C41 A;  2HIJ I;  2B5T I;  2ARQ A;  3NDF A;  2WY1 A;  1AS4 A;  1TB6 I;  2H4Q A;  1IZ2 A;  1F0C A;  4EB1 L;  2WXY C;  1E04 I;  3EVJ I;  3STO A;  3ZHA A;  3PB1 I;  1B3K A;  1DZH I;  3CWM A;  4AU3 A;  1XU8 A;  1IMV A;  1XQJ A;  1D5S A;  2WXW A;  2ZV6 A;  3DY0 A;  5EI0 A;  2XN7 A;  2XN3 A;  3CWL A;  5INW A;  1QLP A;  4IF8 A;  1WZ9 A;  2R9Y A;  1DVN A;  1HP7 A;  3H5C A;  9API A;  4GA7 A;  4IC0 A;  4G8R A;  1JJO C;  3UT3 A;  1AZX I;  2BEH I;  3CVM A;  1K9O I;  2HI9 A;  2WXZ A;  4RO9 A;  2HIJ L;  3F02 A;  4DTE A;  4BB2 A;  4ZK0 A;  2H4R A;  4Y3K A;  1BY7 A;  1NQ9 I;  1XQG A;  2RIW A;  1OVA C;  3Q02 A;  1C8O A;  1BR8 I;  1LQ8 A;  5IO1 A;  5C98 A;  1R1L I;  4ZK3 A;  3LW2 A;  1OVA A;  4PYW A;  1MTP A;  1OC0 A;  5BRR I;  2ZNH A;  1ANT I;  7API A;  1PSI A;  3DLW A;  3OZQ A;  4KDS A;  5CDX A;  5CDZ A;  2WY0 C; 
#chains in the Genus database with same CATH homology
 4CAA A;  2GD4 C;  1OPH A;  2VDY A;  4AFX A;  4AU3 B;  1DZG I;  4DY7 C;  2PEF A;  4X30 A;  2B4X I;  4DY0 A;  2WXX A;  3NE4 A;  3DRU A;  3T1P A;  4P0O A;  1E03 I;  3FGQ A;  2BEH L;  1SEK A;  2QUG A;  1UHG A;  3VVJ A;  4Y40 A;  2VH4 A;  1OO8 A;  1SNG A;  1JMO A;  9PAI A;  1ATH A;  2ACH A;  4AJU A;  1YXA A;  1DB2 A;  1OYH I;  1E05 I;  1QMN A;  2D26 A;  4AJT A;  1DZH L;  3NDA A;  4R9I A;  4AQH A;  1JMJ A;  3Q03 A;  3R4L A;  5HGC A;  4ROA A;  4ROB A;  1QMB A;  3B9F I;  2ARR A;  2CEO A;  1A7C A;  4P0F A;  1JTI A;  1ATU A;  3CAA A;  1DVM A;  2VDX A;  4AU4 A;  2OL2 A;  1DZG L;  1JVQ I;  1OVA B;  4G8O A;  2B4X L;  2DUT A;  3NDD A;  1KCT A;  4EB1 I;  1ATT A;  2PEE A;  3EOX A;  5CE0 A;  2V95 A;  1LJ5 A;  2OAY A;  1EZX A;  2XN6 A;  1JRR A;  3F5N A;  2H4P A;  3F1S A;  4YIA A;  1SR5 A;  8API A;  1M93 B;  3LE2 A;  1T1F A;  1OYH L;  1C5G A;  2ANT I;  1HLE A;  4C49 A;  1LK6 I;  3KCG I;  2RIV A;  2XN5 A;  4AU2 A;  2WXZ C;  3PZF A;  4RSQ A;  3DRM A;  4C41 A;  2HIJ I;  2B5T I;  2ARQ A;  3NDF A;  2WY1 A;  1AS4 A;  1TB6 I;  2H4Q A;  1IZ2 A;  1F0C A;  4EB1 L;  2WXY C;  1E04 I;  3EVJ I;  3STO A;  3ZHA A;  3PB1 I;  1B3K A;  1DZH I;  3CWM A;  4AU3 A;  1XU8 A;  1IMV A;  1XQJ A;  1D5S A;  2WXW A;  2ZV6 A;  3DY0 A;  5EI0 A;  2XN7 A;  2XN3 A;  3CWL A;  5INW A;  1QLP A;  4IF8 A;  1WZ9 A;  2R9Y A;  1DVN A;  1HP7 A;  3H5C A;  9API A;  4GA7 A;  4IC0 A;  4G8R A;  1JJO C;  3UT3 A;  1AZX I;  2BEH I;  3CVM A;  1K9O I;  2HI9 A;  2WXZ A;  4RO9 A;  2HIJ L;  3F02 A;  4DTE A;  4BB2 A;  4ZK0 A;  2H4R A;  4Y3K A;  1BY7 A;  1NQ9 I;  1XQG A;  2RIW A;  1OVA C;  3Q02 A;  1C8O A;  1BR8 I;  1LQ8 A;  5IO1 A;  5C98 A;  1R1L I;  4ZK3 A;  3LW2 A;  1OVA A;  4PYW A;  1MTP A;  1OC0 A;  5BRR I;  2ZNH A;  1ANT I;  7API A;  1PSI A;  3DLW A;  3OZQ A;  4KDS A;  5CDX A;  5CDZ A;  2WY0 C; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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