4YIAA

Structural mechanism of hormone release in thyroxine binding globulin
Total Genus 99
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
99
sequence length
337
structure length
337
Chain Sequence
LYKMSSINADFAFNLYRRFTVETPDKNIFFSPVSISAALVMLSFGACCSTQTEIVETLGFNLTDTPMVEIQHGFQHLICSLNFPKKELELQIGNALFIGKHLKPLAKFLNDVKTLYETEVFSTDFSNISAAKQEINSHVEMQTKGKVVGLIQDLKPNTIMVLVNYIHFKAQWANPFDPSKTEDSSSFLIDKTTTVQVPMMHQMEQYYHLVDMELNCTVLQMDYSKNALALFVLPKEGQMESVEAAMSSKTLKKWNRLLQKGWVDLFVPKFSISATYDLGATLLKMGIQHAYSENADFSGLTEDNGLKLSNAAHKAVLHIGEKGTEAAGAMFLEAIPR
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural mechanism of hormone release in thyroxine Binding globulin
rcsb
molecule tags Signaling protein
source organism Homo sapiens
molecule keywords Thyroxine-binding globulin
total genus 99
structure length 337
sequence length 337
ec nomenclature
pdb deposition date 2015-03-01
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.30.39.10 Mainly Beta Roll Alpha-1-antitrypsin; domain 1 Alpha-1-antitrypsin, domain 1 4yiaA02
3.30.497.10 Alpha Beta 2-Layer Sandwich Antithrombin; Chain I, domain 2 Antithrombin, subunit I, domain 2 4yiaA01
3NDDA 2WXZC 5INWA 1ATTA 4G8RA 4X30A 2CEOA 1F0CA 1SNGA 1C8OA 5CE0A 2WY1A 3NE4A 2WY0C 3T1PA 1DVMA 1ANTI 1OPHA 3LE2A 1E04I 1DZGL 3CVMA 3CWLA 3DRUA 3Q02A 3Q03A 2B4XL 1ATUA 1D5SA 1JTIA 1AZXI 1HP7A 1JVQI 1JRRA 3F5NA 1EZXA 2R9YA 3DLWA 5HGCA 5CDXA 1K9OI 2WXZA 1KCTA 2ACHA 2VDXA 2ZV6A 3FGQA 2HI9A 1QMBA 2H4PA 3F02A 1YXAA 2H4QA 1BR8I 1B3KA 1JJOC 4ROBA 3B9FI 4BB2A 4C49A 1XU8A 3DRMA 1M93B 2RIWA 1DZHI 3UT3A 1LQ8A 1ATHA 1E03I 2WXWA 4DY0A 4EB1I 3ZHAA 1C5GA 1OYHI 4R9IA 5EI0A 2XN6A 7APIA 2XN5A 4AU4A 2ANTI 2VDYA 2DUTA 1JMOA 1XQJA 1DVNA 2BEHI 4EB1L 1IZ2A 1OO8A 3OZQA 3CWMA 3NDAA 4Y3KA 4AJUA 4AU3B 2ZNHA 1IMVA 1SR5A 1OVAC 2ARRA 1OC0A 3H5CA 1OVAB 1AS4A 3LW2A 4KDSA 4RSQA 2BEHL 4AJTA 3NDFA 2WXYC 1UHGA 5BRRI 3R4LA 2H4RA 2HIJI 3VVJA 1JMJA 1E05I 1MTPA 1NQ9I 9PAIA 3CAAA 4PYWA 1PSIA 3EVJI 2HIJL 4AU3A 1DZHL 2D26A 2OL2A 2RIVA 5C98A 5IO1A 1LJ5A 1OYHL 4G8OA 4RO9A 4Y40A 4P0FA 1R1LI 2PEEA 3EOXA 3KCGI 4CAAA 4DTEA 4YIAA 4AFXA 4AU2A 1QMNA 1SEKA 4C41A 1DB2A 2B4XI 2QUGA 4AQHA 4GA7A 4P0OA 4DY7C 2XN3A 2ARQA 9APIA 3STOA 1BY7A 8APIA 3F1SA 5CDZA 1A7CA 4IF8A 1HLEA 4ZK0A 4ROAA 2PEFA 2VH4A 2XN7A 2V95A 2B5TI 1WZ9A 3DY0A 4IC0A 4ZK3A 2OAYA 1TB6I 2GD4C 2WXXA 1OVAA 1T1FA 1LK6I 1QLPA 3PB1I 1XQGA 3PZFA 1DZGI
chains in the Genus database with same CATH superfamily
3NDDA 2WXZC 5INWA 1ATTA 4G8RA 4X30A 2CEOA 1F0CA 1SNGA 1C8OA 5CE0A 2WY1A 3NE4A 2WY0C 3T1PA 1DVMA 1ANTI 1OPHA 3LE2A 1E04I 1DZGL 3CVMA 3CWLA 3DRUA 3Q02A 3Q03A 2B4XL 1ATUA 1D5SA 1JTIA 1AZXI 1HP7A 1JVQI 1JRRA 3F5NA 1EZXA 2R9YA 3DLWA 5HGCA 5CDXA 1K9OI 2WXZA 1KCTA 2ACHA 2VDXA 2ZV6A 3FGQA 2HI9A 1QMBA 2H4PA 3F02A 1YXAA 2H4QA 1BR8I 1B3KA 1JJOC 4ROBA 3B9FI 4BB2A 4C49A 1XU8A 3DRMA 1M93B 2RIWA 1DZHI 3UT3A 1LQ8A 1ATHA 1E03I 2WXWA 4DY0A 4EB1I 3ZHAA 1C5GA 1OYHI 4R9IA 5EI0A 2XN6A 7APIA 2XN5A 4AU4A 2ANTI 2VDYA 2DUTA 1JMOA 1XQJA 1DVNA 2BEHI 4EB1L 1IZ2A 1OO8A 3OZQA 3CWMA 3NDAA 4Y3KA 4AJUA 4AU3B 2ZNHA 1IMVA 1SR5A 1OVAC 2ARRA 1OC0A 3H5CA 1OVAB 1AS4A 3LW2A 4KDSA 4RSQA 2BEHL 4AJTA 3NDFA 2WXYC 1UHGA 5BRRI 3R4LA 2H4RA 2HIJI 3VVJA 1JMJA 1E05I 1MTPA 1NQ9I 9PAIA 3CAAA 4PYWA 1PSIA 3EVJI 2HIJL 4AU3A 1DZHL 2D26A 2OL2A 2RIVA 5C98A 5IO1A 1LJ5A 1OYHL 4G8OA 4RO9A 4Y40A 4P0FA 1R1LI 2PEEA 3EOXA 3KCGI 4CAAA 4DTEA 4YIAA 4AFXA 4AU2A 1QMNA 1SEKA 4C41A 1DB2A 2B4XI 2QUGA 4AQHA 4GA7A 4P0OA 4DY7C 2XN3A 2ARQA 9APIA 3STOA 1BY7A 8APIA 3F1SA 5CDZA 1A7CA 4IF8A 1HLEA 4ZK0A 4ROAA 2PEFA 2VH4A 2XN7A 2V95A 2B5TI 1WZ9A 3DY0A 4IC0A 4ZK3A 2OAYA 1TB6I 2GD4C 2WXXA 1OVAA 1T1FA 1LK6I 1QLPA 3PB1I 1XQGA 3PZFA 1DZGI
chains in the Genus database with same CATH topology
3NDDA 2WXZC 5INWA 1ATTA 4G8RA 4X30A 2CEOA 1F0CA 1SNGA 1C8OA 5CE0A 2WY1A 3NE4A 2WY0C 3T1PA 1DVMA 1ANTI 1OPHA 3LE2A 1E04I 1DZGL 3CVMA 3CWLA 3DRUA 3Q02A 3Q03A 2B4XL 1ATUA 1D5SA 1JTIA 1AZXI 1HP7A 1JVQI 1JRRA 3F5NA 1EZXA 2R9YA 3DLWA 5HGCA 5CDXA 1K9OI 2WXZA 1KCTA 2ACHA 2VDXA 2ZV6A 3FGQA 2HI9A 1QMBA 2H4PA 3F02A 1YXAA 2H4QA 1BR8I 1B3KA 1JJOC 4ROBA 3B9FI 4BB2A 4C49A 1XU8A 3DRMA 1M93B 2RIWA 1DZHI 3UT3A 1LQ8A 1ATHA 1E03I 2WXWA 4DY0A 4EB1I 3ZHAA 1C5GA 1OYHI 4R9IA 5EI0A 2XN6A 7APIA 2XN5A 4AU4A 2ANTI 2VDYA 2DUTA 1JMOA 1XQJA 1DVNA 2BEHI 4EB1L 1IZ2A 1OO8A 3OZQA 3CWMA 3NDAA 4Y3KA 4AJUA 4AU3B 2ZNHA 1IMVA 1SR5A 1OVAC 2ARRA 1OC0A 3H5CA 1OVAB 1AS4A 3LW2A 4KDSA 4RSQA 2BEHL 4AJTA 3NDFA 2WXYC 1UHGA 5BRRI 3R4LA 2H4RA 2HIJI 3VVJA 1JMJA 1E05I 1MTPA 1NQ9I 9PAIA 3CAAA 4PYWA 1PSIA 3EVJI 2HIJL 4AU3A 1DZHL 2D26A 2OL2A 2RIVA 5C98A 5IO1A 1LJ5A 1OYHL 4G8OA 4RO9A 4Y40A 4P0FA 1R1LI 2PEEA 3EOXA 3KCGI 4CAAA 4DTEA 4YIAA 4AFXA 4AU2A 1QMNA 1SEKA 4C41A 1DB2A 2B4XI 2QUGA 4AQHA 4GA7A 4P0OA 4DY7C 2XN3A 2ARQA 9APIA 3STOA 1BY7A 8APIA 3F1SA 5CDZA 1A7CA 4IF8A 1HLEA 4ZK0A 4ROAA 2PEFA 2VH4A 2XN7A 2V95A 2B5TI 1WZ9A 3DY0A 4IC0A 4ZK3A 2OAYA 1TB6I 2GD4C 2WXXA 1OVAA 1T1FA 1LK6I 1QLPA 3PB1I 1XQGA 3PZFA 1DZGI
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3NDD A;  2WXZ C;  5INW A;  1ATT A;  4G8R A;  4X30 A;  2CEO A;  1F0C A;  1SNG A;  1C8O A;  5CE0 A;  2WY1 A;  3NE4 A;  2WY0 C;  3T1P A;  1DVM A;  1ANT I;  1OPH A;  3LE2 A;  1E04 I;  1DZG L;  3CVM A;  3CWL A;  3DRU A;  3Q02 A;  3Q03 A;  2B4X L;  1ATU A;  1D5S A;  1JTI A;  1AZX I;  1HP7 A;  1JVQ I;  1JRR A;  3F5N A;  1EZX A;  2R9Y A;  3DLW A;  5HGC A;  5CDX A;  1K9O I;  2WXZ A;  1KCT A;  2ACH A;  2VDX A;  2ZV6 A;  3FGQ A;  2HI9 A;  1QMB A;  2H4P A;  3F02 A;  1YXA A;  2H4Q A;  1BR8 I;  1B3K A;  1JJO C;  4ROB A;  3B9F I;  4BB2 A;  4C49 A;  1XU8 A;  3DRM A;  1M93 B;  2RIW A;  1DZH I;  3UT3 A;  1LQ8 A;  1ATH A;  1E03 I;  2WXW A;  4DY0 A;  4EB1 I;  3ZHA A;  1C5G A;  1OYH I;  4R9I A;  5EI0 A;  2XN6 A;  7API A;  2XN5 A;  4AU4 A;  2ANT I;  2VDY A;  2DUT A;  1JMO A;  1XQJ A;  1DVN A;  2BEH I;  4EB1 L;  1IZ2 A;  1OO8 A;  3OZQ A;  3CWM A;  3NDA A;  4Y3K A;  4AJU A;  4AU3 B;  2ZNH A;  1IMV A;  1SR5 A;  1OVA C;  2ARR A;  1OC0 A;  3H5C A;  1OVA B;  1AS4 A;  3LW2 A;  4KDS A;  4RSQ A;  2BEH L;  4AJT A;  3NDF A;  2WXY C;  1UHG A;  5BRR I;  3R4L A;  2H4R A;  2HIJ I;  3VVJ A;  1JMJ A;  1E05 I;  1MTP A;  1NQ9 I;  9PAI A;  3CAA A;  4PYW A;  1PSI A;  3EVJ I;  2HIJ L;  4AU3 A;  1DZH L;  2D26 A;  2OL2 A;  2RIV A;  5C98 A;  5IO1 A;  1LJ5 A;  1OYH L;  4G8O A;  4RO9 A;  4Y40 A;  4P0F A;  1R1L I;  2PEE A;  3EOX A;  3KCG I;  4CAA A;  4DTE A;  4YIA A;  4AFX A;  4AU2 A;  1QMN A;  1SEK A;  4C41 A;  1DB2 A;  2B4X I;  2QUG A;  4AQH A;  4GA7 A;  4P0O A;  4DY7 C;  2XN3 A;  2ARQ A;  9API A;  3STO A;  1BY7 A;  8API A;  3F1S A;  5CDZ A;  1A7C A;  4IF8 A;  1HLE A;  4ZK0 A;  4ROA A;  2PEF A;  2VH4 A;  2XN7 A;  2V95 A;  2B5T I;  1WZ9 A;  3DY0 A;  4IC0 A;  4ZK3 A;  2OAY A;  1TB6 I;  2GD4 C;  2WXX A;  1OVA A;  1T1F A;  1LK6 I;  1QLP A;  3PB1 I;  1XQG A;  3PZF A;  1DZG I; 
#chains in the Genus database with same CATH topology
 3NDD A;  2WXZ C;  5INW A;  1ATT A;  4G8R A;  4X30 A;  2CEO A;  1F0C A;  1SNG A;  1C8O A;  5CE0 A;  2WY1 A;  3NE4 A;  2WY0 C;  3T1P A;  1DVM A;  1ANT I;  1OPH A;  3LE2 A;  1E04 I;  1DZG L;  3CVM A;  3CWL A;  3DRU A;  3Q02 A;  3Q03 A;  2B4X L;  1ATU A;  1D5S A;  1JTI A;  1AZX I;  1HP7 A;  1JVQ I;  1JRR A;  3F5N A;  1EZX A;  2R9Y A;  3DLW A;  5HGC A;  5CDX A;  1K9O I;  2WXZ A;  1KCT A;  2ACH A;  2VDX A;  2ZV6 A;  3FGQ A;  2HI9 A;  1QMB A;  2H4P A;  3F02 A;  1YXA A;  2H4Q A;  1BR8 I;  1B3K A;  1JJO C;  4ROB A;  3B9F I;  4BB2 A;  4C49 A;  1XU8 A;  3DRM A;  1M93 B;  2RIW A;  1DZH I;  3UT3 A;  1LQ8 A;  1ATH A;  1E03 I;  2WXW A;  4DY0 A;  4EB1 I;  3ZHA A;  1C5G A;  1OYH I;  4R9I A;  5EI0 A;  2XN6 A;  7API A;  2XN5 A;  4AU4 A;  2ANT I;  2VDY A;  2DUT A;  1JMO A;  1XQJ A;  1DVN A;  2BEH I;  4EB1 L;  1IZ2 A;  1OO8 A;  3OZQ A;  3CWM A;  3NDA A;  4Y3K A;  4AJU A;  4AU3 B;  2ZNH A;  1IMV A;  1SR5 A;  1OVA C;  2ARR A;  1OC0 A;  3H5C A;  1OVA B;  1AS4 A;  3LW2 A;  4KDS A;  4RSQ A;  2BEH L;  4AJT A;  3NDF A;  2WXY C;  1UHG A;  5BRR I;  3R4L A;  2H4R A;  2HIJ I;  3VVJ A;  1JMJ A;  1E05 I;  1MTP A;  1NQ9 I;  9PAI A;  3CAA A;  4PYW A;  1PSI A;  3EVJ I;  2HIJ L;  4AU3 A;  1DZH L;  2D26 A;  2OL2 A;  2RIV A;  5C98 A;  5IO1 A;  1LJ5 A;  1OYH L;  4G8O A;  4RO9 A;  4Y40 A;  4P0F A;  1R1L I;  2PEE A;  3EOX A;  3KCG I;  4CAA A;  4DTE A;  4YIA A;  4AFX A;  4AU2 A;  1QMN A;  1SEK A;  4C41 A;  1DB2 A;  2B4X I;  2QUG A;  4AQH A;  4GA7 A;  4P0O A;  4DY7 C;  2XN3 A;  2ARQ A;  9API A;  3STO A;  1BY7 A;  8API A;  3F1S A;  5CDZ A;  1A7C A;  4IF8 A;  1HLE A;  4ZK0 A;  4ROA A;  2PEF A;  2VH4 A;  2XN7 A;  2V95 A;  2B5T I;  1WZ9 A;  3DY0 A;  4IC0 A;  4ZK3 A;  2OAY A;  1TB6 I;  2GD4 C;  2WXX A;  1OVA A;  1T1F A;  1LK6 I;  1QLP A;  3PB1 I;  1XQG A;  3PZF A;  1DZG I; 
#chains in the Genus database with same CATH homology
 3NDD A;  2WXZ C;  5INW A;  1ATT A;  4G8R A;  4X30 A;  2CEO A;  1F0C A;  1SNG A;  1C8O A;  5CE0 A;  2WY1 A;  3NE4 A;  2WY0 C;  3T1P A;  1DVM A;  1ANT I;  1OPH A;  3LE2 A;  1E04 I;  1DZG L;  3CVM A;  3CWL A;  3DRU A;  3Q02 A;  3Q03 A;  2B4X L;  1ATU A;  1D5S A;  1JTI A;  1AZX I;  1HP7 A;  1JVQ I;  1JRR A;  3F5N A;  1EZX A;  2R9Y A;  3DLW A;  5HGC A;  5CDX A;  1K9O I;  2WXZ A;  1KCT A;  2ACH A;  2VDX A;  2ZV6 A;  3FGQ A;  2HI9 A;  1QMB A;  2H4P A;  3F02 A;  1YXA A;  2H4Q A;  1BR8 I;  1B3K A;  1JJO C;  4ROB A;  3B9F I;  4BB2 A;  4C49 A;  1XU8 A;  3DRM A;  1M93 B;  2RIW A;  1DZH I;  3UT3 A;  1LQ8 A;  1ATH A;  1E03 I;  2WXW A;  4DY0 A;  4EB1 I;  3ZHA A;  1C5G A;  1OYH I;  4R9I A;  5EI0 A;  2XN6 A;  7API A;  2XN5 A;  4AU4 A;  2ANT I;  2VDY A;  2DUT A;  1JMO A;  1XQJ A;  1DVN A;  2BEH I;  4EB1 L;  1IZ2 A;  1OO8 A;  3OZQ A;  3CWM A;  3NDA A;  4Y3K A;  4AJU A;  4AU3 B;  2ZNH A;  1IMV A;  1SR5 A;  1OVA C;  2ARR A;  1OC0 A;  3H5C A;  1OVA B;  1AS4 A;  3LW2 A;  4KDS A;  4RSQ A;  2BEH L;  4AJT A;  3NDF A;  2WXY C;  1UHG A;  5BRR I;  3R4L A;  2H4R A;  2HIJ I;  3VVJ A;  1JMJ A;  1E05 I;  1MTP A;  1NQ9 I;  9PAI A;  3CAA A;  4PYW A;  1PSI A;  3EVJ I;  2HIJ L;  4AU3 A;  1DZH L;  2D26 A;  2OL2 A;  2RIV A;  5C98 A;  5IO1 A;  1LJ5 A;  1OYH L;  4G8O A;  4RO9 A;  4Y40 A;  4P0F A;  1R1L I;  2PEE A;  3EOX A;  3KCG I;  4CAA A;  4DTE A;  4YIA A;  4AFX A;  4AU2 A;  1QMN A;  1SEK A;  4C41 A;  1DB2 A;  2B4X I;  2QUG A;  4AQH A;  4GA7 A;  4P0O A;  4DY7 C;  2XN3 A;  2ARQ A;  9API A;  3STO A;  1BY7 A;  8API A;  3F1S A;  5CDZ A;  1A7C A;  4IF8 A;  1HLE A;  4ZK0 A;  4ROA A;  2PEF A;  2VH4 A;  2XN7 A;  2V95 A;  2B5T I;  1WZ9 A;  3DY0 A;  4IC0 A;  4ZK3 A;  2OAY A;  1TB6 I;  2GD4 C;  2WXX A;  1OVA A;  1T1F A;  1LK6 I;  1QLP A;  3PB1 I;  1XQG A;  3PZF A;  1DZG I; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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