4ZK3A

Psoriasis pathogenesis - pso p27 constitute a compact structure forming large aggregates. low ph structure
Total Genus 112
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
112
sequence length
388
structure length
366
Chain Sequence
SLSEANTKFMFDLFQQFRKSKENNIFYSPISITSALGMVLLGAKDNTAQQIKKVLHFDQVTENVHHQFQKLLTEFNKSTDAYELKIANKLFGEKTYLFLQEYLDAIKKFYQTSVESVDFANAPEESRKKINSWVESQTNEKIKNLIPEGNIGSNTTLVLVNAIYFKGQWEKKFNKEDTKEEKFWPNKNTYKSIQMMRQYTSFHFASLEDVQAKVLEIPYKGKDLSMIVLLPNEIDGLQKLEEKLTAEKLMEWTSLQNMRETRVDLHLPRFKVEESYDLKDTLRTMGMVDIFNGDADLSGMTGSRGLVLSGVLHKAFVEVTEEGAEAAAATAVVGFNEEFHCNHPFLFFIRQNKTNSILFYGRFSSP
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Immune system
source organism Homo sapiens
publication title Psoriasis pathogenesis - Pso p27 constitutes a compact structure forming large aggregates.
pubmed doi rcsb
molecule keywords Serpin B3
total genus 112
structure length 366
sequence length 388
ec nomenclature
pdb deposition date 2015-04-29

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00079 Serpin Serpin (serine protease inhibitor)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.30.39.10 Mainly Beta Roll Alpha-1-antitrypsin; domain 1 Alpha-1-antitrypsin, domain 1 4zk3A02
3.30.497.10 Alpha Beta 2-Layer Sandwich Antithrombin; Chain I, domain 2 Antithrombin, subunit I, domain 2 4zk3A01
2ARQA 1PSIA 1OO8A 2ARRA 2VH4A 2WXZA 4CAAA 4G8OA 1ATTA 2WXZC 4R9IA 4AU3B 8APIA 5IO1A 1DVMA 1HLEA 1D5SA 2R9YA 3LW2A 4KDSA 3OZQA 3Q02A 1A7CA 4P0FA 4RSQA 1QLPA 4Y40A 1KCTA 5C98A 3F02A 3EOXA 1SEKA 4AU3A 2ZV6A 1ANTI 1HP7A 4AFXA 3NDDA 1OC0A 1JVQI 4DY0A 2XN5A 3ZHAA 1LK6I 2CEOA 3DRMA 2D26A 3DRUA 5CDZA 4DY7C 1IZ2A 3F1SA 3R4LA 2PEEA 3EVJI 2H4RA 3CVMA 3UT3A 1DB2A 1BY7A 4EB1I 4P0OA 4RO9A 4AQHA 1IMVA 1MTPA 1WZ9A 2VDXA 2ANTI 1JMOA 1T1FA 2WXWA 2XN3A 9PAIA 3FGQA 3CWMA 3B9FI 1OYHI 3H5CA 4ROBA 1SR5A 4C49A 3DLWA 1E03I 4GA7A 1E04I 1NQ9I 2DUTA 4EB1L 5CE0A 1DZGI 1K9OI 1LJ5A 1DVNA 1M93B 3LE2A 1QMNA 5EI0A 2H4QA 4ROAA 1DZHI 1JMJA 1QMBA 4AJUA 2BEHI 4AU2A 7APIA 1AS4A 1JJOC 3T1PA 1OYHL 4IC0A 2VDYA 1B3KA 1BR8I 2B4XI 4DTEA 3DY0A 5BRRI 1EZXA 1DZGL 4Y3KA 3VVJA 3CWLA 2HI9A 1LQ8A 2V95A 2ZNHA 4C41A 1C5GA 5HGCA 9APIA 5INWA 3CAAA 1OPHA 2BEHL 3NDFA 1ATUA 2QUGA 2WY1A 1JTIA 2B4XL 2OL2A 1E05I 4G8RA 2WXXA 1SNGA 1F0CA 3Q03A 3NE4A 4IF8A 3STOA 4YIAA 4AJTA 1YXAA 2RIWA 3PZFA 1XQJA 4ZK0A 5CDXA 1OVAB 2GD4C 2RIVA 2WXYC 2HIJI 2H4PA 1R1LI 2B5TI 3PB1I 1TB6I 4ZK3A 4BB2A 2XN6A 2ACHA 1XQGA 2WY0C 3KCGI 1ATHA 3NDAA 2PEFA 1XU8A 3F5NA 1AZXI 4AU4A 1DZHL 1OVAA 2HIJL 2OAYA 2XN7A 1OVAC 4PYWA 1C8OA 1JRRA 4X30A 1UHGA
chains in the Genus database with same CATH superfamily
2ARQA 1PSIA 1OO8A 2ARRA 2VH4A 2WXZA 4CAAA 4G8OA 1ATTA 2WXZC 4R9IA 4AU3B 8APIA 5IO1A 1DVMA 1HLEA 1D5SA 2R9YA 3LW2A 4KDSA 3OZQA 3Q02A 1A7CA 4P0FA 4RSQA 1QLPA 4Y40A 1KCTA 5C98A 3F02A 3EOXA 1SEKA 4AU3A 2ZV6A 1ANTI 1HP7A 4AFXA 3NDDA 1OC0A 1JVQI 4DY0A 2XN5A 3ZHAA 1LK6I 2CEOA 3DRMA 2D26A 3DRUA 5CDZA 4DY7C 1IZ2A 3F1SA 3R4LA 2PEEA 3EVJI 2H4RA 3CVMA 3UT3A 1DB2A 1BY7A 4EB1I 4P0OA 4RO9A 4AQHA 1IMVA 1MTPA 1WZ9A 2VDXA 2ANTI 1JMOA 1T1FA 2WXWA 2XN3A 9PAIA 3FGQA 3CWMA 3B9FI 1OYHI 3H5CA 4ROBA 1SR5A 4C49A 3DLWA 1E03I 4GA7A 1E04I 1NQ9I 2DUTA 4EB1L 5CE0A 1DZGI 1K9OI 1LJ5A 1DVNA 1M93B 3LE2A 1QMNA 5EI0A 2H4QA 4ROAA 1DZHI 1JMJA 1QMBA 4AJUA 2BEHI 4AU2A 7APIA 1AS4A 1JJOC 3T1PA 1OYHL 4IC0A 2VDYA 1B3KA 1BR8I 2B4XI 4DTEA 3DY0A 5BRRI 1EZXA 1DZGL 4Y3KA 3VVJA 3CWLA 2HI9A 1LQ8A 2V95A 2ZNHA 4C41A 1C5GA 5HGCA 9APIA 5INWA 3CAAA 1OPHA 2BEHL 3NDFA 1ATUA 2QUGA 2WY1A 1JTIA 2B4XL 2OL2A 1E05I 4G8RA 2WXXA 1SNGA 1F0CA 3Q03A 3NE4A 4IF8A 3STOA 4YIAA 4AJTA 1YXAA 2RIWA 3PZFA 1XQJA 4ZK0A 5CDXA 1OVAB 2GD4C 2RIVA 2WXYC 2HIJI 2H4PA 1R1LI 2B5TI 3PB1I 1TB6I 4ZK3A 4BB2A 2XN6A 2ACHA 1XQGA 2WY0C 3KCGI 1ATHA 3NDAA 2PEFA 1XU8A 3F5NA 1AZXI 4AU4A 1DZHL 1OVAA 2HIJL 2OAYA 2XN7A 1OVAC 4PYWA 1C8OA 1JRRA 4X30A 1UHGA
chains in the Genus database with same CATH topology
2ARQA 1PSIA 1OO8A 2ARRA 2VH4A 2WXZA 4CAAA 4G8OA 1ATTA 2WXZC 4R9IA 4AU3B 8APIA 5IO1A 1DVMA 1HLEA 1D5SA 2R9YA 3LW2A 4KDSA 3OZQA 3Q02A 1A7CA 4P0FA 4RSQA 1QLPA 4Y40A 1KCTA 5C98A 3F02A 3EOXA 1SEKA 4AU3A 2ZV6A 1ANTI 1HP7A 4AFXA 3NDDA 1OC0A 1JVQI 4DY0A 2XN5A 3ZHAA 1LK6I 2CEOA 3DRMA 2D26A 3DRUA 5CDZA 4DY7C 1IZ2A 3F1SA 3R4LA 2PEEA 3EVJI 2H4RA 3CVMA 3UT3A 1DB2A 1BY7A 4EB1I 4P0OA 4RO9A 4AQHA 1IMVA 1MTPA 1WZ9A 2VDXA 2ANTI 1JMOA 1T1FA 2WXWA 2XN3A 9PAIA 3FGQA 3CWMA 3B9FI 1OYHI 3H5CA 4ROBA 1SR5A 4C49A 3DLWA 1E03I 4GA7A 1E04I 1NQ9I 2DUTA 4EB1L 5CE0A 1DZGI 1K9OI 1LJ5A 1DVNA 1M93B 3LE2A 1QMNA 5EI0A 2H4QA 4ROAA 1DZHI 1JMJA 1QMBA 4AJUA 2BEHI 4AU2A 7APIA 1AS4A 1JJOC 3T1PA 1OYHL 4IC0A 2VDYA 1B3KA 1BR8I 2B4XI 4DTEA 3DY0A 5BRRI 1EZXA 1DZGL 4Y3KA 3VVJA 3CWLA 2HI9A 1LQ8A 2V95A 2ZNHA 4C41A 1C5GA 5HGCA 9APIA 5INWA 3CAAA 1OPHA 2BEHL 3NDFA 1ATUA 2QUGA 2WY1A 1JTIA 2B4XL 2OL2A 1E05I 4G8RA 2WXXA 1SNGA 1F0CA 3Q03A 3NE4A 4IF8A 3STOA 4YIAA 4AJTA 1YXAA 2RIWA 3PZFA 1XQJA 4ZK0A 5CDXA 1OVAB 2GD4C 2RIVA 2WXYC 2HIJI 2H4PA 1R1LI 2B5TI 3PB1I 1TB6I 4ZK3A 4BB2A 2XN6A 2ACHA 1XQGA 2WY0C 3KCGI 1ATHA 3NDAA 2PEFA 1XU8A 3F5NA 1AZXI 4AU4A 1DZHL 1OVAA 2HIJL 2OAYA 2XN7A 1OVAC 4PYWA 1C8OA 1JRRA 4X30A 1UHGA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2ARQ A;  1PSI A;  1OO8 A;  2ARR A;  2VH4 A;  2WXZ A;  4CAA A;  4G8O A;  1ATT A;  2WXZ C;  4R9I A;  4AU3 B;  8API A;  5IO1 A;  1DVM A;  1HLE A;  1D5S A;  2R9Y A;  3LW2 A;  4KDS A;  3OZQ A;  3Q02 A;  1A7C A;  4P0F A;  4RSQ A;  1QLP A;  4Y40 A;  1KCT A;  5C98 A;  3F02 A;  3EOX A;  1SEK A;  4AU3 A;  2ZV6 A;  1ANT I;  1HP7 A;  4AFX A;  3NDD A;  1OC0 A;  1JVQ I;  4DY0 A;  2XN5 A;  3ZHA A;  1LK6 I;  2CEO A;  3DRM A;  2D26 A;  3DRU A;  5CDZ A;  4DY7 C;  1IZ2 A;  3F1S A;  3R4L A;  2PEE A;  3EVJ I;  2H4R A;  3CVM A;  3UT3 A;  1DB2 A;  1BY7 A;  4EB1 I;  4P0O A;  4RO9 A;  4AQH A;  1IMV A;  1MTP A;  1WZ9 A;  2VDX A;  2ANT I;  1JMO A;  1T1F A;  2WXW A;  2XN3 A;  9PAI A;  3FGQ A;  3CWM A;  3B9F I;  1OYH I;  3H5C A;  4ROB A;  1SR5 A;  4C49 A;  3DLW A;  1E03 I;  4GA7 A;  1E04 I;  1NQ9 I;  2DUT A;  4EB1 L;  5CE0 A;  1DZG I;  1K9O I;  1LJ5 A;  1DVN A;  1M93 B;  3LE2 A;  1QMN A;  5EI0 A;  2H4Q A;  4ROA A;  1DZH I;  1JMJ A;  1QMB A;  4AJU A;  2BEH I;  4AU2 A;  7API A;  1AS4 A;  1JJO C;  3T1P A;  1OYH L;  4IC0 A;  2VDY A;  1B3K A;  1BR8 I;  2B4X I;  4DTE A;  3DY0 A;  5BRR I;  1EZX A;  1DZG L;  4Y3K A;  3VVJ A;  3CWL A;  2HI9 A;  1LQ8 A;  2V95 A;  2ZNH A;  4C41 A;  1C5G A;  5HGC A;  9API A;  5INW A;  3CAA A;  1OPH A;  2BEH L;  3NDF A;  1ATU A;  2QUG A;  2WY1 A;  1JTI A;  2B4X L;  2OL2 A;  1E05 I;  4G8R A;  2WXX A;  1SNG A;  1F0C A;  3Q03 A;  3NE4 A;  4IF8 A;  3STO A;  4YIA A;  4AJT A;  1YXA A;  2RIW A;  3PZF A;  1XQJ A;  4ZK0 A;  5CDX A;  1OVA B;  2GD4 C;  2RIV A;  2WXY C;  2HIJ I;  2H4P A;  1R1L I;  2B5T I;  3PB1 I;  1TB6 I;  4ZK3 A;  4BB2 A;  2XN6 A;  2ACH A;  1XQG A;  2WY0 C;  3KCG I;  1ATH A;  3NDA A;  2PEF A;  1XU8 A;  3F5N A;  1AZX I;  4AU4 A;  1DZH L;  1OVA A;  2HIJ L;  2OAY A;  2XN7 A;  1OVA C;  4PYW A;  1C8O A;  1JRR A;  4X30 A;  1UHG A; 
#chains in the Genus database with same CATH topology
 2ARQ A;  1PSI A;  1OO8 A;  2ARR A;  2VH4 A;  2WXZ A;  4CAA A;  4G8O A;  1ATT A;  2WXZ C;  4R9I A;  4AU3 B;  8API A;  5IO1 A;  1DVM A;  1HLE A;  1D5S A;  2R9Y A;  3LW2 A;  4KDS A;  3OZQ A;  3Q02 A;  1A7C A;  4P0F A;  4RSQ A;  1QLP A;  4Y40 A;  1KCT A;  5C98 A;  3F02 A;  3EOX A;  1SEK A;  4AU3 A;  2ZV6 A;  1ANT I;  1HP7 A;  4AFX A;  3NDD A;  1OC0 A;  1JVQ I;  4DY0 A;  2XN5 A;  3ZHA A;  1LK6 I;  2CEO A;  3DRM A;  2D26 A;  3DRU A;  5CDZ A;  4DY7 C;  1IZ2 A;  3F1S A;  3R4L A;  2PEE A;  3EVJ I;  2H4R A;  3CVM A;  3UT3 A;  1DB2 A;  1BY7 A;  4EB1 I;  4P0O A;  4RO9 A;  4AQH A;  1IMV A;  1MTP A;  1WZ9 A;  2VDX A;  2ANT I;  1JMO A;  1T1F A;  2WXW A;  2XN3 A;  9PAI A;  3FGQ A;  3CWM A;  3B9F I;  1OYH I;  3H5C A;  4ROB A;  1SR5 A;  4C49 A;  3DLW A;  1E03 I;  4GA7 A;  1E04 I;  1NQ9 I;  2DUT A;  4EB1 L;  5CE0 A;  1DZG I;  1K9O I;  1LJ5 A;  1DVN A;  1M93 B;  3LE2 A;  1QMN A;  5EI0 A;  2H4Q A;  4ROA A;  1DZH I;  1JMJ A;  1QMB A;  4AJU A;  2BEH I;  4AU2 A;  7API A;  1AS4 A;  1JJO C;  3T1P A;  1OYH L;  4IC0 A;  2VDY A;  1B3K A;  1BR8 I;  2B4X I;  4DTE A;  3DY0 A;  5BRR I;  1EZX A;  1DZG L;  4Y3K A;  3VVJ A;  3CWL A;  2HI9 A;  1LQ8 A;  2V95 A;  2ZNH A;  4C41 A;  1C5G A;  5HGC A;  9API A;  5INW A;  3CAA A;  1OPH A;  2BEH L;  3NDF A;  1ATU A;  2QUG A;  2WY1 A;  1JTI A;  2B4X L;  2OL2 A;  1E05 I;  4G8R A;  2WXX A;  1SNG A;  1F0C A;  3Q03 A;  3NE4 A;  4IF8 A;  3STO A;  4YIA A;  4AJT A;  1YXA A;  2RIW A;  3PZF A;  1XQJ A;  4ZK0 A;  5CDX A;  1OVA B;  2GD4 C;  2RIV A;  2WXY C;  2HIJ I;  2H4P A;  1R1L I;  2B5T I;  3PB1 I;  1TB6 I;  4ZK3 A;  4BB2 A;  2XN6 A;  2ACH A;  1XQG A;  2WY0 C;  3KCG I;  1ATH A;  3NDA A;  2PEF A;  1XU8 A;  3F5N A;  1AZX I;  4AU4 A;  1DZH L;  1OVA A;  2HIJ L;  2OAY A;  2XN7 A;  1OVA C;  4PYW A;  1C8O A;  1JRR A;  4X30 A;  1UHG A; 
#chains in the Genus database with same CATH homology
 2ARQ A;  1PSI A;  1OO8 A;  2ARR A;  2VH4 A;  2WXZ A;  4CAA A;  4G8O A;  1ATT A;  2WXZ C;  4R9I A;  4AU3 B;  8API A;  5IO1 A;  1DVM A;  1HLE A;  1D5S A;  2R9Y A;  3LW2 A;  4KDS A;  3OZQ A;  3Q02 A;  1A7C A;  4P0F A;  4RSQ A;  1QLP A;  4Y40 A;  1KCT A;  5C98 A;  3F02 A;  3EOX A;  1SEK A;  4AU3 A;  2ZV6 A;  1ANT I;  1HP7 A;  4AFX A;  3NDD A;  1OC0 A;  1JVQ I;  4DY0 A;  2XN5 A;  3ZHA A;  1LK6 I;  2CEO A;  3DRM A;  2D26 A;  3DRU A;  5CDZ A;  4DY7 C;  1IZ2 A;  3F1S A;  3R4L A;  2PEE A;  3EVJ I;  2H4R A;  3CVM A;  3UT3 A;  1DB2 A;  1BY7 A;  4EB1 I;  4P0O A;  4RO9 A;  4AQH A;  1IMV A;  1MTP A;  1WZ9 A;  2VDX A;  2ANT I;  1JMO A;  1T1F A;  2WXW A;  2XN3 A;  9PAI A;  3FGQ A;  3CWM A;  3B9F I;  1OYH I;  3H5C A;  4ROB A;  1SR5 A;  4C49 A;  3DLW A;  1E03 I;  4GA7 A;  1E04 I;  1NQ9 I;  2DUT A;  4EB1 L;  5CE0 A;  1DZG I;  1K9O I;  1LJ5 A;  1DVN A;  1M93 B;  3LE2 A;  1QMN A;  5EI0 A;  2H4Q A;  4ROA A;  1DZH I;  1JMJ A;  1QMB A;  4AJU A;  2BEH I;  4AU2 A;  7API A;  1AS4 A;  1JJO C;  3T1P A;  1OYH L;  4IC0 A;  2VDY A;  1B3K A;  1BR8 I;  2B4X I;  4DTE A;  3DY0 A;  5BRR I;  1EZX A;  1DZG L;  4Y3K A;  3VVJ A;  3CWL A;  2HI9 A;  1LQ8 A;  2V95 A;  2ZNH A;  4C41 A;  1C5G A;  5HGC A;  9API A;  5INW A;  3CAA A;  1OPH A;  2BEH L;  3NDF A;  1ATU A;  2QUG A;  2WY1 A;  1JTI A;  2B4X L;  2OL2 A;  1E05 I;  4G8R A;  2WXX A;  1SNG A;  1F0C A;  3Q03 A;  3NE4 A;  4IF8 A;  3STO A;  4YIA A;  4AJT A;  1YXA A;  2RIW A;  3PZF A;  1XQJ A;  4ZK0 A;  5CDX A;  1OVA B;  2GD4 C;  2RIV A;  2WXY C;  2HIJ I;  2H4P A;  1R1L I;  2B5T I;  3PB1 I;  1TB6 I;  4ZK3 A;  4BB2 A;  2XN6 A;  2ACH A;  1XQG A;  2WY0 C;  3KCG I;  1ATH A;  3NDA A;  2PEF A;  1XU8 A;  3F5N A;  1AZX I;  4AU4 A;  1DZH L;  1OVA A;  2HIJ L;  2OAY A;  2XN7 A;  1OVA C;  4PYW A;  1C8O A;  1JRR A;  4X30 A;  1UHG A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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