4AU2A

Crystal structure of a hsp47-collagen complex
Total Genus 125
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
125
sequence length
380
structure length
367
Chain Sequence
MLSPKAATLAERSAGLAFSLYQAMAKDQAVENILLSPVVVASSLGLVSLGGKATTASQAKAVLSAEQLRDEEVHAGLGELLRSLSNVTWKLGSRLYGPSSVSFAEDFVRSSKQHYNCEHSKINFRDKRSALQSINEWAAQTTDGKLPEVTKDVERTDGALLVNAMFFKPHWDEKFHHKMVDNRGFMVTRSYTVGVTMMHRTGLYNYYDDEKEKLQIVEMPLAHKLSSLIILMPHHVEPLERLEKLLTKEQLKIWMGKMQKKAVAISLPKGVVEVTHDLQKHLAGLGLTEAIDKNKADLSRMSGKKDLYLASVFHATAFEWDTEGNPFDLRSPKLFYADHPFIFLVRDTQSGSLLFIGRLVRPKGDKM
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Chaperone/peptide
molecule keywords SERPIN PEPTIDASE INHIBITOR, CLADE H (HEAT SHOCK PROTEIN 47),
publication title Molecular Basis for the Action of the Collagen-Specific Chaperone Hsp47/Serpinh1 and its Structure-Specific Client Recognition.
pubmed doi rcsb
source organism Canis lupus familiaris
total genus 125
structure length 367
sequence length 380
chains with identical sequence B, C, D
ec nomenclature
pdb deposition date 2012-05-13

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00079 Serpin Serpin (serine protease inhibitor)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.30.39.10 Mainly Beta Roll Alpha-1-antitrypsin; domain 1 Alpha-1-antitrypsin, domain 1 4au2A02
3.30.497.10 Alpha Beta 2-Layer Sandwich Antithrombin; Chain I, domain 2 Antithrombin, subunit I, domain 2 4au2A01
2XN3A 3CWLA 4AQHA 4CAAA 2H4QA 3CAAA 4AU3B 5CE0A 1K9OI 1B3KA 2CEOA 9APIA 5EI0A 1EZXA 2XN7A 3DLWA 1SR5A 3OZQA 3F1SA 3LW2A 1JMJA 4Y3KA 1ATUA 1OYHL 4P0FA 4IC0A 2PEEA 4GA7A 1OC0A 1D5SA 2RIVA 2VDYA 2WXZC 3UT3A 3PZFA 1R1LI 3DRMA 1YXAA 1DZGL 4DTEA 2QUGA 4R9IA 2RIWA 3ZHAA 1XQJA 1ATHA 3EVJI 1SNGA 3NDFA 3Q02A 2V95A 4AU3A 3LE2A 2DUTA 2ZV6A 4KDSA 5BRRI 4RSQA 2WY0C 3DRUA 4C41A 1JMOA 4ZK3A 2GD4C 1AS4A 1SEKA 1XQGA 1JTIA 5CDZA 1PSIA 2BEHL 1ATTA 3CVMA 1LQ8A 3NE4A 2B4XI 1LJ5A 4ZK0A 2PEFA 1NQ9I 2WXXA 3DY0A 5INWA 2H4RA 1XU8A 2R9YA 1JRRA 1HP7A 1DZHL 1QLPA 2ACHA 1WZ9A 1HLEA 1BR8I 4G8OA 3F02A 2HIJL 1OVAA 4DY7C 4AJTA 3KCGI 1LK6I 1TB6I 1MTPA 4EB1I 1OVAB 3PB1I 1C5GA 3NDAA 3T1PA 1OO8A 3R4LA 1DB2A 1JVQI 3STOA 3EOXA 5HGCA 2OAYA 4Y40A 4RO9A 1IMVA 3CWMA 1F0CA 5C98A 4PYWA 2WXWA 2ARQA 4AU2A 3VVJA 1JJOC 4DY0A 1E05I 2XN5A 4BB2A 4P0OA 7APIA 1QMBA 3F5NA 5IO1A 4AJUA 1DVMA 2B4XL 4IF8A 5CDXA 2ARRA 8APIA 1OVAC 1M93B 2H4PA 3FGQA 2B5TI 3B9FI 2ZNHA 3H5CA 2XN6A 4AU4A 4X30A 9PAIA 4EB1L 1KCTA 1A7CA 4YIAA 3NDDA 4ROAA 2BEHI 1BY7A 3Q03A 1C8OA 1OYHI 4AFXA 2HI9A 2D26A 1ANTI 2WXYC 1DVNA 1T1FA 1AZXI 4ROBA 1E03I 1DZHI 1QMNA 1E04I 1IZ2A 1DZGI 4G8RA 4C49A 2WXZA 2HIJI 1OPHA 2OL2A 1UHGA 2VDXA 2VH4A 2WY1A 2ANTI
chains in the Genus database with same CATH superfamily
2XN3A 3CWLA 4AQHA 4CAAA 2H4QA 3CAAA 4AU3B 5CE0A 1K9OI 1B3KA 2CEOA 9APIA 5EI0A 1EZXA 2XN7A 3DLWA 1SR5A 3OZQA 3F1SA 3LW2A 1JMJA 4Y3KA 1ATUA 1OYHL 4P0FA 4IC0A 2PEEA 4GA7A 1OC0A 1D5SA 2RIVA 2VDYA 2WXZC 3UT3A 3PZFA 1R1LI 3DRMA 1YXAA 1DZGL 4DTEA 2QUGA 4R9IA 2RIWA 3ZHAA 1XQJA 1ATHA 3EVJI 1SNGA 3NDFA 3Q02A 2V95A 4AU3A 3LE2A 2DUTA 2ZV6A 4KDSA 5BRRI 4RSQA 2WY0C 3DRUA 4C41A 1JMOA 4ZK3A 2GD4C 1AS4A 1SEKA 1XQGA 1JTIA 5CDZA 1PSIA 2BEHL 1ATTA 3CVMA 1LQ8A 3NE4A 2B4XI 1LJ5A 4ZK0A 2PEFA 1NQ9I 2WXXA 3DY0A 5INWA 2H4RA 1XU8A 2R9YA 1JRRA 1HP7A 1DZHL 1QLPA 2ACHA 1WZ9A 1HLEA 1BR8I 4G8OA 3F02A 2HIJL 1OVAA 4DY7C 4AJTA 3KCGI 1LK6I 1TB6I 1MTPA 4EB1I 1OVAB 3PB1I 1C5GA 3NDAA 3T1PA 1OO8A 3R4LA 1DB2A 1JVQI 3STOA 3EOXA 5HGCA 2OAYA 4Y40A 4RO9A 1IMVA 3CWMA 1F0CA 5C98A 4PYWA 2WXWA 2ARQA 4AU2A 3VVJA 1JJOC 4DY0A 1E05I 2XN5A 4BB2A 4P0OA 7APIA 1QMBA 3F5NA 5IO1A 4AJUA 1DVMA 2B4XL 4IF8A 5CDXA 2ARRA 8APIA 1OVAC 1M93B 2H4PA 3FGQA 2B5TI 3B9FI 2ZNHA 3H5CA 2XN6A 4AU4A 4X30A 9PAIA 4EB1L 1KCTA 1A7CA 4YIAA 3NDDA 4ROAA 2BEHI 1BY7A 3Q03A 1C8OA 1OYHI 4AFXA 2HI9A 2D26A 1ANTI 2WXYC 1DVNA 1T1FA 1AZXI 4ROBA 1E03I 1DZHI 1QMNA 1E04I 1IZ2A 1DZGI 4G8RA 4C49A 2WXZA 2HIJI 1OPHA 2OL2A 1UHGA 2VDXA 2VH4A 2WY1A 2ANTI
chains in the Genus database with same CATH topology
2XN3A 3CWLA 4AQHA 4CAAA 2H4QA 3CAAA 4AU3B 5CE0A 1K9OI 1B3KA 2CEOA 9APIA 5EI0A 1EZXA 2XN7A 3DLWA 1SR5A 3OZQA 3F1SA 3LW2A 1JMJA 4Y3KA 1ATUA 1OYHL 4P0FA 4IC0A 2PEEA 4GA7A 1OC0A 1D5SA 2RIVA 2VDYA 2WXZC 3UT3A 3PZFA 1R1LI 3DRMA 1YXAA 1DZGL 4DTEA 2QUGA 4R9IA 2RIWA 3ZHAA 1XQJA 1ATHA 3EVJI 1SNGA 3NDFA 3Q02A 2V95A 4AU3A 3LE2A 2DUTA 2ZV6A 4KDSA 5BRRI 4RSQA 2WY0C 3DRUA 4C41A 1JMOA 4ZK3A 2GD4C 1AS4A 1SEKA 1XQGA 1JTIA 5CDZA 1PSIA 2BEHL 1ATTA 3CVMA 1LQ8A 3NE4A 2B4XI 1LJ5A 4ZK0A 2PEFA 1NQ9I 2WXXA 3DY0A 5INWA 2H4RA 1XU8A 2R9YA 1JRRA 1HP7A 1DZHL 1QLPA 2ACHA 1WZ9A 1HLEA 1BR8I 4G8OA 3F02A 2HIJL 1OVAA 4DY7C 4AJTA 3KCGI 1LK6I 1TB6I 1MTPA 4EB1I 1OVAB 3PB1I 1C5GA 3NDAA 3T1PA 1OO8A 3R4LA 1DB2A 1JVQI 3STOA 3EOXA 5HGCA 2OAYA 4Y40A 4RO9A 1IMVA 3CWMA 1F0CA 5C98A 4PYWA 2WXWA 2ARQA 4AU2A 3VVJA 1JJOC 4DY0A 1E05I 2XN5A 4BB2A 4P0OA 7APIA 1QMBA 3F5NA 5IO1A 4AJUA 1DVMA 2B4XL 4IF8A 5CDXA 2ARRA 8APIA 1OVAC 1M93B 2H4PA 3FGQA 2B5TI 3B9FI 2ZNHA 3H5CA 2XN6A 4AU4A 4X30A 9PAIA 4EB1L 1KCTA 1A7CA 4YIAA 3NDDA 4ROAA 2BEHI 1BY7A 3Q03A 1C8OA 1OYHI 4AFXA 2HI9A 2D26A 1ANTI 2WXYC 1DVNA 1T1FA 1AZXI 4ROBA 1E03I 1DZHI 1QMNA 1E04I 1IZ2A 1DZGI 4G8RA 4C49A 2WXZA 2HIJI 1OPHA 2OL2A 1UHGA 2VDXA 2VH4A 2WY1A 2ANTI
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2XN3 A;  3CWL A;  4AQH A;  4CAA A;  2H4Q A;  3CAA A;  4AU3 B;  5CE0 A;  1K9O I;  1B3K A;  2CEO A;  9API A;  5EI0 A;  1EZX A;  2XN7 A;  3DLW A;  1SR5 A;  3OZQ A;  3F1S A;  3LW2 A;  1JMJ A;  4Y3K A;  1ATU A;  1OYH L;  4P0F A;  4IC0 A;  2PEE A;  4GA7 A;  1OC0 A;  1D5S A;  2RIV A;  2VDY A;  2WXZ C;  3UT3 A;  3PZF A;  1R1L I;  3DRM A;  1YXA A;  1DZG L;  4DTE A;  2QUG A;  4R9I A;  2RIW A;  3ZHA A;  1XQJ A;  1ATH A;  3EVJ I;  1SNG A;  3NDF A;  3Q02 A;  2V95 A;  4AU3 A;  3LE2 A;  2DUT A;  2ZV6 A;  4KDS A;  5BRR I;  4RSQ A;  2WY0 C;  3DRU A;  4C41 A;  1JMO A;  4ZK3 A;  2GD4 C;  1AS4 A;  1SEK A;  1XQG A;  1JTI A;  5CDZ A;  1PSI A;  2BEH L;  1ATT A;  3CVM A;  1LQ8 A;  3NE4 A;  2B4X I;  1LJ5 A;  4ZK0 A;  2PEF A;  1NQ9 I;  2WXX A;  3DY0 A;  5INW A;  2H4R A;  1XU8 A;  2R9Y A;  1JRR A;  1HP7 A;  1DZH L;  1QLP A;  2ACH A;  1WZ9 A;  1HLE A;  1BR8 I;  4G8O A;  3F02 A;  2HIJ L;  1OVA A;  4DY7 C;  4AJT A;  3KCG I;  1LK6 I;  1TB6 I;  1MTP A;  4EB1 I;  1OVA B;  3PB1 I;  1C5G A;  3NDA A;  3T1P A;  1OO8 A;  3R4L A;  1DB2 A;  1JVQ I;  3STO A;  3EOX A;  5HGC A;  2OAY A;  4Y40 A;  4RO9 A;  1IMV A;  3CWM A;  1F0C A;  5C98 A;  4PYW A;  2WXW A;  2ARQ A;  4AU2 A;  3VVJ A;  1JJO C;  4DY0 A;  1E05 I;  2XN5 A;  4BB2 A;  4P0O A;  7API A;  1QMB A;  3F5N A;  5IO1 A;  4AJU A;  1DVM A;  2B4X L;  4IF8 A;  5CDX A;  2ARR A;  8API A;  1OVA C;  1M93 B;  2H4P A;  3FGQ A;  2B5T I;  3B9F I;  2ZNH A;  3H5C A;  2XN6 A;  4AU4 A;  4X30 A;  9PAI A;  4EB1 L;  1KCT A;  1A7C A;  4YIA A;  3NDD A;  4ROA A;  2BEH I;  1BY7 A;  3Q03 A;  1C8O A;  1OYH I;  4AFX A;  2HI9 A;  2D26 A;  1ANT I;  2WXY C;  1DVN A;  1T1F A;  1AZX I;  4ROB A;  1E03 I;  1DZH I;  1QMN A;  1E04 I;  1IZ2 A;  1DZG I;  4G8R A;  4C49 A;  2WXZ A;  2HIJ I;  1OPH A;  2OL2 A;  1UHG A;  2VDX A;  2VH4 A;  2WY1 A;  2ANT I; 
#chains in the Genus database with same CATH topology
 2XN3 A;  3CWL A;  4AQH A;  4CAA A;  2H4Q A;  3CAA A;  4AU3 B;  5CE0 A;  1K9O I;  1B3K A;  2CEO A;  9API A;  5EI0 A;  1EZX A;  2XN7 A;  3DLW A;  1SR5 A;  3OZQ A;  3F1S A;  3LW2 A;  1JMJ A;  4Y3K A;  1ATU A;  1OYH L;  4P0F A;  4IC0 A;  2PEE A;  4GA7 A;  1OC0 A;  1D5S A;  2RIV A;  2VDY A;  2WXZ C;  3UT3 A;  3PZF A;  1R1L I;  3DRM A;  1YXA A;  1DZG L;  4DTE A;  2QUG A;  4R9I A;  2RIW A;  3ZHA A;  1XQJ A;  1ATH A;  3EVJ I;  1SNG A;  3NDF A;  3Q02 A;  2V95 A;  4AU3 A;  3LE2 A;  2DUT A;  2ZV6 A;  4KDS A;  5BRR I;  4RSQ A;  2WY0 C;  3DRU A;  4C41 A;  1JMO A;  4ZK3 A;  2GD4 C;  1AS4 A;  1SEK A;  1XQG A;  1JTI A;  5CDZ A;  1PSI A;  2BEH L;  1ATT A;  3CVM A;  1LQ8 A;  3NE4 A;  2B4X I;  1LJ5 A;  4ZK0 A;  2PEF A;  1NQ9 I;  2WXX A;  3DY0 A;  5INW A;  2H4R A;  1XU8 A;  2R9Y A;  1JRR A;  1HP7 A;  1DZH L;  1QLP A;  2ACH A;  1WZ9 A;  1HLE A;  1BR8 I;  4G8O A;  3F02 A;  2HIJ L;  1OVA A;  4DY7 C;  4AJT A;  3KCG I;  1LK6 I;  1TB6 I;  1MTP A;  4EB1 I;  1OVA B;  3PB1 I;  1C5G A;  3NDA A;  3T1P A;  1OO8 A;  3R4L A;  1DB2 A;  1JVQ I;  3STO A;  3EOX A;  5HGC A;  2OAY A;  4Y40 A;  4RO9 A;  1IMV A;  3CWM A;  1F0C A;  5C98 A;  4PYW A;  2WXW A;  2ARQ A;  4AU2 A;  3VVJ A;  1JJO C;  4DY0 A;  1E05 I;  2XN5 A;  4BB2 A;  4P0O A;  7API A;  1QMB A;  3F5N A;  5IO1 A;  4AJU A;  1DVM A;  2B4X L;  4IF8 A;  5CDX A;  2ARR A;  8API A;  1OVA C;  1M93 B;  2H4P A;  3FGQ A;  2B5T I;  3B9F I;  2ZNH A;  3H5C A;  2XN6 A;  4AU4 A;  4X30 A;  9PAI A;  4EB1 L;  1KCT A;  1A7C A;  4YIA A;  3NDD A;  4ROA A;  2BEH I;  1BY7 A;  3Q03 A;  1C8O A;  1OYH I;  4AFX A;  2HI9 A;  2D26 A;  1ANT I;  2WXY C;  1DVN A;  1T1F A;  1AZX I;  4ROB A;  1E03 I;  1DZH I;  1QMN A;  1E04 I;  1IZ2 A;  1DZG I;  4G8R A;  4C49 A;  2WXZ A;  2HIJ I;  1OPH A;  2OL2 A;  1UHG A;  2VDX A;  2VH4 A;  2WY1 A;  2ANT I; 
#chains in the Genus database with same CATH homology
 2XN3 A;  3CWL A;  4AQH A;  4CAA A;  2H4Q A;  3CAA A;  4AU3 B;  5CE0 A;  1K9O I;  1B3K A;  2CEO A;  9API A;  5EI0 A;  1EZX A;  2XN7 A;  3DLW A;  1SR5 A;  3OZQ A;  3F1S A;  3LW2 A;  1JMJ A;  4Y3K A;  1ATU A;  1OYH L;  4P0F A;  4IC0 A;  2PEE A;  4GA7 A;  1OC0 A;  1D5S A;  2RIV A;  2VDY A;  2WXZ C;  3UT3 A;  3PZF A;  1R1L I;  3DRM A;  1YXA A;  1DZG L;  4DTE A;  2QUG A;  4R9I A;  2RIW A;  3ZHA A;  1XQJ A;  1ATH A;  3EVJ I;  1SNG A;  3NDF A;  3Q02 A;  2V95 A;  4AU3 A;  3LE2 A;  2DUT A;  2ZV6 A;  4KDS A;  5BRR I;  4RSQ A;  2WY0 C;  3DRU A;  4C41 A;  1JMO A;  4ZK3 A;  2GD4 C;  1AS4 A;  1SEK A;  1XQG A;  1JTI A;  5CDZ A;  1PSI A;  2BEH L;  1ATT A;  3CVM A;  1LQ8 A;  3NE4 A;  2B4X I;  1LJ5 A;  4ZK0 A;  2PEF A;  1NQ9 I;  2WXX A;  3DY0 A;  5INW A;  2H4R A;  1XU8 A;  2R9Y A;  1JRR A;  1HP7 A;  1DZH L;  1QLP A;  2ACH A;  1WZ9 A;  1HLE A;  1BR8 I;  4G8O A;  3F02 A;  2HIJ L;  1OVA A;  4DY7 C;  4AJT A;  3KCG I;  1LK6 I;  1TB6 I;  1MTP A;  4EB1 I;  1OVA B;  3PB1 I;  1C5G A;  3NDA A;  3T1P A;  1OO8 A;  3R4L A;  1DB2 A;  1JVQ I;  3STO A;  3EOX A;  5HGC A;  2OAY A;  4Y40 A;  4RO9 A;  1IMV A;  3CWM A;  1F0C A;  5C98 A;  4PYW A;  2WXW A;  2ARQ A;  4AU2 A;  3VVJ A;  1JJO C;  4DY0 A;  1E05 I;  2XN5 A;  4BB2 A;  4P0O A;  7API A;  1QMB A;  3F5N A;  5IO1 A;  4AJU A;  1DVM A;  2B4X L;  4IF8 A;  5CDX A;  2ARR A;  8API A;  1OVA C;  1M93 B;  2H4P A;  3FGQ A;  2B5T I;  3B9F I;  2ZNH A;  3H5C A;  2XN6 A;  4AU4 A;  4X30 A;  9PAI A;  4EB1 L;  1KCT A;  1A7C A;  4YIA A;  3NDD A;  4ROA A;  2BEH I;  1BY7 A;  3Q03 A;  1C8O A;  1OYH I;  4AFX A;  2HI9 A;  2D26 A;  1ANT I;  2WXY C;  1DVN A;  1T1F A;  1AZX I;  4ROB A;  1E03 I;  1DZH I;  1QMN A;  1E04 I;  1IZ2 A;  1DZG I;  4G8R A;  4C49 A;  2WXZ A;  2HIJ I;  1OPH A;  2OL2 A;  1UHG A;  2VDX A;  2VH4 A;  2WY1 A;  2ANT I; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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