4AU3A

Crystal structure of a hsp47-collagen complex
Total Genus 112
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
112
sequence length
380
structure length
367
Chain Sequence
MLSPKAATLAERSAGLAFSLYQAMAKDQAVENILLSPVVVASSLGLVSLGGKATTASQAKAVLSAEQLRDEEVHAGLGELLRSLSNVTWKLGSRLYGPSSVSFAEDFVRSSKQHYNCEHSKINFRDKRSALQSINEWAAQTTDGKLPEVTKDVERTDGALLVNAMFFKPHWDEKFHHKMVDNRGFMVTRSYTVGVTMMHRTGLYNYYDDEKEKLQIVEMPLAHKLSSLIILMPHHVEPLERLEKLLTKEQLKIWMGKMQKKAVAISLPKGVVEVTHDLQKHLAGLGLTEAIDKNKADLSRMSGKKDLYLASVFHATAFEWDTEGNPFDLRSPKLFYADHPFIFLVRDTQSGSLLFIGRLVRPKGDKM
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Chaperone/peptide
molecule keywords SERPIN PEPTIDASE INHIBITOR, CLADE H (HEAT SHOCK PROTEIN 47 )
publication title Molecular Basis for the Action of the Collagen-Specific Chaperone Hsp47/Serpinh1 and its Structure-Specific Client Recognition.
pubmed doi rcsb
source organism Canis lupus familiaris
total genus 112
structure length 367
sequence length 380
chains with identical sequence C, D
ec nomenclature
pdb deposition date 2012-05-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00079 Serpin Serpin (serine protease inhibitor)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.30.39.10 Mainly Beta Roll Alpha-1-antitrypsin; domain 1 Alpha-1-antitrypsin, domain 1 4au3A02
3.30.497.10 Alpha Beta 2-Layer Sandwich Antithrombin; Chain I, domain 2 Antithrombin, subunit I, domain 2 4au3A01
4X30A 1OVAC 3NDFA 4KDSA 3ZHAA 1AS4A 2ARQA 1M93B 5CDZA 7APIA 3DY0A 1ANTI 1D5SA 1OVAA 3KCGI 1DVMA 4YIAA 2HIJL 4AFXA 2RIWA 2WXXA 2R9YA 1LQ8A 4P0OA 1QLPA 4Y3KA 1K9OI 2QUGA 3F1SA 4GA7A 2PEFA 2ARRA 1BR8I 1R1LI 1JMJA 2B5TI 1ATHA 3DRMA 4DY0A 1PSIA 2WY1A 2CEOA 2XN5A 3CVMA 3R4LA 2XN3A 1E05I 1MTPA 1WZ9A 4IC0A 1XQJA 1BY7A 2B4XI 3Q03A 4BB2A 5BRRI 4EB1I 1XU8A 5CE0A 1EZXA 2ZV6A 3EOXA 1A7CA 1SNGA 2RIVA 1JMOA 4G8RA 1DZHI 4CAAA 2ZNHA 8APIA 4AU3B 2XN7A 3H5CA 2B4XL 2VDXA 4DY7C 4AU4A 1UHGA 1QMBA 4EB1L 1F0CA 3DLWA 2V95A 4DTEA 4AJTA 1OC0A 1OYHI 2HI9A 2HIJI 4IF8A 4C41A 1DZHL 2GD4C 3UT3A 2DUTA 4RSQA 2H4RA 4AU2A 3NDDA 1B3KA 2VDYA 2BEHI 1KCTA 1DZGI 1OO8A 1T1FA 1JRRA 2XN6A 3CWMA 1ATUA 3DRUA 1JTIA 5C98A 3EVJI 1OYHL 4ZK3A 4C49A 1HP7A 2OAYA 3F02A 4AU3A 4AQHA 1DVNA 4AJUA 1DB2A 2H4PA 2OL2A 3CAAA 1JVQI 2H4QA 1ATTA 4ROBA 3NE4A 3NDAA 1AZXI 4G8OA 2PEEA 1JJOC 4ZK0A 3Q02A 3LW2A 2ACHA 2WXWA 2WXZC 2BEHL 5CDXA 1DZGL 3B9FI 1E04I 5INWA 2ANTI 1IMVA 4P0FA 4R9IA 9PAIA 3FGQA 3PB1I 3F5NA 9APIA 1E03I 1LJ5A 1XQGA 2VH4A 2WXZA 4PYWA 1SR5A 3STOA 4ROAA 3OZQA 1QMNA 1NQ9I 2WXYC 3LE2A 5IO1A 3VVJA 2WY0C 1OVAB 1IZ2A 1HLEA 3T1PA 1OPHA 1YXAA 5HGCA 3PZFA 4RO9A 1LK6I 1TB6I 1SEKA 4Y40A 2D26A 3CWLA 1C8OA 5EI0A 1C5GA
chains in the Genus database with same CATH superfamily
4X30A 1OVAC 3NDFA 4KDSA 3ZHAA 1AS4A 2ARQA 1M93B 5CDZA 7APIA 3DY0A 1ANTI 1D5SA 1OVAA 3KCGI 1DVMA 4YIAA 2HIJL 4AFXA 2RIWA 2WXXA 2R9YA 1LQ8A 4P0OA 1QLPA 4Y3KA 1K9OI 2QUGA 3F1SA 4GA7A 2PEFA 2ARRA 1BR8I 1R1LI 1JMJA 2B5TI 1ATHA 3DRMA 4DY0A 1PSIA 2WY1A 2CEOA 2XN5A 3CVMA 3R4LA 2XN3A 1E05I 1MTPA 1WZ9A 4IC0A 1XQJA 1BY7A 2B4XI 3Q03A 4BB2A 5BRRI 4EB1I 1XU8A 5CE0A 1EZXA 2ZV6A 3EOXA 1A7CA 1SNGA 2RIVA 1JMOA 4G8RA 1DZHI 4CAAA 2ZNHA 8APIA 4AU3B 2XN7A 3H5CA 2B4XL 2VDXA 4DY7C 4AU4A 1UHGA 1QMBA 4EB1L 1F0CA 3DLWA 2V95A 4DTEA 4AJTA 1OC0A 1OYHI 2HI9A 2HIJI 4IF8A 4C41A 1DZHL 2GD4C 3UT3A 2DUTA 4RSQA 2H4RA 4AU2A 3NDDA 1B3KA 2VDYA 2BEHI 1KCTA 1DZGI 1OO8A 1T1FA 1JRRA 2XN6A 3CWMA 1ATUA 3DRUA 1JTIA 5C98A 3EVJI 1OYHL 4ZK3A 4C49A 1HP7A 2OAYA 3F02A 4AU3A 4AQHA 1DVNA 4AJUA 1DB2A 2H4PA 2OL2A 3CAAA 1JVQI 2H4QA 1ATTA 4ROBA 3NE4A 3NDAA 1AZXI 4G8OA 2PEEA 1JJOC 4ZK0A 3Q02A 3LW2A 2ACHA 2WXWA 2WXZC 2BEHL 5CDXA 1DZGL 3B9FI 1E04I 5INWA 2ANTI 1IMVA 4P0FA 4R9IA 9PAIA 3FGQA 3PB1I 3F5NA 9APIA 1E03I 1LJ5A 1XQGA 2VH4A 2WXZA 4PYWA 1SR5A 3STOA 4ROAA 3OZQA 1QMNA 1NQ9I 2WXYC 3LE2A 5IO1A 3VVJA 2WY0C 1OVAB 1IZ2A 1HLEA 3T1PA 1OPHA 1YXAA 5HGCA 3PZFA 4RO9A 1LK6I 1TB6I 1SEKA 4Y40A 2D26A 3CWLA 1C8OA 5EI0A 1C5GA
chains in the Genus database with same CATH topology
4X30A 1OVAC 3NDFA 4KDSA 3ZHAA 1AS4A 2ARQA 1M93B 5CDZA 7APIA 3DY0A 1ANTI 1D5SA 1OVAA 3KCGI 1DVMA 4YIAA 2HIJL 4AFXA 2RIWA 2WXXA 2R9YA 1LQ8A 4P0OA 1QLPA 4Y3KA 1K9OI 2QUGA 3F1SA 4GA7A 2PEFA 2ARRA 1BR8I 1R1LI 1JMJA 2B5TI 1ATHA 3DRMA 4DY0A 1PSIA 2WY1A 2CEOA 2XN5A 3CVMA 3R4LA 2XN3A 1E05I 1MTPA 1WZ9A 4IC0A 1XQJA 1BY7A 2B4XI 3Q03A 4BB2A 5BRRI 4EB1I 1XU8A 5CE0A 1EZXA 2ZV6A 3EOXA 1A7CA 1SNGA 2RIVA 1JMOA 4G8RA 1DZHI 4CAAA 2ZNHA 8APIA 4AU3B 2XN7A 3H5CA 2B4XL 2VDXA 4DY7C 4AU4A 1UHGA 1QMBA 4EB1L 1F0CA 3DLWA 2V95A 4DTEA 4AJTA 1OC0A 1OYHI 2HI9A 2HIJI 4IF8A 4C41A 1DZHL 2GD4C 3UT3A 2DUTA 4RSQA 2H4RA 4AU2A 3NDDA 1B3KA 2VDYA 2BEHI 1KCTA 1DZGI 1OO8A 1T1FA 1JRRA 2XN6A 3CWMA 1ATUA 3DRUA 1JTIA 5C98A 3EVJI 1OYHL 4ZK3A 4C49A 1HP7A 2OAYA 3F02A 4AU3A 4AQHA 1DVNA 4AJUA 1DB2A 2H4PA 2OL2A 3CAAA 1JVQI 2H4QA 1ATTA 4ROBA 3NE4A 3NDAA 1AZXI 4G8OA 2PEEA 1JJOC 4ZK0A 3Q02A 3LW2A 2ACHA 2WXWA 2WXZC 2BEHL 5CDXA 1DZGL 3B9FI 1E04I 5INWA 2ANTI 1IMVA 4P0FA 4R9IA 9PAIA 3FGQA 3PB1I 3F5NA 9APIA 1E03I 1LJ5A 1XQGA 2VH4A 2WXZA 4PYWA 1SR5A 3STOA 4ROAA 3OZQA 1QMNA 1NQ9I 2WXYC 3LE2A 5IO1A 3VVJA 2WY0C 1OVAB 1IZ2A 1HLEA 3T1PA 1OPHA 1YXAA 5HGCA 3PZFA 4RO9A 1LK6I 1TB6I 1SEKA 4Y40A 2D26A 3CWLA 1C8OA 5EI0A 1C5GA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4X30 A;  1OVA C;  3NDF A;  4KDS A;  3ZHA A;  1AS4 A;  2ARQ A;  1M93 B;  5CDZ A;  7API A;  3DY0 A;  1ANT I;  1D5S A;  1OVA A;  3KCG I;  1DVM A;  4YIA A;  2HIJ L;  4AFX A;  2RIW A;  2WXX A;  2R9Y A;  1LQ8 A;  4P0O A;  1QLP A;  4Y3K A;  1K9O I;  2QUG A;  3F1S A;  4GA7 A;  2PEF A;  2ARR A;  1BR8 I;  1R1L I;  1JMJ A;  2B5T I;  1ATH A;  3DRM A;  4DY0 A;  1PSI A;  2WY1 A;  2CEO A;  2XN5 A;  3CVM A;  3R4L A;  2XN3 A;  1E05 I;  1MTP A;  1WZ9 A;  4IC0 A;  1XQJ A;  1BY7 A;  2B4X I;  3Q03 A;  4BB2 A;  5BRR I;  4EB1 I;  1XU8 A;  5CE0 A;  1EZX A;  2ZV6 A;  3EOX A;  1A7C A;  1SNG A;  2RIV A;  1JMO A;  4G8R A;  1DZH I;  4CAA A;  2ZNH A;  8API A;  4AU3 B;  2XN7 A;  3H5C A;  2B4X L;  2VDX A;  4DY7 C;  4AU4 A;  1UHG A;  1QMB A;  4EB1 L;  1F0C A;  3DLW A;  2V95 A;  4DTE A;  4AJT A;  1OC0 A;  1OYH I;  2HI9 A;  2HIJ I;  4IF8 A;  4C41 A;  1DZH L;  2GD4 C;  3UT3 A;  2DUT A;  4RSQ A;  2H4R A;  4AU2 A;  3NDD A;  1B3K A;  2VDY A;  2BEH I;  1KCT A;  1DZG I;  1OO8 A;  1T1F A;  1JRR A;  2XN6 A;  3CWM A;  1ATU A;  3DRU A;  1JTI A;  5C98 A;  3EVJ I;  1OYH L;  4ZK3 A;  4C49 A;  1HP7 A;  2OAY A;  3F02 A;  4AU3 A;  4AQH A;  1DVN A;  4AJU A;  1DB2 A;  2H4P A;  2OL2 A;  3CAA A;  1JVQ I;  2H4Q A;  1ATT A;  4ROB A;  3NE4 A;  3NDA A;  1AZX I;  4G8O A;  2PEE A;  1JJO C;  4ZK0 A;  3Q02 A;  3LW2 A;  2ACH A;  2WXW A;  2WXZ C;  2BEH L;  5CDX A;  1DZG L;  3B9F I;  1E04 I;  5INW A;  2ANT I;  1IMV A;  4P0F A;  4R9I A;  9PAI A;  3FGQ A;  3PB1 I;  3F5N A;  9API A;  1E03 I;  1LJ5 A;  1XQG A;  2VH4 A;  2WXZ A;  4PYW A;  1SR5 A;  3STO A;  4ROA A;  3OZQ A;  1QMN A;  1NQ9 I;  2WXY C;  3LE2 A;  5IO1 A;  3VVJ A;  2WY0 C;  1OVA B;  1IZ2 A;  1HLE A;  3T1P A;  1OPH A;  1YXA A;  5HGC A;  3PZF A;  4RO9 A;  1LK6 I;  1TB6 I;  1SEK A;  4Y40 A;  2D26 A;  3CWL A;  1C8O A;  5EI0 A;  1C5G A; 
#chains in the Genus database with same CATH topology
 4X30 A;  1OVA C;  3NDF A;  4KDS A;  3ZHA A;  1AS4 A;  2ARQ A;  1M93 B;  5CDZ A;  7API A;  3DY0 A;  1ANT I;  1D5S A;  1OVA A;  3KCG I;  1DVM A;  4YIA A;  2HIJ L;  4AFX A;  2RIW A;  2WXX A;  2R9Y A;  1LQ8 A;  4P0O A;  1QLP A;  4Y3K A;  1K9O I;  2QUG A;  3F1S A;  4GA7 A;  2PEF A;  2ARR A;  1BR8 I;  1R1L I;  1JMJ A;  2B5T I;  1ATH A;  3DRM A;  4DY0 A;  1PSI A;  2WY1 A;  2CEO A;  2XN5 A;  3CVM A;  3R4L A;  2XN3 A;  1E05 I;  1MTP A;  1WZ9 A;  4IC0 A;  1XQJ A;  1BY7 A;  2B4X I;  3Q03 A;  4BB2 A;  5BRR I;  4EB1 I;  1XU8 A;  5CE0 A;  1EZX A;  2ZV6 A;  3EOX A;  1A7C A;  1SNG A;  2RIV A;  1JMO A;  4G8R A;  1DZH I;  4CAA A;  2ZNH A;  8API A;  4AU3 B;  2XN7 A;  3H5C A;  2B4X L;  2VDX A;  4DY7 C;  4AU4 A;  1UHG A;  1QMB A;  4EB1 L;  1F0C A;  3DLW A;  2V95 A;  4DTE A;  4AJT A;  1OC0 A;  1OYH I;  2HI9 A;  2HIJ I;  4IF8 A;  4C41 A;  1DZH L;  2GD4 C;  3UT3 A;  2DUT A;  4RSQ A;  2H4R A;  4AU2 A;  3NDD A;  1B3K A;  2VDY A;  2BEH I;  1KCT A;  1DZG I;  1OO8 A;  1T1F A;  1JRR A;  2XN6 A;  3CWM A;  1ATU A;  3DRU A;  1JTI A;  5C98 A;  3EVJ I;  1OYH L;  4ZK3 A;  4C49 A;  1HP7 A;  2OAY A;  3F02 A;  4AU3 A;  4AQH A;  1DVN A;  4AJU A;  1DB2 A;  2H4P A;  2OL2 A;  3CAA A;  1JVQ I;  2H4Q A;  1ATT A;  4ROB A;  3NE4 A;  3NDA A;  1AZX I;  4G8O A;  2PEE A;  1JJO C;  4ZK0 A;  3Q02 A;  3LW2 A;  2ACH A;  2WXW A;  2WXZ C;  2BEH L;  5CDX A;  1DZG L;  3B9F I;  1E04 I;  5INW A;  2ANT I;  1IMV A;  4P0F A;  4R9I A;  9PAI A;  3FGQ A;  3PB1 I;  3F5N A;  9API A;  1E03 I;  1LJ5 A;  1XQG A;  2VH4 A;  2WXZ A;  4PYW A;  1SR5 A;  3STO A;  4ROA A;  3OZQ A;  1QMN A;  1NQ9 I;  2WXY C;  3LE2 A;  5IO1 A;  3VVJ A;  2WY0 C;  1OVA B;  1IZ2 A;  1HLE A;  3T1P A;  1OPH A;  1YXA A;  5HGC A;  3PZF A;  4RO9 A;  1LK6 I;  1TB6 I;  1SEK A;  4Y40 A;  2D26 A;  3CWL A;  1C8O A;  5EI0 A;  1C5G A; 
#chains in the Genus database with same CATH homology
 4X30 A;  1OVA C;  3NDF A;  4KDS A;  3ZHA A;  1AS4 A;  2ARQ A;  1M93 B;  5CDZ A;  7API A;  3DY0 A;  1ANT I;  1D5S A;  1OVA A;  3KCG I;  1DVM A;  4YIA A;  2HIJ L;  4AFX A;  2RIW A;  2WXX A;  2R9Y A;  1LQ8 A;  4P0O A;  1QLP A;  4Y3K A;  1K9O I;  2QUG A;  3F1S A;  4GA7 A;  2PEF A;  2ARR A;  1BR8 I;  1R1L I;  1JMJ A;  2B5T I;  1ATH A;  3DRM A;  4DY0 A;  1PSI A;  2WY1 A;  2CEO A;  2XN5 A;  3CVM A;  3R4L A;  2XN3 A;  1E05 I;  1MTP A;  1WZ9 A;  4IC0 A;  1XQJ A;  1BY7 A;  2B4X I;  3Q03 A;  4BB2 A;  5BRR I;  4EB1 I;  1XU8 A;  5CE0 A;  1EZX A;  2ZV6 A;  3EOX A;  1A7C A;  1SNG A;  2RIV A;  1JMO A;  4G8R A;  1DZH I;  4CAA A;  2ZNH A;  8API A;  4AU3 B;  2XN7 A;  3H5C A;  2B4X L;  2VDX A;  4DY7 C;  4AU4 A;  1UHG A;  1QMB A;  4EB1 L;  1F0C A;  3DLW A;  2V95 A;  4DTE A;  4AJT A;  1OC0 A;  1OYH I;  2HI9 A;  2HIJ I;  4IF8 A;  4C41 A;  1DZH L;  2GD4 C;  3UT3 A;  2DUT A;  4RSQ A;  2H4R A;  4AU2 A;  3NDD A;  1B3K A;  2VDY A;  2BEH I;  1KCT A;  1DZG I;  1OO8 A;  1T1F A;  1JRR A;  2XN6 A;  3CWM A;  1ATU A;  3DRU A;  1JTI A;  5C98 A;  3EVJ I;  1OYH L;  4ZK3 A;  4C49 A;  1HP7 A;  2OAY A;  3F02 A;  4AU3 A;  4AQH A;  1DVN A;  4AJU A;  1DB2 A;  2H4P A;  2OL2 A;  3CAA A;  1JVQ I;  2H4Q A;  1ATT A;  4ROB A;  3NE4 A;  3NDA A;  1AZX I;  4G8O A;  2PEE A;  1JJO C;  4ZK0 A;  3Q02 A;  3LW2 A;  2ACH A;  2WXW A;  2WXZ C;  2BEH L;  5CDX A;  1DZG L;  3B9F I;  1E04 I;  5INW A;  2ANT I;  1IMV A;  4P0F A;  4R9I A;  9PAI A;  3FGQ A;  3PB1 I;  3F5N A;  9API A;  1E03 I;  1LJ5 A;  1XQG A;  2VH4 A;  2WXZ A;  4PYW A;  1SR5 A;  3STO A;  4ROA A;  3OZQ A;  1QMN A;  1NQ9 I;  2WXY C;  3LE2 A;  5IO1 A;  3VVJ A;  2WY0 C;  1OVA B;  1IZ2 A;  1HLE A;  3T1P A;  1OPH A;  1YXA A;  5HGC A;  3PZF A;  4RO9 A;  1LK6 I;  1TB6 I;  1SEK A;  4Y40 A;  2D26 A;  3CWL A;  1C8O A;  5EI0 A;  1C5G A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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