4AU3B

Crystal structure of a hsp47-collagen complex
Total Genus 111
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
111
sequence length
380
structure length
364
Chain Sequence
MLSPKAATLAERSAGLAFSLYQAMAKDQAVENILLSPVVVASSLGLVSLGGKATTASQAKAVLSAEQLRDEEVHAGLGELLRSLSNVTWKLGSRLYGPSSVSFAEDFVRSSKQHYNCEHSKINFRDKRSALQSINEWAAQTTDGKLPEVTKDVERTDGALLVNAMFFKPHWDEKFHHKMVDNRGFMVTRSYTVGVTMMHRTGLYNYYDDEKEKLQIVEMPLAHKLSSLIILMPHHVEPLERLEKLLTKEQLKIWMGKMQKKAVAISLPKGVVEVTHDLQKHLAGLGLTEAIDKNKSDLSRMSGKKDLYLASVFHATAFEWDTEGNPRSPKLFYADHPFIFLVRDTQSGSLLFIGRLVRPKGDKM
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Chaperone/peptide
molecule keywords SERPIN PEPTIDASE INHIBITOR, CLADE H (HEAT SHOCK PROTEIN 47 )
publication title Molecular Basis for the Action of the Collagen-Specific Chaperone Hsp47/Serpinh1 and its Structure-Specific Client Recognition.
pubmed doi rcsb
source organism Canis lupus familiaris
total genus 111
structure length 364
sequence length 380
ec nomenclature
pdb deposition date 2012-05-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
B PF00079 Serpin Serpin (serine protease inhibitor)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.30.39.10 Mainly Beta Roll Alpha-1-antitrypsin; domain 1 Alpha-1-antitrypsin, domain 1 4au3B02
3.30.497.10 Alpha Beta 2-Layer Sandwich Antithrombin; Chain I, domain 2 Antithrombin, subunit I, domain 2 4au3B01
4RSQA 1E05I 1E04I 3EOXA 1EZXA 4P0FA 4AU3B 1LJ5A 1NQ9I 4DTEA 3NDFA 3R4LA 2RIWA 1OVAC 2ZNHA 2B4XI 2VH4A 2DUTA 2WXWA 4CAAA 4Y3KA 9APIA 2XN7A 1IZ2A 1E03I 1HLEA 4AFXA 2B4XL 3OZQA 3CWMA 1BR8I 1OVAA 2XN3A 1IMVA 4G8RA 3PB1I 5EI0A 7APIA 3Q03A 1JJOC 4AQHA 8APIA 2WXZA 3NE4A 2VDXA 1YXAA 2OL2A 2ZV6A 4KDSA 1BY7A 2BEHI 1ATTA 4DY7C 4AJTA 2V95A 4R9IA 2VDYA 4IF8A 2BEHL 3DLWA 4ZK0A 1HP7A 2B5TI 3CWLA 2RIVA 3ZHAA 2R9YA 1DVNA 1OO8A 2H4PA 2PEFA 1PSIA 2OAYA 2ANTI 1JRRA 4ROAA 5C98A 3FGQA 5BRRI 2D26A 2WY1A 1A7CA 1R1LI 1DZHI 3F1SA 1K9OI 5HGCA 1XQJA 4BB2A 1UHGA 1OVAB 1WZ9A 1DZHL 1ANTI 2H4RA 1QMNA 1SNGA 2WXXA 3STOA 4RO9A 1B3KA 1KCTA 4Y40A 4AU2A 3LE2A 3F5NA 1XU8A 4P0OA 2ARQA 3DRMA 4ZK3A 1C5GA 4ROBA 4GA7A 1JTIA 2HI9A 1JMOA 3NDAA 3CVMA 3UT3A 3KCGI 4C41A 3T1PA 2CEOA 2XN6A 9PAIA 4C49A 4AU3A 5CDXA 5CDZA 1QLPA 1XQGA 5INWA 1MTPA 1LK6I 1T1FA 1ATUA 1M93B 2PEEA 3F02A 4YIAA 4DY0A 4EB1I 2QUGA 3H5CA 2WY0C 1QMBA 2WXYC 3DY0A 4AJUA 1AS4A 2WXZC 3PZFA 4G8OA 1JMJA 3DRUA 3LW2A 4IC0A 1TB6I 2HIJI 3NDDA 4EB1L 3B9FI 4X30A 1DVMA 1OYHI 1DZGI 3EVJI 1JVQI 2GD4C 2ARRA 2HIJL 1OPHA 4AU4A 5IO1A 1AZXI 1ATHA 3CAAA 1LQ8A 1C8OA 1OYHL 1SEKA 3VVJA 1D5SA 1DB2A 1DZGL 5CE0A 1F0CA 2XN5A 3Q02A 1OC0A 2H4QA 2ACHA 1SR5A 4PYWA
chains in the Genus database with same CATH superfamily
4RSQA 1E05I 1E04I 3EOXA 1EZXA 4P0FA 4AU3B 1LJ5A 1NQ9I 4DTEA 3NDFA 3R4LA 2RIWA 1OVAC 2ZNHA 2B4XI 2VH4A 2DUTA 2WXWA 4CAAA 4Y3KA 9APIA 2XN7A 1IZ2A 1E03I 1HLEA 4AFXA 2B4XL 3OZQA 3CWMA 1BR8I 1OVAA 2XN3A 1IMVA 4G8RA 3PB1I 5EI0A 7APIA 3Q03A 1JJOC 4AQHA 8APIA 2WXZA 3NE4A 2VDXA 1YXAA 2OL2A 2ZV6A 4KDSA 1BY7A 2BEHI 1ATTA 4DY7C 4AJTA 2V95A 4R9IA 2VDYA 4IF8A 2BEHL 3DLWA 4ZK0A 1HP7A 2B5TI 3CWLA 2RIVA 3ZHAA 2R9YA 1DVNA 1OO8A 2H4PA 2PEFA 1PSIA 2OAYA 2ANTI 1JRRA 4ROAA 5C98A 3FGQA 5BRRI 2D26A 2WY1A 1A7CA 1R1LI 1DZHI 3F1SA 1K9OI 5HGCA 1XQJA 4BB2A 1UHGA 1OVAB 1WZ9A 1DZHL 1ANTI 2H4RA 1QMNA 1SNGA 2WXXA 3STOA 4RO9A 1B3KA 1KCTA 4Y40A 4AU2A 3LE2A 3F5NA 1XU8A 4P0OA 2ARQA 3DRMA 4ZK3A 1C5GA 4ROBA 4GA7A 1JTIA 2HI9A 1JMOA 3NDAA 3CVMA 3UT3A 3KCGI 4C41A 3T1PA 2CEOA 2XN6A 9PAIA 4C49A 4AU3A 5CDXA 5CDZA 1QLPA 1XQGA 5INWA 1MTPA 1LK6I 1T1FA 1ATUA 1M93B 2PEEA 3F02A 4YIAA 4DY0A 4EB1I 2QUGA 3H5CA 2WY0C 1QMBA 2WXYC 3DY0A 4AJUA 1AS4A 2WXZC 3PZFA 4G8OA 1JMJA 3DRUA 3LW2A 4IC0A 1TB6I 2HIJI 3NDDA 4EB1L 3B9FI 4X30A 1DVMA 1OYHI 1DZGI 3EVJI 1JVQI 2GD4C 2ARRA 2HIJL 1OPHA 4AU4A 5IO1A 1AZXI 1ATHA 3CAAA 1LQ8A 1C8OA 1OYHL 1SEKA 3VVJA 1D5SA 1DB2A 1DZGL 5CE0A 1F0CA 2XN5A 3Q02A 1OC0A 2H4QA 2ACHA 1SR5A 4PYWA
chains in the Genus database with same CATH topology
4RSQA 1E05I 1E04I 3EOXA 1EZXA 4P0FA 4AU3B 1LJ5A 1NQ9I 4DTEA 3NDFA 3R4LA 2RIWA 1OVAC 2ZNHA 2B4XI 2VH4A 2DUTA 2WXWA 4CAAA 4Y3KA 9APIA 2XN7A 1IZ2A 1E03I 1HLEA 4AFXA 2B4XL 3OZQA 3CWMA 1BR8I 1OVAA 2XN3A 1IMVA 4G8RA 3PB1I 5EI0A 7APIA 3Q03A 1JJOC 4AQHA 8APIA 2WXZA 3NE4A 2VDXA 1YXAA 2OL2A 2ZV6A 4KDSA 1BY7A 2BEHI 1ATTA 4DY7C 4AJTA 2V95A 4R9IA 2VDYA 4IF8A 2BEHL 3DLWA 4ZK0A 1HP7A 2B5TI 3CWLA 2RIVA 3ZHAA 2R9YA 1DVNA 1OO8A 2H4PA 2PEFA 1PSIA 2OAYA 2ANTI 1JRRA 4ROAA 5C98A 3FGQA 5BRRI 2D26A 2WY1A 1A7CA 1R1LI 1DZHI 3F1SA 1K9OI 5HGCA 1XQJA 4BB2A 1UHGA 1OVAB 1WZ9A 1DZHL 1ANTI 2H4RA 1QMNA 1SNGA 2WXXA 3STOA 4RO9A 1B3KA 1KCTA 4Y40A 4AU2A 3LE2A 3F5NA 1XU8A 4P0OA 2ARQA 3DRMA 4ZK3A 1C5GA 4ROBA 4GA7A 1JTIA 2HI9A 1JMOA 3NDAA 3CVMA 3UT3A 3KCGI 4C41A 3T1PA 2CEOA 2XN6A 9PAIA 4C49A 4AU3A 5CDXA 5CDZA 1QLPA 1XQGA 5INWA 1MTPA 1LK6I 1T1FA 1ATUA 1M93B 2PEEA 3F02A 4YIAA 4DY0A 4EB1I 2QUGA 3H5CA 2WY0C 1QMBA 2WXYC 3DY0A 4AJUA 1AS4A 2WXZC 3PZFA 4G8OA 1JMJA 3DRUA 3LW2A 4IC0A 1TB6I 2HIJI 3NDDA 4EB1L 3B9FI 4X30A 1DVMA 1OYHI 1DZGI 3EVJI 1JVQI 2GD4C 2ARRA 2HIJL 1OPHA 4AU4A 5IO1A 1AZXI 1ATHA 3CAAA 1LQ8A 1C8OA 1OYHL 1SEKA 3VVJA 1D5SA 1DB2A 1DZGL 5CE0A 1F0CA 2XN5A 3Q02A 1OC0A 2H4QA 2ACHA 1SR5A 4PYWA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4RSQ A;  1E05 I;  1E04 I;  3EOX A;  1EZX A;  4P0F A;  4AU3 B;  1LJ5 A;  1NQ9 I;  4DTE A;  3NDF A;  3R4L A;  2RIW A;  1OVA C;  2ZNH A;  2B4X I;  2VH4 A;  2DUT A;  2WXW A;  4CAA A;  4Y3K A;  9API A;  2XN7 A;  1IZ2 A;  1E03 I;  1HLE A;  4AFX A;  2B4X L;  3OZQ A;  3CWM A;  1BR8 I;  1OVA A;  2XN3 A;  1IMV A;  4G8R A;  3PB1 I;  5EI0 A;  7API A;  3Q03 A;  1JJO C;  4AQH A;  8API A;  2WXZ A;  3NE4 A;  2VDX A;  1YXA A;  2OL2 A;  2ZV6 A;  4KDS A;  1BY7 A;  2BEH I;  1ATT A;  4DY7 C;  4AJT A;  2V95 A;  4R9I A;  2VDY A;  4IF8 A;  2BEH L;  3DLW A;  4ZK0 A;  1HP7 A;  2B5T I;  3CWL A;  2RIV A;  3ZHA A;  2R9Y A;  1DVN A;  1OO8 A;  2H4P A;  2PEF A;  1PSI A;  2OAY A;  2ANT I;  1JRR A;  4ROA A;  5C98 A;  3FGQ A;  5BRR I;  2D26 A;  2WY1 A;  1A7C A;  1R1L I;  1DZH I;  3F1S A;  1K9O I;  5HGC A;  1XQJ A;  4BB2 A;  1UHG A;  1OVA B;  1WZ9 A;  1DZH L;  1ANT I;  2H4R A;  1QMN A;  1SNG A;  2WXX A;  3STO A;  4RO9 A;  1B3K A;  1KCT A;  4Y40 A;  4AU2 A;  3LE2 A;  3F5N A;  1XU8 A;  4P0O A;  2ARQ A;  3DRM A;  4ZK3 A;  1C5G A;  4ROB A;  4GA7 A;  1JTI A;  2HI9 A;  1JMO A;  3NDA A;  3CVM A;  3UT3 A;  3KCG I;  4C41 A;  3T1P A;  2CEO A;  2XN6 A;  9PAI A;  4C49 A;  4AU3 A;  5CDX A;  5CDZ A;  1QLP A;  1XQG A;  5INW A;  1MTP A;  1LK6 I;  1T1F A;  1ATU A;  1M93 B;  2PEE A;  3F02 A;  4YIA A;  4DY0 A;  4EB1 I;  2QUG A;  3H5C A;  2WY0 C;  1QMB A;  2WXY C;  3DY0 A;  4AJU A;  1AS4 A;  2WXZ C;  3PZF A;  4G8O A;  1JMJ A;  3DRU A;  3LW2 A;  4IC0 A;  1TB6 I;  2HIJ I;  3NDD A;  4EB1 L;  3B9F I;  4X30 A;  1DVM A;  1OYH I;  1DZG I;  3EVJ I;  1JVQ I;  2GD4 C;  2ARR A;  2HIJ L;  1OPH A;  4AU4 A;  5IO1 A;  1AZX I;  1ATH A;  3CAA A;  1LQ8 A;  1C8O A;  1OYH L;  1SEK A;  3VVJ A;  1D5S A;  1DB2 A;  1DZG L;  5CE0 A;  1F0C A;  2XN5 A;  3Q02 A;  1OC0 A;  2H4Q A;  2ACH A;  1SR5 A;  4PYW A; 
#chains in the Genus database with same CATH topology
 4RSQ A;  1E05 I;  1E04 I;  3EOX A;  1EZX A;  4P0F A;  4AU3 B;  1LJ5 A;  1NQ9 I;  4DTE A;  3NDF A;  3R4L A;  2RIW A;  1OVA C;  2ZNH A;  2B4X I;  2VH4 A;  2DUT A;  2WXW A;  4CAA A;  4Y3K A;  9API A;  2XN7 A;  1IZ2 A;  1E03 I;  1HLE A;  4AFX A;  2B4X L;  3OZQ A;  3CWM A;  1BR8 I;  1OVA A;  2XN3 A;  1IMV A;  4G8R A;  3PB1 I;  5EI0 A;  7API A;  3Q03 A;  1JJO C;  4AQH A;  8API A;  2WXZ A;  3NE4 A;  2VDX A;  1YXA A;  2OL2 A;  2ZV6 A;  4KDS A;  1BY7 A;  2BEH I;  1ATT A;  4DY7 C;  4AJT A;  2V95 A;  4R9I A;  2VDY A;  4IF8 A;  2BEH L;  3DLW A;  4ZK0 A;  1HP7 A;  2B5T I;  3CWL A;  2RIV A;  3ZHA A;  2R9Y A;  1DVN A;  1OO8 A;  2H4P A;  2PEF A;  1PSI A;  2OAY A;  2ANT I;  1JRR A;  4ROA A;  5C98 A;  3FGQ A;  5BRR I;  2D26 A;  2WY1 A;  1A7C A;  1R1L I;  1DZH I;  3F1S A;  1K9O I;  5HGC A;  1XQJ A;  4BB2 A;  1UHG A;  1OVA B;  1WZ9 A;  1DZH L;  1ANT I;  2H4R A;  1QMN A;  1SNG A;  2WXX A;  3STO A;  4RO9 A;  1B3K A;  1KCT A;  4Y40 A;  4AU2 A;  3LE2 A;  3F5N A;  1XU8 A;  4P0O A;  2ARQ A;  3DRM A;  4ZK3 A;  1C5G A;  4ROB A;  4GA7 A;  1JTI A;  2HI9 A;  1JMO A;  3NDA A;  3CVM A;  3UT3 A;  3KCG I;  4C41 A;  3T1P A;  2CEO A;  2XN6 A;  9PAI A;  4C49 A;  4AU3 A;  5CDX A;  5CDZ A;  1QLP A;  1XQG A;  5INW A;  1MTP A;  1LK6 I;  1T1F A;  1ATU A;  1M93 B;  2PEE A;  3F02 A;  4YIA A;  4DY0 A;  4EB1 I;  2QUG A;  3H5C A;  2WY0 C;  1QMB A;  2WXY C;  3DY0 A;  4AJU A;  1AS4 A;  2WXZ C;  3PZF A;  4G8O A;  1JMJ A;  3DRU A;  3LW2 A;  4IC0 A;  1TB6 I;  2HIJ I;  3NDD A;  4EB1 L;  3B9F I;  4X30 A;  1DVM A;  1OYH I;  1DZG I;  3EVJ I;  1JVQ I;  2GD4 C;  2ARR A;  2HIJ L;  1OPH A;  4AU4 A;  5IO1 A;  1AZX I;  1ATH A;  3CAA A;  1LQ8 A;  1C8O A;  1OYH L;  1SEK A;  3VVJ A;  1D5S A;  1DB2 A;  1DZG L;  5CE0 A;  1F0C A;  2XN5 A;  3Q02 A;  1OC0 A;  2H4Q A;  2ACH A;  1SR5 A;  4PYW A; 
#chains in the Genus database with same CATH homology
 4RSQ A;  1E05 I;  1E04 I;  3EOX A;  1EZX A;  4P0F A;  4AU3 B;  1LJ5 A;  1NQ9 I;  4DTE A;  3NDF A;  3R4L A;  2RIW A;  1OVA C;  2ZNH A;  2B4X I;  2VH4 A;  2DUT A;  2WXW A;  4CAA A;  4Y3K A;  9API A;  2XN7 A;  1IZ2 A;  1E03 I;  1HLE A;  4AFX A;  2B4X L;  3OZQ A;  3CWM A;  1BR8 I;  1OVA A;  2XN3 A;  1IMV A;  4G8R A;  3PB1 I;  5EI0 A;  7API A;  3Q03 A;  1JJO C;  4AQH A;  8API A;  2WXZ A;  3NE4 A;  2VDX A;  1YXA A;  2OL2 A;  2ZV6 A;  4KDS A;  1BY7 A;  2BEH I;  1ATT A;  4DY7 C;  4AJT A;  2V95 A;  4R9I A;  2VDY A;  4IF8 A;  2BEH L;  3DLW A;  4ZK0 A;  1HP7 A;  2B5T I;  3CWL A;  2RIV A;  3ZHA A;  2R9Y A;  1DVN A;  1OO8 A;  2H4P A;  2PEF A;  1PSI A;  2OAY A;  2ANT I;  1JRR A;  4ROA A;  5C98 A;  3FGQ A;  5BRR I;  2D26 A;  2WY1 A;  1A7C A;  1R1L I;  1DZH I;  3F1S A;  1K9O I;  5HGC A;  1XQJ A;  4BB2 A;  1UHG A;  1OVA B;  1WZ9 A;  1DZH L;  1ANT I;  2H4R A;  1QMN A;  1SNG A;  2WXX A;  3STO A;  4RO9 A;  1B3K A;  1KCT A;  4Y40 A;  4AU2 A;  3LE2 A;  3F5N A;  1XU8 A;  4P0O A;  2ARQ A;  3DRM A;  4ZK3 A;  1C5G A;  4ROB A;  4GA7 A;  1JTI A;  2HI9 A;  1JMO A;  3NDA A;  3CVM A;  3UT3 A;  3KCG I;  4C41 A;  3T1P A;  2CEO A;  2XN6 A;  9PAI A;  4C49 A;  4AU3 A;  5CDX A;  5CDZ A;  1QLP A;  1XQG A;  5INW A;  1MTP A;  1LK6 I;  1T1F A;  1ATU A;  1M93 B;  2PEE A;  3F02 A;  4YIA A;  4DY0 A;  4EB1 I;  2QUG A;  3H5C A;  2WY0 C;  1QMB A;  2WXY C;  3DY0 A;  4AJU A;  1AS4 A;  2WXZ C;  3PZF A;  4G8O A;  1JMJ A;  3DRU A;  3LW2 A;  4IC0 A;  1TB6 I;  2HIJ I;  3NDD A;  4EB1 L;  3B9F I;  4X30 A;  1DVM A;  1OYH I;  1DZG I;  3EVJ I;  1JVQ I;  2GD4 C;  2ARR A;  2HIJ L;  1OPH A;  4AU4 A;  5IO1 A;  1AZX I;  1ATH A;  3CAA A;  1LQ8 A;  1C8O A;  1OYH L;  1SEK A;  3VVJ A;  1D5S A;  1DB2 A;  1DZG L;  5CE0 A;  1F0C A;  2XN5 A;  3Q02 A;  1OC0 A;  2H4Q A;  2ACH A;  1SR5 A;  4PYW A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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