4AU4A

Crystal structure of hsp47
Total Genus 123
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
123
sequence length
380
structure length
366
Chain Sequence
MLSPKAATLAERSAGLAFSLYQAMAKDQAVENILLSPVVVASSLGLVSLGGKATTASQAKAVLSAEQLRDEEVHAGLGELLRSLSNTWKLGSRLYGPSSVSFAEDFVRSSKQHYNCEHSKINFRDKRSALQSINEWAAQTTDGKLPEVTKDVERTDGALLVNAMFFKPHWDEKFHHKMVDNRGFMVTRSYTVGVTMMHRTGLYNYYDDEKEKLQIVEMPLAHKLSSLIILMPHHVEPLERLEKLLTKEQLKIWMGKMQKKAVAISLPKGVVEVTHDLQKHLAGLGLTEAIDKNKADLSRMSGKKDLYLASVFHATAFEWDTEGNPFELRSPKLFYADHPFIFLVRDTQSGSLLFIGRLVRPKGDKM
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Chaperone
molecule keywords SERPIN PEPTIDASE INHIBITOR, CLADE H (HEAT SHOCK PROTEIN 47),
publication title Molecular Basis for the Action of the Collagen-Specific Chaperone Hsp47/Serpinh1 and its Structure-Specific Client Recognition.
pubmed doi rcsb
source organism Canis lupus familiaris
total genus 123
structure length 366
sequence length 380
chains with identical sequence B, C, D, E, F, G
ec nomenclature
pdb deposition date 2012-05-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00079 Serpin Serpin (serine protease inhibitor)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.30.39.10 Mainly Beta Roll Alpha-1-antitrypsin; domain 1 Alpha-1-antitrypsin, domain 1 4au4A02
3.30.497.10 Alpha Beta 2-Layer Sandwich Antithrombin; Chain I, domain 2 Antithrombin, subunit I, domain 2 4au4A01
2H4QA 4DY7C 3DRMA 9APIA 3CWLA 4P0OA 1DZGI 1OC0A 1K9OI 1OVAC 1OYHL 2BEHL 4CAAA 4YIAA 1AZXI 2DUTA 3DLWA 3F1SA 5CE0A 2B5TI 2H4RA 3DY0A 5C98A 3PB1I 2H4PA 2ZNHA 1DZHL 2V95A 2VDYA 5IO1A 4P0FA 3NDFA 1D5SA 2HIJL 1JRRA 2OL2A 2B4XL 3EVJI 4AJTA 2WXWA 4AU3A 4DY0A 4C41A 1C8OA 1AS4A 2PEFA 1JVQI 2WY0C 1BY7A 1BR8I 1EZXA 2XN6A 1YXAA 1ATUA 1JTIA 1ATHA 3DRUA 1JJOC 4ZK0A 1E03I 2CEOA 2WXZA 3F5NA 2ARRA 3KCGI 4IF8A 1JMJA 1E04I 3STOA 2GD4C 1OO8A 4EB1I 4ROBA 1R1LI 4AFXA 4KDSA 2RIWA 4Y3KA 3UT3A 1XU8A 3Q02A 9PAIA 1MTPA 3VVJA 2HI9A 1ANTI 1KCTA 2VH4A 4AU2A 4X30A 1OVAA 3NDAA 1OYHI 3CAAA 1QMBA 2BEHI 3CVMA 1QLPA 2R9YA 3R4LA 4RSQA 1DVMA 2WY1A 1XQGA 3T1PA 4AU3B 4IC0A 1DVNA 1DZHI 3B9FI 3LE2A 1M93B 4GA7A 5CDXA 2HIJI 4Y40A 1SR5A 2B4XI 4RO9A 5INWA 1TB6I 4DTEA 1LJ5A 1XQJA 5EI0A 1E05I 4AQHA 1B3KA 1LQ8A 1T1FA 1LK6I 1DZGL 2WXXA 4C49A 5CDZA 8APIA 3LW2A 4G8OA 4PYWA 2ACHA 2D26A 3F02A 4G8RA 2RIVA 2PEEA 2ZV6A 4R9IA 2QUGA 3FGQA 1JMOA 1SNGA 2OAYA 1UHGA 2XN5A 3NDDA 2ARQA 2WXYC 4ZK3A 2ANTI 1NQ9I 3PZFA 1C5GA 1OVAB 1SEKA 1HLEA 3CWMA 1IMVA 3OZQA 4BB2A 1F0CA 4AU4A 3Q03A 1HP7A 5HGCA 2WXZC 4AJUA 5BRRI 1ATTA 2XN3A 3H5CA 3NE4A 2XN7A 1IZ2A 4EB1L 3EOXA 1QMNA 1A7CA 1PSIA 1OPHA 1DB2A 1WZ9A 2VDXA 4ROAA 7APIA 3ZHAA
chains in the Genus database with same CATH superfamily
2H4QA 4DY7C 3DRMA 9APIA 3CWLA 4P0OA 1DZGI 1OC0A 1K9OI 1OVAC 1OYHL 2BEHL 4CAAA 4YIAA 1AZXI 2DUTA 3DLWA 3F1SA 5CE0A 2B5TI 2H4RA 3DY0A 5C98A 3PB1I 2H4PA 2ZNHA 1DZHL 2V95A 2VDYA 5IO1A 4P0FA 3NDFA 1D5SA 2HIJL 1JRRA 2OL2A 2B4XL 3EVJI 4AJTA 2WXWA 4AU3A 4DY0A 4C41A 1C8OA 1AS4A 2PEFA 1JVQI 2WY0C 1BY7A 1BR8I 1EZXA 2XN6A 1YXAA 1ATUA 1JTIA 1ATHA 3DRUA 1JJOC 4ZK0A 1E03I 2CEOA 2WXZA 3F5NA 2ARRA 3KCGI 4IF8A 1JMJA 1E04I 3STOA 2GD4C 1OO8A 4EB1I 4ROBA 1R1LI 4AFXA 4KDSA 2RIWA 4Y3KA 3UT3A 1XU8A 3Q02A 9PAIA 1MTPA 3VVJA 2HI9A 1ANTI 1KCTA 2VH4A 4AU2A 4X30A 1OVAA 3NDAA 1OYHI 3CAAA 1QMBA 2BEHI 3CVMA 1QLPA 2R9YA 3R4LA 4RSQA 1DVMA 2WY1A 1XQGA 3T1PA 4AU3B 4IC0A 1DVNA 1DZHI 3B9FI 3LE2A 1M93B 4GA7A 5CDXA 2HIJI 4Y40A 1SR5A 2B4XI 4RO9A 5INWA 1TB6I 4DTEA 1LJ5A 1XQJA 5EI0A 1E05I 4AQHA 1B3KA 1LQ8A 1T1FA 1LK6I 1DZGL 2WXXA 4C49A 5CDZA 8APIA 3LW2A 4G8OA 4PYWA 2ACHA 2D26A 3F02A 4G8RA 2RIVA 2PEEA 2ZV6A 4R9IA 2QUGA 3FGQA 1JMOA 1SNGA 2OAYA 1UHGA 2XN5A 3NDDA 2ARQA 2WXYC 4ZK3A 2ANTI 1NQ9I 3PZFA 1C5GA 1OVAB 1SEKA 1HLEA 3CWMA 1IMVA 3OZQA 4BB2A 1F0CA 4AU4A 3Q03A 1HP7A 5HGCA 2WXZC 4AJUA 5BRRI 1ATTA 2XN3A 3H5CA 3NE4A 2XN7A 1IZ2A 4EB1L 3EOXA 1QMNA 1A7CA 1PSIA 1OPHA 1DB2A 1WZ9A 2VDXA 4ROAA 7APIA 3ZHAA
chains in the Genus database with same CATH topology
2H4QA 4DY7C 3DRMA 9APIA 3CWLA 4P0OA 1DZGI 1OC0A 1K9OI 1OVAC 1OYHL 2BEHL 4CAAA 4YIAA 1AZXI 2DUTA 3DLWA 3F1SA 5CE0A 2B5TI 2H4RA 3DY0A 5C98A 3PB1I 2H4PA 2ZNHA 1DZHL 2V95A 2VDYA 5IO1A 4P0FA 3NDFA 1D5SA 2HIJL 1JRRA 2OL2A 2B4XL 3EVJI 4AJTA 2WXWA 4AU3A 4DY0A 4C41A 1C8OA 1AS4A 2PEFA 1JVQI 2WY0C 1BY7A 1BR8I 1EZXA 2XN6A 1YXAA 1ATUA 1JTIA 1ATHA 3DRUA 1JJOC 4ZK0A 1E03I 2CEOA 2WXZA 3F5NA 2ARRA 3KCGI 4IF8A 1JMJA 1E04I 3STOA 2GD4C 1OO8A 4EB1I 4ROBA 1R1LI 4AFXA 4KDSA 2RIWA 4Y3KA 3UT3A 1XU8A 3Q02A 9PAIA 1MTPA 3VVJA 2HI9A 1ANTI 1KCTA 2VH4A 4AU2A 4X30A 1OVAA 3NDAA 1OYHI 3CAAA 1QMBA 2BEHI 3CVMA 1QLPA 2R9YA 3R4LA 4RSQA 1DVMA 2WY1A 1XQGA 3T1PA 4AU3B 4IC0A 1DVNA 1DZHI 3B9FI 3LE2A 1M93B 4GA7A 5CDXA 2HIJI 4Y40A 1SR5A 2B4XI 4RO9A 5INWA 1TB6I 4DTEA 1LJ5A 1XQJA 5EI0A 1E05I 4AQHA 1B3KA 1LQ8A 1T1FA 1LK6I 1DZGL 2WXXA 4C49A 5CDZA 8APIA 3LW2A 4G8OA 4PYWA 2ACHA 2D26A 3F02A 4G8RA 2RIVA 2PEEA 2ZV6A 4R9IA 2QUGA 3FGQA 1JMOA 1SNGA 2OAYA 1UHGA 2XN5A 3NDDA 2ARQA 2WXYC 4ZK3A 2ANTI 1NQ9I 3PZFA 1C5GA 1OVAB 1SEKA 1HLEA 3CWMA 1IMVA 3OZQA 4BB2A 1F0CA 4AU4A 3Q03A 1HP7A 5HGCA 2WXZC 4AJUA 5BRRI 1ATTA 2XN3A 3H5CA 3NE4A 2XN7A 1IZ2A 4EB1L 3EOXA 1QMNA 1A7CA 1PSIA 1OPHA 1DB2A 1WZ9A 2VDXA 4ROAA 7APIA 3ZHAA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2H4Q A;  4DY7 C;  3DRM A;  9API A;  3CWL A;  4P0O A;  1DZG I;  1OC0 A;  1K9O I;  1OVA C;  1OYH L;  2BEH L;  4CAA A;  4YIA A;  1AZX I;  2DUT A;  3DLW A;  3F1S A;  5CE0 A;  2B5T I;  2H4R A;  3DY0 A;  5C98 A;  3PB1 I;  2H4P A;  2ZNH A;  1DZH L;  2V95 A;  2VDY A;  5IO1 A;  4P0F A;  3NDF A;  1D5S A;  2HIJ L;  1JRR A;  2OL2 A;  2B4X L;  3EVJ I;  4AJT A;  2WXW A;  4AU3 A;  4DY0 A;  4C41 A;  1C8O A;  1AS4 A;  2PEF A;  1JVQ I;  2WY0 C;  1BY7 A;  1BR8 I;  1EZX A;  2XN6 A;  1YXA A;  1ATU A;  1JTI A;  1ATH A;  3DRU A;  1JJO C;  4ZK0 A;  1E03 I;  2CEO A;  2WXZ A;  3F5N A;  2ARR A;  3KCG I;  4IF8 A;  1JMJ A;  1E04 I;  3STO A;  2GD4 C;  1OO8 A;  4EB1 I;  4ROB A;  1R1L I;  4AFX A;  4KDS A;  2RIW A;  4Y3K A;  3UT3 A;  1XU8 A;  3Q02 A;  9PAI A;  1MTP A;  3VVJ A;  2HI9 A;  1ANT I;  1KCT A;  2VH4 A;  4AU2 A;  4X30 A;  1OVA A;  3NDA A;  1OYH I;  3CAA A;  1QMB A;  2BEH I;  3CVM A;  1QLP A;  2R9Y A;  3R4L A;  4RSQ A;  1DVM A;  2WY1 A;  1XQG A;  3T1P A;  4AU3 B;  4IC0 A;  1DVN A;  1DZH I;  3B9F I;  3LE2 A;  1M93 B;  4GA7 A;  5CDX A;  2HIJ I;  4Y40 A;  1SR5 A;  2B4X I;  4RO9 A;  5INW A;  1TB6 I;  4DTE A;  1LJ5 A;  1XQJ A;  5EI0 A;  1E05 I;  4AQH A;  1B3K A;  1LQ8 A;  1T1F A;  1LK6 I;  1DZG L;  2WXX A;  4C49 A;  5CDZ A;  8API A;  3LW2 A;  4G8O A;  4PYW A;  2ACH A;  2D26 A;  3F02 A;  4G8R A;  2RIV A;  2PEE A;  2ZV6 A;  4R9I A;  2QUG A;  3FGQ A;  1JMO A;  1SNG A;  2OAY A;  1UHG A;  2XN5 A;  3NDD A;  2ARQ A;  2WXY C;  4ZK3 A;  2ANT I;  1NQ9 I;  3PZF A;  1C5G A;  1OVA B;  1SEK A;  1HLE A;  3CWM A;  1IMV A;  3OZQ A;  4BB2 A;  1F0C A;  4AU4 A;  3Q03 A;  1HP7 A;  5HGC A;  2WXZ C;  4AJU A;  5BRR I;  1ATT A;  2XN3 A;  3H5C A;  3NE4 A;  2XN7 A;  1IZ2 A;  4EB1 L;  3EOX A;  1QMN A;  1A7C A;  1PSI A;  1OPH A;  1DB2 A;  1WZ9 A;  2VDX A;  4ROA A;  7API A;  3ZHA A; 
#chains in the Genus database with same CATH topology
 2H4Q A;  4DY7 C;  3DRM A;  9API A;  3CWL A;  4P0O A;  1DZG I;  1OC0 A;  1K9O I;  1OVA C;  1OYH L;  2BEH L;  4CAA A;  4YIA A;  1AZX I;  2DUT A;  3DLW A;  3F1S A;  5CE0 A;  2B5T I;  2H4R A;  3DY0 A;  5C98 A;  3PB1 I;  2H4P A;  2ZNH A;  1DZH L;  2V95 A;  2VDY A;  5IO1 A;  4P0F A;  3NDF A;  1D5S A;  2HIJ L;  1JRR A;  2OL2 A;  2B4X L;  3EVJ I;  4AJT A;  2WXW A;  4AU3 A;  4DY0 A;  4C41 A;  1C8O A;  1AS4 A;  2PEF A;  1JVQ I;  2WY0 C;  1BY7 A;  1BR8 I;  1EZX A;  2XN6 A;  1YXA A;  1ATU A;  1JTI A;  1ATH A;  3DRU A;  1JJO C;  4ZK0 A;  1E03 I;  2CEO A;  2WXZ A;  3F5N A;  2ARR A;  3KCG I;  4IF8 A;  1JMJ A;  1E04 I;  3STO A;  2GD4 C;  1OO8 A;  4EB1 I;  4ROB A;  1R1L I;  4AFX A;  4KDS A;  2RIW A;  4Y3K A;  3UT3 A;  1XU8 A;  3Q02 A;  9PAI A;  1MTP A;  3VVJ A;  2HI9 A;  1ANT I;  1KCT A;  2VH4 A;  4AU2 A;  4X30 A;  1OVA A;  3NDA A;  1OYH I;  3CAA A;  1QMB A;  2BEH I;  3CVM A;  1QLP A;  2R9Y A;  3R4L A;  4RSQ A;  1DVM A;  2WY1 A;  1XQG A;  3T1P A;  4AU3 B;  4IC0 A;  1DVN A;  1DZH I;  3B9F I;  3LE2 A;  1M93 B;  4GA7 A;  5CDX A;  2HIJ I;  4Y40 A;  1SR5 A;  2B4X I;  4RO9 A;  5INW A;  1TB6 I;  4DTE A;  1LJ5 A;  1XQJ A;  5EI0 A;  1E05 I;  4AQH A;  1B3K A;  1LQ8 A;  1T1F A;  1LK6 I;  1DZG L;  2WXX A;  4C49 A;  5CDZ A;  8API A;  3LW2 A;  4G8O A;  4PYW A;  2ACH A;  2D26 A;  3F02 A;  4G8R A;  2RIV A;  2PEE A;  2ZV6 A;  4R9I A;  2QUG A;  3FGQ A;  1JMO A;  1SNG A;  2OAY A;  1UHG A;  2XN5 A;  3NDD A;  2ARQ A;  2WXY C;  4ZK3 A;  2ANT I;  1NQ9 I;  3PZF A;  1C5G A;  1OVA B;  1SEK A;  1HLE A;  3CWM A;  1IMV A;  3OZQ A;  4BB2 A;  1F0C A;  4AU4 A;  3Q03 A;  1HP7 A;  5HGC A;  2WXZ C;  4AJU A;  5BRR I;  1ATT A;  2XN3 A;  3H5C A;  3NE4 A;  2XN7 A;  1IZ2 A;  4EB1 L;  3EOX A;  1QMN A;  1A7C A;  1PSI A;  1OPH A;  1DB2 A;  1WZ9 A;  2VDX A;  4ROA A;  7API A;  3ZHA A; 
#chains in the Genus database with same CATH homology
 2H4Q A;  4DY7 C;  3DRM A;  9API A;  3CWL A;  4P0O A;  1DZG I;  1OC0 A;  1K9O I;  1OVA C;  1OYH L;  2BEH L;  4CAA A;  4YIA A;  1AZX I;  2DUT A;  3DLW A;  3F1S A;  5CE0 A;  2B5T I;  2H4R A;  3DY0 A;  5C98 A;  3PB1 I;  2H4P A;  2ZNH A;  1DZH L;  2V95 A;  2VDY A;  5IO1 A;  4P0F A;  3NDF A;  1D5S A;  2HIJ L;  1JRR A;  2OL2 A;  2B4X L;  3EVJ I;  4AJT A;  2WXW A;  4AU3 A;  4DY0 A;  4C41 A;  1C8O A;  1AS4 A;  2PEF A;  1JVQ I;  2WY0 C;  1BY7 A;  1BR8 I;  1EZX A;  2XN6 A;  1YXA A;  1ATU A;  1JTI A;  1ATH A;  3DRU A;  1JJO C;  4ZK0 A;  1E03 I;  2CEO A;  2WXZ A;  3F5N A;  2ARR A;  3KCG I;  4IF8 A;  1JMJ A;  1E04 I;  3STO A;  2GD4 C;  1OO8 A;  4EB1 I;  4ROB A;  1R1L I;  4AFX A;  4KDS A;  2RIW A;  4Y3K A;  3UT3 A;  1XU8 A;  3Q02 A;  9PAI A;  1MTP A;  3VVJ A;  2HI9 A;  1ANT I;  1KCT A;  2VH4 A;  4AU2 A;  4X30 A;  1OVA A;  3NDA A;  1OYH I;  3CAA A;  1QMB A;  2BEH I;  3CVM A;  1QLP A;  2R9Y A;  3R4L A;  4RSQ A;  1DVM A;  2WY1 A;  1XQG A;  3T1P A;  4AU3 B;  4IC0 A;  1DVN A;  1DZH I;  3B9F I;  3LE2 A;  1M93 B;  4GA7 A;  5CDX A;  2HIJ I;  4Y40 A;  1SR5 A;  2B4X I;  4RO9 A;  5INW A;  1TB6 I;  4DTE A;  1LJ5 A;  1XQJ A;  5EI0 A;  1E05 I;  4AQH A;  1B3K A;  1LQ8 A;  1T1F A;  1LK6 I;  1DZG L;  2WXX A;  4C49 A;  5CDZ A;  8API A;  3LW2 A;  4G8O A;  4PYW A;  2ACH A;  2D26 A;  3F02 A;  4G8R A;  2RIV A;  2PEE A;  2ZV6 A;  4R9I A;  2QUG A;  3FGQ A;  1JMO A;  1SNG A;  2OAY A;  1UHG A;  2XN5 A;  3NDD A;  2ARQ A;  2WXY C;  4ZK3 A;  2ANT I;  1NQ9 I;  3PZF A;  1C5G A;  1OVA B;  1SEK A;  1HLE A;  3CWM A;  1IMV A;  3OZQ A;  4BB2 A;  1F0C A;  4AU4 A;  3Q03 A;  1HP7 A;  5HGC A;  2WXZ C;  4AJU A;  5BRR I;  1ATT A;  2XN3 A;  3H5C A;  3NE4 A;  2XN7 A;  1IZ2 A;  4EB1 L;  3EOX A;  1QMN A;  1A7C A;  1PSI A;  1OPH A;  1DB2 A;  1WZ9 A;  2VDX A;  4ROA A;  7API A;  3ZHA A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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