4C41A

Corticosteroid-binding globulin with engineered disulphide bridge between residues 100 and 236
Total Genus 117
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
117
sequence length
369
structure length
367
Chain Sequence
RGLASANVDFAFSLYKHLVALSPKKNIFISPVSISMALAMLSLGTCGHTRAQLLQGLGFNLTERSETEIHQGFQHLHQLFAKSDTCLEMTMGNALFLDGSLELLESFSADIKHYYESEVLAMNFQDWATASRQINSYVKNKTQGKIVDLFSGLDSPAILVLVNYIFFKGTWTQPFDLASTREENFYVDETTVVKVPMMLQSSTISYLHDSELPCQLVQMNYCGNGTVFFILPDKGKMNTVIAALSRDTINRWSAGLTSSQVDLYIPKVTISGVYDLGDVLEEMGIADLFTNQANFSRITQDAQLKSSKVVHKAVLQLNEEGVDTAGSTGVTLNLRPIILRFNQPFIIMIFDHFTWSSLFLARVMNPV
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Transport protein
molecule keywords CORTICOSTEROID-BINDING GLOBULIN
publication title Towards Engineering Hormone-Binding Globulins as Drug Delivery Agents.
pubmed doi rcsb
source organism Homo sapiens
total genus 117
structure length 367
sequence length 369
ec nomenclature
pdb deposition date 2013-08-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00079 Serpin Serpin (serine protease inhibitor)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.30.39.10 Mainly Beta Roll Alpha-1-antitrypsin; domain 1 Alpha-1-antitrypsin, domain 1 4c41A02
3.30.497.10 Alpha Beta 2-Layer Sandwich Antithrombin; Chain I, domain 2 Antithrombin, subunit I, domain 2 4c41A01
1JTIA 1IZ2A 2PEFA 1OYHL 3NDDA 1AZXI 2WXZC 4AU3A 4PYWA 1LK6I 5HGCA 1DZHL 2VDYA 1JRRA 2RIWA 1C5GA 4AU3B 3F02A 4DY0A 3CVMA 9APIA 4C41A 1M93B 3ZHAA 2VH4A 1DVNA 1IMVA 2PEEA 3DRMA 4ZK3A 5CDZA 4Y40A 1HP7A 4KDSA 1OO8A 1OVAC 4RO9A 2XN3A 1DZGL 2XN6A 2R9YA 4AFXA 3LW2A 3F1SA 5IO1A 1B3KA 1MTPA 2B4XL 1OPHA 4AU4A 3R4LA 1HLEA 2QUGA 3PB1I 3PZFA 4P0OA 3Q02A 1BY7A 1LQ8A 1ANTI 8APIA 1WZ9A 2B5TI 2H4QA 2XN7A 4AU2A 4G8OA 1F0CA 1AS4A 3H5CA 1EZXA 4IC0A 1SR5A 1JMOA 2VDXA 3DRUA 1ATUA 2DUTA 4IF8A 2WY1A 2V95A 1ATHA 1T1FA 3KCGI 1OC0A 4EB1I 2BEHI 3CWLA 3DLWA 3NDAA 4R9IA 2H4PA 1YXAA 1A7CA 1E04I 4X30A 4RSQA 1ATTA 4C49A 3Q03A 3CWMA 2OL2A 1XU8A 1K9OI 4ZK0A 5CDXA 3NDFA 2ACHA 4BB2A 2RIVA 5CE0A 1JMJA 5BRRI 4AJUA 5C98A 2CEOA 4YIAA 4GA7A 1JJOC 1LJ5A 1KCTA 1QMBA 4AJTA 1UHGA 3UT3A 1XQJA 2HIJI 2XN5A 1D5SA 1NQ9I 3FGQA 2ARRA 1PSIA 1DB2A 4ROAA 2GD4C 1OYHI 3NE4A 4DTEA 3DY0A 2ARQA 1DZHI 3EVJI 4CAAA 1SEKA 2WY0C 2WXZA 2WXWA 3STOA 4EB1L 2BEHL 3B9FI 2ZNHA 4DY7C 4G8RA 3F5NA 1E03I 1TB6I 1DVMA 2HI9A 4AQHA 2OAYA 1E05I 3CAAA 2H4RA 2ANTI 5EI0A 9PAIA 1C8OA 1DZGI 4P0FA 2ZV6A 3OZQA 3T1PA 4Y3KA 1OVAA 1XQGA 2B4XI 3VVJA 7APIA 1R1LI 1SNGA 2WXXA 3EOXA 4ROBA 1QLPA 1QMNA 2WXYC 1JVQI 1OVAB 5INWA 2D26A 3LE2A 2HIJL 1BR8I
chains in the Genus database with same CATH superfamily
1JTIA 1IZ2A 2PEFA 1OYHL 3NDDA 1AZXI 2WXZC 4AU3A 4PYWA 1LK6I 5HGCA 1DZHL 2VDYA 1JRRA 2RIWA 1C5GA 4AU3B 3F02A 4DY0A 3CVMA 9APIA 4C41A 1M93B 3ZHAA 2VH4A 1DVNA 1IMVA 2PEEA 3DRMA 4ZK3A 5CDZA 4Y40A 1HP7A 4KDSA 1OO8A 1OVAC 4RO9A 2XN3A 1DZGL 2XN6A 2R9YA 4AFXA 3LW2A 3F1SA 5IO1A 1B3KA 1MTPA 2B4XL 1OPHA 4AU4A 3R4LA 1HLEA 2QUGA 3PB1I 3PZFA 4P0OA 3Q02A 1BY7A 1LQ8A 1ANTI 8APIA 1WZ9A 2B5TI 2H4QA 2XN7A 4AU2A 4G8OA 1F0CA 1AS4A 3H5CA 1EZXA 4IC0A 1SR5A 1JMOA 2VDXA 3DRUA 1ATUA 2DUTA 4IF8A 2WY1A 2V95A 1ATHA 1T1FA 3KCGI 1OC0A 4EB1I 2BEHI 3CWLA 3DLWA 3NDAA 4R9IA 2H4PA 1YXAA 1A7CA 1E04I 4X30A 4RSQA 1ATTA 4C49A 3Q03A 3CWMA 2OL2A 1XU8A 1K9OI 4ZK0A 5CDXA 3NDFA 2ACHA 4BB2A 2RIVA 5CE0A 1JMJA 5BRRI 4AJUA 5C98A 2CEOA 4YIAA 4GA7A 1JJOC 1LJ5A 1KCTA 1QMBA 4AJTA 1UHGA 3UT3A 1XQJA 2HIJI 2XN5A 1D5SA 1NQ9I 3FGQA 2ARRA 1PSIA 1DB2A 4ROAA 2GD4C 1OYHI 3NE4A 4DTEA 3DY0A 2ARQA 1DZHI 3EVJI 4CAAA 1SEKA 2WY0C 2WXZA 2WXWA 3STOA 4EB1L 2BEHL 3B9FI 2ZNHA 4DY7C 4G8RA 3F5NA 1E03I 1TB6I 1DVMA 2HI9A 4AQHA 2OAYA 1E05I 3CAAA 2H4RA 2ANTI 5EI0A 9PAIA 1C8OA 1DZGI 4P0FA 2ZV6A 3OZQA 3T1PA 4Y3KA 1OVAA 1XQGA 2B4XI 3VVJA 7APIA 1R1LI 1SNGA 2WXXA 3EOXA 4ROBA 1QLPA 1QMNA 2WXYC 1JVQI 1OVAB 5INWA 2D26A 3LE2A 2HIJL 1BR8I
chains in the Genus database with same CATH topology
1JTIA 1IZ2A 2PEFA 1OYHL 3NDDA 1AZXI 2WXZC 4AU3A 4PYWA 1LK6I 5HGCA 1DZHL 2VDYA 1JRRA 2RIWA 1C5GA 4AU3B 3F02A 4DY0A 3CVMA 9APIA 4C41A 1M93B 3ZHAA 2VH4A 1DVNA 1IMVA 2PEEA 3DRMA 4ZK3A 5CDZA 4Y40A 1HP7A 4KDSA 1OO8A 1OVAC 4RO9A 2XN3A 1DZGL 2XN6A 2R9YA 4AFXA 3LW2A 3F1SA 5IO1A 1B3KA 1MTPA 2B4XL 1OPHA 4AU4A 3R4LA 1HLEA 2QUGA 3PB1I 3PZFA 4P0OA 3Q02A 1BY7A 1LQ8A 1ANTI 8APIA 1WZ9A 2B5TI 2H4QA 2XN7A 4AU2A 4G8OA 1F0CA 1AS4A 3H5CA 1EZXA 4IC0A 1SR5A 1JMOA 2VDXA 3DRUA 1ATUA 2DUTA 4IF8A 2WY1A 2V95A 1ATHA 1T1FA 3KCGI 1OC0A 4EB1I 2BEHI 3CWLA 3DLWA 3NDAA 4R9IA 2H4PA 1YXAA 1A7CA 1E04I 4X30A 4RSQA 1ATTA 4C49A 3Q03A 3CWMA 2OL2A 1XU8A 1K9OI 4ZK0A 5CDXA 3NDFA 2ACHA 4BB2A 2RIVA 5CE0A 1JMJA 5BRRI 4AJUA 5C98A 2CEOA 4YIAA 4GA7A 1JJOC 1LJ5A 1KCTA 1QMBA 4AJTA 1UHGA 3UT3A 1XQJA 2HIJI 2XN5A 1D5SA 1NQ9I 3FGQA 2ARRA 1PSIA 1DB2A 4ROAA 2GD4C 1OYHI 3NE4A 4DTEA 3DY0A 2ARQA 1DZHI 3EVJI 4CAAA 1SEKA 2WY0C 2WXZA 2WXWA 3STOA 4EB1L 2BEHL 3B9FI 2ZNHA 4DY7C 4G8RA 3F5NA 1E03I 1TB6I 1DVMA 2HI9A 4AQHA 2OAYA 1E05I 3CAAA 2H4RA 2ANTI 5EI0A 9PAIA 1C8OA 1DZGI 4P0FA 2ZV6A 3OZQA 3T1PA 4Y3KA 1OVAA 1XQGA 2B4XI 3VVJA 7APIA 1R1LI 1SNGA 2WXXA 3EOXA 4ROBA 1QLPA 1QMNA 2WXYC 1JVQI 1OVAB 5INWA 2D26A 3LE2A 2HIJL 1BR8I
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1JTI A;  1IZ2 A;  2PEF A;  1OYH L;  3NDD A;  1AZX I;  2WXZ C;  4AU3 A;  4PYW A;  1LK6 I;  5HGC A;  1DZH L;  2VDY A;  1JRR A;  2RIW A;  1C5G A;  4AU3 B;  3F02 A;  4DY0 A;  3CVM A;  9API A;  4C41 A;  1M93 B;  3ZHA A;  2VH4 A;  1DVN A;  1IMV A;  2PEE A;  3DRM A;  4ZK3 A;  5CDZ A;  4Y40 A;  1HP7 A;  4KDS A;  1OO8 A;  1OVA C;  4RO9 A;  2XN3 A;  1DZG L;  2XN6 A;  2R9Y A;  4AFX A;  3LW2 A;  3F1S A;  5IO1 A;  1B3K A;  1MTP A;  2B4X L;  1OPH A;  4AU4 A;  3R4L A;  1HLE A;  2QUG A;  3PB1 I;  3PZF A;  4P0O A;  3Q02 A;  1BY7 A;  1LQ8 A;  1ANT I;  8API A;  1WZ9 A;  2B5T I;  2H4Q A;  2XN7 A;  4AU2 A;  4G8O A;  1F0C A;  1AS4 A;  3H5C A;  1EZX A;  4IC0 A;  1SR5 A;  1JMO A;  2VDX A;  3DRU A;  1ATU A;  2DUT A;  4IF8 A;  2WY1 A;  2V95 A;  1ATH A;  1T1F A;  3KCG I;  1OC0 A;  4EB1 I;  2BEH I;  3CWL A;  3DLW A;  3NDA A;  4R9I A;  2H4P A;  1YXA A;  1A7C A;  1E04 I;  4X30 A;  4RSQ A;  1ATT A;  4C49 A;  3Q03 A;  3CWM A;  2OL2 A;  1XU8 A;  1K9O I;  4ZK0 A;  5CDX A;  3NDF A;  2ACH A;  4BB2 A;  2RIV A;  5CE0 A;  1JMJ A;  5BRR I;  4AJU A;  5C98 A;  2CEO A;  4YIA A;  4GA7 A;  1JJO C;  1LJ5 A;  1KCT A;  1QMB A;  4AJT A;  1UHG A;  3UT3 A;  1XQJ A;  2HIJ I;  2XN5 A;  1D5S A;  1NQ9 I;  3FGQ A;  2ARR A;  1PSI A;  1DB2 A;  4ROA A;  2GD4 C;  1OYH I;  3NE4 A;  4DTE A;  3DY0 A;  2ARQ A;  1DZH I;  3EVJ I;  4CAA A;  1SEK A;  2WY0 C;  2WXZ A;  2WXW A;  3STO A;  4EB1 L;  2BEH L;  3B9F I;  2ZNH A;  4DY7 C;  4G8R A;  3F5N A;  1E03 I;  1TB6 I;  1DVM A;  2HI9 A;  4AQH A;  2OAY A;  1E05 I;  3CAA A;  2H4R A;  2ANT I;  5EI0 A;  9PAI A;  1C8O A;  1DZG I;  4P0F A;  2ZV6 A;  3OZQ A;  3T1P A;  4Y3K A;  1OVA A;  1XQG A;  2B4X I;  3VVJ A;  7API A;  1R1L I;  1SNG A;  2WXX A;  3EOX A;  4ROB A;  1QLP A;  1QMN A;  2WXY C;  1JVQ I;  1OVA B;  5INW A;  2D26 A;  3LE2 A;  2HIJ L;  1BR8 I; 
#chains in the Genus database with same CATH topology
 1JTI A;  1IZ2 A;  2PEF A;  1OYH L;  3NDD A;  1AZX I;  2WXZ C;  4AU3 A;  4PYW A;  1LK6 I;  5HGC A;  1DZH L;  2VDY A;  1JRR A;  2RIW A;  1C5G A;  4AU3 B;  3F02 A;  4DY0 A;  3CVM A;  9API A;  4C41 A;  1M93 B;  3ZHA A;  2VH4 A;  1DVN A;  1IMV A;  2PEE A;  3DRM A;  4ZK3 A;  5CDZ A;  4Y40 A;  1HP7 A;  4KDS A;  1OO8 A;  1OVA C;  4RO9 A;  2XN3 A;  1DZG L;  2XN6 A;  2R9Y A;  4AFX A;  3LW2 A;  3F1S A;  5IO1 A;  1B3K A;  1MTP A;  2B4X L;  1OPH A;  4AU4 A;  3R4L A;  1HLE A;  2QUG A;  3PB1 I;  3PZF A;  4P0O A;  3Q02 A;  1BY7 A;  1LQ8 A;  1ANT I;  8API A;  1WZ9 A;  2B5T I;  2H4Q A;  2XN7 A;  4AU2 A;  4G8O A;  1F0C A;  1AS4 A;  3H5C A;  1EZX A;  4IC0 A;  1SR5 A;  1JMO A;  2VDX A;  3DRU A;  1ATU A;  2DUT A;  4IF8 A;  2WY1 A;  2V95 A;  1ATH A;  1T1F A;  3KCG I;  1OC0 A;  4EB1 I;  2BEH I;  3CWL A;  3DLW A;  3NDA A;  4R9I A;  2H4P A;  1YXA A;  1A7C A;  1E04 I;  4X30 A;  4RSQ A;  1ATT A;  4C49 A;  3Q03 A;  3CWM A;  2OL2 A;  1XU8 A;  1K9O I;  4ZK0 A;  5CDX A;  3NDF A;  2ACH A;  4BB2 A;  2RIV A;  5CE0 A;  1JMJ A;  5BRR I;  4AJU A;  5C98 A;  2CEO A;  4YIA A;  4GA7 A;  1JJO C;  1LJ5 A;  1KCT A;  1QMB A;  4AJT A;  1UHG A;  3UT3 A;  1XQJ A;  2HIJ I;  2XN5 A;  1D5S A;  1NQ9 I;  3FGQ A;  2ARR A;  1PSI A;  1DB2 A;  4ROA A;  2GD4 C;  1OYH I;  3NE4 A;  4DTE A;  3DY0 A;  2ARQ A;  1DZH I;  3EVJ I;  4CAA A;  1SEK A;  2WY0 C;  2WXZ A;  2WXW A;  3STO A;  4EB1 L;  2BEH L;  3B9F I;  2ZNH A;  4DY7 C;  4G8R A;  3F5N A;  1E03 I;  1TB6 I;  1DVM A;  2HI9 A;  4AQH A;  2OAY A;  1E05 I;  3CAA A;  2H4R A;  2ANT I;  5EI0 A;  9PAI A;  1C8O A;  1DZG I;  4P0F A;  2ZV6 A;  3OZQ A;  3T1P A;  4Y3K A;  1OVA A;  1XQG A;  2B4X I;  3VVJ A;  7API A;  1R1L I;  1SNG A;  2WXX A;  3EOX A;  4ROB A;  1QLP A;  1QMN A;  2WXY C;  1JVQ I;  1OVA B;  5INW A;  2D26 A;  3LE2 A;  2HIJ L;  1BR8 I; 
#chains in the Genus database with same CATH homology
 1JTI A;  1IZ2 A;  2PEF A;  1OYH L;  3NDD A;  1AZX I;  2WXZ C;  4AU3 A;  4PYW A;  1LK6 I;  5HGC A;  1DZH L;  2VDY A;  1JRR A;  2RIW A;  1C5G A;  4AU3 B;  3F02 A;  4DY0 A;  3CVM A;  9API A;  4C41 A;  1M93 B;  3ZHA A;  2VH4 A;  1DVN A;  1IMV A;  2PEE A;  3DRM A;  4ZK3 A;  5CDZ A;  4Y40 A;  1HP7 A;  4KDS A;  1OO8 A;  1OVA C;  4RO9 A;  2XN3 A;  1DZG L;  2XN6 A;  2R9Y A;  4AFX A;  3LW2 A;  3F1S A;  5IO1 A;  1B3K A;  1MTP A;  2B4X L;  1OPH A;  4AU4 A;  3R4L A;  1HLE A;  2QUG A;  3PB1 I;  3PZF A;  4P0O A;  3Q02 A;  1BY7 A;  1LQ8 A;  1ANT I;  8API A;  1WZ9 A;  2B5T I;  2H4Q A;  2XN7 A;  4AU2 A;  4G8O A;  1F0C A;  1AS4 A;  3H5C A;  1EZX A;  4IC0 A;  1SR5 A;  1JMO A;  2VDX A;  3DRU A;  1ATU A;  2DUT A;  4IF8 A;  2WY1 A;  2V95 A;  1ATH A;  1T1F A;  3KCG I;  1OC0 A;  4EB1 I;  2BEH I;  3CWL A;  3DLW A;  3NDA A;  4R9I A;  2H4P A;  1YXA A;  1A7C A;  1E04 I;  4X30 A;  4RSQ A;  1ATT A;  4C49 A;  3Q03 A;  3CWM A;  2OL2 A;  1XU8 A;  1K9O I;  4ZK0 A;  5CDX A;  3NDF A;  2ACH A;  4BB2 A;  2RIV A;  5CE0 A;  1JMJ A;  5BRR I;  4AJU A;  5C98 A;  2CEO A;  4YIA A;  4GA7 A;  1JJO C;  1LJ5 A;  1KCT A;  1QMB A;  4AJT A;  1UHG A;  3UT3 A;  1XQJ A;  2HIJ I;  2XN5 A;  1D5S A;  1NQ9 I;  3FGQ A;  2ARR A;  1PSI A;  1DB2 A;  4ROA A;  2GD4 C;  1OYH I;  3NE4 A;  4DTE A;  3DY0 A;  2ARQ A;  1DZH I;  3EVJ I;  4CAA A;  1SEK A;  2WY0 C;  2WXZ A;  2WXW A;  3STO A;  4EB1 L;  2BEH L;  3B9F I;  2ZNH A;  4DY7 C;  4G8R A;  3F5N A;  1E03 I;  1TB6 I;  1DVM A;  2HI9 A;  4AQH A;  2OAY A;  1E05 I;  3CAA A;  2H4R A;  2ANT I;  5EI0 A;  9PAI A;  1C8O A;  1DZG I;  4P0F A;  2ZV6 A;  3OZQ A;  3T1P A;  4Y3K A;  1OVA A;  1XQG A;  2B4X I;  3VVJ A;  7API A;  1R1L I;  1SNG A;  2WXX A;  3EOX A;  4ROB A;  1QLP A;  1QMN A;  2WXY C;  1JVQ I;  1OVA B;  5INW A;  2D26 A;  3LE2 A;  2HIJ L;  1BR8 I; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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