4C49A

Reactive loop cleaved human cbg in complex with cortisol
Total Genus 105
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
105
sequence length
368
structure length
367
Chain Sequence
GLASANVDFAFSLYKHLVALSPKKNIFISPVSISMALAMLSLGTCGHTRAQLLQGLGFNLTERSETEIHQGFQHLHQLFAKSDTSLEMTMGNALFLDGSLELLESFSADIKHYYESEVLAMNFQDWATASRQINSYVKNKTQGKIVDLFSGLDSPAILVLVNYIFFKGTWTQPFDLASTREENFYVDETTVVKVPMMLQSSTISYLHDSELPCQLVQMNYVGNGTVFFILPDKGKMNTVIAALSRDTINRWSAGLTSSQVDLYIPKVTISGVYDLGDVLEEMGIADLFTNQANFSRITQDAQLKSSKVVHKAVLQLNEEGVDTAGSTGVTLNLRKPIILRFNQPFIIMIFDHFTWSSLFLARVMNPV
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Role of Sa-Hd Loop Movement in Cortisol Release Mechanism of Cbg
rcsb
molecule tags Transport protein
source organism Homo sapiens
molecule keywords CORTICOSTEROID-BINDING GLOBULIN
total genus 105
structure length 367
sequence length 368
chains with identical sequence B, C, D
ec nomenclature
pdb deposition date 2013-09-02

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00079 Serpin Serpin (serine protease inhibitor)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.30.39.10 Mainly Beta Roll Alpha-1-antitrypsin; domain 1 Alpha-1-antitrypsin, domain 1 4c49A02
3.30.497.10 Alpha Beta 2-Layer Sandwich Antithrombin; Chain I, domain 2 Antithrombin, subunit I, domain 2 4c49A01
3NDAA 2H4PA 3EVJI 2BEHI 4DY0A 9APIA 1C8OA 2ARRA 1JRRA 2PEEA 4X30A 4DY7C 3PZFA 1DZGI 2HIJL 8APIA 2XN3A 2XN7A 1D5SA 1EZXA 2B4XI 1LK6I 2XN5A 1HLEA 1BY7A 1OVAA 3FGQA 1BR8I 1JMJA 1XQGA 1SR5A 2WXZC 2WXWA 3DLWA 4Y40A 3STOA 4AJTA 3LW2A 1ATTA 4G8OA 5BRRI 1QMNA 5CDXA 1JTIA 5CE0A 1OC0A 2GD4C 3OZQA 3T1PA 1OVAB 2VDYA 3H5CA 5CDZA 3Q02A 2VDXA 3VVJA 3EOXA 2ZNHA 1SEKA 1DVMA 1JJOC 1AS4A 1KCTA 2WXYC 1NQ9I 2ARQA 2HIJI 3DRUA 4P0FA 4BB2A 4DTEA 1QLPA 1DZHL 4AU3A 1JMOA 1QMBA 3NDFA 1PSIA 1SNGA 3NDDA 4Y3KA 5HGCA 4AU3B 4AU2A 3CWMA 4G8RA 1R1LI 4IF8A 1HP7A 2CEOA 1YXAA 4ZK3A 4RSQA 4AFXA 2OAYA 1OPHA 1OO8A 4PYWA 1OYHL 2WY1A 4EB1L 1C5GA 4ROAA 1ATHA 3ZHAA 1XQJA 1AZXI 4GA7A 2XN6A 3Q03A 1OVAC 2PEFA 3NE4A 3F5NA 2RIWA 1DZHI 2D26A 4C49A 5INWA 1XU8A 3CWLA 2HI9A 1B3KA 3PB1I 3F1SA 4AQHA 1E05I 3F02A 1WZ9A 2WY0C 4CAAA 1JVQI 1K9OI 2OL2A 9PAIA 4R9IA 2H4QA 1E03I 1M93B 1OYHI 3DRMA 4EB1I 1IMVA 1DVNA 3KCGI 2WXZA 4P0OA 2DUTA 4IC0A 2QUGA 4AJUA 7APIA 2V95A 2BEHL 2ZV6A 4ZK0A 1TB6I 2ACHA 1LQ8A 1T1FA 2ANTI 2WXXA 2R9YA 1DZGL 2H4RA 3DY0A 1A7CA 1E04I 1MTPA 2B4XL 3LE2A 1DB2A 4ROBA 3CVMA 4RO9A 2B5TI 2VH4A 1IZ2A 1UHGA 3R4LA 4YIAA 5EI0A 3B9FI 1LJ5A 1ATUA 4C41A 1F0CA 1ANTI 3CAAA 5C98A 3UT3A 5IO1A 4KDSA 4AU4A 2RIVA
chains in the Genus database with same CATH superfamily
3NDAA 2H4PA 3EVJI 2BEHI 4DY0A 9APIA 1C8OA 2ARRA 1JRRA 2PEEA 4X30A 4DY7C 3PZFA 1DZGI 2HIJL 8APIA 2XN3A 2XN7A 1D5SA 1EZXA 2B4XI 1LK6I 2XN5A 1HLEA 1BY7A 1OVAA 3FGQA 1BR8I 1JMJA 1XQGA 1SR5A 2WXZC 2WXWA 3DLWA 4Y40A 3STOA 4AJTA 3LW2A 1ATTA 4G8OA 5BRRI 1QMNA 5CDXA 1JTIA 5CE0A 1OC0A 2GD4C 3OZQA 3T1PA 1OVAB 2VDYA 3H5CA 5CDZA 3Q02A 2VDXA 3VVJA 3EOXA 2ZNHA 1SEKA 1DVMA 1JJOC 1AS4A 1KCTA 2WXYC 1NQ9I 2ARQA 2HIJI 3DRUA 4P0FA 4BB2A 4DTEA 1QLPA 1DZHL 4AU3A 1JMOA 1QMBA 3NDFA 1PSIA 1SNGA 3NDDA 4Y3KA 5HGCA 4AU3B 4AU2A 3CWMA 4G8RA 1R1LI 4IF8A 1HP7A 2CEOA 1YXAA 4ZK3A 4RSQA 4AFXA 2OAYA 1OPHA 1OO8A 4PYWA 1OYHL 2WY1A 4EB1L 1C5GA 4ROAA 1ATHA 3ZHAA 1XQJA 1AZXI 4GA7A 2XN6A 3Q03A 1OVAC 2PEFA 3NE4A 3F5NA 2RIWA 1DZHI 2D26A 4C49A 5INWA 1XU8A 3CWLA 2HI9A 1B3KA 3PB1I 3F1SA 4AQHA 1E05I 3F02A 1WZ9A 2WY0C 4CAAA 1JVQI 1K9OI 2OL2A 9PAIA 4R9IA 2H4QA 1E03I 1M93B 1OYHI 3DRMA 4EB1I 1IMVA 1DVNA 3KCGI 2WXZA 4P0OA 2DUTA 4IC0A 2QUGA 4AJUA 7APIA 2V95A 2BEHL 2ZV6A 4ZK0A 1TB6I 2ACHA 1LQ8A 1T1FA 2ANTI 2WXXA 2R9YA 1DZGL 2H4RA 3DY0A 1A7CA 1E04I 1MTPA 2B4XL 3LE2A 1DB2A 4ROBA 3CVMA 4RO9A 2B5TI 2VH4A 1IZ2A 1UHGA 3R4LA 4YIAA 5EI0A 3B9FI 1LJ5A 1ATUA 4C41A 1F0CA 1ANTI 3CAAA 5C98A 3UT3A 5IO1A 4KDSA 4AU4A 2RIVA
chains in the Genus database with same CATH topology
3NDAA 2H4PA 3EVJI 2BEHI 4DY0A 9APIA 1C8OA 2ARRA 1JRRA 2PEEA 4X30A 4DY7C 3PZFA 1DZGI 2HIJL 8APIA 2XN3A 2XN7A 1D5SA 1EZXA 2B4XI 1LK6I 2XN5A 1HLEA 1BY7A 1OVAA 3FGQA 1BR8I 1JMJA 1XQGA 1SR5A 2WXZC 2WXWA 3DLWA 4Y40A 3STOA 4AJTA 3LW2A 1ATTA 4G8OA 5BRRI 1QMNA 5CDXA 1JTIA 5CE0A 1OC0A 2GD4C 3OZQA 3T1PA 1OVAB 2VDYA 3H5CA 5CDZA 3Q02A 2VDXA 3VVJA 3EOXA 2ZNHA 1SEKA 1DVMA 1JJOC 1AS4A 1KCTA 2WXYC 1NQ9I 2ARQA 2HIJI 3DRUA 4P0FA 4BB2A 4DTEA 1QLPA 1DZHL 4AU3A 1JMOA 1QMBA 3NDFA 1PSIA 1SNGA 3NDDA 4Y3KA 5HGCA 4AU3B 4AU2A 3CWMA 4G8RA 1R1LI 4IF8A 1HP7A 2CEOA 1YXAA 4ZK3A 4RSQA 4AFXA 2OAYA 1OPHA 1OO8A 4PYWA 1OYHL 2WY1A 4EB1L 1C5GA 4ROAA 1ATHA 3ZHAA 1XQJA 1AZXI 4GA7A 2XN6A 3Q03A 1OVAC 2PEFA 3NE4A 3F5NA 2RIWA 1DZHI 2D26A 4C49A 5INWA 1XU8A 3CWLA 2HI9A 1B3KA 3PB1I 3F1SA 4AQHA 1E05I 3F02A 1WZ9A 2WY0C 4CAAA 1JVQI 1K9OI 2OL2A 9PAIA 4R9IA 2H4QA 1E03I 1M93B 1OYHI 3DRMA 4EB1I 1IMVA 1DVNA 3KCGI 2WXZA 4P0OA 2DUTA 4IC0A 2QUGA 4AJUA 7APIA 2V95A 2BEHL 2ZV6A 4ZK0A 1TB6I 2ACHA 1LQ8A 1T1FA 2ANTI 2WXXA 2R9YA 1DZGL 2H4RA 3DY0A 1A7CA 1E04I 1MTPA 2B4XL 3LE2A 1DB2A 4ROBA 3CVMA 4RO9A 2B5TI 2VH4A 1IZ2A 1UHGA 3R4LA 4YIAA 5EI0A 3B9FI 1LJ5A 1ATUA 4C41A 1F0CA 1ANTI 3CAAA 5C98A 3UT3A 5IO1A 4KDSA 4AU4A 2RIVA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3NDA A;  2H4P A;  3EVJ I;  2BEH I;  4DY0 A;  9API A;  1C8O A;  2ARR A;  1JRR A;  2PEE A;  4X30 A;  4DY7 C;  3PZF A;  1DZG I;  2HIJ L;  8API A;  2XN3 A;  2XN7 A;  1D5S A;  1EZX A;  2B4X I;  1LK6 I;  2XN5 A;  1HLE A;  1BY7 A;  1OVA A;  3FGQ A;  1BR8 I;  1JMJ A;  1XQG A;  1SR5 A;  2WXZ C;  2WXW A;  3DLW A;  4Y40 A;  3STO A;  4AJT A;  3LW2 A;  1ATT A;  4G8O A;  5BRR I;  1QMN A;  5CDX A;  1JTI A;  5CE0 A;  1OC0 A;  2GD4 C;  3OZQ A;  3T1P A;  1OVA B;  2VDY A;  3H5C A;  5CDZ A;  3Q02 A;  2VDX A;  3VVJ A;  3EOX A;  2ZNH A;  1SEK A;  1DVM A;  1JJO C;  1AS4 A;  1KCT A;  2WXY C;  1NQ9 I;  2ARQ A;  2HIJ I;  3DRU A;  4P0F A;  4BB2 A;  4DTE A;  1QLP A;  1DZH L;  4AU3 A;  1JMO A;  1QMB A;  3NDF A;  1PSI A;  1SNG A;  3NDD A;  4Y3K A;  5HGC A;  4AU3 B;  4AU2 A;  3CWM A;  4G8R A;  1R1L I;  4IF8 A;  1HP7 A;  2CEO A;  1YXA A;  4ZK3 A;  4RSQ A;  4AFX A;  2OAY A;  1OPH A;  1OO8 A;  4PYW A;  1OYH L;  2WY1 A;  4EB1 L;  1C5G A;  4ROA A;  1ATH A;  3ZHA A;  1XQJ A;  1AZX I;  4GA7 A;  2XN6 A;  3Q03 A;  1OVA C;  2PEF A;  3NE4 A;  3F5N A;  2RIW A;  1DZH I;  2D26 A;  4C49 A;  5INW A;  1XU8 A;  3CWL A;  2HI9 A;  1B3K A;  3PB1 I;  3F1S A;  4AQH A;  1E05 I;  3F02 A;  1WZ9 A;  2WY0 C;  4CAA A;  1JVQ I;  1K9O I;  2OL2 A;  9PAI A;  4R9I A;  2H4Q A;  1E03 I;  1M93 B;  1OYH I;  3DRM A;  4EB1 I;  1IMV A;  1DVN A;  3KCG I;  2WXZ A;  4P0O A;  2DUT A;  4IC0 A;  2QUG A;  4AJU A;  7API A;  2V95 A;  2BEH L;  2ZV6 A;  4ZK0 A;  1TB6 I;  2ACH A;  1LQ8 A;  1T1F A;  2ANT I;  2WXX A;  2R9Y A;  1DZG L;  2H4R A;  3DY0 A;  1A7C A;  1E04 I;  1MTP A;  2B4X L;  3LE2 A;  1DB2 A;  4ROB A;  3CVM A;  4RO9 A;  2B5T I;  2VH4 A;  1IZ2 A;  1UHG A;  3R4L A;  4YIA A;  5EI0 A;  3B9F I;  1LJ5 A;  1ATU A;  4C41 A;  1F0C A;  1ANT I;  3CAA A;  5C98 A;  3UT3 A;  5IO1 A;  4KDS A;  4AU4 A;  2RIV A; 
#chains in the Genus database with same CATH topology
 3NDA A;  2H4P A;  3EVJ I;  2BEH I;  4DY0 A;  9API A;  1C8O A;  2ARR A;  1JRR A;  2PEE A;  4X30 A;  4DY7 C;  3PZF A;  1DZG I;  2HIJ L;  8API A;  2XN3 A;  2XN7 A;  1D5S A;  1EZX A;  2B4X I;  1LK6 I;  2XN5 A;  1HLE A;  1BY7 A;  1OVA A;  3FGQ A;  1BR8 I;  1JMJ A;  1XQG A;  1SR5 A;  2WXZ C;  2WXW A;  3DLW A;  4Y40 A;  3STO A;  4AJT A;  3LW2 A;  1ATT A;  4G8O A;  5BRR I;  1QMN A;  5CDX A;  1JTI A;  5CE0 A;  1OC0 A;  2GD4 C;  3OZQ A;  3T1P A;  1OVA B;  2VDY A;  3H5C A;  5CDZ A;  3Q02 A;  2VDX A;  3VVJ A;  3EOX A;  2ZNH A;  1SEK A;  1DVM A;  1JJO C;  1AS4 A;  1KCT A;  2WXY C;  1NQ9 I;  2ARQ A;  2HIJ I;  3DRU A;  4P0F A;  4BB2 A;  4DTE A;  1QLP A;  1DZH L;  4AU3 A;  1JMO A;  1QMB A;  3NDF A;  1PSI A;  1SNG A;  3NDD A;  4Y3K A;  5HGC A;  4AU3 B;  4AU2 A;  3CWM A;  4G8R A;  1R1L I;  4IF8 A;  1HP7 A;  2CEO A;  1YXA A;  4ZK3 A;  4RSQ A;  4AFX A;  2OAY A;  1OPH A;  1OO8 A;  4PYW A;  1OYH L;  2WY1 A;  4EB1 L;  1C5G A;  4ROA A;  1ATH A;  3ZHA A;  1XQJ A;  1AZX I;  4GA7 A;  2XN6 A;  3Q03 A;  1OVA C;  2PEF A;  3NE4 A;  3F5N A;  2RIW A;  1DZH I;  2D26 A;  4C49 A;  5INW A;  1XU8 A;  3CWL A;  2HI9 A;  1B3K A;  3PB1 I;  3F1S A;  4AQH A;  1E05 I;  3F02 A;  1WZ9 A;  2WY0 C;  4CAA A;  1JVQ I;  1K9O I;  2OL2 A;  9PAI A;  4R9I A;  2H4Q A;  1E03 I;  1M93 B;  1OYH I;  3DRM A;  4EB1 I;  1IMV A;  1DVN A;  3KCG I;  2WXZ A;  4P0O A;  2DUT A;  4IC0 A;  2QUG A;  4AJU A;  7API A;  2V95 A;  2BEH L;  2ZV6 A;  4ZK0 A;  1TB6 I;  2ACH A;  1LQ8 A;  1T1F A;  2ANT I;  2WXX A;  2R9Y A;  1DZG L;  2H4R A;  3DY0 A;  1A7C A;  1E04 I;  1MTP A;  2B4X L;  3LE2 A;  1DB2 A;  4ROB A;  3CVM A;  4RO9 A;  2B5T I;  2VH4 A;  1IZ2 A;  1UHG A;  3R4L A;  4YIA A;  5EI0 A;  3B9F I;  1LJ5 A;  1ATU A;  4C41 A;  1F0C A;  1ANT I;  3CAA A;  5C98 A;  3UT3 A;  5IO1 A;  4KDS A;  4AU4 A;  2RIV A; 
#chains in the Genus database with same CATH homology
 3NDA A;  2H4P A;  3EVJ I;  2BEH I;  4DY0 A;  9API A;  1C8O A;  2ARR A;  1JRR A;  2PEE A;  4X30 A;  4DY7 C;  3PZF A;  1DZG I;  2HIJ L;  8API A;  2XN3 A;  2XN7 A;  1D5S A;  1EZX A;  2B4X I;  1LK6 I;  2XN5 A;  1HLE A;  1BY7 A;  1OVA A;  3FGQ A;  1BR8 I;  1JMJ A;  1XQG A;  1SR5 A;  2WXZ C;  2WXW A;  3DLW A;  4Y40 A;  3STO A;  4AJT A;  3LW2 A;  1ATT A;  4G8O A;  5BRR I;  1QMN A;  5CDX A;  1JTI A;  5CE0 A;  1OC0 A;  2GD4 C;  3OZQ A;  3T1P A;  1OVA B;  2VDY A;  3H5C A;  5CDZ A;  3Q02 A;  2VDX A;  3VVJ A;  3EOX A;  2ZNH A;  1SEK A;  1DVM A;  1JJO C;  1AS4 A;  1KCT A;  2WXY C;  1NQ9 I;  2ARQ A;  2HIJ I;  3DRU A;  4P0F A;  4BB2 A;  4DTE A;  1QLP A;  1DZH L;  4AU3 A;  1JMO A;  1QMB A;  3NDF A;  1PSI A;  1SNG A;  3NDD A;  4Y3K A;  5HGC A;  4AU3 B;  4AU2 A;  3CWM A;  4G8R A;  1R1L I;  4IF8 A;  1HP7 A;  2CEO A;  1YXA A;  4ZK3 A;  4RSQ A;  4AFX A;  2OAY A;  1OPH A;  1OO8 A;  4PYW A;  1OYH L;  2WY1 A;  4EB1 L;  1C5G A;  4ROA A;  1ATH A;  3ZHA A;  1XQJ A;  1AZX I;  4GA7 A;  2XN6 A;  3Q03 A;  1OVA C;  2PEF A;  3NE4 A;  3F5N A;  2RIW A;  1DZH I;  2D26 A;  4C49 A;  5INW A;  1XU8 A;  3CWL A;  2HI9 A;  1B3K A;  3PB1 I;  3F1S A;  4AQH A;  1E05 I;  3F02 A;  1WZ9 A;  2WY0 C;  4CAA A;  1JVQ I;  1K9O I;  2OL2 A;  9PAI A;  4R9I A;  2H4Q A;  1E03 I;  1M93 B;  1OYH I;  3DRM A;  4EB1 I;  1IMV A;  1DVN A;  3KCG I;  2WXZ A;  4P0O A;  2DUT A;  4IC0 A;  2QUG A;  4AJU A;  7API A;  2V95 A;  2BEH L;  2ZV6 A;  4ZK0 A;  1TB6 I;  2ACH A;  1LQ8 A;  1T1F A;  2ANT I;  2WXX A;  2R9Y A;  1DZG L;  2H4R A;  3DY0 A;  1A7C A;  1E04 I;  1MTP A;  2B4X L;  3LE2 A;  1DB2 A;  4ROB A;  3CVM A;  4RO9 A;  2B5T I;  2VH4 A;  1IZ2 A;  1UHG A;  3R4L A;  4YIA A;  5EI0 A;  3B9F I;  1LJ5 A;  1ATU A;  4C41 A;  1F0C A;  1ANT I;  3CAA A;  5C98 A;  3UT3 A;  5IO1 A;  4KDS A;  4AU4 A;  2RIV A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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