4CAAA

Cleaved antichymotrypsin t345r
Total Genus 99
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
99
sequence length
333
structure length
333
Chain Sequence
SANVDFAFSLYKQLVLKAPDKNVIFSPLSISTALAFLSLGAHNTTLTEILKGLKFNLTETSEAEIHQSFQHLLRTLNQSSDELQLSMGNAMFVKEQLSLLDRFTEDAKRLYGSEAFATDFQDSAAAKKLINDYVKNGTRGKITDLIKDLDSQTMMVLVNYIFFKAKWEMPFDPQDTHQSRFYLSKKKWVMVPMMSLHHLTIPYFRDEELSCTVVELKYTGNASALFILPDQDKMEEVEAMLLPETLKRWRDSLEFREIGELYLPKFSISRDYNLNDILLQLGIEEAFTSKADLSGITGARNLAVSQVVHKAVLDVFEEGREASAATAVKITLL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Serpin
molecule keywords ANTICHYMOTRYPSIN
publication title Engineering an anion-binding cavity in antichymotrypsin modulates the "spring-loaded" serpin-protease interaction.
pubmed doi rcsb
source organism Homo sapiens
total genus 99
structure length 333
sequence length 333
ec nomenclature
pdb deposition date 1997-08-14
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.30.39.10 Mainly Beta Roll Alpha-1-antitrypsin; domain 1 Alpha-1-antitrypsin, domain 1 4caaA01
3.30.497.10 Alpha Beta 2-Layer Sandwich Antithrombin; Chain I, domain 2 Antithrombin, subunit I, domain 2 4caaA02
3VVJA 4AJTA 3NDAA 2VDXA 1D5SA 3NDDA 2WXYC 4PYWA 3DLWA 3DY0A 4Y40A 2GD4C 4P0OA 3H5CA 4BB2A 1AZXI 5INWA 1JTIA 2OL2A 4R9IA 1DZGL 3NE4A 1B3KA 1F0CA 1QLPA 4CAAA 4G8OA 2HI9A 4AU3B 2ARRA 2V95A 3KCGI 5EI0A 3T1PA 2BEHI 1T1FA 2R9YA 1OVAC 2B4XL 1UHGA 1LQ8A 1JRRA 1KCTA 9PAIA 3FGQA 1SEKA 1MTPA 1BY7A 4G8RA 1TB6I 4AU3A 1QMBA 2H4RA 1DZHL 2OAYA 1EZXA 3EOXA 3LE2A 3Q02A 2H4QA 2WXZC 4ROAA 1M93B 4RO9A 1NQ9I 2ZV6A 1ANTI 3LW2A 1SNGA 3CWMA 2WY0C 2ZNHA 1DZGI 1YXAA 1OC0A 4GA7A 4C49A 1IZ2A 1LK6I 5CDZA 1ATTA 3F1SA 3DRMA 1HP7A 1DVNA 1R1LI 3ZHAA 2D26A 2DUTA 4EB1L 4AU2A 2CEOA 4YIAA 1JVQI 3PB1I 2B4XI 2XN6A 3STOA 3NDFA 1OPHA 1OVAB 4IF8A 9APIA 4X30A 2ANTI 4P0FA 4ROBA 4ZK3A 4DY7C 1OO8A 1DZHI 1E05I 1QMNA 1SR5A 3EVJI 5IO1A 1ATHA 3DRUA 2RIVA 4AU4A 1BR8I 3CAAA 3PZFA 4KDSA 4Y3KA 4AFXA 1K9OI 1OVAA 8APIA 2XN7A 2ACHA 1E03I 2ARQA 1C8OA 1XU8A 2WXWA 1DB2A 1XQJA 2RIWA 1IMVA 3Q03A 3UT3A 4C41A 4EB1I 1OYHI 1OYHL 2VH4A 3CWLA 5BRRI 5CDXA 1WZ9A 3F02A 2WXZA 1DVMA 4DTEA 4RSQA 4AJUA 1AS4A 3B9FI 2HIJI 2HIJL 5CE0A 1HLEA 2PEEA 2B5TI 3OZQA 5C98A 1XQGA 3CVMA 1JMJA 2WY1A 1LJ5A 2QUGA 2WXXA 1E04I 1C5GA 3R4LA 1PSIA 4AQHA 1ATUA 2PEFA 5HGCA 1JMOA 2BEHL 2H4PA 4DY0A 2VDYA 4IC0A 7APIA 1JJOC 4ZK0A 3F5NA 2XN5A 2XN3A 1A7CA
chains in the Genus database with same CATH superfamily
3VVJA 4AJTA 3NDAA 2VDXA 1D5SA 3NDDA 2WXYC 4PYWA 3DLWA 3DY0A 4Y40A 2GD4C 4P0OA 3H5CA 4BB2A 1AZXI 5INWA 1JTIA 2OL2A 4R9IA 1DZGL 3NE4A 1B3KA 1F0CA 1QLPA 4CAAA 4G8OA 2HI9A 4AU3B 2ARRA 2V95A 3KCGI 5EI0A 3T1PA 2BEHI 1T1FA 2R9YA 1OVAC 2B4XL 1UHGA 1LQ8A 1JRRA 1KCTA 9PAIA 3FGQA 1SEKA 1MTPA 1BY7A 4G8RA 1TB6I 4AU3A 1QMBA 2H4RA 1DZHL 2OAYA 1EZXA 3EOXA 3LE2A 3Q02A 2H4QA 2WXZC 4ROAA 1M93B 4RO9A 1NQ9I 2ZV6A 1ANTI 3LW2A 1SNGA 3CWMA 2WY0C 2ZNHA 1DZGI 1YXAA 1OC0A 4GA7A 4C49A 1IZ2A 1LK6I 5CDZA 1ATTA 3F1SA 3DRMA 1HP7A 1DVNA 1R1LI 3ZHAA 2D26A 2DUTA 4EB1L 4AU2A 2CEOA 4YIAA 1JVQI 3PB1I 2B4XI 2XN6A 3STOA 3NDFA 1OPHA 1OVAB 4IF8A 9APIA 4X30A 2ANTI 4P0FA 4ROBA 4ZK3A 4DY7C 1OO8A 1DZHI 1E05I 1QMNA 1SR5A 3EVJI 5IO1A 1ATHA 3DRUA 2RIVA 4AU4A 1BR8I 3CAAA 3PZFA 4KDSA 4Y3KA 4AFXA 1K9OI 1OVAA 8APIA 2XN7A 2ACHA 1E03I 2ARQA 1C8OA 1XU8A 2WXWA 1DB2A 1XQJA 2RIWA 1IMVA 3Q03A 3UT3A 4C41A 4EB1I 1OYHI 1OYHL 2VH4A 3CWLA 5BRRI 5CDXA 1WZ9A 3F02A 2WXZA 1DVMA 4DTEA 4RSQA 4AJUA 1AS4A 3B9FI 2HIJI 2HIJL 5CE0A 1HLEA 2PEEA 2B5TI 3OZQA 5C98A 1XQGA 3CVMA 1JMJA 2WY1A 1LJ5A 2QUGA 2WXXA 1E04I 1C5GA 3R4LA 1PSIA 4AQHA 1ATUA 2PEFA 5HGCA 1JMOA 2BEHL 2H4PA 4DY0A 2VDYA 4IC0A 7APIA 1JJOC 4ZK0A 3F5NA 2XN5A 2XN3A 1A7CA
chains in the Genus database with same CATH topology
3VVJA 4AJTA 3NDAA 2VDXA 1D5SA 3NDDA 2WXYC 4PYWA 3DLWA 3DY0A 4Y40A 2GD4C 4P0OA 3H5CA 4BB2A 1AZXI 5INWA 1JTIA 2OL2A 4R9IA 1DZGL 3NE4A 1B3KA 1F0CA 1QLPA 4CAAA 4G8OA 2HI9A 4AU3B 2ARRA 2V95A 3KCGI 5EI0A 3T1PA 2BEHI 1T1FA 2R9YA 1OVAC 2B4XL 1UHGA 1LQ8A 1JRRA 1KCTA 9PAIA 3FGQA 1SEKA 1MTPA 1BY7A 4G8RA 1TB6I 4AU3A 1QMBA 2H4RA 1DZHL 2OAYA 1EZXA 3EOXA 3LE2A 3Q02A 2H4QA 2WXZC 4ROAA 1M93B 4RO9A 1NQ9I 2ZV6A 1ANTI 3LW2A 1SNGA 3CWMA 2WY0C 2ZNHA 1DZGI 1YXAA 1OC0A 4GA7A 4C49A 1IZ2A 1LK6I 5CDZA 1ATTA 3F1SA 3DRMA 1HP7A 1DVNA 1R1LI 3ZHAA 2D26A 2DUTA 4EB1L 4AU2A 2CEOA 4YIAA 1JVQI 3PB1I 2B4XI 2XN6A 3STOA 3NDFA 1OPHA 1OVAB 4IF8A 9APIA 4X30A 2ANTI 4P0FA 4ROBA 4ZK3A 4DY7C 1OO8A 1DZHI 1E05I 1QMNA 1SR5A 3EVJI 5IO1A 1ATHA 3DRUA 2RIVA 4AU4A 1BR8I 3CAAA 3PZFA 4KDSA 4Y3KA 4AFXA 1K9OI 1OVAA 8APIA 2XN7A 2ACHA 1E03I 2ARQA 1C8OA 1XU8A 2WXWA 1DB2A 1XQJA 2RIWA 1IMVA 3Q03A 3UT3A 4C41A 4EB1I 1OYHI 1OYHL 2VH4A 3CWLA 5BRRI 5CDXA 1WZ9A 3F02A 2WXZA 1DVMA 4DTEA 4RSQA 4AJUA 1AS4A 3B9FI 2HIJI 2HIJL 5CE0A 1HLEA 2PEEA 2B5TI 3OZQA 5C98A 1XQGA 3CVMA 1JMJA 2WY1A 1LJ5A 2QUGA 2WXXA 1E04I 1C5GA 3R4LA 1PSIA 4AQHA 1ATUA 2PEFA 5HGCA 1JMOA 2BEHL 2H4PA 4DY0A 2VDYA 4IC0A 7APIA 1JJOC 4ZK0A 3F5NA 2XN5A 2XN3A 1A7CA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3VVJ A;  4AJT A;  3NDA A;  2VDX A;  1D5S A;  3NDD A;  2WXY C;  4PYW A;  3DLW A;  3DY0 A;  4Y40 A;  2GD4 C;  4P0O A;  3H5C A;  4BB2 A;  1AZX I;  5INW A;  1JTI A;  2OL2 A;  4R9I A;  1DZG L;  3NE4 A;  1B3K A;  1F0C A;  1QLP A;  4CAA A;  4G8O A;  2HI9 A;  4AU3 B;  2ARR A;  2V95 A;  3KCG I;  5EI0 A;  3T1P A;  2BEH I;  1T1F A;  2R9Y A;  1OVA C;  2B4X L;  1UHG A;  1LQ8 A;  1JRR A;  1KCT A;  9PAI A;  3FGQ A;  1SEK A;  1MTP A;  1BY7 A;  4G8R A;  1TB6 I;  4AU3 A;  1QMB A;  2H4R A;  1DZH L;  2OAY A;  1EZX A;  3EOX A;  3LE2 A;  3Q02 A;  2H4Q A;  2WXZ C;  4ROA A;  1M93 B;  4RO9 A;  1NQ9 I;  2ZV6 A;  1ANT I;  3LW2 A;  1SNG A;  3CWM A;  2WY0 C;  2ZNH A;  1DZG I;  1YXA A;  1OC0 A;  4GA7 A;  4C49 A;  1IZ2 A;  1LK6 I;  5CDZ A;  1ATT A;  3F1S A;  3DRM A;  1HP7 A;  1DVN A;  1R1L I;  3ZHA A;  2D26 A;  2DUT A;  4EB1 L;  4AU2 A;  2CEO A;  4YIA A;  1JVQ I;  3PB1 I;  2B4X I;  2XN6 A;  3STO A;  3NDF A;  1OPH A;  1OVA B;  4IF8 A;  9API A;  4X30 A;  2ANT I;  4P0F A;  4ROB A;  4ZK3 A;  4DY7 C;  1OO8 A;  1DZH I;  1E05 I;  1QMN A;  1SR5 A;  3EVJ I;  5IO1 A;  1ATH A;  3DRU A;  2RIV A;  4AU4 A;  1BR8 I;  3CAA A;  3PZF A;  4KDS A;  4Y3K A;  4AFX A;  1K9O I;  1OVA A;  8API A;  2XN7 A;  2ACH A;  1E03 I;  2ARQ A;  1C8O A;  1XU8 A;  2WXW A;  1DB2 A;  1XQJ A;  2RIW A;  1IMV A;  3Q03 A;  3UT3 A;  4C41 A;  4EB1 I;  1OYH I;  1OYH L;  2VH4 A;  3CWL A;  5BRR I;  5CDX A;  1WZ9 A;  3F02 A;  2WXZ A;  1DVM A;  4DTE A;  4RSQ A;  4AJU A;  1AS4 A;  3B9F I;  2HIJ I;  2HIJ L;  5CE0 A;  1HLE A;  2PEE A;  2B5T I;  3OZQ A;  5C98 A;  1XQG A;  3CVM A;  1JMJ A;  2WY1 A;  1LJ5 A;  2QUG A;  2WXX A;  1E04 I;  1C5G A;  3R4L A;  1PSI A;  4AQH A;  1ATU A;  2PEF A;  5HGC A;  1JMO A;  2BEH L;  2H4P A;  4DY0 A;  2VDY A;  4IC0 A;  7API A;  1JJO C;  4ZK0 A;  3F5N A;  2XN5 A;  2XN3 A;  1A7C A; 
#chains in the Genus database with same CATH topology
 3VVJ A;  4AJT A;  3NDA A;  2VDX A;  1D5S A;  3NDD A;  2WXY C;  4PYW A;  3DLW A;  3DY0 A;  4Y40 A;  2GD4 C;  4P0O A;  3H5C A;  4BB2 A;  1AZX I;  5INW A;  1JTI A;  2OL2 A;  4R9I A;  1DZG L;  3NE4 A;  1B3K A;  1F0C A;  1QLP A;  4CAA A;  4G8O A;  2HI9 A;  4AU3 B;  2ARR A;  2V95 A;  3KCG I;  5EI0 A;  3T1P A;  2BEH I;  1T1F A;  2R9Y A;  1OVA C;  2B4X L;  1UHG A;  1LQ8 A;  1JRR A;  1KCT A;  9PAI A;  3FGQ A;  1SEK A;  1MTP A;  1BY7 A;  4G8R A;  1TB6 I;  4AU3 A;  1QMB A;  2H4R A;  1DZH L;  2OAY A;  1EZX A;  3EOX A;  3LE2 A;  3Q02 A;  2H4Q A;  2WXZ C;  4ROA A;  1M93 B;  4RO9 A;  1NQ9 I;  2ZV6 A;  1ANT I;  3LW2 A;  1SNG A;  3CWM A;  2WY0 C;  2ZNH A;  1DZG I;  1YXA A;  1OC0 A;  4GA7 A;  4C49 A;  1IZ2 A;  1LK6 I;  5CDZ A;  1ATT A;  3F1S A;  3DRM A;  1HP7 A;  1DVN A;  1R1L I;  3ZHA A;  2D26 A;  2DUT A;  4EB1 L;  4AU2 A;  2CEO A;  4YIA A;  1JVQ I;  3PB1 I;  2B4X I;  2XN6 A;  3STO A;  3NDF A;  1OPH A;  1OVA B;  4IF8 A;  9API A;  4X30 A;  2ANT I;  4P0F A;  4ROB A;  4ZK3 A;  4DY7 C;  1OO8 A;  1DZH I;  1E05 I;  1QMN A;  1SR5 A;  3EVJ I;  5IO1 A;  1ATH A;  3DRU A;  2RIV A;  4AU4 A;  1BR8 I;  3CAA A;  3PZF A;  4KDS A;  4Y3K A;  4AFX A;  1K9O I;  1OVA A;  8API A;  2XN7 A;  2ACH A;  1E03 I;  2ARQ A;  1C8O A;  1XU8 A;  2WXW A;  1DB2 A;  1XQJ A;  2RIW A;  1IMV A;  3Q03 A;  3UT3 A;  4C41 A;  4EB1 I;  1OYH I;  1OYH L;  2VH4 A;  3CWL A;  5BRR I;  5CDX A;  1WZ9 A;  3F02 A;  2WXZ A;  1DVM A;  4DTE A;  4RSQ A;  4AJU A;  1AS4 A;  3B9F I;  2HIJ I;  2HIJ L;  5CE0 A;  1HLE A;  2PEE A;  2B5T I;  3OZQ A;  5C98 A;  1XQG A;  3CVM A;  1JMJ A;  2WY1 A;  1LJ5 A;  2QUG A;  2WXX A;  1E04 I;  1C5G A;  3R4L A;  1PSI A;  4AQH A;  1ATU A;  2PEF A;  5HGC A;  1JMO A;  2BEH L;  2H4P A;  4DY0 A;  2VDY A;  4IC0 A;  7API A;  1JJO C;  4ZK0 A;  3F5N A;  2XN5 A;  2XN3 A;  1A7C A; 
#chains in the Genus database with same CATH homology
 3VVJ A;  4AJT A;  3NDA A;  2VDX A;  1D5S A;  3NDD A;  2WXY C;  4PYW A;  3DLW A;  3DY0 A;  4Y40 A;  2GD4 C;  4P0O A;  3H5C A;  4BB2 A;  1AZX I;  5INW A;  1JTI A;  2OL2 A;  4R9I A;  1DZG L;  3NE4 A;  1B3K A;  1F0C A;  1QLP A;  4CAA A;  4G8O A;  2HI9 A;  4AU3 B;  2ARR A;  2V95 A;  3KCG I;  5EI0 A;  3T1P A;  2BEH I;  1T1F A;  2R9Y A;  1OVA C;  2B4X L;  1UHG A;  1LQ8 A;  1JRR A;  1KCT A;  9PAI A;  3FGQ A;  1SEK A;  1MTP A;  1BY7 A;  4G8R A;  1TB6 I;  4AU3 A;  1QMB A;  2H4R A;  1DZH L;  2OAY A;  1EZX A;  3EOX A;  3LE2 A;  3Q02 A;  2H4Q A;  2WXZ C;  4ROA A;  1M93 B;  4RO9 A;  1NQ9 I;  2ZV6 A;  1ANT I;  3LW2 A;  1SNG A;  3CWM A;  2WY0 C;  2ZNH A;  1DZG I;  1YXA A;  1OC0 A;  4GA7 A;  4C49 A;  1IZ2 A;  1LK6 I;  5CDZ A;  1ATT A;  3F1S A;  3DRM A;  1HP7 A;  1DVN A;  1R1L I;  3ZHA A;  2D26 A;  2DUT A;  4EB1 L;  4AU2 A;  2CEO A;  4YIA A;  1JVQ I;  3PB1 I;  2B4X I;  2XN6 A;  3STO A;  3NDF A;  1OPH A;  1OVA B;  4IF8 A;  9API A;  4X30 A;  2ANT I;  4P0F A;  4ROB A;  4ZK3 A;  4DY7 C;  1OO8 A;  1DZH I;  1E05 I;  1QMN A;  1SR5 A;  3EVJ I;  5IO1 A;  1ATH A;  3DRU A;  2RIV A;  4AU4 A;  1BR8 I;  3CAA A;  3PZF A;  4KDS A;  4Y3K A;  4AFX A;  1K9O I;  1OVA A;  8API A;  2XN7 A;  2ACH A;  1E03 I;  2ARQ A;  1C8O A;  1XU8 A;  2WXW A;  1DB2 A;  1XQJ A;  2RIW A;  1IMV A;  3Q03 A;  3UT3 A;  4C41 A;  4EB1 I;  1OYH I;  1OYH L;  2VH4 A;  3CWL A;  5BRR I;  5CDX A;  1WZ9 A;  3F02 A;  2WXZ A;  1DVM A;  4DTE A;  4RSQ A;  4AJU A;  1AS4 A;  3B9F I;  2HIJ I;  2HIJ L;  5CE0 A;  1HLE A;  2PEE A;  2B5T I;  3OZQ A;  5C98 A;  1XQG A;  3CVM A;  1JMJ A;  2WY1 A;  1LJ5 A;  2QUG A;  2WXX A;  1E04 I;  1C5G A;  3R4L A;  1PSI A;  4AQH A;  1ATU A;  2PEF A;  5HGC A;  1JMO A;  2BEH L;  2H4P A;  4DY0 A;  2VDY A;  4IC0 A;  7API A;  1JJO C;  4ZK0 A;  3F5N A;  2XN5 A;  2XN3 A;  1A7C A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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