4DTEA

Crystal structure of zebrafish plasminogen activator inhibitor-1 (pai-1)
Total Genus 119
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
119
sequence length
374
structure length
374
Chain Sequence
NLIQDKQTDFGLQVFAEAVQSAPDRNLALSPYGIASVLGMAQMGAYGATLKLLASKMGYSLQERGMPKLQRLLQRDLASEDGVEVASGVMVDRKIILEKVFRRSLSKAFQSVPHQIDFSQPEMARQVINSWTSDHTDGMISEFLPSGVLSELTRLVFLNALHFHGVWKTPFDPRNTREQLFHTVNGSAVSVPMMTTTQKFNYGEFVSKDGVDYDVIEMPYEGESISMLLVTPFEKDVPLSALNKELSSSRIHQWRQEMRKISKQLSIPRFSMDTEIDLKSTLSRMGLGDIFSQSRADFSRITTEEPLCVSKVLQRVKLEVNEEGTKGSSATAAVIYSRMAVEEITLDRPFFFLIQHKPTGALLFSGQLTQPQEY
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase inhibitor
molecule keywords Serpin peptidase inhibitor, clade E (nexin, plasminogen acti
publication title Protein conformational change delayed by steric hindrance from an N-linked glycan.
pubmed doi rcsb
source organism Danio rerio
total genus 119
structure length 374
sequence length 374
chains with identical sequence B
ec nomenclature
pdb deposition date 2012-02-21

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00079 Serpin Serpin (serine protease inhibitor)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.30.39.10 Mainly Beta Roll Alpha-1-antitrypsin; domain 1 Alpha-1-antitrypsin, domain 1 4dteA02
3.30.497.10 Alpha Beta 2-Layer Sandwich Antithrombin; Chain I, domain 2 Antithrombin, subunit I, domain 2 4dteA01
1JTIA 1C5GA 1DZGI 1M93B 3CVMA 2B4XL 2QUGA 3R4LA 2ARQA 4ZK3A 3F02A 4X30A 1JRRA 4AU3B 3EVJI 4AQHA 3FGQA 2WXYC 1SEKA 1XQJA 2ACHA 3NDFA 4DTEA 1OYHL 3Q02A 2HI9A 3EOXA 2BEHL 4R9IA 4IC0A 1EZXA 5CDZA 4BB2A 4P0FA 1HP7A 3NE4A 2WXZA 1LJ5A 2VDYA 2PEFA 1ATTA 4C41A 1SR5A 1XQGA 2CEOA 4AU2A 3F5NA 1HLEA 1OVAB 2HIJL 2V95A 3NDDA 5C98A 1KCTA 1E03I 4AJTA 3F1SA 4KDSA 1JJOC 1F0CA 2ZNHA 1AS4A 3Q03A 8APIA 4GA7A 5IO1A 2XN6A 1DZHI 3LW2A 4Y40A 2WXZC 1PSIA 7APIA 9PAIA 1B3KA 1D5SA 2H4QA 2ARRA 2B4XI 2B5TI 2R9YA 1UHGA 4AU3A 2OAYA 3DLWA 1OVAC 3STOA 3B9FI 1T1FA 3DRUA 1E04I 1OC0A 4ZK0A 3PB1I 1TB6I 1IMVA 2DUTA 5INWA 2BEHI 3H5CA 1C8OA 1DVNA 2XN7A 3T1PA 5CE0A 2WY0C 1AZXI 5EI0A 1YXAA 3OZQA 1OVAA 4G8OA 1ATHA 2HIJI 4CAAA 3PZFA 4DY7C 1QMBA 4EB1I 3DY0A 5HGCA 2XN5A 1LK6I 1ATUA 3CAAA 3NDAA 1K9OI 1DZGL 1QMNA 2RIWA 1WZ9A 1MTPA 1ANTI 4G8RA 4IF8A 2ANTI 1LQ8A 2WXXA 2WY1A 1E05I 4AFXA 1A7CA 2RIVA 4AU4A 4Y3KA 4ROAA 1DVMA 1XU8A 4DY0A 1OYHI 2H4PA 1DB2A 5CDXA 1JVQI 2PEEA 2ZV6A 4P0OA 1OPHA 3CWLA 3DRMA 1IZ2A 1BY7A 1JMJA 4AJUA 1SNGA 2GD4C 4RO9A 3VVJA 2D26A 9APIA 4ROBA 4EB1L 4YIAA 1QLPA 1OO8A 4RSQA 3LE2A 3KCGI 5BRRI 2VDXA 2H4RA 2OL2A 2VH4A 1R1LI 1DZHL 4PYWA 3UT3A 3ZHAA 4C49A 2XN3A 1BR8I 1JMOA 2WXWA 3CWMA 1NQ9I
chains in the Genus database with same CATH superfamily
1JTIA 1C5GA 1DZGI 1M93B 3CVMA 2B4XL 2QUGA 3R4LA 2ARQA 4ZK3A 3F02A 4X30A 1JRRA 4AU3B 3EVJI 4AQHA 3FGQA 2WXYC 1SEKA 1XQJA 2ACHA 3NDFA 4DTEA 1OYHL 3Q02A 2HI9A 3EOXA 2BEHL 4R9IA 4IC0A 1EZXA 5CDZA 4BB2A 4P0FA 1HP7A 3NE4A 2WXZA 1LJ5A 2VDYA 2PEFA 1ATTA 4C41A 1SR5A 1XQGA 2CEOA 4AU2A 3F5NA 1HLEA 1OVAB 2HIJL 2V95A 3NDDA 5C98A 1KCTA 1E03I 4AJTA 3F1SA 4KDSA 1JJOC 1F0CA 2ZNHA 1AS4A 3Q03A 8APIA 4GA7A 5IO1A 2XN6A 1DZHI 3LW2A 4Y40A 2WXZC 1PSIA 7APIA 9PAIA 1B3KA 1D5SA 2H4QA 2ARRA 2B4XI 2B5TI 2R9YA 1UHGA 4AU3A 2OAYA 3DLWA 1OVAC 3STOA 3B9FI 1T1FA 3DRUA 1E04I 1OC0A 4ZK0A 3PB1I 1TB6I 1IMVA 2DUTA 5INWA 2BEHI 3H5CA 1C8OA 1DVNA 2XN7A 3T1PA 5CE0A 2WY0C 1AZXI 5EI0A 1YXAA 3OZQA 1OVAA 4G8OA 1ATHA 2HIJI 4CAAA 3PZFA 4DY7C 1QMBA 4EB1I 3DY0A 5HGCA 2XN5A 1LK6I 1ATUA 3CAAA 3NDAA 1K9OI 1DZGL 1QMNA 2RIWA 1WZ9A 1MTPA 1ANTI 4G8RA 4IF8A 2ANTI 1LQ8A 2WXXA 2WY1A 1E05I 4AFXA 1A7CA 2RIVA 4AU4A 4Y3KA 4ROAA 1DVMA 1XU8A 4DY0A 1OYHI 2H4PA 1DB2A 5CDXA 1JVQI 2PEEA 2ZV6A 4P0OA 1OPHA 3CWLA 3DRMA 1IZ2A 1BY7A 1JMJA 4AJUA 1SNGA 2GD4C 4RO9A 3VVJA 2D26A 9APIA 4ROBA 4EB1L 4YIAA 1QLPA 1OO8A 4RSQA 3LE2A 3KCGI 5BRRI 2VDXA 2H4RA 2OL2A 2VH4A 1R1LI 1DZHL 4PYWA 3UT3A 3ZHAA 4C49A 2XN3A 1BR8I 1JMOA 2WXWA 3CWMA 1NQ9I
chains in the Genus database with same CATH topology
1JTIA 1C5GA 1DZGI 1M93B 3CVMA 2B4XL 2QUGA 3R4LA 2ARQA 4ZK3A 3F02A 4X30A 1JRRA 4AU3B 3EVJI 4AQHA 3FGQA 2WXYC 1SEKA 1XQJA 2ACHA 3NDFA 4DTEA 1OYHL 3Q02A 2HI9A 3EOXA 2BEHL 4R9IA 4IC0A 1EZXA 5CDZA 4BB2A 4P0FA 1HP7A 3NE4A 2WXZA 1LJ5A 2VDYA 2PEFA 1ATTA 4C41A 1SR5A 1XQGA 2CEOA 4AU2A 3F5NA 1HLEA 1OVAB 2HIJL 2V95A 3NDDA 5C98A 1KCTA 1E03I 4AJTA 3F1SA 4KDSA 1JJOC 1F0CA 2ZNHA 1AS4A 3Q03A 8APIA 4GA7A 5IO1A 2XN6A 1DZHI 3LW2A 4Y40A 2WXZC 1PSIA 7APIA 9PAIA 1B3KA 1D5SA 2H4QA 2ARRA 2B4XI 2B5TI 2R9YA 1UHGA 4AU3A 2OAYA 3DLWA 1OVAC 3STOA 3B9FI 1T1FA 3DRUA 1E04I 1OC0A 4ZK0A 3PB1I 1TB6I 1IMVA 2DUTA 5INWA 2BEHI 3H5CA 1C8OA 1DVNA 2XN7A 3T1PA 5CE0A 2WY0C 1AZXI 5EI0A 1YXAA 3OZQA 1OVAA 4G8OA 1ATHA 2HIJI 4CAAA 3PZFA 4DY7C 1QMBA 4EB1I 3DY0A 5HGCA 2XN5A 1LK6I 1ATUA 3CAAA 3NDAA 1K9OI 1DZGL 1QMNA 2RIWA 1WZ9A 1MTPA 1ANTI 4G8RA 4IF8A 2ANTI 1LQ8A 2WXXA 2WY1A 1E05I 4AFXA 1A7CA 2RIVA 4AU4A 4Y3KA 4ROAA 1DVMA 1XU8A 4DY0A 1OYHI 2H4PA 1DB2A 5CDXA 1JVQI 2PEEA 2ZV6A 4P0OA 1OPHA 3CWLA 3DRMA 1IZ2A 1BY7A 1JMJA 4AJUA 1SNGA 2GD4C 4RO9A 3VVJA 2D26A 9APIA 4ROBA 4EB1L 4YIAA 1QLPA 1OO8A 4RSQA 3LE2A 3KCGI 5BRRI 2VDXA 2H4RA 2OL2A 2VH4A 1R1LI 1DZHL 4PYWA 3UT3A 3ZHAA 4C49A 2XN3A 1BR8I 1JMOA 2WXWA 3CWMA 1NQ9I
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1JTI A;  1C5G A;  1DZG I;  1M93 B;  3CVM A;  2B4X L;  2QUG A;  3R4L A;  2ARQ A;  4ZK3 A;  3F02 A;  4X30 A;  1JRR A;  4AU3 B;  3EVJ I;  4AQH A;  3FGQ A;  2WXY C;  1SEK A;  1XQJ A;  2ACH A;  3NDF A;  4DTE A;  1OYH L;  3Q02 A;  2HI9 A;  3EOX A;  2BEH L;  4R9I A;  4IC0 A;  1EZX A;  5CDZ A;  4BB2 A;  4P0F A;  1HP7 A;  3NE4 A;  2WXZ A;  1LJ5 A;  2VDY A;  2PEF A;  1ATT A;  4C41 A;  1SR5 A;  1XQG A;  2CEO A;  4AU2 A;  3F5N A;  1HLE A;  1OVA B;  2HIJ L;  2V95 A;  3NDD A;  5C98 A;  1KCT A;  1E03 I;  4AJT A;  3F1S A;  4KDS A;  1JJO C;  1F0C A;  2ZNH A;  1AS4 A;  3Q03 A;  8API A;  4GA7 A;  5IO1 A;  2XN6 A;  1DZH I;  3LW2 A;  4Y40 A;  2WXZ C;  1PSI A;  7API A;  9PAI A;  1B3K A;  1D5S A;  2H4Q A;  2ARR A;  2B4X I;  2B5T I;  2R9Y A;  1UHG A;  4AU3 A;  2OAY A;  3DLW A;  1OVA C;  3STO A;  3B9F I;  1T1F A;  3DRU A;  1E04 I;  1OC0 A;  4ZK0 A;  3PB1 I;  1TB6 I;  1IMV A;  2DUT A;  5INW A;  2BEH I;  3H5C A;  1C8O A;  1DVN A;  2XN7 A;  3T1P A;  5CE0 A;  2WY0 C;  1AZX I;  5EI0 A;  1YXA A;  3OZQ A;  1OVA A;  4G8O A;  1ATH A;  2HIJ I;  4CAA A;  3PZF A;  4DY7 C;  1QMB A;  4EB1 I;  3DY0 A;  5HGC A;  2XN5 A;  1LK6 I;  1ATU A;  3CAA A;  3NDA A;  1K9O I;  1DZG L;  1QMN A;  2RIW A;  1WZ9 A;  1MTP A;  1ANT I;  4G8R A;  4IF8 A;  2ANT I;  1LQ8 A;  2WXX A;  2WY1 A;  1E05 I;  4AFX A;  1A7C A;  2RIV A;  4AU4 A;  4Y3K A;  4ROA A;  1DVM A;  1XU8 A;  4DY0 A;  1OYH I;  2H4P A;  1DB2 A;  5CDX A;  1JVQ I;  2PEE A;  2ZV6 A;  4P0O A;  1OPH A;  3CWL A;  3DRM A;  1IZ2 A;  1BY7 A;  1JMJ A;  4AJU A;  1SNG A;  2GD4 C;  4RO9 A;  3VVJ A;  2D26 A;  9API A;  4ROB A;  4EB1 L;  4YIA A;  1QLP A;  1OO8 A;  4RSQ A;  3LE2 A;  3KCG I;  5BRR I;  2VDX A;  2H4R A;  2OL2 A;  2VH4 A;  1R1L I;  1DZH L;  4PYW A;  3UT3 A;  3ZHA A;  4C49 A;  2XN3 A;  1BR8 I;  1JMO A;  2WXW A;  3CWM A;  1NQ9 I; 
#chains in the Genus database with same CATH topology
 1JTI A;  1C5G A;  1DZG I;  1M93 B;  3CVM A;  2B4X L;  2QUG A;  3R4L A;  2ARQ A;  4ZK3 A;  3F02 A;  4X30 A;  1JRR A;  4AU3 B;  3EVJ I;  4AQH A;  3FGQ A;  2WXY C;  1SEK A;  1XQJ A;  2ACH A;  3NDF A;  4DTE A;  1OYH L;  3Q02 A;  2HI9 A;  3EOX A;  2BEH L;  4R9I A;  4IC0 A;  1EZX A;  5CDZ A;  4BB2 A;  4P0F A;  1HP7 A;  3NE4 A;  2WXZ A;  1LJ5 A;  2VDY A;  2PEF A;  1ATT A;  4C41 A;  1SR5 A;  1XQG A;  2CEO A;  4AU2 A;  3F5N A;  1HLE A;  1OVA B;  2HIJ L;  2V95 A;  3NDD A;  5C98 A;  1KCT A;  1E03 I;  4AJT A;  3F1S A;  4KDS A;  1JJO C;  1F0C A;  2ZNH A;  1AS4 A;  3Q03 A;  8API A;  4GA7 A;  5IO1 A;  2XN6 A;  1DZH I;  3LW2 A;  4Y40 A;  2WXZ C;  1PSI A;  7API A;  9PAI A;  1B3K A;  1D5S A;  2H4Q A;  2ARR A;  2B4X I;  2B5T I;  2R9Y A;  1UHG A;  4AU3 A;  2OAY A;  3DLW A;  1OVA C;  3STO A;  3B9F I;  1T1F A;  3DRU A;  1E04 I;  1OC0 A;  4ZK0 A;  3PB1 I;  1TB6 I;  1IMV A;  2DUT A;  5INW A;  2BEH I;  3H5C A;  1C8O A;  1DVN A;  2XN7 A;  3T1P A;  5CE0 A;  2WY0 C;  1AZX I;  5EI0 A;  1YXA A;  3OZQ A;  1OVA A;  4G8O A;  1ATH A;  2HIJ I;  4CAA A;  3PZF A;  4DY7 C;  1QMB A;  4EB1 I;  3DY0 A;  5HGC A;  2XN5 A;  1LK6 I;  1ATU A;  3CAA A;  3NDA A;  1K9O I;  1DZG L;  1QMN A;  2RIW A;  1WZ9 A;  1MTP A;  1ANT I;  4G8R A;  4IF8 A;  2ANT I;  1LQ8 A;  2WXX A;  2WY1 A;  1E05 I;  4AFX A;  1A7C A;  2RIV A;  4AU4 A;  4Y3K A;  4ROA A;  1DVM A;  1XU8 A;  4DY0 A;  1OYH I;  2H4P A;  1DB2 A;  5CDX A;  1JVQ I;  2PEE A;  2ZV6 A;  4P0O A;  1OPH A;  3CWL A;  3DRM A;  1IZ2 A;  1BY7 A;  1JMJ A;  4AJU A;  1SNG A;  2GD4 C;  4RO9 A;  3VVJ A;  2D26 A;  9API A;  4ROB A;  4EB1 L;  4YIA A;  1QLP A;  1OO8 A;  4RSQ A;  3LE2 A;  3KCG I;  5BRR I;  2VDX A;  2H4R A;  2OL2 A;  2VH4 A;  1R1L I;  1DZH L;  4PYW A;  3UT3 A;  3ZHA A;  4C49 A;  2XN3 A;  1BR8 I;  1JMO A;  2WXW A;  3CWM A;  1NQ9 I; 
#chains in the Genus database with same CATH homology
 1JTI A;  1C5G A;  1DZG I;  1M93 B;  3CVM A;  2B4X L;  2QUG A;  3R4L A;  2ARQ A;  4ZK3 A;  3F02 A;  4X30 A;  1JRR A;  4AU3 B;  3EVJ I;  4AQH A;  3FGQ A;  2WXY C;  1SEK A;  1XQJ A;  2ACH A;  3NDF A;  4DTE A;  1OYH L;  3Q02 A;  2HI9 A;  3EOX A;  2BEH L;  4R9I A;  4IC0 A;  1EZX A;  5CDZ A;  4BB2 A;  4P0F A;  1HP7 A;  3NE4 A;  2WXZ A;  1LJ5 A;  2VDY A;  2PEF A;  1ATT A;  4C41 A;  1SR5 A;  1XQG A;  2CEO A;  4AU2 A;  3F5N A;  1HLE A;  1OVA B;  2HIJ L;  2V95 A;  3NDD A;  5C98 A;  1KCT A;  1E03 I;  4AJT A;  3F1S A;  4KDS A;  1JJO C;  1F0C A;  2ZNH A;  1AS4 A;  3Q03 A;  8API A;  4GA7 A;  5IO1 A;  2XN6 A;  1DZH I;  3LW2 A;  4Y40 A;  2WXZ C;  1PSI A;  7API A;  9PAI A;  1B3K A;  1D5S A;  2H4Q A;  2ARR A;  2B4X I;  2B5T I;  2R9Y A;  1UHG A;  4AU3 A;  2OAY A;  3DLW A;  1OVA C;  3STO A;  3B9F I;  1T1F A;  3DRU A;  1E04 I;  1OC0 A;  4ZK0 A;  3PB1 I;  1TB6 I;  1IMV A;  2DUT A;  5INW A;  2BEH I;  3H5C A;  1C8O A;  1DVN A;  2XN7 A;  3T1P A;  5CE0 A;  2WY0 C;  1AZX I;  5EI0 A;  1YXA A;  3OZQ A;  1OVA A;  4G8O A;  1ATH A;  2HIJ I;  4CAA A;  3PZF A;  4DY7 C;  1QMB A;  4EB1 I;  3DY0 A;  5HGC A;  2XN5 A;  1LK6 I;  1ATU A;  3CAA A;  3NDA A;  1K9O I;  1DZG L;  1QMN A;  2RIW A;  1WZ9 A;  1MTP A;  1ANT I;  4G8R A;  4IF8 A;  2ANT I;  1LQ8 A;  2WXX A;  2WY1 A;  1E05 I;  4AFX A;  1A7C A;  2RIV A;  4AU4 A;  4Y3K A;  4ROA A;  1DVM A;  1XU8 A;  4DY0 A;  1OYH I;  2H4P A;  1DB2 A;  5CDX A;  1JVQ I;  2PEE A;  2ZV6 A;  4P0O A;  1OPH A;  3CWL A;  3DRM A;  1IZ2 A;  1BY7 A;  1JMJ A;  4AJU A;  1SNG A;  2GD4 C;  4RO9 A;  3VVJ A;  2D26 A;  9API A;  4ROB A;  4EB1 L;  4YIA A;  1QLP A;  1OO8 A;  4RSQ A;  3LE2 A;  3KCG I;  5BRR I;  2VDX A;  2H4R A;  2OL2 A;  2VH4 A;  1R1L I;  1DZH L;  4PYW A;  3UT3 A;  3ZHA A;  4C49 A;  2XN3 A;  1BR8 I;  1JMO A;  2WXW A;  3CWM A;  1NQ9 I; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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