4DY0A

Crystal structure of native protease nexin-1 with heparin
Total Genus 110
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
110
sequence length
377
structure length
362
Chain Sequence
FNPLSLEELGSNTGIQVFNQIVKSRPHDNIVISPHGIASVLGMLQLGADGRTKKQLAMVMRYGVNGVGKILKKINKAIVSKKNKDIVTVANAVFVKNASEIEVPFVTRNKDVFQCEVRNVNFEDPASACDSINAWVKNETRDMIDNLLSPDLIDGVLTRLVLVNAVYFKGLWKSRFQPENTKKRTFVAADGKSYQVPMLAQLSVFRCGSTSAPNDLWYNFIELPYHGESISMLIALPTESSTPLSAIIPHISTKTIDSWMSIMVPKRVQVILPKFTAVAQTDLKEPLKVLGITDMFDSSKANFAKITTNLHVSHILQKAKIEVSEDGTRSSPPWFIVDRPFLFFIRHNPTGAVLFMGQINKP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase inhibitor
molecule keywords Glia-derived nexin
publication title Crystal structures of protease nexin-1 in complex with heparin and thrombin suggest a 2-step recognition mechanism.
pubmed doi rcsb
source organism Homo sapiens
total genus 110
structure length 362
sequence length 377
chains with identical sequence B
ec nomenclature
pdb deposition date 2012-02-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00079 Serpin Serpin (serine protease inhibitor)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.30.39.10 Mainly Beta Roll Alpha-1-antitrypsin; domain 1 Alpha-1-antitrypsin, domain 1 4dy0A02
3.30.497.10 Alpha Beta 2-Layer Sandwich Antithrombin; Chain I, domain 2 Antithrombin, subunit I, domain 2 4dy0A01
2VDYA 2QUGA 3VVJA 3T1PA 4AU2A 1T1FA 5C98A 9APIA 4RO9A 3UT3A 1IZ2A 4ROBA 3F5NA 2WXWA 3DRUA 3ZHAA 5CDZA 2GD4C 2B4XL 1F0CA 2B5TI 2V95A 3KCGI 1DVNA 1JTIA 1HP7A 2ZNHA 1LQ8A 2HI9A 4P0FA 2XN3A 2OAYA 3FGQA 4RSQA 1TB6I 1JMOA 3B9FI 4C49A 4EB1L 2ANTI 4AJUA 1ANTI 2PEFA 1OYHL 1UHGA 2ARRA 1AS4A 1SR5A 1ATHA 4BB2A 1DZHI 1BY7A 2WY0C 1R1LI 1C5GA 3PB1I 3CAAA 1MTPA 1LK6I 2BEHI 3OZQA 4P0OA 4AQHA 4KDSA 1OVAB 4X30A 4DY0A 2VH4A 4ZK3A 3CVMA 1OVAC 4IF8A 1DB2A 7APIA 1JVQI 4Y3KA 4IC0A 1YXAA 2OL2A 3DRMA 4AU3B 3F1SA 2DUTA 1B3KA 1DZHL 4DY7C 2WXXA 3LW2A 3NDDA 1OO8A 1OPHA 9PAIA 1ATTA 5CE0A 1M93B 2XN7A 1AZXI 1K9OI 1E03I 2BEHL 1E04I 2D26A 1OVAA 4R9IA 5EI0A 5BRRI 1XQGA 2HIJI 5HGCA 2CEOA 4AU4A 1DZGI 1QLPA 1QMNA 3DLWA 2WXZC 3DY0A 3R4LA 3H5CA 1KCTA 1WZ9A 1SNGA 2RIVA 2RIWA 1C8OA 1OC0A 4AFXA 4G8RA 4G8OA 1BR8I 2H4PA 4GA7A 4DTEA 2WY1A 8APIA 1E05I 5INWA 4C41A 1NQ9I 3NE4A 2WXYC 2VDXA 3EVJI 3NDFA 3LE2A 1ATUA 2WXZA 2H4QA 2R9YA 1D5SA 1HLEA 5CDXA 4PYWA 3CWMA 4ZK0A 2HIJL 3STOA 1JJOC 1DZGL 4Y40A 1A7CA 1JRRA 3NDAA 3Q03A 1QMBA 2B4XI 1OYHI 1DVMA 3CWLA 3F02A 3Q02A 5IO1A 2ZV6A 2H4RA 1EZXA 1XQJA 4AU3A 4ROAA 1SEKA 4CAAA 4AJTA 1IMVA 2ACHA 4YIAA 1JMJA 2ARQA 2PEEA 4EB1I 3EOXA 2XN6A 2XN5A 3PZFA 1LJ5A 1XU8A 1PSIA
chains in the Genus database with same CATH superfamily
2VDYA 2QUGA 3VVJA 3T1PA 4AU2A 1T1FA 5C98A 9APIA 4RO9A 3UT3A 1IZ2A 4ROBA 3F5NA 2WXWA 3DRUA 3ZHAA 5CDZA 2GD4C 2B4XL 1F0CA 2B5TI 2V95A 3KCGI 1DVNA 1JTIA 1HP7A 2ZNHA 1LQ8A 2HI9A 4P0FA 2XN3A 2OAYA 3FGQA 4RSQA 1TB6I 1JMOA 3B9FI 4C49A 4EB1L 2ANTI 4AJUA 1ANTI 2PEFA 1OYHL 1UHGA 2ARRA 1AS4A 1SR5A 1ATHA 4BB2A 1DZHI 1BY7A 2WY0C 1R1LI 1C5GA 3PB1I 3CAAA 1MTPA 1LK6I 2BEHI 3OZQA 4P0OA 4AQHA 4KDSA 1OVAB 4X30A 4DY0A 2VH4A 4ZK3A 3CVMA 1OVAC 4IF8A 1DB2A 7APIA 1JVQI 4Y3KA 4IC0A 1YXAA 2OL2A 3DRMA 4AU3B 3F1SA 2DUTA 1B3KA 1DZHL 4DY7C 2WXXA 3LW2A 3NDDA 1OO8A 1OPHA 9PAIA 1ATTA 5CE0A 1M93B 2XN7A 1AZXI 1K9OI 1E03I 2BEHL 1E04I 2D26A 1OVAA 4R9IA 5EI0A 5BRRI 1XQGA 2HIJI 5HGCA 2CEOA 4AU4A 1DZGI 1QLPA 1QMNA 3DLWA 2WXZC 3DY0A 3R4LA 3H5CA 1KCTA 1WZ9A 1SNGA 2RIVA 2RIWA 1C8OA 1OC0A 4AFXA 4G8RA 4G8OA 1BR8I 2H4PA 4GA7A 4DTEA 2WY1A 8APIA 1E05I 5INWA 4C41A 1NQ9I 3NE4A 2WXYC 2VDXA 3EVJI 3NDFA 3LE2A 1ATUA 2WXZA 2H4QA 2R9YA 1D5SA 1HLEA 5CDXA 4PYWA 3CWMA 4ZK0A 2HIJL 3STOA 1JJOC 1DZGL 4Y40A 1A7CA 1JRRA 3NDAA 3Q03A 1QMBA 2B4XI 1OYHI 1DVMA 3CWLA 3F02A 3Q02A 5IO1A 2ZV6A 2H4RA 1EZXA 1XQJA 4AU3A 4ROAA 1SEKA 4CAAA 4AJTA 1IMVA 2ACHA 4YIAA 1JMJA 2ARQA 2PEEA 4EB1I 3EOXA 2XN6A 2XN5A 3PZFA 1LJ5A 1XU8A 1PSIA
chains in the Genus database with same CATH topology
2VDYA 2QUGA 3VVJA 3T1PA 4AU2A 1T1FA 5C98A 9APIA 4RO9A 3UT3A 1IZ2A 4ROBA 3F5NA 2WXWA 3DRUA 3ZHAA 5CDZA 2GD4C 2B4XL 1F0CA 2B5TI 2V95A 3KCGI 1DVNA 1JTIA 1HP7A 2ZNHA 1LQ8A 2HI9A 4P0FA 2XN3A 2OAYA 3FGQA 4RSQA 1TB6I 1JMOA 3B9FI 4C49A 4EB1L 2ANTI 4AJUA 1ANTI 2PEFA 1OYHL 1UHGA 2ARRA 1AS4A 1SR5A 1ATHA 4BB2A 1DZHI 1BY7A 2WY0C 1R1LI 1C5GA 3PB1I 3CAAA 1MTPA 1LK6I 2BEHI 3OZQA 4P0OA 4AQHA 4KDSA 1OVAB 4X30A 4DY0A 2VH4A 4ZK3A 3CVMA 1OVAC 4IF8A 1DB2A 7APIA 1JVQI 4Y3KA 4IC0A 1YXAA 2OL2A 3DRMA 4AU3B 3F1SA 2DUTA 1B3KA 1DZHL 4DY7C 2WXXA 3LW2A 3NDDA 1OO8A 1OPHA 9PAIA 1ATTA 5CE0A 1M93B 2XN7A 1AZXI 1K9OI 1E03I 2BEHL 1E04I 2D26A 1OVAA 4R9IA 5EI0A 5BRRI 1XQGA 2HIJI 5HGCA 2CEOA 4AU4A 1DZGI 1QLPA 1QMNA 3DLWA 2WXZC 3DY0A 3R4LA 3H5CA 1KCTA 1WZ9A 1SNGA 2RIVA 2RIWA 1C8OA 1OC0A 4AFXA 4G8RA 4G8OA 1BR8I 2H4PA 4GA7A 4DTEA 2WY1A 8APIA 1E05I 5INWA 4C41A 1NQ9I 3NE4A 2WXYC 2VDXA 3EVJI 3NDFA 3LE2A 1ATUA 2WXZA 2H4QA 2R9YA 1D5SA 1HLEA 5CDXA 4PYWA 3CWMA 4ZK0A 2HIJL 3STOA 1JJOC 1DZGL 4Y40A 1A7CA 1JRRA 3NDAA 3Q03A 1QMBA 2B4XI 1OYHI 1DVMA 3CWLA 3F02A 3Q02A 5IO1A 2ZV6A 2H4RA 1EZXA 1XQJA 4AU3A 4ROAA 1SEKA 4CAAA 4AJTA 1IMVA 2ACHA 4YIAA 1JMJA 2ARQA 2PEEA 4EB1I 3EOXA 2XN6A 2XN5A 3PZFA 1LJ5A 1XU8A 1PSIA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2VDY A;  2QUG A;  3VVJ A;  3T1P A;  4AU2 A;  1T1F A;  5C98 A;  9API A;  4RO9 A;  3UT3 A;  1IZ2 A;  4ROB A;  3F5N A;  2WXW A;  3DRU A;  3ZHA A;  5CDZ A;  2GD4 C;  2B4X L;  1F0C A;  2B5T I;  2V95 A;  3KCG I;  1DVN A;  1JTI A;  1HP7 A;  2ZNH A;  1LQ8 A;  2HI9 A;  4P0F A;  2XN3 A;  2OAY A;  3FGQ A;  4RSQ A;  1TB6 I;  1JMO A;  3B9F I;  4C49 A;  4EB1 L;  2ANT I;  4AJU A;  1ANT I;  2PEF A;  1OYH L;  1UHG A;  2ARR A;  1AS4 A;  1SR5 A;  1ATH A;  4BB2 A;  1DZH I;  1BY7 A;  2WY0 C;  1R1L I;  1C5G A;  3PB1 I;  3CAA A;  1MTP A;  1LK6 I;  2BEH I;  3OZQ A;  4P0O A;  4AQH A;  4KDS A;  1OVA B;  4X30 A;  4DY0 A;  2VH4 A;  4ZK3 A;  3CVM A;  1OVA C;  4IF8 A;  1DB2 A;  7API A;  1JVQ I;  4Y3K A;  4IC0 A;  1YXA A;  2OL2 A;  3DRM A;  4AU3 B;  3F1S A;  2DUT A;  1B3K A;  1DZH L;  4DY7 C;  2WXX A;  3LW2 A;  3NDD A;  1OO8 A;  1OPH A;  9PAI A;  1ATT A;  5CE0 A;  1M93 B;  2XN7 A;  1AZX I;  1K9O I;  1E03 I;  2BEH L;  1E04 I;  2D26 A;  1OVA A;  4R9I A;  5EI0 A;  5BRR I;  1XQG A;  2HIJ I;  5HGC A;  2CEO A;  4AU4 A;  1DZG I;  1QLP A;  1QMN A;  3DLW A;  2WXZ C;  3DY0 A;  3R4L A;  3H5C A;  1KCT A;  1WZ9 A;  1SNG A;  2RIV A;  2RIW A;  1C8O A;  1OC0 A;  4AFX A;  4G8R A;  4G8O A;  1BR8 I;  2H4P A;  4GA7 A;  4DTE A;  2WY1 A;  8API A;  1E05 I;  5INW A;  4C41 A;  1NQ9 I;  3NE4 A;  2WXY C;  2VDX A;  3EVJ I;  3NDF A;  3LE2 A;  1ATU A;  2WXZ A;  2H4Q A;  2R9Y A;  1D5S A;  1HLE A;  5CDX A;  4PYW A;  3CWM A;  4ZK0 A;  2HIJ L;  3STO A;  1JJO C;  1DZG L;  4Y40 A;  1A7C A;  1JRR A;  3NDA A;  3Q03 A;  1QMB A;  2B4X I;  1OYH I;  1DVM A;  3CWL A;  3F02 A;  3Q02 A;  5IO1 A;  2ZV6 A;  2H4R A;  1EZX A;  1XQJ A;  4AU3 A;  4ROA A;  1SEK A;  4CAA A;  4AJT A;  1IMV A;  2ACH A;  4YIA A;  1JMJ A;  2ARQ A;  2PEE A;  4EB1 I;  3EOX A;  2XN6 A;  2XN5 A;  3PZF A;  1LJ5 A;  1XU8 A;  1PSI A; 
#chains in the Genus database with same CATH topology
 2VDY A;  2QUG A;  3VVJ A;  3T1P A;  4AU2 A;  1T1F A;  5C98 A;  9API A;  4RO9 A;  3UT3 A;  1IZ2 A;  4ROB A;  3F5N A;  2WXW A;  3DRU A;  3ZHA A;  5CDZ A;  2GD4 C;  2B4X L;  1F0C A;  2B5T I;  2V95 A;  3KCG I;  1DVN A;  1JTI A;  1HP7 A;  2ZNH A;  1LQ8 A;  2HI9 A;  4P0F A;  2XN3 A;  2OAY A;  3FGQ A;  4RSQ A;  1TB6 I;  1JMO A;  3B9F I;  4C49 A;  4EB1 L;  2ANT I;  4AJU A;  1ANT I;  2PEF A;  1OYH L;  1UHG A;  2ARR A;  1AS4 A;  1SR5 A;  1ATH A;  4BB2 A;  1DZH I;  1BY7 A;  2WY0 C;  1R1L I;  1C5G A;  3PB1 I;  3CAA A;  1MTP A;  1LK6 I;  2BEH I;  3OZQ A;  4P0O A;  4AQH A;  4KDS A;  1OVA B;  4X30 A;  4DY0 A;  2VH4 A;  4ZK3 A;  3CVM A;  1OVA C;  4IF8 A;  1DB2 A;  7API A;  1JVQ I;  4Y3K A;  4IC0 A;  1YXA A;  2OL2 A;  3DRM A;  4AU3 B;  3F1S A;  2DUT A;  1B3K A;  1DZH L;  4DY7 C;  2WXX A;  3LW2 A;  3NDD A;  1OO8 A;  1OPH A;  9PAI A;  1ATT A;  5CE0 A;  1M93 B;  2XN7 A;  1AZX I;  1K9O I;  1E03 I;  2BEH L;  1E04 I;  2D26 A;  1OVA A;  4R9I A;  5EI0 A;  5BRR I;  1XQG A;  2HIJ I;  5HGC A;  2CEO A;  4AU4 A;  1DZG I;  1QLP A;  1QMN A;  3DLW A;  2WXZ C;  3DY0 A;  3R4L A;  3H5C A;  1KCT A;  1WZ9 A;  1SNG A;  2RIV A;  2RIW A;  1C8O A;  1OC0 A;  4AFX A;  4G8R A;  4G8O A;  1BR8 I;  2H4P A;  4GA7 A;  4DTE A;  2WY1 A;  8API A;  1E05 I;  5INW A;  4C41 A;  1NQ9 I;  3NE4 A;  2WXY C;  2VDX A;  3EVJ I;  3NDF A;  3LE2 A;  1ATU A;  2WXZ A;  2H4Q A;  2R9Y A;  1D5S A;  1HLE A;  5CDX A;  4PYW A;  3CWM A;  4ZK0 A;  2HIJ L;  3STO A;  1JJO C;  1DZG L;  4Y40 A;  1A7C A;  1JRR A;  3NDA A;  3Q03 A;  1QMB A;  2B4X I;  1OYH I;  1DVM A;  3CWL A;  3F02 A;  3Q02 A;  5IO1 A;  2ZV6 A;  2H4R A;  1EZX A;  1XQJ A;  4AU3 A;  4ROA A;  1SEK A;  4CAA A;  4AJT A;  1IMV A;  2ACH A;  4YIA A;  1JMJ A;  2ARQ A;  2PEE A;  4EB1 I;  3EOX A;  2XN6 A;  2XN5 A;  3PZF A;  1LJ5 A;  1XU8 A;  1PSI A; 
#chains in the Genus database with same CATH homology
 2VDY A;  2QUG A;  3VVJ A;  3T1P A;  4AU2 A;  1T1F A;  5C98 A;  9API A;  4RO9 A;  3UT3 A;  1IZ2 A;  4ROB A;  3F5N A;  2WXW A;  3DRU A;  3ZHA A;  5CDZ A;  2GD4 C;  2B4X L;  1F0C A;  2B5T I;  2V95 A;  3KCG I;  1DVN A;  1JTI A;  1HP7 A;  2ZNH A;  1LQ8 A;  2HI9 A;  4P0F A;  2XN3 A;  2OAY A;  3FGQ A;  4RSQ A;  1TB6 I;  1JMO A;  3B9F I;  4C49 A;  4EB1 L;  2ANT I;  4AJU A;  1ANT I;  2PEF A;  1OYH L;  1UHG A;  2ARR A;  1AS4 A;  1SR5 A;  1ATH A;  4BB2 A;  1DZH I;  1BY7 A;  2WY0 C;  1R1L I;  1C5G A;  3PB1 I;  3CAA A;  1MTP A;  1LK6 I;  2BEH I;  3OZQ A;  4P0O A;  4AQH A;  4KDS A;  1OVA B;  4X30 A;  4DY0 A;  2VH4 A;  4ZK3 A;  3CVM A;  1OVA C;  4IF8 A;  1DB2 A;  7API A;  1JVQ I;  4Y3K A;  4IC0 A;  1YXA A;  2OL2 A;  3DRM A;  4AU3 B;  3F1S A;  2DUT A;  1B3K A;  1DZH L;  4DY7 C;  2WXX A;  3LW2 A;  3NDD A;  1OO8 A;  1OPH A;  9PAI A;  1ATT A;  5CE0 A;  1M93 B;  2XN7 A;  1AZX I;  1K9O I;  1E03 I;  2BEH L;  1E04 I;  2D26 A;  1OVA A;  4R9I A;  5EI0 A;  5BRR I;  1XQG A;  2HIJ I;  5HGC A;  2CEO A;  4AU4 A;  1DZG I;  1QLP A;  1QMN A;  3DLW A;  2WXZ C;  3DY0 A;  3R4L A;  3H5C A;  1KCT A;  1WZ9 A;  1SNG A;  2RIV A;  2RIW A;  1C8O A;  1OC0 A;  4AFX A;  4G8R A;  4G8O A;  1BR8 I;  2H4P A;  4GA7 A;  4DTE A;  2WY1 A;  8API A;  1E05 I;  5INW A;  4C41 A;  1NQ9 I;  3NE4 A;  2WXY C;  2VDX A;  3EVJ I;  3NDF A;  3LE2 A;  1ATU A;  2WXZ A;  2H4Q A;  2R9Y A;  1D5S A;  1HLE A;  5CDX A;  4PYW A;  3CWM A;  4ZK0 A;  2HIJ L;  3STO A;  1JJO C;  1DZG L;  4Y40 A;  1A7C A;  1JRR A;  3NDA A;  3Q03 A;  1QMB A;  2B4X I;  1OYH I;  1DVM A;  3CWL A;  3F02 A;  3Q02 A;  5IO1 A;  2ZV6 A;  2H4R A;  1EZX A;  1XQJ A;  4AU3 A;  4ROA A;  1SEK A;  4CAA A;  4AJT A;  1IMV A;  2ACH A;  4YIA A;  1JMJ A;  2ARQ A;  2PEE A;  4EB1 I;  3EOX A;  2XN6 A;  2XN5 A;  3PZF A;  1LJ5 A;  1XU8 A;  1PSI A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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