4DY7C

Crystal structures of protease nexin-1 in complex with s195a thrombin
Total Genus 110
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
110
sequence length
377
structure length
377
Chain Sequence
FNPLSLEELGSNTGIQVFNQIVKSRPHDNIVISPHGIASVLGMLQLGADGRTKKQLAMVMRYGVNGVGKILKKINKAIVSKKNKDIVTVANAVFVKNASEIEVPFVTRNKDVFQCEVRNVNFEDPASACDSINAWVKNETRDMIDNLLSPDLIDGVLTRLVLVNAVYFKGLWKSRFQPENTKKRTFVAADGKSYQVPMLAQLSVFRCGSTSAPNDLWYNFIELPYHGESISMLIALPTESSTPLSAIIPHISTKTIDSWMSIMVPKRVQVILPKFTAVAQTDLKEPLKVLGITDMFDSSKANFAKITTGSENLHVSHILQKAKIEVSEDGTKASAATTAILIARSSPPWFIVDRPFLFFIRHNPTGAVLFMGQINKP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase/hydrolase inhibitor
molecule keywords Thrombin light chain
publication title Crystal structures of protease nexin-1 in complex with heparin and thrombin suggest a 2-step recognition mechanism.
pubmed doi rcsb
source organism Homo sapiens
total genus 110
structure length 377
sequence length 377
chains with identical sequence F
ec nomenclature
pdb deposition date 2012-02-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
C PF00079 Serpin Serpin (serine protease inhibitor)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.30.39.10 Mainly Beta Roll Alpha-1-antitrypsin; domain 1 Alpha-1-antitrypsin, domain 1 4dy7C02
3.30.497.10 Alpha Beta 2-Layer Sandwich Antithrombin; Chain I, domain 2 Antithrombin, subunit I, domain 2 4dy7C01
2ANTI 4R9IA 1M93B 3DRUA 1TB6I 2ARQA 4KDSA 2WXWA 2ACHA 2WXZC 3DRMA 3NE4A 2PEEA 2ARRA 3PZFA 2RIVA 2HIJL 1DVMA 4GA7A 2WXYC 2ZV6A 3CVMA 3ZHAA 2D26A 4IF8A 3OZQA 1MTPA 3Q02A 9APIA 1OC0A 2XN6A 4EB1I 4AU4A 3EOXA 1A7CA 2V95A 1BY7A 1C8OA 1NQ9I 5INWA 4G8OA 2QUGA 4YIAA 1JRRA 1IMVA 4P0OA 4AJUA 2OL2A 1QLPA 1OVAA 1E03I 2H4QA 4ZK0A 4PYWA 2VH4A 1SEKA 2GD4C 2WY1A 1ANTI 1DZGI 2VDYA 1JMJA 7APIA 1PSIA 1OYHL 1UHGA 1C5GA 1ATHA 3NDAA 1EZXA 1E04I 2ZNHA 3UT3A 2H4PA 4RO9A 4AU3A 1LK6I 1HP7A 1QMNA 2CEOA 2H4RA 3NDDA 1DZHI 1XQJA 3F1SA 1SNGA 9PAIA 5CDXA 1QMBA 1JJOC 3KCGI 5C98A 1HLEA 2RIWA 8APIA 4AQHA 1T1FA 4ROBA 3CWMA 3DY0A 4EB1L 4ROAA 4C49A 1B3KA 2XN3A 3PB1I 2BEHI 3EVJI 1OVAB 4DTEA 3R4LA 1R1LI 2DUTA 2B4XI 1BR8I 1LJ5A 2WXXA 1IZ2A 4X30A 2XN7A 2VDXA 1E05I 1DB2A 1ATTA 1LQ8A 2WXZA 1AZXI 1JTIA 2R9YA 1DVNA 2BEHL 3H5CA 4Y40A 1XU8A 5EI0A 1YXAA 1JMOA 2HI9A 3STOA 3T1PA 4AU3B 1DZGL 4BB2A 1OPHA 1OVAC 3F5NA 1KCTA 3LE2A 1F0CA 4AJTA 4C41A 3NDFA 1SR5A 3LW2A 3VVJA 3DLWA 4G8RA 4IC0A 2PEFA 3Q03A 1OO8A 1DZHL 4ZK3A 1D5SA 2WY0C 4Y3KA 1WZ9A 4DY7C 4DY0A 4AFXA 5IO1A 3CWLA 1ATUA 4P0FA 5CDZA 4RSQA 1K9OI 5HGCA 5BRRI 3CAAA 2B5TI 4AU2A 1JVQI 2B4XL 3F02A 4CAAA 2XN5A 1XQGA 1AS4A 3FGQA 5CE0A 3B9FI 1OYHI 2HIJI 2OAYA
chains in the Genus database with same CATH superfamily
2ANTI 4R9IA 1M93B 3DRUA 1TB6I 2ARQA 4KDSA 2WXWA 2ACHA 2WXZC 3DRMA 3NE4A 2PEEA 2ARRA 3PZFA 2RIVA 2HIJL 1DVMA 4GA7A 2WXYC 2ZV6A 3CVMA 3ZHAA 2D26A 4IF8A 3OZQA 1MTPA 3Q02A 9APIA 1OC0A 2XN6A 4EB1I 4AU4A 3EOXA 1A7CA 2V95A 1BY7A 1C8OA 1NQ9I 5INWA 4G8OA 2QUGA 4YIAA 1JRRA 1IMVA 4P0OA 4AJUA 2OL2A 1QLPA 1OVAA 1E03I 2H4QA 4ZK0A 4PYWA 2VH4A 1SEKA 2GD4C 2WY1A 1ANTI 1DZGI 2VDYA 1JMJA 7APIA 1PSIA 1OYHL 1UHGA 1C5GA 1ATHA 3NDAA 1EZXA 1E04I 2ZNHA 3UT3A 2H4PA 4RO9A 4AU3A 1LK6I 1HP7A 1QMNA 2CEOA 2H4RA 3NDDA 1DZHI 1XQJA 3F1SA 1SNGA 9PAIA 5CDXA 1QMBA 1JJOC 3KCGI 5C98A 1HLEA 2RIWA 8APIA 4AQHA 1T1FA 4ROBA 3CWMA 3DY0A 4EB1L 4ROAA 4C49A 1B3KA 2XN3A 3PB1I 2BEHI 3EVJI 1OVAB 4DTEA 3R4LA 1R1LI 2DUTA 2B4XI 1BR8I 1LJ5A 2WXXA 1IZ2A 4X30A 2XN7A 2VDXA 1E05I 1DB2A 1ATTA 1LQ8A 2WXZA 1AZXI 1JTIA 2R9YA 1DVNA 2BEHL 3H5CA 4Y40A 1XU8A 5EI0A 1YXAA 1JMOA 2HI9A 3STOA 3T1PA 4AU3B 1DZGL 4BB2A 1OPHA 1OVAC 3F5NA 1KCTA 3LE2A 1F0CA 4AJTA 4C41A 3NDFA 1SR5A 3LW2A 3VVJA 3DLWA 4G8RA 4IC0A 2PEFA 3Q03A 1OO8A 1DZHL 4ZK3A 1D5SA 2WY0C 4Y3KA 1WZ9A 4DY7C 4DY0A 4AFXA 5IO1A 3CWLA 1ATUA 4P0FA 5CDZA 4RSQA 1K9OI 5HGCA 5BRRI 3CAAA 2B5TI 4AU2A 1JVQI 2B4XL 3F02A 4CAAA 2XN5A 1XQGA 1AS4A 3FGQA 5CE0A 3B9FI 1OYHI 2HIJI 2OAYA
chains in the Genus database with same CATH topology
2ANTI 4R9IA 1M93B 3DRUA 1TB6I 2ARQA 4KDSA 2WXWA 2ACHA 2WXZC 3DRMA 3NE4A 2PEEA 2ARRA 3PZFA 2RIVA 2HIJL 1DVMA 4GA7A 2WXYC 2ZV6A 3CVMA 3ZHAA 2D26A 4IF8A 3OZQA 1MTPA 3Q02A 9APIA 1OC0A 2XN6A 4EB1I 4AU4A 3EOXA 1A7CA 2V95A 1BY7A 1C8OA 1NQ9I 5INWA 4G8OA 2QUGA 4YIAA 1JRRA 1IMVA 4P0OA 4AJUA 2OL2A 1QLPA 1OVAA 1E03I 2H4QA 4ZK0A 4PYWA 2VH4A 1SEKA 2GD4C 2WY1A 1ANTI 1DZGI 2VDYA 1JMJA 7APIA 1PSIA 1OYHL 1UHGA 1C5GA 1ATHA 3NDAA 1EZXA 1E04I 2ZNHA 3UT3A 2H4PA 4RO9A 4AU3A 1LK6I 1HP7A 1QMNA 2CEOA 2H4RA 3NDDA 1DZHI 1XQJA 3F1SA 1SNGA 9PAIA 5CDXA 1QMBA 1JJOC 3KCGI 5C98A 1HLEA 2RIWA 8APIA 4AQHA 1T1FA 4ROBA 3CWMA 3DY0A 4EB1L 4ROAA 4C49A 1B3KA 2XN3A 3PB1I 2BEHI 3EVJI 1OVAB 4DTEA 3R4LA 1R1LI 2DUTA 2B4XI 1BR8I 1LJ5A 2WXXA 1IZ2A 4X30A 2XN7A 2VDXA 1E05I 1DB2A 1ATTA 1LQ8A 2WXZA 1AZXI 1JTIA 2R9YA 1DVNA 2BEHL 3H5CA 4Y40A 1XU8A 5EI0A 1YXAA 1JMOA 2HI9A 3STOA 3T1PA 4AU3B 1DZGL 4BB2A 1OPHA 1OVAC 3F5NA 1KCTA 3LE2A 1F0CA 4AJTA 4C41A 3NDFA 1SR5A 3LW2A 3VVJA 3DLWA 4G8RA 4IC0A 2PEFA 3Q03A 1OO8A 1DZHL 4ZK3A 1D5SA 2WY0C 4Y3KA 1WZ9A 4DY7C 4DY0A 4AFXA 5IO1A 3CWLA 1ATUA 4P0FA 5CDZA 4RSQA 1K9OI 5HGCA 5BRRI 3CAAA 2B5TI 4AU2A 1JVQI 2B4XL 3F02A 4CAAA 2XN5A 1XQGA 1AS4A 3FGQA 5CE0A 3B9FI 1OYHI 2HIJI 2OAYA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2ANT I;  4R9I A;  1M93 B;  3DRU A;  1TB6 I;  2ARQ A;  4KDS A;  2WXW A;  2ACH A;  2WXZ C;  3DRM A;  3NE4 A;  2PEE A;  2ARR A;  3PZF A;  2RIV A;  2HIJ L;  1DVM A;  4GA7 A;  2WXY C;  2ZV6 A;  3CVM A;  3ZHA A;  2D26 A;  4IF8 A;  3OZQ A;  1MTP A;  3Q02 A;  9API A;  1OC0 A;  2XN6 A;  4EB1 I;  4AU4 A;  3EOX A;  1A7C A;  2V95 A;  1BY7 A;  1C8O A;  1NQ9 I;  5INW A;  4G8O A;  2QUG A;  4YIA A;  1JRR A;  1IMV A;  4P0O A;  4AJU A;  2OL2 A;  1QLP A;  1OVA A;  1E03 I;  2H4Q A;  4ZK0 A;  4PYW A;  2VH4 A;  1SEK A;  2GD4 C;  2WY1 A;  1ANT I;  1DZG I;  2VDY A;  1JMJ A;  7API A;  1PSI A;  1OYH L;  1UHG A;  1C5G A;  1ATH A;  3NDA A;  1EZX A;  1E04 I;  2ZNH A;  3UT3 A;  2H4P A;  4RO9 A;  4AU3 A;  1LK6 I;  1HP7 A;  1QMN A;  2CEO A;  2H4R A;  3NDD A;  1DZH I;  1XQJ A;  3F1S A;  1SNG A;  9PAI A;  5CDX A;  1QMB A;  1JJO C;  3KCG I;  5C98 A;  1HLE A;  2RIW A;  8API A;  4AQH A;  1T1F A;  4ROB A;  3CWM A;  3DY0 A;  4EB1 L;  4ROA A;  4C49 A;  1B3K A;  2XN3 A;  3PB1 I;  2BEH I;  3EVJ I;  1OVA B;  4DTE A;  3R4L A;  1R1L I;  2DUT A;  2B4X I;  1BR8 I;  1LJ5 A;  2WXX A;  1IZ2 A;  4X30 A;  2XN7 A;  2VDX A;  1E05 I;  1DB2 A;  1ATT A;  1LQ8 A;  2WXZ A;  1AZX I;  1JTI A;  2R9Y A;  1DVN A;  2BEH L;  3H5C A;  4Y40 A;  1XU8 A;  5EI0 A;  1YXA A;  1JMO A;  2HI9 A;  3STO A;  3T1P A;  4AU3 B;  1DZG L;  4BB2 A;  1OPH A;  1OVA C;  3F5N A;  1KCT A;  3LE2 A;  1F0C A;  4AJT A;  4C41 A;  3NDF A;  1SR5 A;  3LW2 A;  3VVJ A;  3DLW A;  4G8R A;  4IC0 A;  2PEF A;  3Q03 A;  1OO8 A;  1DZH L;  4ZK3 A;  1D5S A;  2WY0 C;  4Y3K A;  1WZ9 A;  4DY7 C;  4DY0 A;  4AFX A;  5IO1 A;  3CWL A;  1ATU A;  4P0F A;  5CDZ A;  4RSQ A;  1K9O I;  5HGC A;  5BRR I;  3CAA A;  2B5T I;  4AU2 A;  1JVQ I;  2B4X L;  3F02 A;  4CAA A;  2XN5 A;  1XQG A;  1AS4 A;  3FGQ A;  5CE0 A;  3B9F I;  1OYH I;  2HIJ I;  2OAY A; 
#chains in the Genus database with same CATH topology
 2ANT I;  4R9I A;  1M93 B;  3DRU A;  1TB6 I;  2ARQ A;  4KDS A;  2WXW A;  2ACH A;  2WXZ C;  3DRM A;  3NE4 A;  2PEE A;  2ARR A;  3PZF A;  2RIV A;  2HIJ L;  1DVM A;  4GA7 A;  2WXY C;  2ZV6 A;  3CVM A;  3ZHA A;  2D26 A;  4IF8 A;  3OZQ A;  1MTP A;  3Q02 A;  9API A;  1OC0 A;  2XN6 A;  4EB1 I;  4AU4 A;  3EOX A;  1A7C A;  2V95 A;  1BY7 A;  1C8O A;  1NQ9 I;  5INW A;  4G8O A;  2QUG A;  4YIA A;  1JRR A;  1IMV A;  4P0O A;  4AJU A;  2OL2 A;  1QLP A;  1OVA A;  1E03 I;  2H4Q A;  4ZK0 A;  4PYW A;  2VH4 A;  1SEK A;  2GD4 C;  2WY1 A;  1ANT I;  1DZG I;  2VDY A;  1JMJ A;  7API A;  1PSI A;  1OYH L;  1UHG A;  1C5G A;  1ATH A;  3NDA A;  1EZX A;  1E04 I;  2ZNH A;  3UT3 A;  2H4P A;  4RO9 A;  4AU3 A;  1LK6 I;  1HP7 A;  1QMN A;  2CEO A;  2H4R A;  3NDD A;  1DZH I;  1XQJ A;  3F1S A;  1SNG A;  9PAI A;  5CDX A;  1QMB A;  1JJO C;  3KCG I;  5C98 A;  1HLE A;  2RIW A;  8API A;  4AQH A;  1T1F A;  4ROB A;  3CWM A;  3DY0 A;  4EB1 L;  4ROA A;  4C49 A;  1B3K A;  2XN3 A;  3PB1 I;  2BEH I;  3EVJ I;  1OVA B;  4DTE A;  3R4L A;  1R1L I;  2DUT A;  2B4X I;  1BR8 I;  1LJ5 A;  2WXX A;  1IZ2 A;  4X30 A;  2XN7 A;  2VDX A;  1E05 I;  1DB2 A;  1ATT A;  1LQ8 A;  2WXZ A;  1AZX I;  1JTI A;  2R9Y A;  1DVN A;  2BEH L;  3H5C A;  4Y40 A;  1XU8 A;  5EI0 A;  1YXA A;  1JMO A;  2HI9 A;  3STO A;  3T1P A;  4AU3 B;  1DZG L;  4BB2 A;  1OPH A;  1OVA C;  3F5N A;  1KCT A;  3LE2 A;  1F0C A;  4AJT A;  4C41 A;  3NDF A;  1SR5 A;  3LW2 A;  3VVJ A;  3DLW A;  4G8R A;  4IC0 A;  2PEF A;  3Q03 A;  1OO8 A;  1DZH L;  4ZK3 A;  1D5S A;  2WY0 C;  4Y3K A;  1WZ9 A;  4DY7 C;  4DY0 A;  4AFX A;  5IO1 A;  3CWL A;  1ATU A;  4P0F A;  5CDZ A;  4RSQ A;  1K9O I;  5HGC A;  5BRR I;  3CAA A;  2B5T I;  4AU2 A;  1JVQ I;  2B4X L;  3F02 A;  4CAA A;  2XN5 A;  1XQG A;  1AS4 A;  3FGQ A;  5CE0 A;  3B9F I;  1OYH I;  2HIJ I;  2OAY A; 
#chains in the Genus database with same CATH homology
 2ANT I;  4R9I A;  1M93 B;  3DRU A;  1TB6 I;  2ARQ A;  4KDS A;  2WXW A;  2ACH A;  2WXZ C;  3DRM A;  3NE4 A;  2PEE A;  2ARR A;  3PZF A;  2RIV A;  2HIJ L;  1DVM A;  4GA7 A;  2WXY C;  2ZV6 A;  3CVM A;  3ZHA A;  2D26 A;  4IF8 A;  3OZQ A;  1MTP A;  3Q02 A;  9API A;  1OC0 A;  2XN6 A;  4EB1 I;  4AU4 A;  3EOX A;  1A7C A;  2V95 A;  1BY7 A;  1C8O A;  1NQ9 I;  5INW A;  4G8O A;  2QUG A;  4YIA A;  1JRR A;  1IMV A;  4P0O A;  4AJU A;  2OL2 A;  1QLP A;  1OVA A;  1E03 I;  2H4Q A;  4ZK0 A;  4PYW A;  2VH4 A;  1SEK A;  2GD4 C;  2WY1 A;  1ANT I;  1DZG I;  2VDY A;  1JMJ A;  7API A;  1PSI A;  1OYH L;  1UHG A;  1C5G A;  1ATH A;  3NDA A;  1EZX A;  1E04 I;  2ZNH A;  3UT3 A;  2H4P A;  4RO9 A;  4AU3 A;  1LK6 I;  1HP7 A;  1QMN A;  2CEO A;  2H4R A;  3NDD A;  1DZH I;  1XQJ A;  3F1S A;  1SNG A;  9PAI A;  5CDX A;  1QMB A;  1JJO C;  3KCG I;  5C98 A;  1HLE A;  2RIW A;  8API A;  4AQH A;  1T1F A;  4ROB A;  3CWM A;  3DY0 A;  4EB1 L;  4ROA A;  4C49 A;  1B3K A;  2XN3 A;  3PB1 I;  2BEH I;  3EVJ I;  1OVA B;  4DTE A;  3R4L A;  1R1L I;  2DUT A;  2B4X I;  1BR8 I;  1LJ5 A;  2WXX A;  1IZ2 A;  4X30 A;  2XN7 A;  2VDX A;  1E05 I;  1DB2 A;  1ATT A;  1LQ8 A;  2WXZ A;  1AZX I;  1JTI A;  2R9Y A;  1DVN A;  2BEH L;  3H5C A;  4Y40 A;  1XU8 A;  5EI0 A;  1YXA A;  1JMO A;  2HI9 A;  3STO A;  3T1P A;  4AU3 B;  1DZG L;  4BB2 A;  1OPH A;  1OVA C;  3F5N A;  1KCT A;  3LE2 A;  1F0C A;  4AJT A;  4C41 A;  3NDF A;  1SR5 A;  3LW2 A;  3VVJ A;  3DLW A;  4G8R A;  4IC0 A;  2PEF A;  3Q03 A;  1OO8 A;  1DZH L;  4ZK3 A;  1D5S A;  2WY0 C;  4Y3K A;  1WZ9 A;  4DY7 C;  4DY0 A;  4AFX A;  5IO1 A;  3CWL A;  1ATU A;  4P0F A;  5CDZ A;  4RSQ A;  1K9O I;  5HGC A;  5BRR I;  3CAA A;  2B5T I;  4AU2 A;  1JVQ I;  2B4X L;  3F02 A;  4CAA A;  2XN5 A;  1XQG A;  1AS4 A;  3FGQ A;  5CE0 A;  3B9F I;  1OYH I;  2HIJ I;  2OAY A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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