4EB1I

Hyperstable in-frame insertion variant of antithrombin
Total Genus 118
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
118
sequence length
436
structure length
411
Chain Sequence
VDICTAKPRDIPMNPMCIYRSPENRRVWELSKANSRFATTFYQHLADSKNDNDNIFLSPLSISTAFAMTKLGACNDTLQQLMEVFKFDTISEKTSDQIHFFFAKLNCRLYRKANKASKLVSANRLFGDKSLTFNETYQDISELVYGAKLQPLDFKENAEQSRAAINKWVSNKTEDVIPSEAINVLVLVNTRTSTVLVLVNTIYFKGLWKSKFSPENTRKELFYKADGESCSASMMYQEGKFRYRRVAEGTQVLELPFKGDDITMVLILPKPEKSLAKVEKELTPEVLQEWLDELEEMMLVVHMPRFRIEDGFSLKEQLQDMGLVDLFSPEKSKLPGIVADLYVSDAFHKAFLEVNEEGSEAAASTAVVIAGRSLNPNRVTFKANRPFLVFIREVPLNTIIFMGRVANPCVK
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Blood clotting
molecule keywords Antithrombin-III
publication title Type II antithrombin deficiency caused by a large in-frame insertion: structural, functional and pathological relevance.
pubmed doi rcsb
source organism Homo sapiens
total genus 118
structure length 411
sequence length 436
ec nomenclature
pdb deposition date 2012-03-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
I PF00079 Serpin Serpin (serine protease inhibitor)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.30.39.10 Mainly Beta Roll Alpha-1-antitrypsin; domain 1 Alpha-1-antitrypsin, domain 1 4eb1I02
3.30.497.10 Alpha Beta 2-Layer Sandwich Antithrombin; Chain I, domain 2 Antithrombin, subunit I, domain 2 4eb1I01
2OAYA 2XN7A 2BEHI 3F5NA 4RSQA 1OC0A 1DZHL 4DY7C 2XN3A 1OVAC 3VVJA 1JVQI 1E04I 1UHGA 3KCGI 4AU3B 4Y40A 1E03I 3PB1I 4AQHA 5CE0A 1JMOA 5C98A 2R9YA 3CWLA 1E05I 3CWMA 3F1SA 3F02A 2DUTA 2GD4C 3STOA 2QUGA 1SNGA 3T1PA 2WY0C 5CDZA 2HIJL 2WXXA 4X30A 4EB1I 4RO9A 2B4XL 1JJOC 2B5TI 2WXZA 3R4LA 2D26A 1ATUA 1OO8A 5IO1A 3FGQA 5INWA 4AU2A 1QMNA 4R9IA 1IZ2A 3OZQA 1B3KA 4BB2A 1ANTI 3PZFA 2H4QA 1WZ9A 1K9OI 3NDAA 4G8OA 1OYHI 1IMVA 2PEFA 1QLPA 1HLEA 2XN5A 1NQ9I 4G8RA 1F0CA 2ARRA 4ZK3A 1ATTA 1DZGL 3H5CA 1DVMA 3EOXA 1XQGA 2VH4A 2H4RA 1DZHI 1SEKA 3CVMA 4C41A 1YXAA 3B9FI 2PEEA 4IF8A 4ROBA 2RIVA 1JTIA 1D5SA 3NDDA 1HP7A 1OVAB 3DLWA 3EVJI 2RIWA 1AS4A 5BRRI 1OPHA 4C49A 1JRRA 7APIA 2WXZC 4ROAA 2H4PA 1EZXA 4AJUA 2HIJI 1BR8I 2B4XI 2CEOA 1C8OA 2VDYA 1BY7A 3NE4A 4PYWA 4ZK0A 2ACHA 1LJ5A 5HGCA 8APIA 4YIAA 2XN6A 3Q02A 1SR5A 3UT3A 2HI9A 1LK6I 4DY0A 2BEHL 1DVNA 4P0OA 1MTPA 1ATHA 2ARQA 4AU3A 1DZGI 1DB2A 1R1LI 4AU4A 1A7CA 4P0FA 1AZXI 3DRUA 1C5GA 4CAAA 1QMBA 1TB6I 9APIA 1KCTA 2OL2A 1OVAA 1T1FA 3LW2A 3NDFA 1LQ8A 2ANTI 5CDXA 1PSIA 4DTEA 2WY1A 4EB1L 3LE2A 2VDXA 1JMJA 2ZV6A 4KDSA 1XQJA 4IC0A 1M93B 4AFXA 3DRMA 2ZNHA 1XU8A 2WXYC 3CAAA 9PAIA 4Y3KA 3ZHAA 4AJTA 2V95A 2WXWA 4GA7A 3Q03A 5EI0A 1OYHL 3DY0A
chains in the Genus database with same CATH superfamily
2OAYA 2XN7A 2BEHI 3F5NA 4RSQA 1OC0A 1DZHL 4DY7C 2XN3A 1OVAC 3VVJA 1JVQI 1E04I 1UHGA 3KCGI 4AU3B 4Y40A 1E03I 3PB1I 4AQHA 5CE0A 1JMOA 5C98A 2R9YA 3CWLA 1E05I 3CWMA 3F1SA 3F02A 2DUTA 2GD4C 3STOA 2QUGA 1SNGA 3T1PA 2WY0C 5CDZA 2HIJL 2WXXA 4X30A 4EB1I 4RO9A 2B4XL 1JJOC 2B5TI 2WXZA 3R4LA 2D26A 1ATUA 1OO8A 5IO1A 3FGQA 5INWA 4AU2A 1QMNA 4R9IA 1IZ2A 3OZQA 1B3KA 4BB2A 1ANTI 3PZFA 2H4QA 1WZ9A 1K9OI 3NDAA 4G8OA 1OYHI 1IMVA 2PEFA 1QLPA 1HLEA 2XN5A 1NQ9I 4G8RA 1F0CA 2ARRA 4ZK3A 1ATTA 1DZGL 3H5CA 1DVMA 3EOXA 1XQGA 2VH4A 2H4RA 1DZHI 1SEKA 3CVMA 4C41A 1YXAA 3B9FI 2PEEA 4IF8A 4ROBA 2RIVA 1JTIA 1D5SA 3NDDA 1HP7A 1OVAB 3DLWA 3EVJI 2RIWA 1AS4A 5BRRI 1OPHA 4C49A 1JRRA 7APIA 2WXZC 4ROAA 2H4PA 1EZXA 4AJUA 2HIJI 1BR8I 2B4XI 2CEOA 1C8OA 2VDYA 1BY7A 3NE4A 4PYWA 4ZK0A 2ACHA 1LJ5A 5HGCA 8APIA 4YIAA 2XN6A 3Q02A 1SR5A 3UT3A 2HI9A 1LK6I 4DY0A 2BEHL 1DVNA 4P0OA 1MTPA 1ATHA 2ARQA 4AU3A 1DZGI 1DB2A 1R1LI 4AU4A 1A7CA 4P0FA 1AZXI 3DRUA 1C5GA 4CAAA 1QMBA 1TB6I 9APIA 1KCTA 2OL2A 1OVAA 1T1FA 3LW2A 3NDFA 1LQ8A 2ANTI 5CDXA 1PSIA 4DTEA 2WY1A 4EB1L 3LE2A 2VDXA 1JMJA 2ZV6A 4KDSA 1XQJA 4IC0A 1M93B 4AFXA 3DRMA 2ZNHA 1XU8A 2WXYC 3CAAA 9PAIA 4Y3KA 3ZHAA 4AJTA 2V95A 2WXWA 4GA7A 3Q03A 5EI0A 1OYHL 3DY0A
chains in the Genus database with same CATH topology
2OAYA 2XN7A 2BEHI 3F5NA 4RSQA 1OC0A 1DZHL 4DY7C 2XN3A 1OVAC 3VVJA 1JVQI 1E04I 1UHGA 3KCGI 4AU3B 4Y40A 1E03I 3PB1I 4AQHA 5CE0A 1JMOA 5C98A 2R9YA 3CWLA 1E05I 3CWMA 3F1SA 3F02A 2DUTA 2GD4C 3STOA 2QUGA 1SNGA 3T1PA 2WY0C 5CDZA 2HIJL 2WXXA 4X30A 4EB1I 4RO9A 2B4XL 1JJOC 2B5TI 2WXZA 3R4LA 2D26A 1ATUA 1OO8A 5IO1A 3FGQA 5INWA 4AU2A 1QMNA 4R9IA 1IZ2A 3OZQA 1B3KA 4BB2A 1ANTI 3PZFA 2H4QA 1WZ9A 1K9OI 3NDAA 4G8OA 1OYHI 1IMVA 2PEFA 1QLPA 1HLEA 2XN5A 1NQ9I 4G8RA 1F0CA 2ARRA 4ZK3A 1ATTA 1DZGL 3H5CA 1DVMA 3EOXA 1XQGA 2VH4A 2H4RA 1DZHI 1SEKA 3CVMA 4C41A 1YXAA 3B9FI 2PEEA 4IF8A 4ROBA 2RIVA 1JTIA 1D5SA 3NDDA 1HP7A 1OVAB 3DLWA 3EVJI 2RIWA 1AS4A 5BRRI 1OPHA 4C49A 1JRRA 7APIA 2WXZC 4ROAA 2H4PA 1EZXA 4AJUA 2HIJI 1BR8I 2B4XI 2CEOA 1C8OA 2VDYA 1BY7A 3NE4A 4PYWA 4ZK0A 2ACHA 1LJ5A 5HGCA 8APIA 4YIAA 2XN6A 3Q02A 1SR5A 3UT3A 2HI9A 1LK6I 4DY0A 2BEHL 1DVNA 4P0OA 1MTPA 1ATHA 2ARQA 4AU3A 1DZGI 1DB2A 1R1LI 4AU4A 1A7CA 4P0FA 1AZXI 3DRUA 1C5GA 4CAAA 1QMBA 1TB6I 9APIA 1KCTA 2OL2A 1OVAA 1T1FA 3LW2A 3NDFA 1LQ8A 2ANTI 5CDXA 1PSIA 4DTEA 2WY1A 4EB1L 3LE2A 2VDXA 1JMJA 2ZV6A 4KDSA 1XQJA 4IC0A 1M93B 4AFXA 3DRMA 2ZNHA 1XU8A 2WXYC 3CAAA 9PAIA 4Y3KA 3ZHAA 4AJTA 2V95A 2WXWA 4GA7A 3Q03A 5EI0A 1OYHL 3DY0A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2OAY A;  2XN7 A;  2BEH I;  3F5N A;  4RSQ A;  1OC0 A;  1DZH L;  4DY7 C;  2XN3 A;  1OVA C;  3VVJ A;  1JVQ I;  1E04 I;  1UHG A;  3KCG I;  4AU3 B;  4Y40 A;  1E03 I;  3PB1 I;  4AQH A;  5CE0 A;  1JMO A;  5C98 A;  2R9Y A;  3CWL A;  1E05 I;  3CWM A;  3F1S A;  3F02 A;  2DUT A;  2GD4 C;  3STO A;  2QUG A;  1SNG A;  3T1P A;  2WY0 C;  5CDZ A;  2HIJ L;  2WXX A;  4X30 A;  4EB1 I;  4RO9 A;  2B4X L;  1JJO C;  2B5T I;  2WXZ A;  3R4L A;  2D26 A;  1ATU A;  1OO8 A;  5IO1 A;  3FGQ A;  5INW A;  4AU2 A;  1QMN A;  4R9I A;  1IZ2 A;  3OZQ A;  1B3K A;  4BB2 A;  1ANT I;  3PZF A;  2H4Q A;  1WZ9 A;  1K9O I;  3NDA A;  4G8O A;  1OYH I;  1IMV A;  2PEF A;  1QLP A;  1HLE A;  2XN5 A;  1NQ9 I;  4G8R A;  1F0C A;  2ARR A;  4ZK3 A;  1ATT A;  1DZG L;  3H5C A;  1DVM A;  3EOX A;  1XQG A;  2VH4 A;  2H4R A;  1DZH I;  1SEK A;  3CVM A;  4C41 A;  1YXA A;  3B9F I;  2PEE A;  4IF8 A;  4ROB A;  2RIV A;  1JTI A;  1D5S A;  3NDD A;  1HP7 A;  1OVA B;  3DLW A;  3EVJ I;  2RIW A;  1AS4 A;  5BRR I;  1OPH A;  4C49 A;  1JRR A;  7API A;  2WXZ C;  4ROA A;  2H4P A;  1EZX A;  4AJU A;  2HIJ I;  1BR8 I;  2B4X I;  2CEO A;  1C8O A;  2VDY A;  1BY7 A;  3NE4 A;  4PYW A;  4ZK0 A;  2ACH A;  1LJ5 A;  5HGC A;  8API A;  4YIA A;  2XN6 A;  3Q02 A;  1SR5 A;  3UT3 A;  2HI9 A;  1LK6 I;  4DY0 A;  2BEH L;  1DVN A;  4P0O A;  1MTP A;  1ATH A;  2ARQ A;  4AU3 A;  1DZG I;  1DB2 A;  1R1L I;  4AU4 A;  1A7C A;  4P0F A;  1AZX I;  3DRU A;  1C5G A;  4CAA A;  1QMB A;  1TB6 I;  9API A;  1KCT A;  2OL2 A;  1OVA A;  1T1F A;  3LW2 A;  3NDF A;  1LQ8 A;  2ANT I;  5CDX A;  1PSI A;  4DTE A;  2WY1 A;  4EB1 L;  3LE2 A;  2VDX A;  1JMJ A;  2ZV6 A;  4KDS A;  1XQJ A;  4IC0 A;  1M93 B;  4AFX A;  3DRM A;  2ZNH A;  1XU8 A;  2WXY C;  3CAA A;  9PAI A;  4Y3K A;  3ZHA A;  4AJT A;  2V95 A;  2WXW A;  4GA7 A;  3Q03 A;  5EI0 A;  1OYH L;  3DY0 A; 
#chains in the Genus database with same CATH topology
 2OAY A;  2XN7 A;  2BEH I;  3F5N A;  4RSQ A;  1OC0 A;  1DZH L;  4DY7 C;  2XN3 A;  1OVA C;  3VVJ A;  1JVQ I;  1E04 I;  1UHG A;  3KCG I;  4AU3 B;  4Y40 A;  1E03 I;  3PB1 I;  4AQH A;  5CE0 A;  1JMO A;  5C98 A;  2R9Y A;  3CWL A;  1E05 I;  3CWM A;  3F1S A;  3F02 A;  2DUT A;  2GD4 C;  3STO A;  2QUG A;  1SNG A;  3T1P A;  2WY0 C;  5CDZ A;  2HIJ L;  2WXX A;  4X30 A;  4EB1 I;  4RO9 A;  2B4X L;  1JJO C;  2B5T I;  2WXZ A;  3R4L A;  2D26 A;  1ATU A;  1OO8 A;  5IO1 A;  3FGQ A;  5INW A;  4AU2 A;  1QMN A;  4R9I A;  1IZ2 A;  3OZQ A;  1B3K A;  4BB2 A;  1ANT I;  3PZF A;  2H4Q A;  1WZ9 A;  1K9O I;  3NDA A;  4G8O A;  1OYH I;  1IMV A;  2PEF A;  1QLP A;  1HLE A;  2XN5 A;  1NQ9 I;  4G8R A;  1F0C A;  2ARR A;  4ZK3 A;  1ATT A;  1DZG L;  3H5C A;  1DVM A;  3EOX A;  1XQG A;  2VH4 A;  2H4R A;  1DZH I;  1SEK A;  3CVM A;  4C41 A;  1YXA A;  3B9F I;  2PEE A;  4IF8 A;  4ROB A;  2RIV A;  1JTI A;  1D5S A;  3NDD A;  1HP7 A;  1OVA B;  3DLW A;  3EVJ I;  2RIW A;  1AS4 A;  5BRR I;  1OPH A;  4C49 A;  1JRR A;  7API A;  2WXZ C;  4ROA A;  2H4P A;  1EZX A;  4AJU A;  2HIJ I;  1BR8 I;  2B4X I;  2CEO A;  1C8O A;  2VDY A;  1BY7 A;  3NE4 A;  4PYW A;  4ZK0 A;  2ACH A;  1LJ5 A;  5HGC A;  8API A;  4YIA A;  2XN6 A;  3Q02 A;  1SR5 A;  3UT3 A;  2HI9 A;  1LK6 I;  4DY0 A;  2BEH L;  1DVN A;  4P0O A;  1MTP A;  1ATH A;  2ARQ A;  4AU3 A;  1DZG I;  1DB2 A;  1R1L I;  4AU4 A;  1A7C A;  4P0F A;  1AZX I;  3DRU A;  1C5G A;  4CAA A;  1QMB A;  1TB6 I;  9API A;  1KCT A;  2OL2 A;  1OVA A;  1T1F A;  3LW2 A;  3NDF A;  1LQ8 A;  2ANT I;  5CDX A;  1PSI A;  4DTE A;  2WY1 A;  4EB1 L;  3LE2 A;  2VDX A;  1JMJ A;  2ZV6 A;  4KDS A;  1XQJ A;  4IC0 A;  1M93 B;  4AFX A;  3DRM A;  2ZNH A;  1XU8 A;  2WXY C;  3CAA A;  9PAI A;  4Y3K A;  3ZHA A;  4AJT A;  2V95 A;  2WXW A;  4GA7 A;  3Q03 A;  5EI0 A;  1OYH L;  3DY0 A; 
#chains in the Genus database with same CATH homology
 2OAY A;  2XN7 A;  2BEH I;  3F5N A;  4RSQ A;  1OC0 A;  1DZH L;  4DY7 C;  2XN3 A;  1OVA C;  3VVJ A;  1JVQ I;  1E04 I;  1UHG A;  3KCG I;  4AU3 B;  4Y40 A;  1E03 I;  3PB1 I;  4AQH A;  5CE0 A;  1JMO A;  5C98 A;  2R9Y A;  3CWL A;  1E05 I;  3CWM A;  3F1S A;  3F02 A;  2DUT A;  2GD4 C;  3STO A;  2QUG A;  1SNG A;  3T1P A;  2WY0 C;  5CDZ A;  2HIJ L;  2WXX A;  4X30 A;  4EB1 I;  4RO9 A;  2B4X L;  1JJO C;  2B5T I;  2WXZ A;  3R4L A;  2D26 A;  1ATU A;  1OO8 A;  5IO1 A;  3FGQ A;  5INW A;  4AU2 A;  1QMN A;  4R9I A;  1IZ2 A;  3OZQ A;  1B3K A;  4BB2 A;  1ANT I;  3PZF A;  2H4Q A;  1WZ9 A;  1K9O I;  3NDA A;  4G8O A;  1OYH I;  1IMV A;  2PEF A;  1QLP A;  1HLE A;  2XN5 A;  1NQ9 I;  4G8R A;  1F0C A;  2ARR A;  4ZK3 A;  1ATT A;  1DZG L;  3H5C A;  1DVM A;  3EOX A;  1XQG A;  2VH4 A;  2H4R A;  1DZH I;  1SEK A;  3CVM A;  4C41 A;  1YXA A;  3B9F I;  2PEE A;  4IF8 A;  4ROB A;  2RIV A;  1JTI A;  1D5S A;  3NDD A;  1HP7 A;  1OVA B;  3DLW A;  3EVJ I;  2RIW A;  1AS4 A;  5BRR I;  1OPH A;  4C49 A;  1JRR A;  7API A;  2WXZ C;  4ROA A;  2H4P A;  1EZX A;  4AJU A;  2HIJ I;  1BR8 I;  2B4X I;  2CEO A;  1C8O A;  2VDY A;  1BY7 A;  3NE4 A;  4PYW A;  4ZK0 A;  2ACH A;  1LJ5 A;  5HGC A;  8API A;  4YIA A;  2XN6 A;  3Q02 A;  1SR5 A;  3UT3 A;  2HI9 A;  1LK6 I;  4DY0 A;  2BEH L;  1DVN A;  4P0O A;  1MTP A;  1ATH A;  2ARQ A;  4AU3 A;  1DZG I;  1DB2 A;  1R1L I;  4AU4 A;  1A7C A;  4P0F A;  1AZX I;  3DRU A;  1C5G A;  4CAA A;  1QMB A;  1TB6 I;  9API A;  1KCT A;  2OL2 A;  1OVA A;  1T1F A;  3LW2 A;  3NDF A;  1LQ8 A;  2ANT I;  5CDX A;  1PSI A;  4DTE A;  2WY1 A;  4EB1 L;  3LE2 A;  2VDX A;  1JMJ A;  2ZV6 A;  4KDS A;  1XQJ A;  4IC0 A;  1M93 B;  4AFX A;  3DRM A;  2ZNH A;  1XU8 A;  2WXY C;  3CAA A;  9PAI A;  4Y3K A;  3ZHA A;  4AJT A;  2V95 A;  2WXW A;  4GA7 A;  3Q03 A;  5EI0 A;  1OYH L;  3DY0 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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