4EB1L

Hyperstable in-frame insertion variant of antithrombin
Total Genus 109
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
109
sequence length
424
structure length
392
Chain Sequence
ICTAKPIPMNPMCIYTNRRVWELSKANSRFATTFYQHLADSKNDNDNIFLSPLSISTAFAMTKLGACNDTLQQLMEVFKFDTISEKTSDQIHFFFAKLNCRLYRKSSKLVSANRLFGDKSLTFNETYQDISELVYGAKLQPLDFKENAEQSRAAINKWVSNKTEGRITDVIPSEAINELTVLVLVNTIYFKGLWKSKFSPENTRKELFYKADGESCSASMMYQEGKFRYRRVAEGTQVLELPFKGDDITMVLILPKPEKSLAKVEKELTPEVLQEWLDELEEMMLVVHMPRFRIEDGFSLKEQLQDMGLVDLFSPEKSKLPGIVAERDDLYVSDAFHKAFLEVNEEGSEAAASTAVVIAGRSLFKANRPFLVFIREVPLNTIIFMGRVANPC
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Blood clotting
molecule keywords Antithrombin-III
publication title Type II antithrombin deficiency caused by a large in-frame insertion: structural, functional and pathological relevance.
pubmed doi rcsb
source organism Homo sapiens
total genus 109
structure length 392
sequence length 424
ec nomenclature
pdb deposition date 2012-03-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
L PF00079 Serpin Serpin (serine protease inhibitor)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.30.39.10 Mainly Beta Roll Alpha-1-antitrypsin; domain 1 Alpha-1-antitrypsin, domain 1 4eb1L02
3.30.497.10 Alpha Beta 2-Layer Sandwich Antithrombin; Chain I, domain 2 Antithrombin, subunit I, domain 2 4eb1L01
3R4LA 1BY7A 2OAYA 1JTIA 3Q03A 4EB1I 2WY1A 1JVQI 3UT3A 1ATUA 1ATTA 2WXXA 3T1PA 2XN6A 3F02A 3CVMA 4IC0A 9APIA 3F1SA 1C5GA 4AJTA 1EZXA 3LW2A 3CWMA 2QUGA 1XQJA 3DLWA 3DRUA 2WY0C 1C8OA 1T1FA 4RO9A 1E05I 1XU8A 2ARQA 2BEHI 4X30A 1OC0A 1DZGI 2HIJL 1R1LI 3VVJA 1DZHL 3FGQA 3EOXA 1B3KA 2H4QA 1LQ8A 1OPHA 2VDYA 4G8RA 1ATHA 4AJUA 1SR5A 9PAIA 2ZV6A 4Y40A 2WXYC 2WXWA 2RIVA 2XN7A 4ROAA 4GA7A 3CWLA 4C41A 4ZK3A 1WZ9A 4KDSA 4AQHA 4G8OA 1K9OI 1HLEA 2B4XI 1JRRA 3CAAA 1SEKA 1LK6I 2RIWA 5IO1A 1SNGA 4AFXA 5C98A 5CDXA 1XQGA 2GD4C 2D26A 2ZNHA 2ACHA 1HP7A 2XN5A 1MTPA 1OYHL 2ARRA 2CEOA 1LJ5A 2VH4A 8APIA 2VDXA 3STOA 1AS4A 2H4RA 1OVAB 4P0FA 4CAAA 2H4PA 2HI9A 4DY7C 1M93B 2DUTA 1QMNA 1OVAC 2ANTI 3DY0A 4EB1L 3F5NA 3LE2A 1F0CA 2HIJI 4RSQA 3ZHAA 4P0OA 1DZHI 1D5SA 1QMBA 3PZFA 3NDAA 2XN3A 4C49A 1QLPA 2WXZC 4YIAA 5EI0A 2PEEA 5INWA 4ZK0A 4AU3A 4R9IA 4AU3B 4DY0A 2BEHL 3NDFA 1IMVA 4Y3KA 3OZQA 1DZGL 1JMJA 3B9FI 4AU4A 1AZXI 3H5CA 5HGCA 5BRRI 5CDZA 1OVAA 1KCTA 2R9YA 1A7CA 4ROBA 3PB1I 3DRMA 1TB6I 3EVJI 1DVMA 5CE0A 2V95A 1DB2A 2B5TI 7APIA 2WXZA 1IZ2A 2PEFA 1BR8I 1ANTI 4BB2A 1PSIA 1JJOC 1E03I 3KCGI 1OYHI 3Q02A 4PYWA 1NQ9I 4IF8A 1E04I 1JMOA 3NDDA 1OO8A 2B4XL 2OL2A 1DVNA 4AU2A 1UHGA 3NE4A 4DTEA 1YXAA
chains in the Genus database with same CATH superfamily
3R4LA 1BY7A 2OAYA 1JTIA 3Q03A 4EB1I 2WY1A 1JVQI 3UT3A 1ATUA 1ATTA 2WXXA 3T1PA 2XN6A 3F02A 3CVMA 4IC0A 9APIA 3F1SA 1C5GA 4AJTA 1EZXA 3LW2A 3CWMA 2QUGA 1XQJA 3DLWA 3DRUA 2WY0C 1C8OA 1T1FA 4RO9A 1E05I 1XU8A 2ARQA 2BEHI 4X30A 1OC0A 1DZGI 2HIJL 1R1LI 3VVJA 1DZHL 3FGQA 3EOXA 1B3KA 2H4QA 1LQ8A 1OPHA 2VDYA 4G8RA 1ATHA 4AJUA 1SR5A 9PAIA 2ZV6A 4Y40A 2WXYC 2WXWA 2RIVA 2XN7A 4ROAA 4GA7A 3CWLA 4C41A 4ZK3A 1WZ9A 4KDSA 4AQHA 4G8OA 1K9OI 1HLEA 2B4XI 1JRRA 3CAAA 1SEKA 1LK6I 2RIWA 5IO1A 1SNGA 4AFXA 5C98A 5CDXA 1XQGA 2GD4C 2D26A 2ZNHA 2ACHA 1HP7A 2XN5A 1MTPA 1OYHL 2ARRA 2CEOA 1LJ5A 2VH4A 8APIA 2VDXA 3STOA 1AS4A 2H4RA 1OVAB 4P0FA 4CAAA 2H4PA 2HI9A 4DY7C 1M93B 2DUTA 1QMNA 1OVAC 2ANTI 3DY0A 4EB1L 3F5NA 3LE2A 1F0CA 2HIJI 4RSQA 3ZHAA 4P0OA 1DZHI 1D5SA 1QMBA 3PZFA 3NDAA 2XN3A 4C49A 1QLPA 2WXZC 4YIAA 5EI0A 2PEEA 5INWA 4ZK0A 4AU3A 4R9IA 4AU3B 4DY0A 2BEHL 3NDFA 1IMVA 4Y3KA 3OZQA 1DZGL 1JMJA 3B9FI 4AU4A 1AZXI 3H5CA 5HGCA 5BRRI 5CDZA 1OVAA 1KCTA 2R9YA 1A7CA 4ROBA 3PB1I 3DRMA 1TB6I 3EVJI 1DVMA 5CE0A 2V95A 1DB2A 2B5TI 7APIA 2WXZA 1IZ2A 2PEFA 1BR8I 1ANTI 4BB2A 1PSIA 1JJOC 1E03I 3KCGI 1OYHI 3Q02A 4PYWA 1NQ9I 4IF8A 1E04I 1JMOA 3NDDA 1OO8A 2B4XL 2OL2A 1DVNA 4AU2A 1UHGA 3NE4A 4DTEA 1YXAA
chains in the Genus database with same CATH topology
3R4LA 1BY7A 2OAYA 1JTIA 3Q03A 4EB1I 2WY1A 1JVQI 3UT3A 1ATUA 1ATTA 2WXXA 3T1PA 2XN6A 3F02A 3CVMA 4IC0A 9APIA 3F1SA 1C5GA 4AJTA 1EZXA 3LW2A 3CWMA 2QUGA 1XQJA 3DLWA 3DRUA 2WY0C 1C8OA 1T1FA 4RO9A 1E05I 1XU8A 2ARQA 2BEHI 4X30A 1OC0A 1DZGI 2HIJL 1R1LI 3VVJA 1DZHL 3FGQA 3EOXA 1B3KA 2H4QA 1LQ8A 1OPHA 2VDYA 4G8RA 1ATHA 4AJUA 1SR5A 9PAIA 2ZV6A 4Y40A 2WXYC 2WXWA 2RIVA 2XN7A 4ROAA 4GA7A 3CWLA 4C41A 4ZK3A 1WZ9A 4KDSA 4AQHA 4G8OA 1K9OI 1HLEA 2B4XI 1JRRA 3CAAA 1SEKA 1LK6I 2RIWA 5IO1A 1SNGA 4AFXA 5C98A 5CDXA 1XQGA 2GD4C 2D26A 2ZNHA 2ACHA 1HP7A 2XN5A 1MTPA 1OYHL 2ARRA 2CEOA 1LJ5A 2VH4A 8APIA 2VDXA 3STOA 1AS4A 2H4RA 1OVAB 4P0FA 4CAAA 2H4PA 2HI9A 4DY7C 1M93B 2DUTA 1QMNA 1OVAC 2ANTI 3DY0A 4EB1L 3F5NA 3LE2A 1F0CA 2HIJI 4RSQA 3ZHAA 4P0OA 1DZHI 1D5SA 1QMBA 3PZFA 3NDAA 2XN3A 4C49A 1QLPA 2WXZC 4YIAA 5EI0A 2PEEA 5INWA 4ZK0A 4AU3A 4R9IA 4AU3B 4DY0A 2BEHL 3NDFA 1IMVA 4Y3KA 3OZQA 1DZGL 1JMJA 3B9FI 4AU4A 1AZXI 3H5CA 5HGCA 5BRRI 5CDZA 1OVAA 1KCTA 2R9YA 1A7CA 4ROBA 3PB1I 3DRMA 1TB6I 3EVJI 1DVMA 5CE0A 2V95A 1DB2A 2B5TI 7APIA 2WXZA 1IZ2A 2PEFA 1BR8I 1ANTI 4BB2A 1PSIA 1JJOC 1E03I 3KCGI 1OYHI 3Q02A 4PYWA 1NQ9I 4IF8A 1E04I 1JMOA 3NDDA 1OO8A 2B4XL 2OL2A 1DVNA 4AU2A 1UHGA 3NE4A 4DTEA 1YXAA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3R4L A;  1BY7 A;  2OAY A;  1JTI A;  3Q03 A;  4EB1 I;  2WY1 A;  1JVQ I;  3UT3 A;  1ATU A;  1ATT A;  2WXX A;  3T1P A;  2XN6 A;  3F02 A;  3CVM A;  4IC0 A;  9API A;  3F1S A;  1C5G A;  4AJT A;  1EZX A;  3LW2 A;  3CWM A;  2QUG A;  1XQJ A;  3DLW A;  3DRU A;  2WY0 C;  1C8O A;  1T1F A;  4RO9 A;  1E05 I;  1XU8 A;  2ARQ A;  2BEH I;  4X30 A;  1OC0 A;  1DZG I;  2HIJ L;  1R1L I;  3VVJ A;  1DZH L;  3FGQ A;  3EOX A;  1B3K A;  2H4Q A;  1LQ8 A;  1OPH A;  2VDY A;  4G8R A;  1ATH A;  4AJU A;  1SR5 A;  9PAI A;  2ZV6 A;  4Y40 A;  2WXY C;  2WXW A;  2RIV A;  2XN7 A;  4ROA A;  4GA7 A;  3CWL A;  4C41 A;  4ZK3 A;  1WZ9 A;  4KDS A;  4AQH A;  4G8O A;  1K9O I;  1HLE A;  2B4X I;  1JRR A;  3CAA A;  1SEK A;  1LK6 I;  2RIW A;  5IO1 A;  1SNG A;  4AFX A;  5C98 A;  5CDX A;  1XQG A;  2GD4 C;  2D26 A;  2ZNH A;  2ACH A;  1HP7 A;  2XN5 A;  1MTP A;  1OYH L;  2ARR A;  2CEO A;  1LJ5 A;  2VH4 A;  8API A;  2VDX A;  3STO A;  1AS4 A;  2H4R A;  1OVA B;  4P0F A;  4CAA A;  2H4P A;  2HI9 A;  4DY7 C;  1M93 B;  2DUT A;  1QMN A;  1OVA C;  2ANT I;  3DY0 A;  4EB1 L;  3F5N A;  3LE2 A;  1F0C A;  2HIJ I;  4RSQ A;  3ZHA A;  4P0O A;  1DZH I;  1D5S A;  1QMB A;  3PZF A;  3NDA A;  2XN3 A;  4C49 A;  1QLP A;  2WXZ C;  4YIA A;  5EI0 A;  2PEE A;  5INW A;  4ZK0 A;  4AU3 A;  4R9I A;  4AU3 B;  4DY0 A;  2BEH L;  3NDF A;  1IMV A;  4Y3K A;  3OZQ A;  1DZG L;  1JMJ A;  3B9F I;  4AU4 A;  1AZX I;  3H5C A;  5HGC A;  5BRR I;  5CDZ A;  1OVA A;  1KCT A;  2R9Y A;  1A7C A;  4ROB A;  3PB1 I;  3DRM A;  1TB6 I;  3EVJ I;  1DVM A;  5CE0 A;  2V95 A;  1DB2 A;  2B5T I;  7API A;  2WXZ A;  1IZ2 A;  2PEF A;  1BR8 I;  1ANT I;  4BB2 A;  1PSI A;  1JJO C;  1E03 I;  3KCG I;  1OYH I;  3Q02 A;  4PYW A;  1NQ9 I;  4IF8 A;  1E04 I;  1JMO A;  3NDD A;  1OO8 A;  2B4X L;  2OL2 A;  1DVN A;  4AU2 A;  1UHG A;  3NE4 A;  4DTE A;  1YXA A; 
#chains in the Genus database with same CATH topology
 3R4L A;  1BY7 A;  2OAY A;  1JTI A;  3Q03 A;  4EB1 I;  2WY1 A;  1JVQ I;  3UT3 A;  1ATU A;  1ATT A;  2WXX A;  3T1P A;  2XN6 A;  3F02 A;  3CVM A;  4IC0 A;  9API A;  3F1S A;  1C5G A;  4AJT A;  1EZX A;  3LW2 A;  3CWM A;  2QUG A;  1XQJ A;  3DLW A;  3DRU A;  2WY0 C;  1C8O A;  1T1F A;  4RO9 A;  1E05 I;  1XU8 A;  2ARQ A;  2BEH I;  4X30 A;  1OC0 A;  1DZG I;  2HIJ L;  1R1L I;  3VVJ A;  1DZH L;  3FGQ A;  3EOX A;  1B3K A;  2H4Q A;  1LQ8 A;  1OPH A;  2VDY A;  4G8R A;  1ATH A;  4AJU A;  1SR5 A;  9PAI A;  2ZV6 A;  4Y40 A;  2WXY C;  2WXW A;  2RIV A;  2XN7 A;  4ROA A;  4GA7 A;  3CWL A;  4C41 A;  4ZK3 A;  1WZ9 A;  4KDS A;  4AQH A;  4G8O A;  1K9O I;  1HLE A;  2B4X I;  1JRR A;  3CAA A;  1SEK A;  1LK6 I;  2RIW A;  5IO1 A;  1SNG A;  4AFX A;  5C98 A;  5CDX A;  1XQG A;  2GD4 C;  2D26 A;  2ZNH A;  2ACH A;  1HP7 A;  2XN5 A;  1MTP A;  1OYH L;  2ARR A;  2CEO A;  1LJ5 A;  2VH4 A;  8API A;  2VDX A;  3STO A;  1AS4 A;  2H4R A;  1OVA B;  4P0F A;  4CAA A;  2H4P A;  2HI9 A;  4DY7 C;  1M93 B;  2DUT A;  1QMN A;  1OVA C;  2ANT I;  3DY0 A;  4EB1 L;  3F5N A;  3LE2 A;  1F0C A;  2HIJ I;  4RSQ A;  3ZHA A;  4P0O A;  1DZH I;  1D5S A;  1QMB A;  3PZF A;  3NDA A;  2XN3 A;  4C49 A;  1QLP A;  2WXZ C;  4YIA A;  5EI0 A;  2PEE A;  5INW A;  4ZK0 A;  4AU3 A;  4R9I A;  4AU3 B;  4DY0 A;  2BEH L;  3NDF A;  1IMV A;  4Y3K A;  3OZQ A;  1DZG L;  1JMJ A;  3B9F I;  4AU4 A;  1AZX I;  3H5C A;  5HGC A;  5BRR I;  5CDZ A;  1OVA A;  1KCT A;  2R9Y A;  1A7C A;  4ROB A;  3PB1 I;  3DRM A;  1TB6 I;  3EVJ I;  1DVM A;  5CE0 A;  2V95 A;  1DB2 A;  2B5T I;  7API A;  2WXZ A;  1IZ2 A;  2PEF A;  1BR8 I;  1ANT I;  4BB2 A;  1PSI A;  1JJO C;  1E03 I;  3KCG I;  1OYH I;  3Q02 A;  4PYW A;  1NQ9 I;  4IF8 A;  1E04 I;  1JMO A;  3NDD A;  1OO8 A;  2B4X L;  2OL2 A;  1DVN A;  4AU2 A;  1UHG A;  3NE4 A;  4DTE A;  1YXA A; 
#chains in the Genus database with same CATH homology
 3R4L A;  1BY7 A;  2OAY A;  1JTI A;  3Q03 A;  4EB1 I;  2WY1 A;  1JVQ I;  3UT3 A;  1ATU A;  1ATT A;  2WXX A;  3T1P A;  2XN6 A;  3F02 A;  3CVM A;  4IC0 A;  9API A;  3F1S A;  1C5G A;  4AJT A;  1EZX A;  3LW2 A;  3CWM A;  2QUG A;  1XQJ A;  3DLW A;  3DRU A;  2WY0 C;  1C8O A;  1T1F A;  4RO9 A;  1E05 I;  1XU8 A;  2ARQ A;  2BEH I;  4X30 A;  1OC0 A;  1DZG I;  2HIJ L;  1R1L I;  3VVJ A;  1DZH L;  3FGQ A;  3EOX A;  1B3K A;  2H4Q A;  1LQ8 A;  1OPH A;  2VDY A;  4G8R A;  1ATH A;  4AJU A;  1SR5 A;  9PAI A;  2ZV6 A;  4Y40 A;  2WXY C;  2WXW A;  2RIV A;  2XN7 A;  4ROA A;  4GA7 A;  3CWL A;  4C41 A;  4ZK3 A;  1WZ9 A;  4KDS A;  4AQH A;  4G8O A;  1K9O I;  1HLE A;  2B4X I;  1JRR A;  3CAA A;  1SEK A;  1LK6 I;  2RIW A;  5IO1 A;  1SNG A;  4AFX A;  5C98 A;  5CDX A;  1XQG A;  2GD4 C;  2D26 A;  2ZNH A;  2ACH A;  1HP7 A;  2XN5 A;  1MTP A;  1OYH L;  2ARR A;  2CEO A;  1LJ5 A;  2VH4 A;  8API A;  2VDX A;  3STO A;  1AS4 A;  2H4R A;  1OVA B;  4P0F A;  4CAA A;  2H4P A;  2HI9 A;  4DY7 C;  1M93 B;  2DUT A;  1QMN A;  1OVA C;  2ANT I;  3DY0 A;  4EB1 L;  3F5N A;  3LE2 A;  1F0C A;  2HIJ I;  4RSQ A;  3ZHA A;  4P0O A;  1DZH I;  1D5S A;  1QMB A;  3PZF A;  3NDA A;  2XN3 A;  4C49 A;  1QLP A;  2WXZ C;  4YIA A;  5EI0 A;  2PEE A;  5INW A;  4ZK0 A;  4AU3 A;  4R9I A;  4AU3 B;  4DY0 A;  2BEH L;  3NDF A;  1IMV A;  4Y3K A;  3OZQ A;  1DZG L;  1JMJ A;  3B9F I;  4AU4 A;  1AZX I;  3H5C A;  5HGC A;  5BRR I;  5CDZ A;  1OVA A;  1KCT A;  2R9Y A;  1A7C A;  4ROB A;  3PB1 I;  3DRM A;  1TB6 I;  3EVJ I;  1DVM A;  5CE0 A;  2V95 A;  1DB2 A;  2B5T I;  7API A;  2WXZ A;  1IZ2 A;  2PEF A;  1BR8 I;  1ANT I;  4BB2 A;  1PSI A;  1JJO C;  1E03 I;  3KCG I;  1OYH I;  3Q02 A;  4PYW A;  1NQ9 I;  4IF8 A;  1E04 I;  1JMO A;  3NDD A;  1OO8 A;  2B4X L;  2OL2 A;  1DVN A;  4AU2 A;  1UHG A;  3NE4 A;  4DTE A;  1YXA A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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