4KDSA

Crystal structure of latent rainbow trout plasminogen activator inhibitor 1 (pai-1)
Total Genus 109
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
109
sequence length
370
structure length
370
Chain Sequence
NLQEKQTDFGMRVFSQVAQNSKGSNLAFSPYGVATILAMAQLGAGGNTLKTLNAKLGFSLQERGMARQQRLLQRDISSEEGVELASGVMVERKMALEKGFRRGLGKAFQASPHQLDFSRPDQALDIINAWVSDHTAGTIPSFLSSGALTDETRMVLLNALHFQGLWKVPFDPKMTEERLFHCANGSSVPVPMMRLTHRFKYGEFVTPDGVDYDVIEVPYEGESLSMLLVSPFEPETPVSSLSSELTTQRLQQWRQEMRSVKRQLVLPRFTLDSEVELKSILIQMGLGDMFNLAKADFTRITTEQPLCVSKVLQKVKIEVNEEGTKASAATAAILFSRMAVEEITMNRPFLFLIHHKSTGAVLFMGQVNQP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase inhibitor
molecule keywords Plasminogen activator inhibitor 1
publication title Protein conformational change delayed by steric hindrance from an N-linked glycan.
pubmed doi rcsb
source organism Oncorhynchus mykiss
total genus 109
structure length 370
sequence length 370
ec nomenclature
pdb deposition date 2013-04-25

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00079 Serpin Serpin (serine protease inhibitor)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.30.39.10 Mainly Beta Roll Alpha-1-antitrypsin; domain 1 Alpha-1-antitrypsin, domain 1 4kdsA02
3.30.497.10 Alpha Beta 2-Layer Sandwich Antithrombin; Chain I, domain 2 Antithrombin, subunit I, domain 2 4kdsA01
1SEKA 3F1SA 2WXYC 1E05I 2DUTA 2XN6A 4G8OA 5BRRI 4DY7C 4ROBA 2RIWA 1QLPA 3STOA 1E04I 5CDXA 4KDSA 2GD4C 2QUGA 3KCGI 1KCTA 5HGCA 4AJUA 5C98A 1JTIA 1TB6I 3F02A 1JJOC 1LQ8A 3CAAA 4P0OA 2VDYA 5CDZA 4DTEA 1JMOA 1F0CA 2HIJL 4AU4A 2H4PA 4AU2A 5CE0A 2RIVA 2WXXA 2WXZC 1ANTI 4EB1L 3EVJI 4ZK0A 3DRUA 4AQHA 2XN7A 1OC0A 3CWMA 3VVJA 2H4RA 3CVMA 2OL2A 2ZNHA 1D5SA 1AS4A 2B4XI 1M93B 1NQ9I 3F5NA 1OVAA 4Y3KA 4X30A 1OVAB 2BEHI 2D26A 1EZXA 5INWA 4C49A 1QMBA 1OO8A 1K9OI 3DLWA 4IC0A 2ANTI 1R1LI 1PSIA 3H5CA 1DB2A 1LK6I 2R9YA 1C8OA 4P0FA 3NDFA 3ZHAA 1OYHI 1ATHA 3FGQA 1DZGI 2ACHA 1E03I 1IMVA 3LE2A 4PYWA 1WZ9A 3B9FI 1XU8A 9PAIA 1MTPA 2WY0C 1SR5A 1XQJA 2WXWA 4Y40A 1OPHA 2ZV6A 2PEFA 3Q02A 4RSQA 5EI0A 2WY1A 2H4QA 2B5TI 2XN3A 4ROAA 1AZXI 5IO1A 2VH4A 9APIA 1UHGA 1DZHI 2BEHL 1QMNA 1T1FA 3CWLA 2VDXA 4G8RA 1DVNA 4ZK3A 1SNGA 1YXAA 1B3KA 4EB1I 1HP7A 4IF8A 3DY0A 4DY0A 1A7CA 7APIA 3R4LA 2WXZA 3Q03A 3T1PA 4AFXA 1OYHL 1IZ2A 2ARRA 3NE4A 1ATTA 1DZGL 1XQGA 4BB2A 2ARQA 3EOXA 2CEOA 4C41A 3NDAA 1HLEA 4R9IA 3PZFA 1JRRA 1OVAC 3UT3A 1LJ5A 2B4XL 2OAYA 2V95A 8APIA 1BY7A 1BR8I 1DVMA 3LW2A 2PEEA 2HIJI 3OZQA 2HI9A 1ATUA 1DZHL 4AU3A 1C5GA 4AU3B 2XN5A 4RO9A 4AJTA 3NDDA 4YIAA 4CAAA 1JVQI 4GA7A 3PB1I 1JMJA 3DRMA
chains in the Genus database with same CATH superfamily
1SEKA 3F1SA 2WXYC 1E05I 2DUTA 2XN6A 4G8OA 5BRRI 4DY7C 4ROBA 2RIWA 1QLPA 3STOA 1E04I 5CDXA 4KDSA 2GD4C 2QUGA 3KCGI 1KCTA 5HGCA 4AJUA 5C98A 1JTIA 1TB6I 3F02A 1JJOC 1LQ8A 3CAAA 4P0OA 2VDYA 5CDZA 4DTEA 1JMOA 1F0CA 2HIJL 4AU4A 2H4PA 4AU2A 5CE0A 2RIVA 2WXXA 2WXZC 1ANTI 4EB1L 3EVJI 4ZK0A 3DRUA 4AQHA 2XN7A 1OC0A 3CWMA 3VVJA 2H4RA 3CVMA 2OL2A 2ZNHA 1D5SA 1AS4A 2B4XI 1M93B 1NQ9I 3F5NA 1OVAA 4Y3KA 4X30A 1OVAB 2BEHI 2D26A 1EZXA 5INWA 4C49A 1QMBA 1OO8A 1K9OI 3DLWA 4IC0A 2ANTI 1R1LI 1PSIA 3H5CA 1DB2A 1LK6I 2R9YA 1C8OA 4P0FA 3NDFA 3ZHAA 1OYHI 1ATHA 3FGQA 1DZGI 2ACHA 1E03I 1IMVA 3LE2A 4PYWA 1WZ9A 3B9FI 1XU8A 9PAIA 1MTPA 2WY0C 1SR5A 1XQJA 2WXWA 4Y40A 1OPHA 2ZV6A 2PEFA 3Q02A 4RSQA 5EI0A 2WY1A 2H4QA 2B5TI 2XN3A 4ROAA 1AZXI 5IO1A 2VH4A 9APIA 1UHGA 1DZHI 2BEHL 1QMNA 1T1FA 3CWLA 2VDXA 4G8RA 1DVNA 4ZK3A 1SNGA 1YXAA 1B3KA 4EB1I 1HP7A 4IF8A 3DY0A 4DY0A 1A7CA 7APIA 3R4LA 2WXZA 3Q03A 3T1PA 4AFXA 1OYHL 1IZ2A 2ARRA 3NE4A 1ATTA 1DZGL 1XQGA 4BB2A 2ARQA 3EOXA 2CEOA 4C41A 3NDAA 1HLEA 4R9IA 3PZFA 1JRRA 1OVAC 3UT3A 1LJ5A 2B4XL 2OAYA 2V95A 8APIA 1BY7A 1BR8I 1DVMA 3LW2A 2PEEA 2HIJI 3OZQA 2HI9A 1ATUA 1DZHL 4AU3A 1C5GA 4AU3B 2XN5A 4RO9A 4AJTA 3NDDA 4YIAA 4CAAA 1JVQI 4GA7A 3PB1I 1JMJA 3DRMA
chains in the Genus database with same CATH topology
1SEKA 3F1SA 2WXYC 1E05I 2DUTA 2XN6A 4G8OA 5BRRI 4DY7C 4ROBA 2RIWA 1QLPA 3STOA 1E04I 5CDXA 4KDSA 2GD4C 2QUGA 3KCGI 1KCTA 5HGCA 4AJUA 5C98A 1JTIA 1TB6I 3F02A 1JJOC 1LQ8A 3CAAA 4P0OA 2VDYA 5CDZA 4DTEA 1JMOA 1F0CA 2HIJL 4AU4A 2H4PA 4AU2A 5CE0A 2RIVA 2WXXA 2WXZC 1ANTI 4EB1L 3EVJI 4ZK0A 3DRUA 4AQHA 2XN7A 1OC0A 3CWMA 3VVJA 2H4RA 3CVMA 2OL2A 2ZNHA 1D5SA 1AS4A 2B4XI 1M93B 1NQ9I 3F5NA 1OVAA 4Y3KA 4X30A 1OVAB 2BEHI 2D26A 1EZXA 5INWA 4C49A 1QMBA 1OO8A 1K9OI 3DLWA 4IC0A 2ANTI 1R1LI 1PSIA 3H5CA 1DB2A 1LK6I 2R9YA 1C8OA 4P0FA 3NDFA 3ZHAA 1OYHI 1ATHA 3FGQA 1DZGI 2ACHA 1E03I 1IMVA 3LE2A 4PYWA 1WZ9A 3B9FI 1XU8A 9PAIA 1MTPA 2WY0C 1SR5A 1XQJA 2WXWA 4Y40A 1OPHA 2ZV6A 2PEFA 3Q02A 4RSQA 5EI0A 2WY1A 2H4QA 2B5TI 2XN3A 4ROAA 1AZXI 5IO1A 2VH4A 9APIA 1UHGA 1DZHI 2BEHL 1QMNA 1T1FA 3CWLA 2VDXA 4G8RA 1DVNA 4ZK3A 1SNGA 1YXAA 1B3KA 4EB1I 1HP7A 4IF8A 3DY0A 4DY0A 1A7CA 7APIA 3R4LA 2WXZA 3Q03A 3T1PA 4AFXA 1OYHL 1IZ2A 2ARRA 3NE4A 1ATTA 1DZGL 1XQGA 4BB2A 2ARQA 3EOXA 2CEOA 4C41A 3NDAA 1HLEA 4R9IA 3PZFA 1JRRA 1OVAC 3UT3A 1LJ5A 2B4XL 2OAYA 2V95A 8APIA 1BY7A 1BR8I 1DVMA 3LW2A 2PEEA 2HIJI 3OZQA 2HI9A 1ATUA 1DZHL 4AU3A 1C5GA 4AU3B 2XN5A 4RO9A 4AJTA 3NDDA 4YIAA 4CAAA 1JVQI 4GA7A 3PB1I 1JMJA 3DRMA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1SEK A;  3F1S A;  2WXY C;  1E05 I;  2DUT A;  2XN6 A;  4G8O A;  5BRR I;  4DY7 C;  4ROB A;  2RIW A;  1QLP A;  3STO A;  1E04 I;  5CDX A;  4KDS A;  2GD4 C;  2QUG A;  3KCG I;  1KCT A;  5HGC A;  4AJU A;  5C98 A;  1JTI A;  1TB6 I;  3F02 A;  1JJO C;  1LQ8 A;  3CAA A;  4P0O A;  2VDY A;  5CDZ A;  4DTE A;  1JMO A;  1F0C A;  2HIJ L;  4AU4 A;  2H4P A;  4AU2 A;  5CE0 A;  2RIV A;  2WXX A;  2WXZ C;  1ANT I;  4EB1 L;  3EVJ I;  4ZK0 A;  3DRU A;  4AQH A;  2XN7 A;  1OC0 A;  3CWM A;  3VVJ A;  2H4R A;  3CVM A;  2OL2 A;  2ZNH A;  1D5S A;  1AS4 A;  2B4X I;  1M93 B;  1NQ9 I;  3F5N A;  1OVA A;  4Y3K A;  4X30 A;  1OVA B;  2BEH I;  2D26 A;  1EZX A;  5INW A;  4C49 A;  1QMB A;  1OO8 A;  1K9O I;  3DLW A;  4IC0 A;  2ANT I;  1R1L I;  1PSI A;  3H5C A;  1DB2 A;  1LK6 I;  2R9Y A;  1C8O A;  4P0F A;  3NDF A;  3ZHA A;  1OYH I;  1ATH A;  3FGQ A;  1DZG I;  2ACH A;  1E03 I;  1IMV A;  3LE2 A;  4PYW A;  1WZ9 A;  3B9F I;  1XU8 A;  9PAI A;  1MTP A;  2WY0 C;  1SR5 A;  1XQJ A;  2WXW A;  4Y40 A;  1OPH A;  2ZV6 A;  2PEF A;  3Q02 A;  4RSQ A;  5EI0 A;  2WY1 A;  2H4Q A;  2B5T I;  2XN3 A;  4ROA A;  1AZX I;  5IO1 A;  2VH4 A;  9API A;  1UHG A;  1DZH I;  2BEH L;  1QMN A;  1T1F A;  3CWL A;  2VDX A;  4G8R A;  1DVN A;  4ZK3 A;  1SNG A;  1YXA A;  1B3K A;  4EB1 I;  1HP7 A;  4IF8 A;  3DY0 A;  4DY0 A;  1A7C A;  7API A;  3R4L A;  2WXZ A;  3Q03 A;  3T1P A;  4AFX A;  1OYH L;  1IZ2 A;  2ARR A;  3NE4 A;  1ATT A;  1DZG L;  1XQG A;  4BB2 A;  2ARQ A;  3EOX A;  2CEO A;  4C41 A;  3NDA A;  1HLE A;  4R9I A;  3PZF A;  1JRR A;  1OVA C;  3UT3 A;  1LJ5 A;  2B4X L;  2OAY A;  2V95 A;  8API A;  1BY7 A;  1BR8 I;  1DVM A;  3LW2 A;  2PEE A;  2HIJ I;  3OZQ A;  2HI9 A;  1ATU A;  1DZH L;  4AU3 A;  1C5G A;  4AU3 B;  2XN5 A;  4RO9 A;  4AJT A;  3NDD A;  4YIA A;  4CAA A;  1JVQ I;  4GA7 A;  3PB1 I;  1JMJ A;  3DRM A; 
#chains in the Genus database with same CATH topology
 1SEK A;  3F1S A;  2WXY C;  1E05 I;  2DUT A;  2XN6 A;  4G8O A;  5BRR I;  4DY7 C;  4ROB A;  2RIW A;  1QLP A;  3STO A;  1E04 I;  5CDX A;  4KDS A;  2GD4 C;  2QUG A;  3KCG I;  1KCT A;  5HGC A;  4AJU A;  5C98 A;  1JTI A;  1TB6 I;  3F02 A;  1JJO C;  1LQ8 A;  3CAA A;  4P0O A;  2VDY A;  5CDZ A;  4DTE A;  1JMO A;  1F0C A;  2HIJ L;  4AU4 A;  2H4P A;  4AU2 A;  5CE0 A;  2RIV A;  2WXX A;  2WXZ C;  1ANT I;  4EB1 L;  3EVJ I;  4ZK0 A;  3DRU A;  4AQH A;  2XN7 A;  1OC0 A;  3CWM A;  3VVJ A;  2H4R A;  3CVM A;  2OL2 A;  2ZNH A;  1D5S A;  1AS4 A;  2B4X I;  1M93 B;  1NQ9 I;  3F5N A;  1OVA A;  4Y3K A;  4X30 A;  1OVA B;  2BEH I;  2D26 A;  1EZX A;  5INW A;  4C49 A;  1QMB A;  1OO8 A;  1K9O I;  3DLW A;  4IC0 A;  2ANT I;  1R1L I;  1PSI A;  3H5C A;  1DB2 A;  1LK6 I;  2R9Y A;  1C8O A;  4P0F A;  3NDF A;  3ZHA A;  1OYH I;  1ATH A;  3FGQ A;  1DZG I;  2ACH A;  1E03 I;  1IMV A;  3LE2 A;  4PYW A;  1WZ9 A;  3B9F I;  1XU8 A;  9PAI A;  1MTP A;  2WY0 C;  1SR5 A;  1XQJ A;  2WXW A;  4Y40 A;  1OPH A;  2ZV6 A;  2PEF A;  3Q02 A;  4RSQ A;  5EI0 A;  2WY1 A;  2H4Q A;  2B5T I;  2XN3 A;  4ROA A;  1AZX I;  5IO1 A;  2VH4 A;  9API A;  1UHG A;  1DZH I;  2BEH L;  1QMN A;  1T1F A;  3CWL A;  2VDX A;  4G8R A;  1DVN A;  4ZK3 A;  1SNG A;  1YXA A;  1B3K A;  4EB1 I;  1HP7 A;  4IF8 A;  3DY0 A;  4DY0 A;  1A7C A;  7API A;  3R4L A;  2WXZ A;  3Q03 A;  3T1P A;  4AFX A;  1OYH L;  1IZ2 A;  2ARR A;  3NE4 A;  1ATT A;  1DZG L;  1XQG A;  4BB2 A;  2ARQ A;  3EOX A;  2CEO A;  4C41 A;  3NDA A;  1HLE A;  4R9I A;  3PZF A;  1JRR A;  1OVA C;  3UT3 A;  1LJ5 A;  2B4X L;  2OAY A;  2V95 A;  8API A;  1BY7 A;  1BR8 I;  1DVM A;  3LW2 A;  2PEE A;  2HIJ I;  3OZQ A;  2HI9 A;  1ATU A;  1DZH L;  4AU3 A;  1C5G A;  4AU3 B;  2XN5 A;  4RO9 A;  4AJT A;  3NDD A;  4YIA A;  4CAA A;  1JVQ I;  4GA7 A;  3PB1 I;  1JMJ A;  3DRM A; 
#chains in the Genus database with same CATH homology
 1SEK A;  3F1S A;  2WXY C;  1E05 I;  2DUT A;  2XN6 A;  4G8O A;  5BRR I;  4DY7 C;  4ROB A;  2RIW A;  1QLP A;  3STO A;  1E04 I;  5CDX A;  4KDS A;  2GD4 C;  2QUG A;  3KCG I;  1KCT A;  5HGC A;  4AJU A;  5C98 A;  1JTI A;  1TB6 I;  3F02 A;  1JJO C;  1LQ8 A;  3CAA A;  4P0O A;  2VDY A;  5CDZ A;  4DTE A;  1JMO A;  1F0C A;  2HIJ L;  4AU4 A;  2H4P A;  4AU2 A;  5CE0 A;  2RIV A;  2WXX A;  2WXZ C;  1ANT I;  4EB1 L;  3EVJ I;  4ZK0 A;  3DRU A;  4AQH A;  2XN7 A;  1OC0 A;  3CWM A;  3VVJ A;  2H4R A;  3CVM A;  2OL2 A;  2ZNH A;  1D5S A;  1AS4 A;  2B4X I;  1M93 B;  1NQ9 I;  3F5N A;  1OVA A;  4Y3K A;  4X30 A;  1OVA B;  2BEH I;  2D26 A;  1EZX A;  5INW A;  4C49 A;  1QMB A;  1OO8 A;  1K9O I;  3DLW A;  4IC0 A;  2ANT I;  1R1L I;  1PSI A;  3H5C A;  1DB2 A;  1LK6 I;  2R9Y A;  1C8O A;  4P0F A;  3NDF A;  3ZHA A;  1OYH I;  1ATH A;  3FGQ A;  1DZG I;  2ACH A;  1E03 I;  1IMV A;  3LE2 A;  4PYW A;  1WZ9 A;  3B9F I;  1XU8 A;  9PAI A;  1MTP A;  2WY0 C;  1SR5 A;  1XQJ A;  2WXW A;  4Y40 A;  1OPH A;  2ZV6 A;  2PEF A;  3Q02 A;  4RSQ A;  5EI0 A;  2WY1 A;  2H4Q A;  2B5T I;  2XN3 A;  4ROA A;  1AZX I;  5IO1 A;  2VH4 A;  9API A;  1UHG A;  1DZH I;  2BEH L;  1QMN A;  1T1F A;  3CWL A;  2VDX A;  4G8R A;  1DVN A;  4ZK3 A;  1SNG A;  1YXA A;  1B3K A;  4EB1 I;  1HP7 A;  4IF8 A;  3DY0 A;  4DY0 A;  1A7C A;  7API A;  3R4L A;  2WXZ A;  3Q03 A;  3T1P A;  4AFX A;  1OYH L;  1IZ2 A;  2ARR A;  3NE4 A;  1ATT A;  1DZG L;  1XQG A;  4BB2 A;  2ARQ A;  3EOX A;  2CEO A;  4C41 A;  3NDA A;  1HLE A;  4R9I A;  3PZF A;  1JRR A;  1OVA C;  3UT3 A;  1LJ5 A;  2B4X L;  2OAY A;  2V95 A;  8API A;  1BY7 A;  1BR8 I;  1DVM A;  3LW2 A;  2PEE A;  2HIJ I;  3OZQ A;  2HI9 A;  1ATU A;  1DZH L;  4AU3 A;  1C5G A;  4AU3 B;  2XN5 A;  4RO9 A;  4AJT A;  3NDD A;  4YIA A;  4CAA A;  1JVQ I;  4GA7 A;  3PB1 I;  1JMJ A;  3DRM A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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