4P0FA

Cleaved serpin 42da (c 2 2 21)
Total Genus 112
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
112
sequence length
384
structure length
369
Chain Sequence
AAHQEFARRLALFSINVYGKLSGQKPGENIVFSPFSIQTCAAMARLGAENETATQLDQGLGLASSDPEQIAHSFHQVLAAYQILRIANKIFVMDGYQLRQEFDQLLSKQFLSAAQSVDFSKNVQAAATINNWVEQRTNHLIKDLVPADVLNSESRLVLVNAIHFKGTWQHQFAKHLTRPDTFHLTVQVPMMSLKERFRYADLPALDAMALELPYKDSDLSMLIVLPNTKTGLPALEEKLRLTTLSQITQSLYETKVALKLPRFKAEFQVELSEVFQKLGMSRMFSDQAEFGKMLQSPEPLKVSAIIHKAFIEVNEEGTEAAAATGMAVRRKRPIEFFADHPFTYVLVHQDLPLFWGSVVRLEENTFASS
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title High resolution structure of cleaved Serpin 42 Da from Drosophila melanogaster.
pubmed doi rcsb
molecule tags Hydrolase inhibitor
source organism Drosophila melanogaster
molecule keywords Serine protease inhibitor 4, isoform B
total genus 112
structure length 369
sequence length 384
ec nomenclature
pdb deposition date 2014-02-21

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00079 Serpin Serpin (serine protease inhibitor)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.30.39.10 Mainly Beta Roll Alpha-1-antitrypsin; domain 1 Alpha-1-antitrypsin, domain 1 4p0fA02
3.30.497.10 Alpha Beta 2-Layer Sandwich Antithrombin; Chain I, domain 2 Antithrombin, subunit I, domain 2 4p0fA01
1XQJA 1C8OA 4G8OA 2GD4C 2WXZC 1TB6I 1B3KA 2ACHA 2PEFA 4EB1I 3FGQA 4DY0A 3EVJI 2VDYA 4RO9A 1DVMA 4AU3B 3Q02A 4ROBA 4AJTA 3PB1I 4AU3A 5BRRI 1R1LI 1OYHL 1OVAC 4DTEA 1T1FA 3LW2A 1E05I 1LQ8A 4IC0A 2H4PA 3NDAA 2ZNHA 2BEHL 1XU8A 2H4RA 1LJ5A 3Q03A 2RIVA 4P0OA 3F02A 1IZ2A 4AU2A 7APIA 2B5TI 1A7CA 4Y40A 5INWA 1ATHA 3CWMA 1OC0A 3DY0A 2ARQA 1F0CA 4GA7A 1D5SA 1DZHI 1DB2A 1OYHI 5CDZA 2RIWA 3NDFA 2WY1A 4DY7C 1JJOC 3NDDA 3CVMA 2WXWA 1QLPA 3R4LA 4R9IA 8APIA 1DZHL 5CDXA 2BEHI 4P0FA 5HGCA 2WXXA 1QMBA 1PSIA 1SNGA 3B9FI 3CAAA 4PYWA 2WXZA 1BR8I 1ATUA 4ZK3A 1JTIA 2B4XL 1E04I 1HLEA 2VH4A 9APIA 4X30A 3CWLA 3F1SA 1SR5A 3KCGI 1UHGA 1E03I 2CEOA 2H4QA 1LK6I 3PZFA 2XN7A 1XQGA 4C41A 4ZK0A 1OVAA 2QUGA 3VVJA 2PEEA 1BY7A 1YXAA 2WXYC 4AJUA 1IMVA 1OO8A 2HI9A 1DVNA 4RSQA 4IF8A 3LE2A 1C5GA 2WY0C 2ZV6A 4BB2A 1M93B 2R9YA 3F5NA 3OZQA 2B4XI 1MTPA 1K9OI 2OAYA 4AFXA 2V95A 2ARRA 1KCTA 4YIAA 1DZGL 3T1PA 5EI0A 2XN3A 3DRUA 1AZXI 2XN6A 3DRMA 3EOXA 2HIJL 4Y3KA 2DUTA 1ANTI 5CE0A 4AQHA 4ROAA 1OVAB 2XN5A 3H5CA 4CAAA 3DLWA 4AU4A 1EZXA 4G8RA 5C98A 4EB1L 5IO1A 1WZ9A 2VDXA 1JVQI 1NQ9I 1JRRA 3NE4A 2ANTI 1HP7A 9PAIA 3UT3A 4KDSA 1QMNA 3STOA 1DZGI 3ZHAA 1JMJA 2OL2A 2HIJI 4C49A 1AS4A 1JMOA 1OPHA 2D26A 1SEKA 1ATTA
chains in the Genus database with same CATH superfamily
1XQJA 1C8OA 4G8OA 2GD4C 2WXZC 1TB6I 1B3KA 2ACHA 2PEFA 4EB1I 3FGQA 4DY0A 3EVJI 2VDYA 4RO9A 1DVMA 4AU3B 3Q02A 4ROBA 4AJTA 3PB1I 4AU3A 5BRRI 1R1LI 1OYHL 1OVAC 4DTEA 1T1FA 3LW2A 1E05I 1LQ8A 4IC0A 2H4PA 3NDAA 2ZNHA 2BEHL 1XU8A 2H4RA 1LJ5A 3Q03A 2RIVA 4P0OA 3F02A 1IZ2A 4AU2A 7APIA 2B5TI 1A7CA 4Y40A 5INWA 1ATHA 3CWMA 1OC0A 3DY0A 2ARQA 1F0CA 4GA7A 1D5SA 1DZHI 1DB2A 1OYHI 5CDZA 2RIWA 3NDFA 2WY1A 4DY7C 1JJOC 3NDDA 3CVMA 2WXWA 1QLPA 3R4LA 4R9IA 8APIA 1DZHL 5CDXA 2BEHI 4P0FA 5HGCA 2WXXA 1QMBA 1PSIA 1SNGA 3B9FI 3CAAA 4PYWA 2WXZA 1BR8I 1ATUA 4ZK3A 1JTIA 2B4XL 1E04I 1HLEA 2VH4A 9APIA 4X30A 3CWLA 3F1SA 1SR5A 3KCGI 1UHGA 1E03I 2CEOA 2H4QA 1LK6I 3PZFA 2XN7A 1XQGA 4C41A 4ZK0A 1OVAA 2QUGA 3VVJA 2PEEA 1BY7A 1YXAA 2WXYC 4AJUA 1IMVA 1OO8A 2HI9A 1DVNA 4RSQA 4IF8A 3LE2A 1C5GA 2WY0C 2ZV6A 4BB2A 1M93B 2R9YA 3F5NA 3OZQA 2B4XI 1MTPA 1K9OI 2OAYA 4AFXA 2V95A 2ARRA 1KCTA 4YIAA 1DZGL 3T1PA 5EI0A 2XN3A 3DRUA 1AZXI 2XN6A 3DRMA 3EOXA 2HIJL 4Y3KA 2DUTA 1ANTI 5CE0A 4AQHA 4ROAA 1OVAB 2XN5A 3H5CA 4CAAA 3DLWA 4AU4A 1EZXA 4G8RA 5C98A 4EB1L 5IO1A 1WZ9A 2VDXA 1JVQI 1NQ9I 1JRRA 3NE4A 2ANTI 1HP7A 9PAIA 3UT3A 4KDSA 1QMNA 3STOA 1DZGI 3ZHAA 1JMJA 2OL2A 2HIJI 4C49A 1AS4A 1JMOA 1OPHA 2D26A 1SEKA 1ATTA
chains in the Genus database with same CATH topology
1XQJA 1C8OA 4G8OA 2GD4C 2WXZC 1TB6I 1B3KA 2ACHA 2PEFA 4EB1I 3FGQA 4DY0A 3EVJI 2VDYA 4RO9A 1DVMA 4AU3B 3Q02A 4ROBA 4AJTA 3PB1I 4AU3A 5BRRI 1R1LI 1OYHL 1OVAC 4DTEA 1T1FA 3LW2A 1E05I 1LQ8A 4IC0A 2H4PA 3NDAA 2ZNHA 2BEHL 1XU8A 2H4RA 1LJ5A 3Q03A 2RIVA 4P0OA 3F02A 1IZ2A 4AU2A 7APIA 2B5TI 1A7CA 4Y40A 5INWA 1ATHA 3CWMA 1OC0A 3DY0A 2ARQA 1F0CA 4GA7A 1D5SA 1DZHI 1DB2A 1OYHI 5CDZA 2RIWA 3NDFA 2WY1A 4DY7C 1JJOC 3NDDA 3CVMA 2WXWA 1QLPA 3R4LA 4R9IA 8APIA 1DZHL 5CDXA 2BEHI 4P0FA 5HGCA 2WXXA 1QMBA 1PSIA 1SNGA 3B9FI 3CAAA 4PYWA 2WXZA 1BR8I 1ATUA 4ZK3A 1JTIA 2B4XL 1E04I 1HLEA 2VH4A 9APIA 4X30A 3CWLA 3F1SA 1SR5A 3KCGI 1UHGA 1E03I 2CEOA 2H4QA 1LK6I 3PZFA 2XN7A 1XQGA 4C41A 4ZK0A 1OVAA 2QUGA 3VVJA 2PEEA 1BY7A 1YXAA 2WXYC 4AJUA 1IMVA 1OO8A 2HI9A 1DVNA 4RSQA 4IF8A 3LE2A 1C5GA 2WY0C 2ZV6A 4BB2A 1M93B 2R9YA 3F5NA 3OZQA 2B4XI 1MTPA 1K9OI 2OAYA 4AFXA 2V95A 2ARRA 1KCTA 4YIAA 1DZGL 3T1PA 5EI0A 2XN3A 3DRUA 1AZXI 2XN6A 3DRMA 3EOXA 2HIJL 4Y3KA 2DUTA 1ANTI 5CE0A 4AQHA 4ROAA 1OVAB 2XN5A 3H5CA 4CAAA 3DLWA 4AU4A 1EZXA 4G8RA 5C98A 4EB1L 5IO1A 1WZ9A 2VDXA 1JVQI 1NQ9I 1JRRA 3NE4A 2ANTI 1HP7A 9PAIA 3UT3A 4KDSA 1QMNA 3STOA 1DZGI 3ZHAA 1JMJA 2OL2A 2HIJI 4C49A 1AS4A 1JMOA 1OPHA 2D26A 1SEKA 1ATTA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1XQJ A;  1C8O A;  4G8O A;  2GD4 C;  2WXZ C;  1TB6 I;  1B3K A;  2ACH A;  2PEF A;  4EB1 I;  3FGQ A;  4DY0 A;  3EVJ I;  2VDY A;  4RO9 A;  1DVM A;  4AU3 B;  3Q02 A;  4ROB A;  4AJT A;  3PB1 I;  4AU3 A;  5BRR I;  1R1L I;  1OYH L;  1OVA C;  4DTE A;  1T1F A;  3LW2 A;  1E05 I;  1LQ8 A;  4IC0 A;  2H4P A;  3NDA A;  2ZNH A;  2BEH L;  1XU8 A;  2H4R A;  1LJ5 A;  3Q03 A;  2RIV A;  4P0O A;  3F02 A;  1IZ2 A;  4AU2 A;  7API A;  2B5T I;  1A7C A;  4Y40 A;  5INW A;  1ATH A;  3CWM A;  1OC0 A;  3DY0 A;  2ARQ A;  1F0C A;  4GA7 A;  1D5S A;  1DZH I;  1DB2 A;  1OYH I;  5CDZ A;  2RIW A;  3NDF A;  2WY1 A;  4DY7 C;  1JJO C;  3NDD A;  3CVM A;  2WXW A;  1QLP A;  3R4L A;  4R9I A;  8API A;  1DZH L;  5CDX A;  2BEH I;  4P0F A;  5HGC A;  2WXX A;  1QMB A;  1PSI A;  1SNG A;  3B9F I;  3CAA A;  4PYW A;  2WXZ A;  1BR8 I;  1ATU A;  4ZK3 A;  1JTI A;  2B4X L;  1E04 I;  1HLE A;  2VH4 A;  9API A;  4X30 A;  3CWL A;  3F1S A;  1SR5 A;  3KCG I;  1UHG A;  1E03 I;  2CEO A;  2H4Q A;  1LK6 I;  3PZF A;  2XN7 A;  1XQG A;  4C41 A;  4ZK0 A;  1OVA A;  2QUG A;  3VVJ A;  2PEE A;  1BY7 A;  1YXA A;  2WXY C;  4AJU A;  1IMV A;  1OO8 A;  2HI9 A;  1DVN A;  4RSQ A;  4IF8 A;  3LE2 A;  1C5G A;  2WY0 C;  2ZV6 A;  4BB2 A;  1M93 B;  2R9Y A;  3F5N A;  3OZQ A;  2B4X I;  1MTP A;  1K9O I;  2OAY A;  4AFX A;  2V95 A;  2ARR A;  1KCT A;  4YIA A;  1DZG L;  3T1P A;  5EI0 A;  2XN3 A;  3DRU A;  1AZX I;  2XN6 A;  3DRM A;  3EOX A;  2HIJ L;  4Y3K A;  2DUT A;  1ANT I;  5CE0 A;  4AQH A;  4ROA A;  1OVA B;  2XN5 A;  3H5C A;  4CAA A;  3DLW A;  4AU4 A;  1EZX A;  4G8R A;  5C98 A;  4EB1 L;  5IO1 A;  1WZ9 A;  2VDX A;  1JVQ I;  1NQ9 I;  1JRR A;  3NE4 A;  2ANT I;  1HP7 A;  9PAI A;  3UT3 A;  4KDS A;  1QMN A;  3STO A;  1DZG I;  3ZHA A;  1JMJ A;  2OL2 A;  2HIJ I;  4C49 A;  1AS4 A;  1JMO A;  1OPH A;  2D26 A;  1SEK A;  1ATT A; 
#chains in the Genus database with same CATH topology
 1XQJ A;  1C8O A;  4G8O A;  2GD4 C;  2WXZ C;  1TB6 I;  1B3K A;  2ACH A;  2PEF A;  4EB1 I;  3FGQ A;  4DY0 A;  3EVJ I;  2VDY A;  4RO9 A;  1DVM A;  4AU3 B;  3Q02 A;  4ROB A;  4AJT A;  3PB1 I;  4AU3 A;  5BRR I;  1R1L I;  1OYH L;  1OVA C;  4DTE A;  1T1F A;  3LW2 A;  1E05 I;  1LQ8 A;  4IC0 A;  2H4P A;  3NDA A;  2ZNH A;  2BEH L;  1XU8 A;  2H4R A;  1LJ5 A;  3Q03 A;  2RIV A;  4P0O A;  3F02 A;  1IZ2 A;  4AU2 A;  7API A;  2B5T I;  1A7C A;  4Y40 A;  5INW A;  1ATH A;  3CWM A;  1OC0 A;  3DY0 A;  2ARQ A;  1F0C A;  4GA7 A;  1D5S A;  1DZH I;  1DB2 A;  1OYH I;  5CDZ A;  2RIW A;  3NDF A;  2WY1 A;  4DY7 C;  1JJO C;  3NDD A;  3CVM A;  2WXW A;  1QLP A;  3R4L A;  4R9I A;  8API A;  1DZH L;  5CDX A;  2BEH I;  4P0F A;  5HGC A;  2WXX A;  1QMB A;  1PSI A;  1SNG A;  3B9F I;  3CAA A;  4PYW A;  2WXZ A;  1BR8 I;  1ATU A;  4ZK3 A;  1JTI A;  2B4X L;  1E04 I;  1HLE A;  2VH4 A;  9API A;  4X30 A;  3CWL A;  3F1S A;  1SR5 A;  3KCG I;  1UHG A;  1E03 I;  2CEO A;  2H4Q A;  1LK6 I;  3PZF A;  2XN7 A;  1XQG A;  4C41 A;  4ZK0 A;  1OVA A;  2QUG A;  3VVJ A;  2PEE A;  1BY7 A;  1YXA A;  2WXY C;  4AJU A;  1IMV A;  1OO8 A;  2HI9 A;  1DVN A;  4RSQ A;  4IF8 A;  3LE2 A;  1C5G A;  2WY0 C;  2ZV6 A;  4BB2 A;  1M93 B;  2R9Y A;  3F5N A;  3OZQ A;  2B4X I;  1MTP A;  1K9O I;  2OAY A;  4AFX A;  2V95 A;  2ARR A;  1KCT A;  4YIA A;  1DZG L;  3T1P A;  5EI0 A;  2XN3 A;  3DRU A;  1AZX I;  2XN6 A;  3DRM A;  3EOX A;  2HIJ L;  4Y3K A;  2DUT A;  1ANT I;  5CE0 A;  4AQH A;  4ROA A;  1OVA B;  2XN5 A;  3H5C A;  4CAA A;  3DLW A;  4AU4 A;  1EZX A;  4G8R A;  5C98 A;  4EB1 L;  5IO1 A;  1WZ9 A;  2VDX A;  1JVQ I;  1NQ9 I;  1JRR A;  3NE4 A;  2ANT I;  1HP7 A;  9PAI A;  3UT3 A;  4KDS A;  1QMN A;  3STO A;  1DZG I;  3ZHA A;  1JMJ A;  2OL2 A;  2HIJ I;  4C49 A;  1AS4 A;  1JMO A;  1OPH A;  2D26 A;  1SEK A;  1ATT A; 
#chains in the Genus database with same CATH homology
 1XQJ A;  1C8O A;  4G8O A;  2GD4 C;  2WXZ C;  1TB6 I;  1B3K A;  2ACH A;  2PEF A;  4EB1 I;  3FGQ A;  4DY0 A;  3EVJ I;  2VDY A;  4RO9 A;  1DVM A;  4AU3 B;  3Q02 A;  4ROB A;  4AJT A;  3PB1 I;  4AU3 A;  5BRR I;  1R1L I;  1OYH L;  1OVA C;  4DTE A;  1T1F A;  3LW2 A;  1E05 I;  1LQ8 A;  4IC0 A;  2H4P A;  3NDA A;  2ZNH A;  2BEH L;  1XU8 A;  2H4R A;  1LJ5 A;  3Q03 A;  2RIV A;  4P0O A;  3F02 A;  1IZ2 A;  4AU2 A;  7API A;  2B5T I;  1A7C A;  4Y40 A;  5INW A;  1ATH A;  3CWM A;  1OC0 A;  3DY0 A;  2ARQ A;  1F0C A;  4GA7 A;  1D5S A;  1DZH I;  1DB2 A;  1OYH I;  5CDZ A;  2RIW A;  3NDF A;  2WY1 A;  4DY7 C;  1JJO C;  3NDD A;  3CVM A;  2WXW A;  1QLP A;  3R4L A;  4R9I A;  8API A;  1DZH L;  5CDX A;  2BEH I;  4P0F A;  5HGC A;  2WXX A;  1QMB A;  1PSI A;  1SNG A;  3B9F I;  3CAA A;  4PYW A;  2WXZ A;  1BR8 I;  1ATU A;  4ZK3 A;  1JTI A;  2B4X L;  1E04 I;  1HLE A;  2VH4 A;  9API A;  4X30 A;  3CWL A;  3F1S A;  1SR5 A;  3KCG I;  1UHG A;  1E03 I;  2CEO A;  2H4Q A;  1LK6 I;  3PZF A;  2XN7 A;  1XQG A;  4C41 A;  4ZK0 A;  1OVA A;  2QUG A;  3VVJ A;  2PEE A;  1BY7 A;  1YXA A;  2WXY C;  4AJU A;  1IMV A;  1OO8 A;  2HI9 A;  1DVN A;  4RSQ A;  4IF8 A;  3LE2 A;  1C5G A;  2WY0 C;  2ZV6 A;  4BB2 A;  1M93 B;  2R9Y A;  3F5N A;  3OZQ A;  2B4X I;  1MTP A;  1K9O I;  2OAY A;  4AFX A;  2V95 A;  2ARR A;  1KCT A;  4YIA A;  1DZG L;  3T1P A;  5EI0 A;  2XN3 A;  3DRU A;  1AZX I;  2XN6 A;  3DRM A;  3EOX A;  2HIJ L;  4Y3K A;  2DUT A;  1ANT I;  5CE0 A;  4AQH A;  4ROA A;  1OVA B;  2XN5 A;  3H5C A;  4CAA A;  3DLW A;  4AU4 A;  1EZX A;  4G8R A;  5C98 A;  4EB1 L;  5IO1 A;  1WZ9 A;  2VDX A;  1JVQ I;  1NQ9 I;  1JRR A;  3NE4 A;  2ANT I;  1HP7 A;  9PAI A;  3UT3 A;  4KDS A;  1QMN A;  3STO A;  1DZG I;  3ZHA A;  1JMJ A;  2OL2 A;  2HIJ I;  4C49 A;  1AS4 A;  1JMO A;  1OPH A;  2D26 A;  1SEK A;  1ATT A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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