4P0OA

Cleaved serpin 42da
Total Genus 116
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
116
Knots found
sequence length
378
structure length
371
Chain Sequence
AAHQEFARRLALFSINVYGKLSGQKPGENIVFSPFSIQTCAAMARLGAENETATQLDQGLGLASSDPEQIAHSFHQVLAAYQDSQILRIANKIFVMDGYQLRQEFDQLLSKQFLSAAQSVDFSKNVQAAATINNWVEQRTNHLIKDLVPADVLNSESRLVLVNAIHFKGTWQHQFAKHLTRPDTFHLDGERTVQVPMMSLKERFRYADLPALDAMALELPYKDSDLSMLIVLPNTKTGLPALEEKLRLTTLSQITQSLYETKVALKLPRFKAEFQVELSEVFQKLGMSRMFSDQAEFGKMLQSPEPLKVSAIIHKAFIEVNEEGTEAAAATGMAVRRKEPIEFFADHPFTYVLVHQKDLPLFWGSVVRLEE
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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publication title High resolution structure of cleaved Serpin 42 Da from Drosophila melanogaster.
pubmed doi rcsb
molecule tags Hydrolase inhibitor
source organism Drosophila melanogaster
molecule keywords Serine protease inhibitor 4, isoform B
total genus 116
structure length 371
sequence length 378
other databases KnotProt 2.0: Artifct S 41 -31 -3
ec nomenclature
pdb deposition date 2014-02-21

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00079 Serpin Serpin (serine protease inhibitor)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.30.39.10 Mainly Beta Roll Alpha-1-antitrypsin; domain 1 Alpha-1-antitrypsin, domain 1 4p0oA02
3.30.497.10 Alpha Beta 2-Layer Sandwich Antithrombin; Chain I, domain 2 Antithrombin, subunit I, domain 2 4p0oA01
1ATUA 2OAYA 1R1LI 4AU2A 3CWLA 4EB1I 5BRRI 5EI0A 4RO9A 1AZXI 1DZGL 4CAAA 4G8RA 1M93B 4DY0A 4Y3KA 3H5CA 1DVNA 3EVJI 1OVAB 1DZHL 2WXZA 3F02A 2H4PA 3DLWA 2GD4C 4AJTA 5IO1A 3NDDA 4AU4A 1HLEA 3PZFA 2PEEA 1JTIA 1DZGI 2WY0C 1A7CA 3Q02A 1JMOA 4GA7A 5HGCA 1TB6I 4ROBA 4RSQA 1DZHI 3LW2A 3NDFA 2ACHA 2BEHI 1E03I 1LJ5A 2WXXA 4YIAA 2ANTI 1UHGA 3ZHAA 4KDSA 1OC0A 1NQ9I 1QMBA 3CVMA 1BY7A 3Q03A 2XN5A 4R9IA 4DY7C 1ATTA 2WXYC 1QLPA 2HIJL 1SEKA 3R4LA 1IMVA 4ZK0A 3KCGI 3B9FI 4ROAA 2PEFA 1OVAC 3LE2A 1JVQI 2RIWA 4AU3A 1D5SA 3F5NA 2B4XL 5C98A 2WY1A 4G8OA 2HIJI 2WXWA 5INWA 3T1PA 1E05I 9PAIA 1XU8A 1LQ8A 5CE0A 1LK6I 2CEOA 3CWMA 5CDXA 4AFXA 4AJUA 3CAAA 2HI9A 2B4XI 4C41A 4IF8A 1MTPA 3UT3A 1XQJA 4P0OA 3EOXA 4AU3B 4DTEA 2XN3A 2H4QA 5CDZA 2ZV6A 1B3KA 1OO8A 4PYWA 3VVJA 3DY0A 1OVAA 2ARQA 1PSIA 2QUGA 3NE4A 1JMJA 4P0FA 1C5GA 2H4RA 1KCTA 1ATHA 1IZ2A 4X30A 4IC0A 3STOA 2XN6A 8APIA 1OYHL 1DB2A 1K9OI 1XQGA 1DVMA 3NDAA 1JJOC 1OPHA 1E04I 1EZXA 1ANTI 2VDYA 2VH4A 3DRUA 4ZK3A 4C49A 1BR8I 1AS4A 2WXZC 2OL2A 3F1SA 1OYHI 1T1FA 2XN7A 2BEHL 2DUTA 1C8OA 1QMNA 1YXAA 2ARRA 4AQHA 4Y40A 2R9YA 4EB1L 1F0CA 2B5TI 1JRRA 2RIVA 3PB1I 2ZNHA 9APIA 2V95A 2VDXA 3OZQA 7APIA 1SNGA 1HP7A 1SR5A 2D26A 4BB2A 3FGQA 3DRMA 1WZ9A
chains in the Genus database with same CATH superfamily
1ATUA 2OAYA 1R1LI 4AU2A 3CWLA 4EB1I 5BRRI 5EI0A 4RO9A 1AZXI 1DZGL 4CAAA 4G8RA 1M93B 4DY0A 4Y3KA 3H5CA 1DVNA 3EVJI 1OVAB 1DZHL 2WXZA 3F02A 2H4PA 3DLWA 2GD4C 4AJTA 5IO1A 3NDDA 4AU4A 1HLEA 3PZFA 2PEEA 1JTIA 1DZGI 2WY0C 1A7CA 3Q02A 1JMOA 4GA7A 5HGCA 1TB6I 4ROBA 4RSQA 1DZHI 3LW2A 3NDFA 2ACHA 2BEHI 1E03I 1LJ5A 2WXXA 4YIAA 2ANTI 1UHGA 3ZHAA 4KDSA 1OC0A 1NQ9I 1QMBA 3CVMA 1BY7A 3Q03A 2XN5A 4R9IA 4DY7C 1ATTA 2WXYC 1QLPA 2HIJL 1SEKA 3R4LA 1IMVA 4ZK0A 3KCGI 3B9FI 4ROAA 2PEFA 1OVAC 3LE2A 1JVQI 2RIWA 4AU3A 1D5SA 3F5NA 2B4XL 5C98A 2WY1A 4G8OA 2HIJI 2WXWA 5INWA 3T1PA 1E05I 9PAIA 1XU8A 1LQ8A 5CE0A 1LK6I 2CEOA 3CWMA 5CDXA 4AFXA 4AJUA 3CAAA 2HI9A 2B4XI 4C41A 4IF8A 1MTPA 3UT3A 1XQJA 4P0OA 3EOXA 4AU3B 4DTEA 2XN3A 2H4QA 5CDZA 2ZV6A 1B3KA 1OO8A 4PYWA 3VVJA 3DY0A 1OVAA 2ARQA 1PSIA 2QUGA 3NE4A 1JMJA 4P0FA 1C5GA 2H4RA 1KCTA 1ATHA 1IZ2A 4X30A 4IC0A 3STOA 2XN6A 8APIA 1OYHL 1DB2A 1K9OI 1XQGA 1DVMA 3NDAA 1JJOC 1OPHA 1E04I 1EZXA 1ANTI 2VDYA 2VH4A 3DRUA 4ZK3A 4C49A 1BR8I 1AS4A 2WXZC 2OL2A 3F1SA 1OYHI 1T1FA 2XN7A 2BEHL 2DUTA 1C8OA 1QMNA 1YXAA 2ARRA 4AQHA 4Y40A 2R9YA 4EB1L 1F0CA 2B5TI 1JRRA 2RIVA 3PB1I 2ZNHA 9APIA 2V95A 2VDXA 3OZQA 7APIA 1SNGA 1HP7A 1SR5A 2D26A 4BB2A 3FGQA 3DRMA 1WZ9A
chains in the Genus database with same CATH topology
1ATUA 2OAYA 1R1LI 4AU2A 3CWLA 4EB1I 5BRRI 5EI0A 4RO9A 1AZXI 1DZGL 4CAAA 4G8RA 1M93B 4DY0A 4Y3KA 3H5CA 1DVNA 3EVJI 1OVAB 1DZHL 2WXZA 3F02A 2H4PA 3DLWA 2GD4C 4AJTA 5IO1A 3NDDA 4AU4A 1HLEA 3PZFA 2PEEA 1JTIA 1DZGI 2WY0C 1A7CA 3Q02A 1JMOA 4GA7A 5HGCA 1TB6I 4ROBA 4RSQA 1DZHI 3LW2A 3NDFA 2ACHA 2BEHI 1E03I 1LJ5A 2WXXA 4YIAA 2ANTI 1UHGA 3ZHAA 4KDSA 1OC0A 1NQ9I 1QMBA 3CVMA 1BY7A 3Q03A 2XN5A 4R9IA 4DY7C 1ATTA 2WXYC 1QLPA 2HIJL 1SEKA 3R4LA 1IMVA 4ZK0A 3KCGI 3B9FI 4ROAA 2PEFA 1OVAC 3LE2A 1JVQI 2RIWA 4AU3A 1D5SA 3F5NA 2B4XL 5C98A 2WY1A 4G8OA 2HIJI 2WXWA 5INWA 3T1PA 1E05I 9PAIA 1XU8A 1LQ8A 5CE0A 1LK6I 2CEOA 3CWMA 5CDXA 4AFXA 4AJUA 3CAAA 2HI9A 2B4XI 4C41A 4IF8A 1MTPA 3UT3A 1XQJA 4P0OA 3EOXA 4AU3B 4DTEA 2XN3A 2H4QA 5CDZA 2ZV6A 1B3KA 1OO8A 4PYWA 3VVJA 3DY0A 1OVAA 2ARQA 1PSIA 2QUGA 3NE4A 1JMJA 4P0FA 1C5GA 2H4RA 1KCTA 1ATHA 1IZ2A 4X30A 4IC0A 3STOA 2XN6A 8APIA 1OYHL 1DB2A 1K9OI 1XQGA 1DVMA 3NDAA 1JJOC 1OPHA 1E04I 1EZXA 1ANTI 2VDYA 2VH4A 3DRUA 4ZK3A 4C49A 1BR8I 1AS4A 2WXZC 2OL2A 3F1SA 1OYHI 1T1FA 2XN7A 2BEHL 2DUTA 1C8OA 1QMNA 1YXAA 2ARRA 4AQHA 4Y40A 2R9YA 4EB1L 1F0CA 2B5TI 1JRRA 2RIVA 3PB1I 2ZNHA 9APIA 2V95A 2VDXA 3OZQA 7APIA 1SNGA 1HP7A 1SR5A 2D26A 4BB2A 3FGQA 3DRMA 1WZ9A
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 1ATU A;  2OAY A;  1R1L I;  4AU2 A;  3CWL A;  4EB1 I;  5BRR I;  5EI0 A;  4RO9 A;  1AZX I;  1DZG L;  4CAA A;  4G8R A;  1M93 B;  4DY0 A;  4Y3K A;  3H5C A;  1DVN A;  3EVJ I;  1OVA B;  1DZH L;  2WXZ A;  3F02 A;  2H4P A;  3DLW A;  2GD4 C;  4AJT A;  5IO1 A;  3NDD A;  4AU4 A;  1HLE A;  3PZF A;  2PEE A;  1JTI A;  1DZG I;  2WY0 C;  1A7C A;  3Q02 A;  1JMO A;  4GA7 A;  5HGC A;  1TB6 I;  4ROB A;  4RSQ A;  1DZH I;  3LW2 A;  3NDF A;  2ACH A;  2BEH I;  1E03 I;  1LJ5 A;  2WXX A;  4YIA A;  2ANT I;  1UHG A;  3ZHA A;  4KDS A;  1OC0 A;  1NQ9 I;  1QMB A;  3CVM A;  1BY7 A;  3Q03 A;  2XN5 A;  4R9I A;  4DY7 C;  1ATT A;  2WXY C;  1QLP A;  2HIJ L;  1SEK A;  3R4L A;  1IMV A;  4ZK0 A;  3KCG I;  3B9F I;  4ROA A;  2PEF A;  1OVA C;  3LE2 A;  1JVQ I;  2RIW A;  4AU3 A;  1D5S A;  3F5N A;  2B4X L;  5C98 A;  2WY1 A;  4G8O A;  2HIJ I;  2WXW A;  5INW A;  3T1P A;  1E05 I;  9PAI A;  1XU8 A;  1LQ8 A;  5CE0 A;  1LK6 I;  2CEO A;  3CWM A;  5CDX A;  4AFX A;  4AJU A;  3CAA A;  2HI9 A;  2B4X I;  4C41 A;  4IF8 A;  1MTP A;  3UT3 A;  1XQJ A;  4P0O A;  3EOX A;  4AU3 B;  4DTE A;  2XN3 A;  2H4Q A;  5CDZ A;  2ZV6 A;  1B3K A;  1OO8 A;  4PYW A;  3VVJ A;  3DY0 A;  1OVA A;  2ARQ A;  1PSI A;  2QUG A;  3NE4 A;  1JMJ A;  4P0F A;  1C5G A;  2H4R A;  1KCT A;  1ATH A;  1IZ2 A;  4X30 A;  4IC0 A;  3STO A;  2XN6 A;  8API A;  1OYH L;  1DB2 A;  1K9O I;  1XQG A;  1DVM A;  3NDA A;  1JJO C;  1OPH A;  1E04 I;  1EZX A;  1ANT I;  2VDY A;  2VH4 A;  3DRU A;  4ZK3 A;  4C49 A;  1BR8 I;  1AS4 A;  2WXZ C;  2OL2 A;  3F1S A;  1OYH I;  1T1F A;  2XN7 A;  2BEH L;  2DUT A;  1C8O A;  1QMN A;  1YXA A;  2ARR A;  4AQH A;  4Y40 A;  2R9Y A;  4EB1 L;  1F0C A;  2B5T I;  1JRR A;  2RIV A;  3PB1 I;  2ZNH A;  9API A;  2V95 A;  2VDX A;  3OZQ A;  7API A;  1SNG A;  1HP7 A;  1SR5 A;  2D26 A;  4BB2 A;  3FGQ A;  3DRM A;  1WZ9 A; 
#chains in the Genus database with same CATH topology
 1ATU A;  2OAY A;  1R1L I;  4AU2 A;  3CWL A;  4EB1 I;  5BRR I;  5EI0 A;  4RO9 A;  1AZX I;  1DZG L;  4CAA A;  4G8R A;  1M93 B;  4DY0 A;  4Y3K A;  3H5C A;  1DVN A;  3EVJ I;  1OVA B;  1DZH L;  2WXZ A;  3F02 A;  2H4P A;  3DLW A;  2GD4 C;  4AJT A;  5IO1 A;  3NDD A;  4AU4 A;  1HLE A;  3PZF A;  2PEE A;  1JTI A;  1DZG I;  2WY0 C;  1A7C A;  3Q02 A;  1JMO A;  4GA7 A;  5HGC A;  1TB6 I;  4ROB A;  4RSQ A;  1DZH I;  3LW2 A;  3NDF A;  2ACH A;  2BEH I;  1E03 I;  1LJ5 A;  2WXX A;  4YIA A;  2ANT I;  1UHG A;  3ZHA A;  4KDS A;  1OC0 A;  1NQ9 I;  1QMB A;  3CVM A;  1BY7 A;  3Q03 A;  2XN5 A;  4R9I A;  4DY7 C;  1ATT A;  2WXY C;  1QLP A;  2HIJ L;  1SEK A;  3R4L A;  1IMV A;  4ZK0 A;  3KCG I;  3B9F I;  4ROA A;  2PEF A;  1OVA C;  3LE2 A;  1JVQ I;  2RIW A;  4AU3 A;  1D5S A;  3F5N A;  2B4X L;  5C98 A;  2WY1 A;  4G8O A;  2HIJ I;  2WXW A;  5INW A;  3T1P A;  1E05 I;  9PAI A;  1XU8 A;  1LQ8 A;  5CE0 A;  1LK6 I;  2CEO A;  3CWM A;  5CDX A;  4AFX A;  4AJU A;  3CAA A;  2HI9 A;  2B4X I;  4C41 A;  4IF8 A;  1MTP A;  3UT3 A;  1XQJ A;  4P0O A;  3EOX A;  4AU3 B;  4DTE A;  2XN3 A;  2H4Q A;  5CDZ A;  2ZV6 A;  1B3K A;  1OO8 A;  4PYW A;  3VVJ A;  3DY0 A;  1OVA A;  2ARQ A;  1PSI A;  2QUG A;  3NE4 A;  1JMJ A;  4P0F A;  1C5G A;  2H4R A;  1KCT A;  1ATH A;  1IZ2 A;  4X30 A;  4IC0 A;  3STO A;  2XN6 A;  8API A;  1OYH L;  1DB2 A;  1K9O I;  1XQG A;  1DVM A;  3NDA A;  1JJO C;  1OPH A;  1E04 I;  1EZX A;  1ANT I;  2VDY A;  2VH4 A;  3DRU A;  4ZK3 A;  4C49 A;  1BR8 I;  1AS4 A;  2WXZ C;  2OL2 A;  3F1S A;  1OYH I;  1T1F A;  2XN7 A;  2BEH L;  2DUT A;  1C8O A;  1QMN A;  1YXA A;  2ARR A;  4AQH A;  4Y40 A;  2R9Y A;  4EB1 L;  1F0C A;  2B5T I;  1JRR A;  2RIV A;  3PB1 I;  2ZNH A;  9API A;  2V95 A;  2VDX A;  3OZQ A;  7API A;  1SNG A;  1HP7 A;  1SR5 A;  2D26 A;  4BB2 A;  3FGQ A;  3DRM A;  1WZ9 A; 
#chains in the Genus database with same CATH homology
 1ATU A;  2OAY A;  1R1L I;  4AU2 A;  3CWL A;  4EB1 I;  5BRR I;  5EI0 A;  4RO9 A;  1AZX I;  1DZG L;  4CAA A;  4G8R A;  1M93 B;  4DY0 A;  4Y3K A;  3H5C A;  1DVN A;  3EVJ I;  1OVA B;  1DZH L;  2WXZ A;  3F02 A;  2H4P A;  3DLW A;  2GD4 C;  4AJT A;  5IO1 A;  3NDD A;  4AU4 A;  1HLE A;  3PZF A;  2PEE A;  1JTI A;  1DZG I;  2WY0 C;  1A7C A;  3Q02 A;  1JMO A;  4GA7 A;  5HGC A;  1TB6 I;  4ROB A;  4RSQ A;  1DZH I;  3LW2 A;  3NDF A;  2ACH A;  2BEH I;  1E03 I;  1LJ5 A;  2WXX A;  4YIA A;  2ANT I;  1UHG A;  3ZHA A;  4KDS A;  1OC0 A;  1NQ9 I;  1QMB A;  3CVM A;  1BY7 A;  3Q03 A;  2XN5 A;  4R9I A;  4DY7 C;  1ATT A;  2WXY C;  1QLP A;  2HIJ L;  1SEK A;  3R4L A;  1IMV A;  4ZK0 A;  3KCG I;  3B9F I;  4ROA A;  2PEF A;  1OVA C;  3LE2 A;  1JVQ I;  2RIW A;  4AU3 A;  1D5S A;  3F5N A;  2B4X L;  5C98 A;  2WY1 A;  4G8O A;  2HIJ I;  2WXW A;  5INW A;  3T1P A;  1E05 I;  9PAI A;  1XU8 A;  1LQ8 A;  5CE0 A;  1LK6 I;  2CEO A;  3CWM A;  5CDX A;  4AFX A;  4AJU A;  3CAA A;  2HI9 A;  2B4X I;  4C41 A;  4IF8 A;  1MTP A;  3UT3 A;  1XQJ A;  4P0O A;  3EOX A;  4AU3 B;  4DTE A;  2XN3 A;  2H4Q A;  5CDZ A;  2ZV6 A;  1B3K A;  1OO8 A;  4PYW A;  3VVJ A;  3DY0 A;  1OVA A;  2ARQ A;  1PSI A;  2QUG A;  3NE4 A;  1JMJ A;  4P0F A;  1C5G A;  2H4R A;  1KCT A;  1ATH A;  1IZ2 A;  4X30 A;  4IC0 A;  3STO A;  2XN6 A;  8API A;  1OYH L;  1DB2 A;  1K9O I;  1XQG A;  1DVM A;  3NDA A;  1JJO C;  1OPH A;  1E04 I;  1EZX A;  1ANT I;  2VDY A;  2VH4 A;  3DRU A;  4ZK3 A;  4C49 A;  1BR8 I;  1AS4 A;  2WXZ C;  2OL2 A;  3F1S A;  1OYH I;  1T1F A;  2XN7 A;  2BEH L;  2DUT A;  1C8O A;  1QMN A;  1YXA A;  2ARR A;  4AQH A;  4Y40 A;  2R9Y A;  4EB1 L;  1F0C A;  2B5T I;  1JRR A;  2RIV A;  3PB1 I;  2ZNH A;  9API A;  2V95 A;  2VDX A;  3OZQ A;  7API A;  1SNG A;  1HP7 A;  1SR5 A;  2D26 A;  4BB2 A;  3FGQ A;  3DRM A;  1WZ9 A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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