4R9IA

Crystal structure of cysteine proteinase inhibitor serpin18 from bombyx mori
Total Genus 130
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
130
sequence length
378
structure length
378
Chain Sequence
HHHHHMTKNYTEAQLKYYDANTGLCGIGIDQWFQYEPERNQFSTAFPLLFMLSELSLNSKEDTTAELYKNLNLRSEDEVVNVNQAVNTNLNTKNEVYQSTLILNAYTDIDSPFSETFIQNFAKVFNGTVKNIDYSNDAVATIRDSLQSDSGNDIEIALKDGDINKDTGIILTAYTNIYFPWGEASDSYRPYKQIDISFTALDGTQSNKQAWYSEGAGKYAEIENLGIKVFQFSLKPGLTVVLGTSLNDNNDLSGAFNKLRDPATLAYILTQTESKYLKLAVPIELTMRDSRDYIPEVKRAGLLTELFEKNFDGFDTVYDNKSGYISYMLSHTRLEFEQPTEEQAASVVAEPDFIFDKPYFFLVLDQFNTPAFIGLITN
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase inhibitor
molecule keywords Serpin-18
publication title Structural insights into the unique inhibitory mechanism of the silkworm protease inhibitor serpin18
pubmed doi rcsb
source organism Bombyx mori
total genus 130
structure length 378
sequence length 378
ec nomenclature
pdb deposition date 2014-09-05

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00079 Serpin Serpin (serine protease inhibitor)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.30.39.10 Mainly Beta Roll Alpha-1-antitrypsin; domain 1 Alpha-1-antitrypsin, domain 1 4r9iA02
3.30.497.10 Alpha Beta 2-Layer Sandwich Antithrombin; Chain I, domain 2 Antithrombin, subunit I, domain 2 4r9iA01
4PYWA 7APIA 2B5TI 5HGCA 2WXXA 1ATHA 2PEFA 4DY7C 1K9OI 1QLPA 3ZHAA 1OC0A 3T1PA 1QMBA 2BEHI 1LK6I 3OZQA 4DY0A 4Y3KA 1D5SA 3F5NA 4AFXA 1E05I 1BR8I 2WXZA 3EOXA 4C41A 3CVMA 4YIAA 4IF8A 1OVAC 1EZXA 1LJ5A 3PZFA 2ARRA 1TB6I 2QUGA 4KDSA 3DRUA 2D26A 4AQHA 3NDDA 5EI0A 4EB1I 4ZK3A 1E04I 1NQ9I 1HLEA 2RIWA 2VDXA 1R1LI 1MTPA 4IC0A 4G8RA 2VH4A 1PSIA 2H4QA 2V95A 3LE2A 2XN3A 4P0FA 4Y40A 1JTIA 1M93B 3STOA 1DZHI 3NE4A 1HP7A 4AU4A 1C5GA 4AJTA 4RO9A 1JJOC 2H4RA 3F1SA 2ACHA 3DRMA 4EB1L 2XN7A 1YXAA 4AJUA 3FGQA 1JMJA 2ZNHA 3B9FI 1SNGA 2VDYA 1DZHL 1OYHL 5CDZA 3CWMA 1DVMA 2H4PA 2WXZC 2WY0C 4G8OA 4GA7A 2R9YA 4AU3B 4AU2A 4ZK0A 3DY0A 3Q03A 3CAAA 2DUTA 2ZV6A 2OL2A 2CEOA 1E03I 4X30A 3DLWA 1UHGA 1SR5A 2WXWA 5INWA 1OYHI 4AU3A 3F02A 9APIA 1AS4A 9PAIA 1B3KA 2XN6A 5CDXA 1ATUA 3R4LA 3PB1I 5BRRI 1KCTA 3KCGI 2ANTI 2HIJL 3Q02A 2B4XL 3H5CA 1XQGA 1SEKA 4P0OA 1IMVA 1XU8A 3CWLA 4R9IA 1JRRA 3EVJI 3VVJA 1QMNA 4DTEA 1DZGI 4CAAA 1OVAB 4BB2A 1C8OA 2XN5A 2HIJI 1ATTA 4C49A 1T1FA 2B4XI 2GD4C 1A7CA 1WZ9A 2PEEA 5IO1A 4ROAA 2RIVA 5C98A 1OVAA 1DZGL 2ARQA 2OAYA 5CE0A 3NDFA 4ROBA 3NDAA 2HI9A 1BY7A 1JVQI 1LQ8A 1OO8A 1F0CA 2WY1A 1DVNA 3UT3A 1OPHA 1DB2A 2BEHL 4RSQA 2WXYC 1ANTI 8APIA 1JMOA 1IZ2A 1AZXI 1XQJA 3LW2A
chains in the Genus database with same CATH superfamily
4PYWA 7APIA 2B5TI 5HGCA 2WXXA 1ATHA 2PEFA 4DY7C 1K9OI 1QLPA 3ZHAA 1OC0A 3T1PA 1QMBA 2BEHI 1LK6I 3OZQA 4DY0A 4Y3KA 1D5SA 3F5NA 4AFXA 1E05I 1BR8I 2WXZA 3EOXA 4C41A 3CVMA 4YIAA 4IF8A 1OVAC 1EZXA 1LJ5A 3PZFA 2ARRA 1TB6I 2QUGA 4KDSA 3DRUA 2D26A 4AQHA 3NDDA 5EI0A 4EB1I 4ZK3A 1E04I 1NQ9I 1HLEA 2RIWA 2VDXA 1R1LI 1MTPA 4IC0A 4G8RA 2VH4A 1PSIA 2H4QA 2V95A 3LE2A 2XN3A 4P0FA 4Y40A 1JTIA 1M93B 3STOA 1DZHI 3NE4A 1HP7A 4AU4A 1C5GA 4AJTA 4RO9A 1JJOC 2H4RA 3F1SA 2ACHA 3DRMA 4EB1L 2XN7A 1YXAA 4AJUA 3FGQA 1JMJA 2ZNHA 3B9FI 1SNGA 2VDYA 1DZHL 1OYHL 5CDZA 3CWMA 1DVMA 2H4PA 2WXZC 2WY0C 4G8OA 4GA7A 2R9YA 4AU3B 4AU2A 4ZK0A 3DY0A 3Q03A 3CAAA 2DUTA 2ZV6A 2OL2A 2CEOA 1E03I 4X30A 3DLWA 1UHGA 1SR5A 2WXWA 5INWA 1OYHI 4AU3A 3F02A 9APIA 1AS4A 9PAIA 1B3KA 2XN6A 5CDXA 1ATUA 3R4LA 3PB1I 5BRRI 1KCTA 3KCGI 2ANTI 2HIJL 3Q02A 2B4XL 3H5CA 1XQGA 1SEKA 4P0OA 1IMVA 1XU8A 3CWLA 4R9IA 1JRRA 3EVJI 3VVJA 1QMNA 4DTEA 1DZGI 4CAAA 1OVAB 4BB2A 1C8OA 2XN5A 2HIJI 1ATTA 4C49A 1T1FA 2B4XI 2GD4C 1A7CA 1WZ9A 2PEEA 5IO1A 4ROAA 2RIVA 5C98A 1OVAA 1DZGL 2ARQA 2OAYA 5CE0A 3NDFA 4ROBA 3NDAA 2HI9A 1BY7A 1JVQI 1LQ8A 1OO8A 1F0CA 2WY1A 1DVNA 3UT3A 1OPHA 1DB2A 2BEHL 4RSQA 2WXYC 1ANTI 8APIA 1JMOA 1IZ2A 1AZXI 1XQJA 3LW2A
chains in the Genus database with same CATH topology
4PYWA 7APIA 2B5TI 5HGCA 2WXXA 1ATHA 2PEFA 4DY7C 1K9OI 1QLPA 3ZHAA 1OC0A 3T1PA 1QMBA 2BEHI 1LK6I 3OZQA 4DY0A 4Y3KA 1D5SA 3F5NA 4AFXA 1E05I 1BR8I 2WXZA 3EOXA 4C41A 3CVMA 4YIAA 4IF8A 1OVAC 1EZXA 1LJ5A 3PZFA 2ARRA 1TB6I 2QUGA 4KDSA 3DRUA 2D26A 4AQHA 3NDDA 5EI0A 4EB1I 4ZK3A 1E04I 1NQ9I 1HLEA 2RIWA 2VDXA 1R1LI 1MTPA 4IC0A 4G8RA 2VH4A 1PSIA 2H4QA 2V95A 3LE2A 2XN3A 4P0FA 4Y40A 1JTIA 1M93B 3STOA 1DZHI 3NE4A 1HP7A 4AU4A 1C5GA 4AJTA 4RO9A 1JJOC 2H4RA 3F1SA 2ACHA 3DRMA 4EB1L 2XN7A 1YXAA 4AJUA 3FGQA 1JMJA 2ZNHA 3B9FI 1SNGA 2VDYA 1DZHL 1OYHL 5CDZA 3CWMA 1DVMA 2H4PA 2WXZC 2WY0C 4G8OA 4GA7A 2R9YA 4AU3B 4AU2A 4ZK0A 3DY0A 3Q03A 3CAAA 2DUTA 2ZV6A 2OL2A 2CEOA 1E03I 4X30A 3DLWA 1UHGA 1SR5A 2WXWA 5INWA 1OYHI 4AU3A 3F02A 9APIA 1AS4A 9PAIA 1B3KA 2XN6A 5CDXA 1ATUA 3R4LA 3PB1I 5BRRI 1KCTA 3KCGI 2ANTI 2HIJL 3Q02A 2B4XL 3H5CA 1XQGA 1SEKA 4P0OA 1IMVA 1XU8A 3CWLA 4R9IA 1JRRA 3EVJI 3VVJA 1QMNA 4DTEA 1DZGI 4CAAA 1OVAB 4BB2A 1C8OA 2XN5A 2HIJI 1ATTA 4C49A 1T1FA 2B4XI 2GD4C 1A7CA 1WZ9A 2PEEA 5IO1A 4ROAA 2RIVA 5C98A 1OVAA 1DZGL 2ARQA 2OAYA 5CE0A 3NDFA 4ROBA 3NDAA 2HI9A 1BY7A 1JVQI 1LQ8A 1OO8A 1F0CA 2WY1A 1DVNA 3UT3A 1OPHA 1DB2A 2BEHL 4RSQA 2WXYC 1ANTI 8APIA 1JMOA 1IZ2A 1AZXI 1XQJA 3LW2A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4PYW A;  7API A;  2B5T I;  5HGC A;  2WXX A;  1ATH A;  2PEF A;  4DY7 C;  1K9O I;  1QLP A;  3ZHA A;  1OC0 A;  3T1P A;  1QMB A;  2BEH I;  1LK6 I;  3OZQ A;  4DY0 A;  4Y3K A;  1D5S A;  3F5N A;  4AFX A;  1E05 I;  1BR8 I;  2WXZ A;  3EOX A;  4C41 A;  3CVM A;  4YIA A;  4IF8 A;  1OVA C;  1EZX A;  1LJ5 A;  3PZF A;  2ARR A;  1TB6 I;  2QUG A;  4KDS A;  3DRU A;  2D26 A;  4AQH A;  3NDD A;  5EI0 A;  4EB1 I;  4ZK3 A;  1E04 I;  1NQ9 I;  1HLE A;  2RIW A;  2VDX A;  1R1L I;  1MTP A;  4IC0 A;  4G8R A;  2VH4 A;  1PSI A;  2H4Q A;  2V95 A;  3LE2 A;  2XN3 A;  4P0F A;  4Y40 A;  1JTI A;  1M93 B;  3STO A;  1DZH I;  3NE4 A;  1HP7 A;  4AU4 A;  1C5G A;  4AJT A;  4RO9 A;  1JJO C;  2H4R A;  3F1S A;  2ACH A;  3DRM A;  4EB1 L;  2XN7 A;  1YXA A;  4AJU A;  3FGQ A;  1JMJ A;  2ZNH A;  3B9F I;  1SNG A;  2VDY A;  1DZH L;  1OYH L;  5CDZ A;  3CWM A;  1DVM A;  2H4P A;  2WXZ C;  2WY0 C;  4G8O A;  4GA7 A;  2R9Y A;  4AU3 B;  4AU2 A;  4ZK0 A;  3DY0 A;  3Q03 A;  3CAA A;  2DUT A;  2ZV6 A;  2OL2 A;  2CEO A;  1E03 I;  4X30 A;  3DLW A;  1UHG A;  1SR5 A;  2WXW A;  5INW A;  1OYH I;  4AU3 A;  3F02 A;  9API A;  1AS4 A;  9PAI A;  1B3K A;  2XN6 A;  5CDX A;  1ATU A;  3R4L A;  3PB1 I;  5BRR I;  1KCT A;  3KCG I;  2ANT I;  2HIJ L;  3Q02 A;  2B4X L;  3H5C A;  1XQG A;  1SEK A;  4P0O A;  1IMV A;  1XU8 A;  3CWL A;  4R9I A;  1JRR A;  3EVJ I;  3VVJ A;  1QMN A;  4DTE A;  1DZG I;  4CAA A;  1OVA B;  4BB2 A;  1C8O A;  2XN5 A;  2HIJ I;  1ATT A;  4C49 A;  1T1F A;  2B4X I;  2GD4 C;  1A7C A;  1WZ9 A;  2PEE A;  5IO1 A;  4ROA A;  2RIV A;  5C98 A;  1OVA A;  1DZG L;  2ARQ A;  2OAY A;  5CE0 A;  3NDF A;  4ROB A;  3NDA A;  2HI9 A;  1BY7 A;  1JVQ I;  1LQ8 A;  1OO8 A;  1F0C A;  2WY1 A;  1DVN A;  3UT3 A;  1OPH A;  1DB2 A;  2BEH L;  4RSQ A;  2WXY C;  1ANT I;  8API A;  1JMO A;  1IZ2 A;  1AZX I;  1XQJ A;  3LW2 A; 
#chains in the Genus database with same CATH topology
 4PYW A;  7API A;  2B5T I;  5HGC A;  2WXX A;  1ATH A;  2PEF A;  4DY7 C;  1K9O I;  1QLP A;  3ZHA A;  1OC0 A;  3T1P A;  1QMB A;  2BEH I;  1LK6 I;  3OZQ A;  4DY0 A;  4Y3K A;  1D5S A;  3F5N A;  4AFX A;  1E05 I;  1BR8 I;  2WXZ A;  3EOX A;  4C41 A;  3CVM A;  4YIA A;  4IF8 A;  1OVA C;  1EZX A;  1LJ5 A;  3PZF A;  2ARR A;  1TB6 I;  2QUG A;  4KDS A;  3DRU A;  2D26 A;  4AQH A;  3NDD A;  5EI0 A;  4EB1 I;  4ZK3 A;  1E04 I;  1NQ9 I;  1HLE A;  2RIW A;  2VDX A;  1R1L I;  1MTP A;  4IC0 A;  4G8R A;  2VH4 A;  1PSI A;  2H4Q A;  2V95 A;  3LE2 A;  2XN3 A;  4P0F A;  4Y40 A;  1JTI A;  1M93 B;  3STO A;  1DZH I;  3NE4 A;  1HP7 A;  4AU4 A;  1C5G A;  4AJT A;  4RO9 A;  1JJO C;  2H4R A;  3F1S A;  2ACH A;  3DRM A;  4EB1 L;  2XN7 A;  1YXA A;  4AJU A;  3FGQ A;  1JMJ A;  2ZNH A;  3B9F I;  1SNG A;  2VDY A;  1DZH L;  1OYH L;  5CDZ A;  3CWM A;  1DVM A;  2H4P A;  2WXZ C;  2WY0 C;  4G8O A;  4GA7 A;  2R9Y A;  4AU3 B;  4AU2 A;  4ZK0 A;  3DY0 A;  3Q03 A;  3CAA A;  2DUT A;  2ZV6 A;  2OL2 A;  2CEO A;  1E03 I;  4X30 A;  3DLW A;  1UHG A;  1SR5 A;  2WXW A;  5INW A;  1OYH I;  4AU3 A;  3F02 A;  9API A;  1AS4 A;  9PAI A;  1B3K A;  2XN6 A;  5CDX A;  1ATU A;  3R4L A;  3PB1 I;  5BRR I;  1KCT A;  3KCG I;  2ANT I;  2HIJ L;  3Q02 A;  2B4X L;  3H5C A;  1XQG A;  1SEK A;  4P0O A;  1IMV A;  1XU8 A;  3CWL A;  4R9I A;  1JRR A;  3EVJ I;  3VVJ A;  1QMN A;  4DTE A;  1DZG I;  4CAA A;  1OVA B;  4BB2 A;  1C8O A;  2XN5 A;  2HIJ I;  1ATT A;  4C49 A;  1T1F A;  2B4X I;  2GD4 C;  1A7C A;  1WZ9 A;  2PEE A;  5IO1 A;  4ROA A;  2RIV A;  5C98 A;  1OVA A;  1DZG L;  2ARQ A;  2OAY A;  5CE0 A;  3NDF A;  4ROB A;  3NDA A;  2HI9 A;  1BY7 A;  1JVQ I;  1LQ8 A;  1OO8 A;  1F0C A;  2WY1 A;  1DVN A;  3UT3 A;  1OPH A;  1DB2 A;  2BEH L;  4RSQ A;  2WXY C;  1ANT I;  8API A;  1JMO A;  1IZ2 A;  1AZX I;  1XQJ A;  3LW2 A; 
#chains in the Genus database with same CATH homology
 4PYW A;  7API A;  2B5T I;  5HGC A;  2WXX A;  1ATH A;  2PEF A;  4DY7 C;  1K9O I;  1QLP A;  3ZHA A;  1OC0 A;  3T1P A;  1QMB A;  2BEH I;  1LK6 I;  3OZQ A;  4DY0 A;  4Y3K A;  1D5S A;  3F5N A;  4AFX A;  1E05 I;  1BR8 I;  2WXZ A;  3EOX A;  4C41 A;  3CVM A;  4YIA A;  4IF8 A;  1OVA C;  1EZX A;  1LJ5 A;  3PZF A;  2ARR A;  1TB6 I;  2QUG A;  4KDS A;  3DRU A;  2D26 A;  4AQH A;  3NDD A;  5EI0 A;  4EB1 I;  4ZK3 A;  1E04 I;  1NQ9 I;  1HLE A;  2RIW A;  2VDX A;  1R1L I;  1MTP A;  4IC0 A;  4G8R A;  2VH4 A;  1PSI A;  2H4Q A;  2V95 A;  3LE2 A;  2XN3 A;  4P0F A;  4Y40 A;  1JTI A;  1M93 B;  3STO A;  1DZH I;  3NE4 A;  1HP7 A;  4AU4 A;  1C5G A;  4AJT A;  4RO9 A;  1JJO C;  2H4R A;  3F1S A;  2ACH A;  3DRM A;  4EB1 L;  2XN7 A;  1YXA A;  4AJU A;  3FGQ A;  1JMJ A;  2ZNH A;  3B9F I;  1SNG A;  2VDY A;  1DZH L;  1OYH L;  5CDZ A;  3CWM A;  1DVM A;  2H4P A;  2WXZ C;  2WY0 C;  4G8O A;  4GA7 A;  2R9Y A;  4AU3 B;  4AU2 A;  4ZK0 A;  3DY0 A;  3Q03 A;  3CAA A;  2DUT A;  2ZV6 A;  2OL2 A;  2CEO A;  1E03 I;  4X30 A;  3DLW A;  1UHG A;  1SR5 A;  2WXW A;  5INW A;  1OYH I;  4AU3 A;  3F02 A;  9API A;  1AS4 A;  9PAI A;  1B3K A;  2XN6 A;  5CDX A;  1ATU A;  3R4L A;  3PB1 I;  5BRR I;  1KCT A;  3KCG I;  2ANT I;  2HIJ L;  3Q02 A;  2B4X L;  3H5C A;  1XQG A;  1SEK A;  4P0O A;  1IMV A;  1XU8 A;  3CWL A;  4R9I A;  1JRR A;  3EVJ I;  3VVJ A;  1QMN A;  4DTE A;  1DZG I;  4CAA A;  1OVA B;  4BB2 A;  1C8O A;  2XN5 A;  2HIJ I;  1ATT A;  4C49 A;  1T1F A;  2B4X I;  2GD4 C;  1A7C A;  1WZ9 A;  2PEE A;  5IO1 A;  4ROA A;  2RIV A;  5C98 A;  1OVA A;  1DZG L;  2ARQ A;  2OAY A;  5CE0 A;  3NDF A;  4ROB A;  3NDA A;  2HI9 A;  1BY7 A;  1JVQ I;  1LQ8 A;  1OO8 A;  1F0C A;  2WY1 A;  1DVN A;  3UT3 A;  1OPH A;  1DB2 A;  2BEH L;  4RSQ A;  2WXY C;  1ANT I;  8API A;  1JMO A;  1IZ2 A;  1AZX I;  1XQJ A;  3LW2 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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