4RO9A

2.0a resolution structure of srpn2 (s358e) from anopheles gambiae
Total Genus 112
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
112
sequence length
384
structure length
353
Chain Sequence
HGPFQGQRQNEFDLMFVKEIFKNHNSNVVLSPFSVKILLTLIYEASDSNTKRELSSVIQNDNIDHTRSYYKQLLESAQQDNKDYDLNIATNFFVDDFIEVINKYQQIANTHYHAMLEKVSYSNPTQTAATINNWVSEHTNGRLREIVTPDSLEGAVITLVNVIYFKGLWTYPFPEVANNVKPFYGTPTNAQYMEQNGQFYYDNSADLGAQILRLPYRGNKLAMYFILPNPDNTVNQVLDRINSASLHQALWYMEENEVNVTLPKFKFDFSEQLNEPLQQVGIREIFSQNASLPLLARGEVRVSRIFQKAGITINELGEEAVQIFNANRPFIFFIEDETLGTMLFAGKIENPVF
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
molecule tags Hydrolase inhibitor
molecule keywords Serpin 2
publication title Structural and Inhibitory Effects of Hinge Loop Mutagenesis in Serpin-2 from the Malaria Vector Anopheles gambiae.
pubmed doi rcsb
source organism Anopheles gambiae
total genus 112
structure length 353
sequence length 384
chains with identical sequence B, C
ec nomenclature
pdb deposition date 2014-10-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00079 Serpin Serpin (serine protease inhibitor)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.30.39.10 Mainly Beta Roll Alpha-1-antitrypsin; domain 1 Alpha-1-antitrypsin, domain 1 4ro9A01
3.30.497.10 Alpha Beta 2-Layer Sandwich Antithrombin; Chain I, domain 2 Antithrombin, subunit I, domain 2 4ro9A02
5CE0A 1OC0A 3DRUA 1ATTA 3CWMA 1C8OA 1PSIA 2H4QA 2VDYA 4Y3KA 5EI0A 1DZGL 3KCGI 2ACHA 1IMVA 1M93B 2BEHI 1SR5A 3STOA 2QUGA 4YIAA 2V95A 4AJUA 1BY7A 2XN5A 4AJTA 1AS4A 1HP7A 4R9IA 1JRRA 1F0CA 2CEOA 4AFXA 8APIA 2OL2A 1DZHI 3NDDA 1DB2A 3FGQA 5CDZA 4BB2A 1DVNA 1LJ5A 1AZXI 3Q03A 1OPHA 2WY1A 4G8OA 3UT3A 1R1LI 4GA7A 4ROAA 4Y40A 4IF8A 2BEHL 1E04I 2XN6A 2D26A 4ZK0A 2WXZC 7APIA 4RO9A 3PB1I 2RIVA 2XN3A 1QMNA 3F02A 1JMJA 4P0OA 3T1PA 5HGCA 2ANTI 1DZHL 5IO1A 9PAIA 4AQHA 1E03I 4KDSA 2PEFA 1T1FA 1HLEA 2OAYA 3B9FI 4IC0A 4ZK3A 2WXXA 2ARRA 2H4RA 2HI9A 4P0FA 1BR8I 2HIJI 2ZNHA 4EB1I 1OVAA 4ROBA 4G8RA 3Q02A 2WY0C 4CAAA 4C49A 3H5CA 2B4XI 1SEKA 3DLWA 4AU3B 5CDXA 1K9OI 2WXWA 4C41A 3F5NA 1JJOC 5INWA 1TB6I 2DUTA 2WXZA 1A7CA 3EOXA 1OYHI 1JTIA 3LW2A 3ZHAA 4DY7C 3VVJA 1WZ9A 2WXYC 1MTPA 3CAAA 4AU4A 2HIJL 2RIWA 1QLPA 1JVQI 4EB1L 1IZ2A 1C5GA 3OZQA 2ZV6A 1DVMA 3DY0A 3CWLA 1NQ9I 3LE2A 4DY0A 3NDAA 3R4LA 1LK6I 1LQ8A 1OO8A 3NDFA 2PEEA 2R9YA 1D5SA 1B3KA 4RSQA 1SNGA 1OYHL 1EZXA 1OVAB 3PZFA 1ATUA 1DZGI 1ANTI 1ATHA 2VH4A 1E05I 1KCTA 1XU8A 3CVMA 4PYWA 1JMOA 1QMBA 2GD4C 1OVAC 3DRMA 3F1SA 4DTEA 4X30A 5BRRI 9APIA 2XN7A 1UHGA 4AU3A 2VDXA 3NE4A 2ARQA 2H4PA 3EVJI 1YXAA 1XQGA 4AU2A 2B5TI 5C98A 1XQJA 2B4XL
chains in the Genus database with same CATH superfamily
5CE0A 1OC0A 3DRUA 1ATTA 3CWMA 1C8OA 1PSIA 2H4QA 2VDYA 4Y3KA 5EI0A 1DZGL 3KCGI 2ACHA 1IMVA 1M93B 2BEHI 1SR5A 3STOA 2QUGA 4YIAA 2V95A 4AJUA 1BY7A 2XN5A 4AJTA 1AS4A 1HP7A 4R9IA 1JRRA 1F0CA 2CEOA 4AFXA 8APIA 2OL2A 1DZHI 3NDDA 1DB2A 3FGQA 5CDZA 4BB2A 1DVNA 1LJ5A 1AZXI 3Q03A 1OPHA 2WY1A 4G8OA 3UT3A 1R1LI 4GA7A 4ROAA 4Y40A 4IF8A 2BEHL 1E04I 2XN6A 2D26A 4ZK0A 2WXZC 7APIA 4RO9A 3PB1I 2RIVA 2XN3A 1QMNA 3F02A 1JMJA 4P0OA 3T1PA 5HGCA 2ANTI 1DZHL 5IO1A 9PAIA 4AQHA 1E03I 4KDSA 2PEFA 1T1FA 1HLEA 2OAYA 3B9FI 4IC0A 4ZK3A 2WXXA 2ARRA 2H4RA 2HI9A 4P0FA 1BR8I 2HIJI 2ZNHA 4EB1I 1OVAA 4ROBA 4G8RA 3Q02A 2WY0C 4CAAA 4C49A 3H5CA 2B4XI 1SEKA 3DLWA 4AU3B 5CDXA 1K9OI 2WXWA 4C41A 3F5NA 1JJOC 5INWA 1TB6I 2DUTA 2WXZA 1A7CA 3EOXA 1OYHI 1JTIA 3LW2A 3ZHAA 4DY7C 3VVJA 1WZ9A 2WXYC 1MTPA 3CAAA 4AU4A 2HIJL 2RIWA 1QLPA 1JVQI 4EB1L 1IZ2A 1C5GA 3OZQA 2ZV6A 1DVMA 3DY0A 3CWLA 1NQ9I 3LE2A 4DY0A 3NDAA 3R4LA 1LK6I 1LQ8A 1OO8A 3NDFA 2PEEA 2R9YA 1D5SA 1B3KA 4RSQA 1SNGA 1OYHL 1EZXA 1OVAB 3PZFA 1ATUA 1DZGI 1ANTI 1ATHA 2VH4A 1E05I 1KCTA 1XU8A 3CVMA 4PYWA 1JMOA 1QMBA 2GD4C 1OVAC 3DRMA 3F1SA 4DTEA 4X30A 5BRRI 9APIA 2XN7A 1UHGA 4AU3A 2VDXA 3NE4A 2ARQA 2H4PA 3EVJI 1YXAA 1XQGA 4AU2A 2B5TI 5C98A 1XQJA 2B4XL
chains in the Genus database with same CATH topology
5CE0A 1OC0A 3DRUA 1ATTA 3CWMA 1C8OA 1PSIA 2H4QA 2VDYA 4Y3KA 5EI0A 1DZGL 3KCGI 2ACHA 1IMVA 1M93B 2BEHI 1SR5A 3STOA 2QUGA 4YIAA 2V95A 4AJUA 1BY7A 2XN5A 4AJTA 1AS4A 1HP7A 4R9IA 1JRRA 1F0CA 2CEOA 4AFXA 8APIA 2OL2A 1DZHI 3NDDA 1DB2A 3FGQA 5CDZA 4BB2A 1DVNA 1LJ5A 1AZXI 3Q03A 1OPHA 2WY1A 4G8OA 3UT3A 1R1LI 4GA7A 4ROAA 4Y40A 4IF8A 2BEHL 1E04I 2XN6A 2D26A 4ZK0A 2WXZC 7APIA 4RO9A 3PB1I 2RIVA 2XN3A 1QMNA 3F02A 1JMJA 4P0OA 3T1PA 5HGCA 2ANTI 1DZHL 5IO1A 9PAIA 4AQHA 1E03I 4KDSA 2PEFA 1T1FA 1HLEA 2OAYA 3B9FI 4IC0A 4ZK3A 2WXXA 2ARRA 2H4RA 2HI9A 4P0FA 1BR8I 2HIJI 2ZNHA 4EB1I 1OVAA 4ROBA 4G8RA 3Q02A 2WY0C 4CAAA 4C49A 3H5CA 2B4XI 1SEKA 3DLWA 4AU3B 5CDXA 1K9OI 2WXWA 4C41A 3F5NA 1JJOC 5INWA 1TB6I 2DUTA 2WXZA 1A7CA 3EOXA 1OYHI 1JTIA 3LW2A 3ZHAA 4DY7C 3VVJA 1WZ9A 2WXYC 1MTPA 3CAAA 4AU4A 2HIJL 2RIWA 1QLPA 1JVQI 4EB1L 1IZ2A 1C5GA 3OZQA 2ZV6A 1DVMA 3DY0A 3CWLA 1NQ9I 3LE2A 4DY0A 3NDAA 3R4LA 1LK6I 1LQ8A 1OO8A 3NDFA 2PEEA 2R9YA 1D5SA 1B3KA 4RSQA 1SNGA 1OYHL 1EZXA 1OVAB 3PZFA 1ATUA 1DZGI 1ANTI 1ATHA 2VH4A 1E05I 1KCTA 1XU8A 3CVMA 4PYWA 1JMOA 1QMBA 2GD4C 1OVAC 3DRMA 3F1SA 4DTEA 4X30A 5BRRI 9APIA 2XN7A 1UHGA 4AU3A 2VDXA 3NE4A 2ARQA 2H4PA 3EVJI 1YXAA 1XQGA 4AU2A 2B5TI 5C98A 1XQJA 2B4XL
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5CE0 A;  1OC0 A;  3DRU A;  1ATT A;  3CWM A;  1C8O A;  1PSI A;  2H4Q A;  2VDY A;  4Y3K A;  5EI0 A;  1DZG L;  3KCG I;  2ACH A;  1IMV A;  1M93 B;  2BEH I;  1SR5 A;  3STO A;  2QUG A;  4YIA A;  2V95 A;  4AJU A;  1BY7 A;  2XN5 A;  4AJT A;  1AS4 A;  1HP7 A;  4R9I A;  1JRR A;  1F0C A;  2CEO A;  4AFX A;  8API A;  2OL2 A;  1DZH I;  3NDD A;  1DB2 A;  3FGQ A;  5CDZ A;  4BB2 A;  1DVN A;  1LJ5 A;  1AZX I;  3Q03 A;  1OPH A;  2WY1 A;  4G8O A;  3UT3 A;  1R1L I;  4GA7 A;  4ROA A;  4Y40 A;  4IF8 A;  2BEH L;  1E04 I;  2XN6 A;  2D26 A;  4ZK0 A;  2WXZ C;  7API A;  4RO9 A;  3PB1 I;  2RIV A;  2XN3 A;  1QMN A;  3F02 A;  1JMJ A;  4P0O A;  3T1P A;  5HGC A;  2ANT I;  1DZH L;  5IO1 A;  9PAI A;  4AQH A;  1E03 I;  4KDS A;  2PEF A;  1T1F A;  1HLE A;  2OAY A;  3B9F I;  4IC0 A;  4ZK3 A;  2WXX A;  2ARR A;  2H4R A;  2HI9 A;  4P0F A;  1BR8 I;  2HIJ I;  2ZNH A;  4EB1 I;  1OVA A;  4ROB A;  4G8R A;  3Q02 A;  2WY0 C;  4CAA A;  4C49 A;  3H5C A;  2B4X I;  1SEK A;  3DLW A;  4AU3 B;  5CDX A;  1K9O I;  2WXW A;  4C41 A;  3F5N A;  1JJO C;  5INW A;  1TB6 I;  2DUT A;  2WXZ A;  1A7C A;  3EOX A;  1OYH I;  1JTI A;  3LW2 A;  3ZHA A;  4DY7 C;  3VVJ A;  1WZ9 A;  2WXY C;  1MTP A;  3CAA A;  4AU4 A;  2HIJ L;  2RIW A;  1QLP A;  1JVQ I;  4EB1 L;  1IZ2 A;  1C5G A;  3OZQ A;  2ZV6 A;  1DVM A;  3DY0 A;  3CWL A;  1NQ9 I;  3LE2 A;  4DY0 A;  3NDA A;  3R4L A;  1LK6 I;  1LQ8 A;  1OO8 A;  3NDF A;  2PEE A;  2R9Y A;  1D5S A;  1B3K A;  4RSQ A;  1SNG A;  1OYH L;  1EZX A;  1OVA B;  3PZF A;  1ATU A;  1DZG I;  1ANT I;  1ATH A;  2VH4 A;  1E05 I;  1KCT A;  1XU8 A;  3CVM A;  4PYW A;  1JMO A;  1QMB A;  2GD4 C;  1OVA C;  3DRM A;  3F1S A;  4DTE A;  4X30 A;  5BRR I;  9API A;  2XN7 A;  1UHG A;  4AU3 A;  2VDX A;  3NE4 A;  2ARQ A;  2H4P A;  3EVJ I;  1YXA A;  1XQG A;  4AU2 A;  2B5T I;  5C98 A;  1XQJ A;  2B4X L; 
#chains in the Genus database with same CATH topology
 5CE0 A;  1OC0 A;  3DRU A;  1ATT A;  3CWM A;  1C8O A;  1PSI A;  2H4Q A;  2VDY A;  4Y3K A;  5EI0 A;  1DZG L;  3KCG I;  2ACH A;  1IMV A;  1M93 B;  2BEH I;  1SR5 A;  3STO A;  2QUG A;  4YIA A;  2V95 A;  4AJU A;  1BY7 A;  2XN5 A;  4AJT A;  1AS4 A;  1HP7 A;  4R9I A;  1JRR A;  1F0C A;  2CEO A;  4AFX A;  8API A;  2OL2 A;  1DZH I;  3NDD A;  1DB2 A;  3FGQ A;  5CDZ A;  4BB2 A;  1DVN A;  1LJ5 A;  1AZX I;  3Q03 A;  1OPH A;  2WY1 A;  4G8O A;  3UT3 A;  1R1L I;  4GA7 A;  4ROA A;  4Y40 A;  4IF8 A;  2BEH L;  1E04 I;  2XN6 A;  2D26 A;  4ZK0 A;  2WXZ C;  7API A;  4RO9 A;  3PB1 I;  2RIV A;  2XN3 A;  1QMN A;  3F02 A;  1JMJ A;  4P0O A;  3T1P A;  5HGC A;  2ANT I;  1DZH L;  5IO1 A;  9PAI A;  4AQH A;  1E03 I;  4KDS A;  2PEF A;  1T1F A;  1HLE A;  2OAY A;  3B9F I;  4IC0 A;  4ZK3 A;  2WXX A;  2ARR A;  2H4R A;  2HI9 A;  4P0F A;  1BR8 I;  2HIJ I;  2ZNH A;  4EB1 I;  1OVA A;  4ROB A;  4G8R A;  3Q02 A;  2WY0 C;  4CAA A;  4C49 A;  3H5C A;  2B4X I;  1SEK A;  3DLW A;  4AU3 B;  5CDX A;  1K9O I;  2WXW A;  4C41 A;  3F5N A;  1JJO C;  5INW A;  1TB6 I;  2DUT A;  2WXZ A;  1A7C A;  3EOX A;  1OYH I;  1JTI A;  3LW2 A;  3ZHA A;  4DY7 C;  3VVJ A;  1WZ9 A;  2WXY C;  1MTP A;  3CAA A;  4AU4 A;  2HIJ L;  2RIW A;  1QLP A;  1JVQ I;  4EB1 L;  1IZ2 A;  1C5G A;  3OZQ A;  2ZV6 A;  1DVM A;  3DY0 A;  3CWL A;  1NQ9 I;  3LE2 A;  4DY0 A;  3NDA A;  3R4L A;  1LK6 I;  1LQ8 A;  1OO8 A;  3NDF A;  2PEE A;  2R9Y A;  1D5S A;  1B3K A;  4RSQ A;  1SNG A;  1OYH L;  1EZX A;  1OVA B;  3PZF A;  1ATU A;  1DZG I;  1ANT I;  1ATH A;  2VH4 A;  1E05 I;  1KCT A;  1XU8 A;  3CVM A;  4PYW A;  1JMO A;  1QMB A;  2GD4 C;  1OVA C;  3DRM A;  3F1S A;  4DTE A;  4X30 A;  5BRR I;  9API A;  2XN7 A;  1UHG A;  4AU3 A;  2VDX A;  3NE4 A;  2ARQ A;  2H4P A;  3EVJ I;  1YXA A;  1XQG A;  4AU2 A;  2B5T I;  5C98 A;  1XQJ A;  2B4X L; 
#chains in the Genus database with same CATH homology
 5CE0 A;  1OC0 A;  3DRU A;  1ATT A;  3CWM A;  1C8O A;  1PSI A;  2H4Q A;  2VDY A;  4Y3K A;  5EI0 A;  1DZG L;  3KCG I;  2ACH A;  1IMV A;  1M93 B;  2BEH I;  1SR5 A;  3STO A;  2QUG A;  4YIA A;  2V95 A;  4AJU A;  1BY7 A;  2XN5 A;  4AJT A;  1AS4 A;  1HP7 A;  4R9I A;  1JRR A;  1F0C A;  2CEO A;  4AFX A;  8API A;  2OL2 A;  1DZH I;  3NDD A;  1DB2 A;  3FGQ A;  5CDZ A;  4BB2 A;  1DVN A;  1LJ5 A;  1AZX I;  3Q03 A;  1OPH A;  2WY1 A;  4G8O A;  3UT3 A;  1R1L I;  4GA7 A;  4ROA A;  4Y40 A;  4IF8 A;  2BEH L;  1E04 I;  2XN6 A;  2D26 A;  4ZK0 A;  2WXZ C;  7API A;  4RO9 A;  3PB1 I;  2RIV A;  2XN3 A;  1QMN A;  3F02 A;  1JMJ A;  4P0O A;  3T1P A;  5HGC A;  2ANT I;  1DZH L;  5IO1 A;  9PAI A;  4AQH A;  1E03 I;  4KDS A;  2PEF A;  1T1F A;  1HLE A;  2OAY A;  3B9F I;  4IC0 A;  4ZK3 A;  2WXX A;  2ARR A;  2H4R A;  2HI9 A;  4P0F A;  1BR8 I;  2HIJ I;  2ZNH A;  4EB1 I;  1OVA A;  4ROB A;  4G8R A;  3Q02 A;  2WY0 C;  4CAA A;  4C49 A;  3H5C A;  2B4X I;  1SEK A;  3DLW A;  4AU3 B;  5CDX A;  1K9O I;  2WXW A;  4C41 A;  3F5N A;  1JJO C;  5INW A;  1TB6 I;  2DUT A;  2WXZ A;  1A7C A;  3EOX A;  1OYH I;  1JTI A;  3LW2 A;  3ZHA A;  4DY7 C;  3VVJ A;  1WZ9 A;  2WXY C;  1MTP A;  3CAA A;  4AU4 A;  2HIJ L;  2RIW A;  1QLP A;  1JVQ I;  4EB1 L;  1IZ2 A;  1C5G A;  3OZQ A;  2ZV6 A;  1DVM A;  3DY0 A;  3CWL A;  1NQ9 I;  3LE2 A;  4DY0 A;  3NDA A;  3R4L A;  1LK6 I;  1LQ8 A;  1OO8 A;  3NDF A;  2PEE A;  2R9Y A;  1D5S A;  1B3K A;  4RSQ A;  1SNG A;  1OYH L;  1EZX A;  1OVA B;  3PZF A;  1ATU A;  1DZG I;  1ANT I;  1ATH A;  2VH4 A;  1E05 I;  1KCT A;  1XU8 A;  3CVM A;  4PYW A;  1JMO A;  1QMB A;  2GD4 C;  1OVA C;  3DRM A;  3F1S A;  4DTE A;  4X30 A;  5BRR I;  9API A;  2XN7 A;  1UHG A;  4AU3 A;  2VDX A;  3NE4 A;  2ARQ A;  2H4P A;  3EVJ I;  1YXA A;  1XQG A;  4AU2 A;  2B5T I;  5C98 A;  1XQJ A;  2B4X L; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...