4ROAA

1.90a resolution structure of srpn2 (s358w) from anopheles gambiae
Total Genus 114
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
114
sequence length
384
structure length
364
Chain Sequence
HGPFQGQRQNEFDLMFVKEIFKNHNSNVVLSPFSVKILLTLIYEASDTSFNTKRELSSVIQDNIDHTRSYYKQLLESAQQDNKDYDLNIATNFFVDDFIEVINKYQQIANTHYHAMLEKVSYSNPTQTAATINNWVSEHTNGRLREIVTPDSLEGAVITLVNVIYFKGLWTYPFPEVANNVKPFYGTRGKPTNAQYMEQNGQFYYDNSADLGAQILRLPYRGNKLAMYFILPNPDNTVNQVLDRINSASLHQALWYMEENEVNVTLPKFKFDFSEQLNEPLQQVGIREIFSQNASLPLLARGEVRVSRIFQKAGITINELGWEAYAATEDGVQIFNANRPFIFFIEDETLGTMLFAGKIENPVF
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase inhibitor
molecule keywords Serpin 2
publication title Structural and Inhibitory Effects of Hinge Loop Mutagenesis in Serpin-2 from the Malaria Vector Anopheles gambiae.
pubmed doi rcsb
source organism Anopheles gambiae
total genus 114
structure length 364
sequence length 384
ec nomenclature
pdb deposition date 2014-10-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00079 Serpin Serpin (serine protease inhibitor)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.30.39.10 Mainly Beta Roll Alpha-1-antitrypsin; domain 1 Alpha-1-antitrypsin, domain 1 4roaA01
3.30.497.10 Alpha Beta 2-Layer Sandwich Antithrombin; Chain I, domain 2 Antithrombin, subunit I, domain 2 4roaA02
3LE2A 3DRUA 1E03I 1OYHL 2WXXA 4AU4A 2B4XI 1WZ9A 3STOA 2BEHI 2XN6A 1ATTA 1LQ8A 1HP7A 2VDXA 1UHGA 1JTIA 4IF8A 2XN5A 1B3KA 1E04I 1JMOA 2ZNHA 1TB6I 1OVAA 2HIJI 3ZHAA 1DVNA 1ANTI 4AJTA 2CEOA 3NDDA 3PB1I 2H4PA 3EOXA 3F1SA 3UT3A 1OO8A 4G8RA 2VDYA 4X30A 4ZK0A 2RIVA 2DUTA 2BEHL 4IC0A 1D5SA 4AQHA 1C5GA 8APIA 1EZXA 4GA7A 4DY7C 2ANTI 1OVAC 3VVJA 4P0OA 2HIJL 1IZ2A 2PEEA 4PYWA 4ZK3A 1XQGA 1HLEA 4AU3B 2WXYC 2WY1A 4YIAA 1PSIA 5CDZA 4C41A 4Y3KA 4BB2A 1ATUA 1MTPA 3FGQA 3F5NA 1IMVA 1SR5A 4AU2A 1E05I 4KDSA 3LW2A 1M93B 4ROBA 4C49A 3EVJI 5C98A 2ARRA 3KCGI 1R1LI 2WXZA 3H5CA 4AJUA 1QMNA 4P0FA 1A7CA 1DZGI 1JRRA 3OZQA 1AZXI 1SNGA 3DY0A 4DTEA 3PZFA 2R9YA 2OL2A 4CAAA 1BR8I 1KCTA 2PEFA 4ROAA 1DZHL 3T1PA 2D26A 2WY0C 4R9IA 3NE4A 1DB2A 1C8OA 1OC0A 2RIWA 1ATHA 1JMJA 2XN7A 4Y40A 1DVMA 4EB1I 2V95A 4G8OA 1DZHI 5CE0A 2OAYA 3CWLA 1K9OI 2HI9A 9PAIA 3DRMA 2WXZC 5HGCA 4AU3A 4DY0A 5INWA 1NQ9I 3NDAA 1JJOC 1DZGL 5CDXA 2ARQA 2ACHA 3R4LA 2B5TI 5BRRI 1XU8A 1OVAB 1OYHI 1LJ5A 1F0CA 1QMBA 2H4QA 3NDFA 5EI0A 3F02A 3Q02A 1OPHA 3CWMA 2ZV6A 4RO9A 4EB1L 3CAAA 1LK6I 1AS4A 1BY7A 1JVQI 2XN3A 3B9FI 5IO1A 4AFXA 2WXWA 3DLWA 2QUGA 3Q03A 9APIA 7APIA 1T1FA 2GD4C 2B4XL 1QLPA 2VH4A 3CVMA 4RSQA 1XQJA 2H4RA 1SEKA 1YXAA
chains in the Genus database with same CATH superfamily
3LE2A 3DRUA 1E03I 1OYHL 2WXXA 4AU4A 2B4XI 1WZ9A 3STOA 2BEHI 2XN6A 1ATTA 1LQ8A 1HP7A 2VDXA 1UHGA 1JTIA 4IF8A 2XN5A 1B3KA 1E04I 1JMOA 2ZNHA 1TB6I 1OVAA 2HIJI 3ZHAA 1DVNA 1ANTI 4AJTA 2CEOA 3NDDA 3PB1I 2H4PA 3EOXA 3F1SA 3UT3A 1OO8A 4G8RA 2VDYA 4X30A 4ZK0A 2RIVA 2DUTA 2BEHL 4IC0A 1D5SA 4AQHA 1C5GA 8APIA 1EZXA 4GA7A 4DY7C 2ANTI 1OVAC 3VVJA 4P0OA 2HIJL 1IZ2A 2PEEA 4PYWA 4ZK3A 1XQGA 1HLEA 4AU3B 2WXYC 2WY1A 4YIAA 1PSIA 5CDZA 4C41A 4Y3KA 4BB2A 1ATUA 1MTPA 3FGQA 3F5NA 1IMVA 1SR5A 4AU2A 1E05I 4KDSA 3LW2A 1M93B 4ROBA 4C49A 3EVJI 5C98A 2ARRA 3KCGI 1R1LI 2WXZA 3H5CA 4AJUA 1QMNA 4P0FA 1A7CA 1DZGI 1JRRA 3OZQA 1AZXI 1SNGA 3DY0A 4DTEA 3PZFA 2R9YA 2OL2A 4CAAA 1BR8I 1KCTA 2PEFA 4ROAA 1DZHL 3T1PA 2D26A 2WY0C 4R9IA 3NE4A 1DB2A 1C8OA 1OC0A 2RIWA 1ATHA 1JMJA 2XN7A 4Y40A 1DVMA 4EB1I 2V95A 4G8OA 1DZHI 5CE0A 2OAYA 3CWLA 1K9OI 2HI9A 9PAIA 3DRMA 2WXZC 5HGCA 4AU3A 4DY0A 5INWA 1NQ9I 3NDAA 1JJOC 1DZGL 5CDXA 2ARQA 2ACHA 3R4LA 2B5TI 5BRRI 1XU8A 1OVAB 1OYHI 1LJ5A 1F0CA 1QMBA 2H4QA 3NDFA 5EI0A 3F02A 3Q02A 1OPHA 3CWMA 2ZV6A 4RO9A 4EB1L 3CAAA 1LK6I 1AS4A 1BY7A 1JVQI 2XN3A 3B9FI 5IO1A 4AFXA 2WXWA 3DLWA 2QUGA 3Q03A 9APIA 7APIA 1T1FA 2GD4C 2B4XL 1QLPA 2VH4A 3CVMA 4RSQA 1XQJA 2H4RA 1SEKA 1YXAA
chains in the Genus database with same CATH topology
3LE2A 3DRUA 1E03I 1OYHL 2WXXA 4AU4A 2B4XI 1WZ9A 3STOA 2BEHI 2XN6A 1ATTA 1LQ8A 1HP7A 2VDXA 1UHGA 1JTIA 4IF8A 2XN5A 1B3KA 1E04I 1JMOA 2ZNHA 1TB6I 1OVAA 2HIJI 3ZHAA 1DVNA 1ANTI 4AJTA 2CEOA 3NDDA 3PB1I 2H4PA 3EOXA 3F1SA 3UT3A 1OO8A 4G8RA 2VDYA 4X30A 4ZK0A 2RIVA 2DUTA 2BEHL 4IC0A 1D5SA 4AQHA 1C5GA 8APIA 1EZXA 4GA7A 4DY7C 2ANTI 1OVAC 3VVJA 4P0OA 2HIJL 1IZ2A 2PEEA 4PYWA 4ZK3A 1XQGA 1HLEA 4AU3B 2WXYC 2WY1A 4YIAA 1PSIA 5CDZA 4C41A 4Y3KA 4BB2A 1ATUA 1MTPA 3FGQA 3F5NA 1IMVA 1SR5A 4AU2A 1E05I 4KDSA 3LW2A 1M93B 4ROBA 4C49A 3EVJI 5C98A 2ARRA 3KCGI 1R1LI 2WXZA 3H5CA 4AJUA 1QMNA 4P0FA 1A7CA 1DZGI 1JRRA 3OZQA 1AZXI 1SNGA 3DY0A 4DTEA 3PZFA 2R9YA 2OL2A 4CAAA 1BR8I 1KCTA 2PEFA 4ROAA 1DZHL 3T1PA 2D26A 2WY0C 4R9IA 3NE4A 1DB2A 1C8OA 1OC0A 2RIWA 1ATHA 1JMJA 2XN7A 4Y40A 1DVMA 4EB1I 2V95A 4G8OA 1DZHI 5CE0A 2OAYA 3CWLA 1K9OI 2HI9A 9PAIA 3DRMA 2WXZC 5HGCA 4AU3A 4DY0A 5INWA 1NQ9I 3NDAA 1JJOC 1DZGL 5CDXA 2ARQA 2ACHA 3R4LA 2B5TI 5BRRI 1XU8A 1OVAB 1OYHI 1LJ5A 1F0CA 1QMBA 2H4QA 3NDFA 5EI0A 3F02A 3Q02A 1OPHA 3CWMA 2ZV6A 4RO9A 4EB1L 3CAAA 1LK6I 1AS4A 1BY7A 1JVQI 2XN3A 3B9FI 5IO1A 4AFXA 2WXWA 3DLWA 2QUGA 3Q03A 9APIA 7APIA 1T1FA 2GD4C 2B4XL 1QLPA 2VH4A 3CVMA 4RSQA 1XQJA 2H4RA 1SEKA 1YXAA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3LE2 A;  3DRU A;  1E03 I;  1OYH L;  2WXX A;  4AU4 A;  2B4X I;  1WZ9 A;  3STO A;  2BEH I;  2XN6 A;  1ATT A;  1LQ8 A;  1HP7 A;  2VDX A;  1UHG A;  1JTI A;  4IF8 A;  2XN5 A;  1B3K A;  1E04 I;  1JMO A;  2ZNH A;  1TB6 I;  1OVA A;  2HIJ I;  3ZHA A;  1DVN A;  1ANT I;  4AJT A;  2CEO A;  3NDD A;  3PB1 I;  2H4P A;  3EOX A;  3F1S A;  3UT3 A;  1OO8 A;  4G8R A;  2VDY A;  4X30 A;  4ZK0 A;  2RIV A;  2DUT A;  2BEH L;  4IC0 A;  1D5S A;  4AQH A;  1C5G A;  8API A;  1EZX A;  4GA7 A;  4DY7 C;  2ANT I;  1OVA C;  3VVJ A;  4P0O A;  2HIJ L;  1IZ2 A;  2PEE A;  4PYW A;  4ZK3 A;  1XQG A;  1HLE A;  4AU3 B;  2WXY C;  2WY1 A;  4YIA A;  1PSI A;  5CDZ A;  4C41 A;  4Y3K A;  4BB2 A;  1ATU A;  1MTP A;  3FGQ A;  3F5N A;  1IMV A;  1SR5 A;  4AU2 A;  1E05 I;  4KDS A;  3LW2 A;  1M93 B;  4ROB A;  4C49 A;  3EVJ I;  5C98 A;  2ARR A;  3KCG I;  1R1L I;  2WXZ A;  3H5C A;  4AJU A;  1QMN A;  4P0F A;  1A7C A;  1DZG I;  1JRR A;  3OZQ A;  1AZX I;  1SNG A;  3DY0 A;  4DTE A;  3PZF A;  2R9Y A;  2OL2 A;  4CAA A;  1BR8 I;  1KCT A;  2PEF A;  4ROA A;  1DZH L;  3T1P A;  2D26 A;  2WY0 C;  4R9I A;  3NE4 A;  1DB2 A;  1C8O A;  1OC0 A;  2RIW A;  1ATH A;  1JMJ A;  2XN7 A;  4Y40 A;  1DVM A;  4EB1 I;  2V95 A;  4G8O A;  1DZH I;  5CE0 A;  2OAY A;  3CWL A;  1K9O I;  2HI9 A;  9PAI A;  3DRM A;  2WXZ C;  5HGC A;  4AU3 A;  4DY0 A;  5INW A;  1NQ9 I;  3NDA A;  1JJO C;  1DZG L;  5CDX A;  2ARQ A;  2ACH A;  3R4L A;  2B5T I;  5BRR I;  1XU8 A;  1OVA B;  1OYH I;  1LJ5 A;  1F0C A;  1QMB A;  2H4Q A;  3NDF A;  5EI0 A;  3F02 A;  3Q02 A;  1OPH A;  3CWM A;  2ZV6 A;  4RO9 A;  4EB1 L;  3CAA A;  1LK6 I;  1AS4 A;  1BY7 A;  1JVQ I;  2XN3 A;  3B9F I;  5IO1 A;  4AFX A;  2WXW A;  3DLW A;  2QUG A;  3Q03 A;  9API A;  7API A;  1T1F A;  2GD4 C;  2B4X L;  1QLP A;  2VH4 A;  3CVM A;  4RSQ A;  1XQJ A;  2H4R A;  1SEK A;  1YXA A; 
#chains in the Genus database with same CATH topology
 3LE2 A;  3DRU A;  1E03 I;  1OYH L;  2WXX A;  4AU4 A;  2B4X I;  1WZ9 A;  3STO A;  2BEH I;  2XN6 A;  1ATT A;  1LQ8 A;  1HP7 A;  2VDX A;  1UHG A;  1JTI A;  4IF8 A;  2XN5 A;  1B3K A;  1E04 I;  1JMO A;  2ZNH A;  1TB6 I;  1OVA A;  2HIJ I;  3ZHA A;  1DVN A;  1ANT I;  4AJT A;  2CEO A;  3NDD A;  3PB1 I;  2H4P A;  3EOX A;  3F1S A;  3UT3 A;  1OO8 A;  4G8R A;  2VDY A;  4X30 A;  4ZK0 A;  2RIV A;  2DUT A;  2BEH L;  4IC0 A;  1D5S A;  4AQH A;  1C5G A;  8API A;  1EZX A;  4GA7 A;  4DY7 C;  2ANT I;  1OVA C;  3VVJ A;  4P0O A;  2HIJ L;  1IZ2 A;  2PEE A;  4PYW A;  4ZK3 A;  1XQG A;  1HLE A;  4AU3 B;  2WXY C;  2WY1 A;  4YIA A;  1PSI A;  5CDZ A;  4C41 A;  4Y3K A;  4BB2 A;  1ATU A;  1MTP A;  3FGQ A;  3F5N A;  1IMV A;  1SR5 A;  4AU2 A;  1E05 I;  4KDS A;  3LW2 A;  1M93 B;  4ROB A;  4C49 A;  3EVJ I;  5C98 A;  2ARR A;  3KCG I;  1R1L I;  2WXZ A;  3H5C A;  4AJU A;  1QMN A;  4P0F A;  1A7C A;  1DZG I;  1JRR A;  3OZQ A;  1AZX I;  1SNG A;  3DY0 A;  4DTE A;  3PZF A;  2R9Y A;  2OL2 A;  4CAA A;  1BR8 I;  1KCT A;  2PEF A;  4ROA A;  1DZH L;  3T1P A;  2D26 A;  2WY0 C;  4R9I A;  3NE4 A;  1DB2 A;  1C8O A;  1OC0 A;  2RIW A;  1ATH A;  1JMJ A;  2XN7 A;  4Y40 A;  1DVM A;  4EB1 I;  2V95 A;  4G8O A;  1DZH I;  5CE0 A;  2OAY A;  3CWL A;  1K9O I;  2HI9 A;  9PAI A;  3DRM A;  2WXZ C;  5HGC A;  4AU3 A;  4DY0 A;  5INW A;  1NQ9 I;  3NDA A;  1JJO C;  1DZG L;  5CDX A;  2ARQ A;  2ACH A;  3R4L A;  2B5T I;  5BRR I;  1XU8 A;  1OVA B;  1OYH I;  1LJ5 A;  1F0C A;  1QMB A;  2H4Q A;  3NDF A;  5EI0 A;  3F02 A;  3Q02 A;  1OPH A;  3CWM A;  2ZV6 A;  4RO9 A;  4EB1 L;  3CAA A;  1LK6 I;  1AS4 A;  1BY7 A;  1JVQ I;  2XN3 A;  3B9F I;  5IO1 A;  4AFX A;  2WXW A;  3DLW A;  2QUG A;  3Q03 A;  9API A;  7API A;  1T1F A;  2GD4 C;  2B4X L;  1QLP A;  2VH4 A;  3CVM A;  4RSQ A;  1XQJ A;  2H4R A;  1SEK A;  1YXA A; 
#chains in the Genus database with same CATH homology
 3LE2 A;  3DRU A;  1E03 I;  1OYH L;  2WXX A;  4AU4 A;  2B4X I;  1WZ9 A;  3STO A;  2BEH I;  2XN6 A;  1ATT A;  1LQ8 A;  1HP7 A;  2VDX A;  1UHG A;  1JTI A;  4IF8 A;  2XN5 A;  1B3K A;  1E04 I;  1JMO A;  2ZNH A;  1TB6 I;  1OVA A;  2HIJ I;  3ZHA A;  1DVN A;  1ANT I;  4AJT A;  2CEO A;  3NDD A;  3PB1 I;  2H4P A;  3EOX A;  3F1S A;  3UT3 A;  1OO8 A;  4G8R A;  2VDY A;  4X30 A;  4ZK0 A;  2RIV A;  2DUT A;  2BEH L;  4IC0 A;  1D5S A;  4AQH A;  1C5G A;  8API A;  1EZX A;  4GA7 A;  4DY7 C;  2ANT I;  1OVA C;  3VVJ A;  4P0O A;  2HIJ L;  1IZ2 A;  2PEE A;  4PYW A;  4ZK3 A;  1XQG A;  1HLE A;  4AU3 B;  2WXY C;  2WY1 A;  4YIA A;  1PSI A;  5CDZ A;  4C41 A;  4Y3K A;  4BB2 A;  1ATU A;  1MTP A;  3FGQ A;  3F5N A;  1IMV A;  1SR5 A;  4AU2 A;  1E05 I;  4KDS A;  3LW2 A;  1M93 B;  4ROB A;  4C49 A;  3EVJ I;  5C98 A;  2ARR A;  3KCG I;  1R1L I;  2WXZ A;  3H5C A;  4AJU A;  1QMN A;  4P0F A;  1A7C A;  1DZG I;  1JRR A;  3OZQ A;  1AZX I;  1SNG A;  3DY0 A;  4DTE A;  3PZF A;  2R9Y A;  2OL2 A;  4CAA A;  1BR8 I;  1KCT A;  2PEF A;  4ROA A;  1DZH L;  3T1P A;  2D26 A;  2WY0 C;  4R9I A;  3NE4 A;  1DB2 A;  1C8O A;  1OC0 A;  2RIW A;  1ATH A;  1JMJ A;  2XN7 A;  4Y40 A;  1DVM A;  4EB1 I;  2V95 A;  4G8O A;  1DZH I;  5CE0 A;  2OAY A;  3CWL A;  1K9O I;  2HI9 A;  9PAI A;  3DRM A;  2WXZ C;  5HGC A;  4AU3 A;  4DY0 A;  5INW A;  1NQ9 I;  3NDA A;  1JJO C;  1DZG L;  5CDX A;  2ARQ A;  2ACH A;  3R4L A;  2B5T I;  5BRR I;  1XU8 A;  1OVA B;  1OYH I;  1LJ5 A;  1F0C A;  1QMB A;  2H4Q A;  3NDF A;  5EI0 A;  3F02 A;  3Q02 A;  1OPH A;  3CWM A;  2ZV6 A;  4RO9 A;  4EB1 L;  3CAA A;  1LK6 I;  1AS4 A;  1BY7 A;  1JVQ I;  2XN3 A;  3B9F I;  5IO1 A;  4AFX A;  2WXW A;  3DLW A;  2QUG A;  3Q03 A;  9API A;  7API A;  1T1F A;  2GD4 C;  2B4X L;  1QLP A;  2VH4 A;  3CVM A;  4RSQ A;  1XQJ A;  2H4R A;  1SEK A;  1YXA A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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