4RSQA

2.9a resolution structure of srpn2 (k198c/e359c) from anopheles gambiae
Total Genus 109
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
109
sequence length
383
structure length
356
Chain Sequence
GPFQGQRQNEFDLMFVKEIFKNHNSNVVLSPFSVKILLTLIYEASDTSFGNTKRELSSVIQNDNIDHTRSYYKQLLESAQQDNKDYDLNIATNFFVDDFIEVINKYQQIANTHYHAMLEKVSYSNPTQTAATINNWVSEHTNGRLREIVTPDSLEGAVITLVNVIYFCGLWTYPFPEVNVKPFYGTRGKPTNAQYMEQNGQFYYDNSADLGAQILRLPYRGNKLAMYFILPNPDNTVNQVLDRINSASLHQALWYMEENEVNVTLPKFKFDFSEQLNEPLQQVGIREIFSQNASLPLLARGEVRVSRIFQKAGITINELGSCAVQIFNANRPFIFFIEDETLGTMLFAGKIENPVF
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase inhibitor
molecule keywords Serpin 2
publication title Structural and Inhibitory Effects of Hinge Loop Mutagenesis in Serpin-2 from the Malaria Vector Anopheles gambiae.
pubmed doi rcsb
source organism Anopheles gambiae
total genus 109
structure length 356
sequence length 383
chains with identical sequence B, C, D, E, F, G, H, I, J, K, L
ec nomenclature
pdb deposition date 2014-11-10

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00079 Serpin Serpin (serine protease inhibitor)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.30.39.10 Mainly Beta Roll Alpha-1-antitrypsin; domain 1 Alpha-1-antitrypsin, domain 1 4rsqA01
3.30.497.10 Alpha Beta 2-Layer Sandwich Antithrombin; Chain I, domain 2 Antithrombin, subunit I, domain 2 4rsqA02
1JTIA 3EOXA 3ZHAA 5C98A 3F02A 1QMBA 5CE0A 1E04I 2GD4C 4AFXA 1PSIA 8APIA 3CWMA 4GA7A 1YXAA 4ZK0A 1QLPA 1IZ2A 2ZV6A 3NDFA 2B4XL 2ZNHA 3DRMA 3NE4A 2OL2A 3Q03A 4AU2A 1OO8A 1ANTI 1DVMA 1SR5A 3OZQA 1E03I 5BRRI 1OYHL 1IMVA 1DZGL 2V95A 4X30A 2ANTI 2H4PA 4C41A 2ARRA 1JMOA 4YIAA 1OC0A 3F1SA 3CAAA 1ATUA 1HP7A 2XN7A 2HI9A 5CDXA 4ROBA 3F5NA 1EZXA 5EI0A 1B3KA 3NDDA 3EVJI 4ROAA 1D5SA 2WXXA 3T1PA 1AS4A 9APIA 1JMJA 1SEKA 1MTPA 4G8OA 1E05I 3Q02A 4DY0A 4CAAA 1C5GA 2PEFA 2WY0C 3LE2A 2PEEA 4EB1I 9PAIA 1BR8I 3R4LA 4AQHA 2QUGA 2ACHA 1QMNA 3PZFA 1LQ8A 1LK6I 1R1LI 2VDYA 5HGCA 4Y3KA 1NQ9I 3NDAA 4Y40A 1ATHA 4ZK3A 4RSQA 2WXYC 3KCGI 1A7CA 1UHGA 3VVJA 1OVAB 1JVQI 4P0OA 4IC0A 3UT3A 1TB6I 4R9IA 5IO1A 2B5TI 1LJ5A 1F0CA 3PB1I 1DB2A 4C49A 1OVAC 4EB1L 2H4RA 2RIVA 1OPHA 2H4QA 4AU3B 2WXZC 3STOA 7APIA 1M93B 4RO9A 4DY7C 2DUTA 1XU8A 1T1FA 4PYWA 3DLWA 2D26A 1ATTA 4AJTA 3CVMA 1XQJA 2R9YA 4IF8A 3FGQA 2BEHI 1DZHL 2RIWA 3H5CA 2WXWA 1BY7A 1C8OA 1DZHI 2VH4A 3B9FI 4P0FA 1JJOC 4AJUA 1DVNA 2CEOA 2XN5A 1AZXI 1JRRA 1OVAA 2XN3A 2XN6A 3LW2A 3DY0A 2OAYA 5CDZA 4KDSA 3DRUA 2WXZA 2HIJL 2B4XI 5INWA 2ARQA 1SNGA 2VDXA 1KCTA 4AU4A 2HIJI 1XQGA 4BB2A 4DTEA 4AU3A 2WY1A 1K9OI 1OYHI 2BEHL 1WZ9A 4G8RA 1DZGI 1HLEA 3CWLA
chains in the Genus database with same CATH superfamily
1JTIA 3EOXA 3ZHAA 5C98A 3F02A 1QMBA 5CE0A 1E04I 2GD4C 4AFXA 1PSIA 8APIA 3CWMA 4GA7A 1YXAA 4ZK0A 1QLPA 1IZ2A 2ZV6A 3NDFA 2B4XL 2ZNHA 3DRMA 3NE4A 2OL2A 3Q03A 4AU2A 1OO8A 1ANTI 1DVMA 1SR5A 3OZQA 1E03I 5BRRI 1OYHL 1IMVA 1DZGL 2V95A 4X30A 2ANTI 2H4PA 4C41A 2ARRA 1JMOA 4YIAA 1OC0A 3F1SA 3CAAA 1ATUA 1HP7A 2XN7A 2HI9A 5CDXA 4ROBA 3F5NA 1EZXA 5EI0A 1B3KA 3NDDA 3EVJI 4ROAA 1D5SA 2WXXA 3T1PA 1AS4A 9APIA 1JMJA 1SEKA 1MTPA 4G8OA 1E05I 3Q02A 4DY0A 4CAAA 1C5GA 2PEFA 2WY0C 3LE2A 2PEEA 4EB1I 9PAIA 1BR8I 3R4LA 4AQHA 2QUGA 2ACHA 1QMNA 3PZFA 1LQ8A 1LK6I 1R1LI 2VDYA 5HGCA 4Y3KA 1NQ9I 3NDAA 4Y40A 1ATHA 4ZK3A 4RSQA 2WXYC 3KCGI 1A7CA 1UHGA 3VVJA 1OVAB 1JVQI 4P0OA 4IC0A 3UT3A 1TB6I 4R9IA 5IO1A 2B5TI 1LJ5A 1F0CA 3PB1I 1DB2A 4C49A 1OVAC 4EB1L 2H4RA 2RIVA 1OPHA 2H4QA 4AU3B 2WXZC 3STOA 7APIA 1M93B 4RO9A 4DY7C 2DUTA 1XU8A 1T1FA 4PYWA 3DLWA 2D26A 1ATTA 4AJTA 3CVMA 1XQJA 2R9YA 4IF8A 3FGQA 2BEHI 1DZHL 2RIWA 3H5CA 2WXWA 1BY7A 1C8OA 1DZHI 2VH4A 3B9FI 4P0FA 1JJOC 4AJUA 1DVNA 2CEOA 2XN5A 1AZXI 1JRRA 1OVAA 2XN3A 2XN6A 3LW2A 3DY0A 2OAYA 5CDZA 4KDSA 3DRUA 2WXZA 2HIJL 2B4XI 5INWA 2ARQA 1SNGA 2VDXA 1KCTA 4AU4A 2HIJI 1XQGA 4BB2A 4DTEA 4AU3A 2WY1A 1K9OI 1OYHI 2BEHL 1WZ9A 4G8RA 1DZGI 1HLEA 3CWLA
chains in the Genus database with same CATH topology
1JTIA 3EOXA 3ZHAA 5C98A 3F02A 1QMBA 5CE0A 1E04I 2GD4C 4AFXA 1PSIA 8APIA 3CWMA 4GA7A 1YXAA 4ZK0A 1QLPA 1IZ2A 2ZV6A 3NDFA 2B4XL 2ZNHA 3DRMA 3NE4A 2OL2A 3Q03A 4AU2A 1OO8A 1ANTI 1DVMA 1SR5A 3OZQA 1E03I 5BRRI 1OYHL 1IMVA 1DZGL 2V95A 4X30A 2ANTI 2H4PA 4C41A 2ARRA 1JMOA 4YIAA 1OC0A 3F1SA 3CAAA 1ATUA 1HP7A 2XN7A 2HI9A 5CDXA 4ROBA 3F5NA 1EZXA 5EI0A 1B3KA 3NDDA 3EVJI 4ROAA 1D5SA 2WXXA 3T1PA 1AS4A 9APIA 1JMJA 1SEKA 1MTPA 4G8OA 1E05I 3Q02A 4DY0A 4CAAA 1C5GA 2PEFA 2WY0C 3LE2A 2PEEA 4EB1I 9PAIA 1BR8I 3R4LA 4AQHA 2QUGA 2ACHA 1QMNA 3PZFA 1LQ8A 1LK6I 1R1LI 2VDYA 5HGCA 4Y3KA 1NQ9I 3NDAA 4Y40A 1ATHA 4ZK3A 4RSQA 2WXYC 3KCGI 1A7CA 1UHGA 3VVJA 1OVAB 1JVQI 4P0OA 4IC0A 3UT3A 1TB6I 4R9IA 5IO1A 2B5TI 1LJ5A 1F0CA 3PB1I 1DB2A 4C49A 1OVAC 4EB1L 2H4RA 2RIVA 1OPHA 2H4QA 4AU3B 2WXZC 3STOA 7APIA 1M93B 4RO9A 4DY7C 2DUTA 1XU8A 1T1FA 4PYWA 3DLWA 2D26A 1ATTA 4AJTA 3CVMA 1XQJA 2R9YA 4IF8A 3FGQA 2BEHI 1DZHL 2RIWA 3H5CA 2WXWA 1BY7A 1C8OA 1DZHI 2VH4A 3B9FI 4P0FA 1JJOC 4AJUA 1DVNA 2CEOA 2XN5A 1AZXI 1JRRA 1OVAA 2XN3A 2XN6A 3LW2A 3DY0A 2OAYA 5CDZA 4KDSA 3DRUA 2WXZA 2HIJL 2B4XI 5INWA 2ARQA 1SNGA 2VDXA 1KCTA 4AU4A 2HIJI 1XQGA 4BB2A 4DTEA 4AU3A 2WY1A 1K9OI 1OYHI 2BEHL 1WZ9A 4G8RA 1DZGI 1HLEA 3CWLA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1JTI A;  3EOX A;  3ZHA A;  5C98 A;  3F02 A;  1QMB A;  5CE0 A;  1E04 I;  2GD4 C;  4AFX A;  1PSI A;  8API A;  3CWM A;  4GA7 A;  1YXA A;  4ZK0 A;  1QLP A;  1IZ2 A;  2ZV6 A;  3NDF A;  2B4X L;  2ZNH A;  3DRM A;  3NE4 A;  2OL2 A;  3Q03 A;  4AU2 A;  1OO8 A;  1ANT I;  1DVM A;  1SR5 A;  3OZQ A;  1E03 I;  5BRR I;  1OYH L;  1IMV A;  1DZG L;  2V95 A;  4X30 A;  2ANT I;  2H4P A;  4C41 A;  2ARR A;  1JMO A;  4YIA A;  1OC0 A;  3F1S A;  3CAA A;  1ATU A;  1HP7 A;  2XN7 A;  2HI9 A;  5CDX A;  4ROB A;  3F5N A;  1EZX A;  5EI0 A;  1B3K A;  3NDD A;  3EVJ I;  4ROA A;  1D5S A;  2WXX A;  3T1P A;  1AS4 A;  9API A;  1JMJ A;  1SEK A;  1MTP A;  4G8O A;  1E05 I;  3Q02 A;  4DY0 A;  4CAA A;  1C5G A;  2PEF A;  2WY0 C;  3LE2 A;  2PEE A;  4EB1 I;  9PAI A;  1BR8 I;  3R4L A;  4AQH A;  2QUG A;  2ACH A;  1QMN A;  3PZF A;  1LQ8 A;  1LK6 I;  1R1L I;  2VDY A;  5HGC A;  4Y3K A;  1NQ9 I;  3NDA A;  4Y40 A;  1ATH A;  4ZK3 A;  4RSQ A;  2WXY C;  3KCG I;  1A7C A;  1UHG A;  3VVJ A;  1OVA B;  1JVQ I;  4P0O A;  4IC0 A;  3UT3 A;  1TB6 I;  4R9I A;  5IO1 A;  2B5T I;  1LJ5 A;  1F0C A;  3PB1 I;  1DB2 A;  4C49 A;  1OVA C;  4EB1 L;  2H4R A;  2RIV A;  1OPH A;  2H4Q A;  4AU3 B;  2WXZ C;  3STO A;  7API A;  1M93 B;  4RO9 A;  4DY7 C;  2DUT A;  1XU8 A;  1T1F A;  4PYW A;  3DLW A;  2D26 A;  1ATT A;  4AJT A;  3CVM A;  1XQJ A;  2R9Y A;  4IF8 A;  3FGQ A;  2BEH I;  1DZH L;  2RIW A;  3H5C A;  2WXW A;  1BY7 A;  1C8O A;  1DZH I;  2VH4 A;  3B9F I;  4P0F A;  1JJO C;  4AJU A;  1DVN A;  2CEO A;  2XN5 A;  1AZX I;  1JRR A;  1OVA A;  2XN3 A;  2XN6 A;  3LW2 A;  3DY0 A;  2OAY A;  5CDZ A;  4KDS A;  3DRU A;  2WXZ A;  2HIJ L;  2B4X I;  5INW A;  2ARQ A;  1SNG A;  2VDX A;  1KCT A;  4AU4 A;  2HIJ I;  1XQG A;  4BB2 A;  4DTE A;  4AU3 A;  2WY1 A;  1K9O I;  1OYH I;  2BEH L;  1WZ9 A;  4G8R A;  1DZG I;  1HLE A;  3CWL A; 
#chains in the Genus database with same CATH topology
 1JTI A;  3EOX A;  3ZHA A;  5C98 A;  3F02 A;  1QMB A;  5CE0 A;  1E04 I;  2GD4 C;  4AFX A;  1PSI A;  8API A;  3CWM A;  4GA7 A;  1YXA A;  4ZK0 A;  1QLP A;  1IZ2 A;  2ZV6 A;  3NDF A;  2B4X L;  2ZNH A;  3DRM A;  3NE4 A;  2OL2 A;  3Q03 A;  4AU2 A;  1OO8 A;  1ANT I;  1DVM A;  1SR5 A;  3OZQ A;  1E03 I;  5BRR I;  1OYH L;  1IMV A;  1DZG L;  2V95 A;  4X30 A;  2ANT I;  2H4P A;  4C41 A;  2ARR A;  1JMO A;  4YIA A;  1OC0 A;  3F1S A;  3CAA A;  1ATU A;  1HP7 A;  2XN7 A;  2HI9 A;  5CDX A;  4ROB A;  3F5N A;  1EZX A;  5EI0 A;  1B3K A;  3NDD A;  3EVJ I;  4ROA A;  1D5S A;  2WXX A;  3T1P A;  1AS4 A;  9API A;  1JMJ A;  1SEK A;  1MTP A;  4G8O A;  1E05 I;  3Q02 A;  4DY0 A;  4CAA A;  1C5G A;  2PEF A;  2WY0 C;  3LE2 A;  2PEE A;  4EB1 I;  9PAI A;  1BR8 I;  3R4L A;  4AQH A;  2QUG A;  2ACH A;  1QMN A;  3PZF A;  1LQ8 A;  1LK6 I;  1R1L I;  2VDY A;  5HGC A;  4Y3K A;  1NQ9 I;  3NDA A;  4Y40 A;  1ATH A;  4ZK3 A;  4RSQ A;  2WXY C;  3KCG I;  1A7C A;  1UHG A;  3VVJ A;  1OVA B;  1JVQ I;  4P0O A;  4IC0 A;  3UT3 A;  1TB6 I;  4R9I A;  5IO1 A;  2B5T I;  1LJ5 A;  1F0C A;  3PB1 I;  1DB2 A;  4C49 A;  1OVA C;  4EB1 L;  2H4R A;  2RIV A;  1OPH A;  2H4Q A;  4AU3 B;  2WXZ C;  3STO A;  7API A;  1M93 B;  4RO9 A;  4DY7 C;  2DUT A;  1XU8 A;  1T1F A;  4PYW A;  3DLW A;  2D26 A;  1ATT A;  4AJT A;  3CVM A;  1XQJ A;  2R9Y A;  4IF8 A;  3FGQ A;  2BEH I;  1DZH L;  2RIW A;  3H5C A;  2WXW A;  1BY7 A;  1C8O A;  1DZH I;  2VH4 A;  3B9F I;  4P0F A;  1JJO C;  4AJU A;  1DVN A;  2CEO A;  2XN5 A;  1AZX I;  1JRR A;  1OVA A;  2XN3 A;  2XN6 A;  3LW2 A;  3DY0 A;  2OAY A;  5CDZ A;  4KDS A;  3DRU A;  2WXZ A;  2HIJ L;  2B4X I;  5INW A;  2ARQ A;  1SNG A;  2VDX A;  1KCT A;  4AU4 A;  2HIJ I;  1XQG A;  4BB2 A;  4DTE A;  4AU3 A;  2WY1 A;  1K9O I;  1OYH I;  2BEH L;  1WZ9 A;  4G8R A;  1DZG I;  1HLE A;  3CWL A; 
#chains in the Genus database with same CATH homology
 1JTI A;  3EOX A;  3ZHA A;  5C98 A;  3F02 A;  1QMB A;  5CE0 A;  1E04 I;  2GD4 C;  4AFX A;  1PSI A;  8API A;  3CWM A;  4GA7 A;  1YXA A;  4ZK0 A;  1QLP A;  1IZ2 A;  2ZV6 A;  3NDF A;  2B4X L;  2ZNH A;  3DRM A;  3NE4 A;  2OL2 A;  3Q03 A;  4AU2 A;  1OO8 A;  1ANT I;  1DVM A;  1SR5 A;  3OZQ A;  1E03 I;  5BRR I;  1OYH L;  1IMV A;  1DZG L;  2V95 A;  4X30 A;  2ANT I;  2H4P A;  4C41 A;  2ARR A;  1JMO A;  4YIA A;  1OC0 A;  3F1S A;  3CAA A;  1ATU A;  1HP7 A;  2XN7 A;  2HI9 A;  5CDX A;  4ROB A;  3F5N A;  1EZX A;  5EI0 A;  1B3K A;  3NDD A;  3EVJ I;  4ROA A;  1D5S A;  2WXX A;  3T1P A;  1AS4 A;  9API A;  1JMJ A;  1SEK A;  1MTP A;  4G8O A;  1E05 I;  3Q02 A;  4DY0 A;  4CAA A;  1C5G A;  2PEF A;  2WY0 C;  3LE2 A;  2PEE A;  4EB1 I;  9PAI A;  1BR8 I;  3R4L A;  4AQH A;  2QUG A;  2ACH A;  1QMN A;  3PZF A;  1LQ8 A;  1LK6 I;  1R1L I;  2VDY A;  5HGC A;  4Y3K A;  1NQ9 I;  3NDA A;  4Y40 A;  1ATH A;  4ZK3 A;  4RSQ A;  2WXY C;  3KCG I;  1A7C A;  1UHG A;  3VVJ A;  1OVA B;  1JVQ I;  4P0O A;  4IC0 A;  3UT3 A;  1TB6 I;  4R9I A;  5IO1 A;  2B5T I;  1LJ5 A;  1F0C A;  3PB1 I;  1DB2 A;  4C49 A;  1OVA C;  4EB1 L;  2H4R A;  2RIV A;  1OPH A;  2H4Q A;  4AU3 B;  2WXZ C;  3STO A;  7API A;  1M93 B;  4RO9 A;  4DY7 C;  2DUT A;  1XU8 A;  1T1F A;  4PYW A;  3DLW A;  2D26 A;  1ATT A;  4AJT A;  3CVM A;  1XQJ A;  2R9Y A;  4IF8 A;  3FGQ A;  2BEH I;  1DZH L;  2RIW A;  3H5C A;  2WXW A;  1BY7 A;  1C8O A;  1DZH I;  2VH4 A;  3B9F I;  4P0F A;  1JJO C;  4AJU A;  1DVN A;  2CEO A;  2XN5 A;  1AZX I;  1JRR A;  1OVA A;  2XN3 A;  2XN6 A;  3LW2 A;  3DY0 A;  2OAY A;  5CDZ A;  4KDS A;  3DRU A;  2WXZ A;  2HIJ L;  2B4X I;  5INW A;  2ARQ A;  1SNG A;  2VDX A;  1KCT A;  4AU4 A;  2HIJ I;  1XQG A;  4BB2 A;  4DTE A;  4AU3 A;  2WY1 A;  1K9O I;  1OYH I;  2BEH L;  1WZ9 A;  4G8R A;  1DZG I;  1HLE A;  3CWL A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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