4X30A

Crystal structure of human thyroxine-binding globulin complexed with thyroine at 1.55 angstrom resolution
Total Genus 114
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
114
sequence length
378
structure length
372
Chain Sequence
ATLYKMSSINADFAFNLYRRFTVETPDKNIFFSPVSISAALVMLSFGACCSTQTEIVETLGFNLTDTPMVEIQHGFQHLICSLNFPKKELELQIGNALFIGKHLKPLAKFLNDVKTLYETEVFSTDFSNISAAKQEINSHVEMQTKGKVVGLIQDLKPNTIMVLVNYIHFKAQWANPFDPSKTEDSSSFLIDKTTTVQVPMMHQMEQYYHLVDMELNCTVLQMDYSKNALALFVLPKEGQMESVEAAMSSKTLKKWNRLLQKGWVDLFVPKFSISATYDLGATLLKMGIQHAYSENADFSGLTEDNGLKLSNAAHKAVLHIGEKGTEAAAVPEVELTFLHPIIQIDRSFMLLILERSTRSILFLGKVVNPTE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal structure of human Thyroxine-binding globulin complexed with thyroine at 1.55 Angstrom resolution
rcsb
molecule tags Transport protein
source organism Homo sapiens
molecule keywords Thyroxine-binding globulin
total genus 114
structure length 372
sequence length 378
ec nomenclature
pdb deposition date 2014-11-27

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00079 Serpin Serpin (serine protease inhibitor)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.30.39.10 Mainly Beta Roll Alpha-1-antitrypsin; domain 1 Alpha-1-antitrypsin, domain 1 4x30A02
3.30.497.10 Alpha Beta 2-Layer Sandwich Antithrombin; Chain I, domain 2 Antithrombin, subunit I, domain 2 4x30A01
3T1PA 1HLEA 1ATUA 1E04I 1KCTA 1DZGI 2ANTI 3OZQA 1OC0A 3CWMA 5CE0A 2XN7A 1T1FA 1EZXA 4IC0A 3F1SA 1QMBA 1YXAA 1DB2A 3CVMA 3LE2A 2H4QA 2HIJI 2PEFA 2RIVA 3DRMA 1JMOA 1JRRA 1NQ9I 3CAAA 3NDDA 2XN5A 2H4PA 3EOXA 3FGQA 3B9FI 2HIJL 3DY0A 5EI0A 4AU3A 4GA7A 4AQHA 2RIWA 4EB1I 4AU2A 1TB6I 1ATTA 1OYHI 2B4XL 1C5GA 1BR8I 1WZ9A 1JTIA 1K9OI 2WY0C 2H4RA 8APIA 3F5NA 9PAIA 4ZK0A 1OYHL 4P0OA 4C41A 3LW2A 2ZNHA 1LQ8A 4ROBA 4ZK3A 2GD4C 3CWLA 5INWA 4DY7C 1DZGL 4ROAA 1OVAA 4DTEA 5CDZA 5IO1A 1PSIA 3VVJA 3DRUA 3PZFA 4DY0A 2B5TI 4C49A 2D26A 1E05I 5HGCA 4Y3KA 4IF8A 1ANTI 1SEKA 2QUGA 1B3KA 2WXZA 4AU3B 2WXYC 3EVJI 1HP7A 1JJOC 2WXWA 2VDYA 4G8RA 4EB1L 3STOA 1DZHI 1M93B 2BEHI 2XN3A 2VH4A 1LK6I 1SR5A 1UHGA 4RO9A 1XQGA 2R9YA 2WXXA 4Y40A 1DZHL 2ARQA 2BEHL 4RSQA 4AJUA 5CDXA 2ARRA 1DVNA 3NDAA 1OVAB 1DVMA 4G8OA 3NDFA 1F0CA 1OO8A 3KCGI 2ACHA 2DUTA 7APIA 1AS4A 4AJTA 3Q03A 3H5CA 3Q02A 3ZHAA 1E03I 9APIA 4PYWA 1XU8A 1OVAC 3UT3A 1C8OA 3DLWA 3R4LA 1IZ2A 4AFXA 5BRRI 2PEEA 2HI9A 4BB2A 1XQJA 1D5SA 1SNGA 1LJ5A 2V95A 1OPHA 3PB1I 4AU4A 4X30A 1BY7A 3F02A 1AZXI 2WXZC 2WY1A 4R9IA 1QMNA 1IMVA 2B4XI 1JMJA 2ZV6A 1MTPA 4CAAA 4P0FA 3NE4A 1JVQI 5C98A 1R1LI 2OAYA 2VDXA 1ATHA 2CEOA 4KDSA 1A7CA 2XN6A 1QLPA 4YIAA 2OL2A
chains in the Genus database with same CATH superfamily
3T1PA 1HLEA 1ATUA 1E04I 1KCTA 1DZGI 2ANTI 3OZQA 1OC0A 3CWMA 5CE0A 2XN7A 1T1FA 1EZXA 4IC0A 3F1SA 1QMBA 1YXAA 1DB2A 3CVMA 3LE2A 2H4QA 2HIJI 2PEFA 2RIVA 3DRMA 1JMOA 1JRRA 1NQ9I 3CAAA 3NDDA 2XN5A 2H4PA 3EOXA 3FGQA 3B9FI 2HIJL 3DY0A 5EI0A 4AU3A 4GA7A 4AQHA 2RIWA 4EB1I 4AU2A 1TB6I 1ATTA 1OYHI 2B4XL 1C5GA 1BR8I 1WZ9A 1JTIA 1K9OI 2WY0C 2H4RA 8APIA 3F5NA 9PAIA 4ZK0A 1OYHL 4P0OA 4C41A 3LW2A 2ZNHA 1LQ8A 4ROBA 4ZK3A 2GD4C 3CWLA 5INWA 4DY7C 1DZGL 4ROAA 1OVAA 4DTEA 5CDZA 5IO1A 1PSIA 3VVJA 3DRUA 3PZFA 4DY0A 2B5TI 4C49A 2D26A 1E05I 5HGCA 4Y3KA 4IF8A 1ANTI 1SEKA 2QUGA 1B3KA 2WXZA 4AU3B 2WXYC 3EVJI 1HP7A 1JJOC 2WXWA 2VDYA 4G8RA 4EB1L 3STOA 1DZHI 1M93B 2BEHI 2XN3A 2VH4A 1LK6I 1SR5A 1UHGA 4RO9A 1XQGA 2R9YA 2WXXA 4Y40A 1DZHL 2ARQA 2BEHL 4RSQA 4AJUA 5CDXA 2ARRA 1DVNA 3NDAA 1OVAB 1DVMA 4G8OA 3NDFA 1F0CA 1OO8A 3KCGI 2ACHA 2DUTA 7APIA 1AS4A 4AJTA 3Q03A 3H5CA 3Q02A 3ZHAA 1E03I 9APIA 4PYWA 1XU8A 1OVAC 3UT3A 1C8OA 3DLWA 3R4LA 1IZ2A 4AFXA 5BRRI 2PEEA 2HI9A 4BB2A 1XQJA 1D5SA 1SNGA 1LJ5A 2V95A 1OPHA 3PB1I 4AU4A 4X30A 1BY7A 3F02A 1AZXI 2WXZC 2WY1A 4R9IA 1QMNA 1IMVA 2B4XI 1JMJA 2ZV6A 1MTPA 4CAAA 4P0FA 3NE4A 1JVQI 5C98A 1R1LI 2OAYA 2VDXA 1ATHA 2CEOA 4KDSA 1A7CA 2XN6A 1QLPA 4YIAA 2OL2A
chains in the Genus database with same CATH topology
3T1PA 1HLEA 1ATUA 1E04I 1KCTA 1DZGI 2ANTI 3OZQA 1OC0A 3CWMA 5CE0A 2XN7A 1T1FA 1EZXA 4IC0A 3F1SA 1QMBA 1YXAA 1DB2A 3CVMA 3LE2A 2H4QA 2HIJI 2PEFA 2RIVA 3DRMA 1JMOA 1JRRA 1NQ9I 3CAAA 3NDDA 2XN5A 2H4PA 3EOXA 3FGQA 3B9FI 2HIJL 3DY0A 5EI0A 4AU3A 4GA7A 4AQHA 2RIWA 4EB1I 4AU2A 1TB6I 1ATTA 1OYHI 2B4XL 1C5GA 1BR8I 1WZ9A 1JTIA 1K9OI 2WY0C 2H4RA 8APIA 3F5NA 9PAIA 4ZK0A 1OYHL 4P0OA 4C41A 3LW2A 2ZNHA 1LQ8A 4ROBA 4ZK3A 2GD4C 3CWLA 5INWA 4DY7C 1DZGL 4ROAA 1OVAA 4DTEA 5CDZA 5IO1A 1PSIA 3VVJA 3DRUA 3PZFA 4DY0A 2B5TI 4C49A 2D26A 1E05I 5HGCA 4Y3KA 4IF8A 1ANTI 1SEKA 2QUGA 1B3KA 2WXZA 4AU3B 2WXYC 3EVJI 1HP7A 1JJOC 2WXWA 2VDYA 4G8RA 4EB1L 3STOA 1DZHI 1M93B 2BEHI 2XN3A 2VH4A 1LK6I 1SR5A 1UHGA 4RO9A 1XQGA 2R9YA 2WXXA 4Y40A 1DZHL 2ARQA 2BEHL 4RSQA 4AJUA 5CDXA 2ARRA 1DVNA 3NDAA 1OVAB 1DVMA 4G8OA 3NDFA 1F0CA 1OO8A 3KCGI 2ACHA 2DUTA 7APIA 1AS4A 4AJTA 3Q03A 3H5CA 3Q02A 3ZHAA 1E03I 9APIA 4PYWA 1XU8A 1OVAC 3UT3A 1C8OA 3DLWA 3R4LA 1IZ2A 4AFXA 5BRRI 2PEEA 2HI9A 4BB2A 1XQJA 1D5SA 1SNGA 1LJ5A 2V95A 1OPHA 3PB1I 4AU4A 4X30A 1BY7A 3F02A 1AZXI 2WXZC 2WY1A 4R9IA 1QMNA 1IMVA 2B4XI 1JMJA 2ZV6A 1MTPA 4CAAA 4P0FA 3NE4A 1JVQI 5C98A 1R1LI 2OAYA 2VDXA 1ATHA 2CEOA 4KDSA 1A7CA 2XN6A 1QLPA 4YIAA 2OL2A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3T1P A;  1HLE A;  1ATU A;  1E04 I;  1KCT A;  1DZG I;  2ANT I;  3OZQ A;  1OC0 A;  3CWM A;  5CE0 A;  2XN7 A;  1T1F A;  1EZX A;  4IC0 A;  3F1S A;  1QMB A;  1YXA A;  1DB2 A;  3CVM A;  3LE2 A;  2H4Q A;  2HIJ I;  2PEF A;  2RIV A;  3DRM A;  1JMO A;  1JRR A;  1NQ9 I;  3CAA A;  3NDD A;  2XN5 A;  2H4P A;  3EOX A;  3FGQ A;  3B9F I;  2HIJ L;  3DY0 A;  5EI0 A;  4AU3 A;  4GA7 A;  4AQH A;  2RIW A;  4EB1 I;  4AU2 A;  1TB6 I;  1ATT A;  1OYH I;  2B4X L;  1C5G A;  1BR8 I;  1WZ9 A;  1JTI A;  1K9O I;  2WY0 C;  2H4R A;  8API A;  3F5N A;  9PAI A;  4ZK0 A;  1OYH L;  4P0O A;  4C41 A;  3LW2 A;  2ZNH A;  1LQ8 A;  4ROB A;  4ZK3 A;  2GD4 C;  3CWL A;  5INW A;  4DY7 C;  1DZG L;  4ROA A;  1OVA A;  4DTE A;  5CDZ A;  5IO1 A;  1PSI A;  3VVJ A;  3DRU A;  3PZF A;  4DY0 A;  2B5T I;  4C49 A;  2D26 A;  1E05 I;  5HGC A;  4Y3K A;  4IF8 A;  1ANT I;  1SEK A;  2QUG A;  1B3K A;  2WXZ A;  4AU3 B;  2WXY C;  3EVJ I;  1HP7 A;  1JJO C;  2WXW A;  2VDY A;  4G8R A;  4EB1 L;  3STO A;  1DZH I;  1M93 B;  2BEH I;  2XN3 A;  2VH4 A;  1LK6 I;  1SR5 A;  1UHG A;  4RO9 A;  1XQG A;  2R9Y A;  2WXX A;  4Y40 A;  1DZH L;  2ARQ A;  2BEH L;  4RSQ A;  4AJU A;  5CDX A;  2ARR A;  1DVN A;  3NDA A;  1OVA B;  1DVM A;  4G8O A;  3NDF A;  1F0C A;  1OO8 A;  3KCG I;  2ACH A;  2DUT A;  7API A;  1AS4 A;  4AJT A;  3Q03 A;  3H5C A;  3Q02 A;  3ZHA A;  1E03 I;  9API A;  4PYW A;  1XU8 A;  1OVA C;  3UT3 A;  1C8O A;  3DLW A;  3R4L A;  1IZ2 A;  4AFX A;  5BRR I;  2PEE A;  2HI9 A;  4BB2 A;  1XQJ A;  1D5S A;  1SNG A;  1LJ5 A;  2V95 A;  1OPH A;  3PB1 I;  4AU4 A;  4X30 A;  1BY7 A;  3F02 A;  1AZX I;  2WXZ C;  2WY1 A;  4R9I A;  1QMN A;  1IMV A;  2B4X I;  1JMJ A;  2ZV6 A;  1MTP A;  4CAA A;  4P0F A;  3NE4 A;  1JVQ I;  5C98 A;  1R1L I;  2OAY A;  2VDX A;  1ATH A;  2CEO A;  4KDS A;  1A7C A;  2XN6 A;  1QLP A;  4YIA A;  2OL2 A; 
#chains in the Genus database with same CATH topology
 3T1P A;  1HLE A;  1ATU A;  1E04 I;  1KCT A;  1DZG I;  2ANT I;  3OZQ A;  1OC0 A;  3CWM A;  5CE0 A;  2XN7 A;  1T1F A;  1EZX A;  4IC0 A;  3F1S A;  1QMB A;  1YXA A;  1DB2 A;  3CVM A;  3LE2 A;  2H4Q A;  2HIJ I;  2PEF A;  2RIV A;  3DRM A;  1JMO A;  1JRR A;  1NQ9 I;  3CAA A;  3NDD A;  2XN5 A;  2H4P A;  3EOX A;  3FGQ A;  3B9F I;  2HIJ L;  3DY0 A;  5EI0 A;  4AU3 A;  4GA7 A;  4AQH A;  2RIW A;  4EB1 I;  4AU2 A;  1TB6 I;  1ATT A;  1OYH I;  2B4X L;  1C5G A;  1BR8 I;  1WZ9 A;  1JTI A;  1K9O I;  2WY0 C;  2H4R A;  8API A;  3F5N A;  9PAI A;  4ZK0 A;  1OYH L;  4P0O A;  4C41 A;  3LW2 A;  2ZNH A;  1LQ8 A;  4ROB A;  4ZK3 A;  2GD4 C;  3CWL A;  5INW A;  4DY7 C;  1DZG L;  4ROA A;  1OVA A;  4DTE A;  5CDZ A;  5IO1 A;  1PSI A;  3VVJ A;  3DRU A;  3PZF A;  4DY0 A;  2B5T I;  4C49 A;  2D26 A;  1E05 I;  5HGC A;  4Y3K A;  4IF8 A;  1ANT I;  1SEK A;  2QUG A;  1B3K A;  2WXZ A;  4AU3 B;  2WXY C;  3EVJ I;  1HP7 A;  1JJO C;  2WXW A;  2VDY A;  4G8R A;  4EB1 L;  3STO A;  1DZH I;  1M93 B;  2BEH I;  2XN3 A;  2VH4 A;  1LK6 I;  1SR5 A;  1UHG A;  4RO9 A;  1XQG A;  2R9Y A;  2WXX A;  4Y40 A;  1DZH L;  2ARQ A;  2BEH L;  4RSQ A;  4AJU A;  5CDX A;  2ARR A;  1DVN A;  3NDA A;  1OVA B;  1DVM A;  4G8O A;  3NDF A;  1F0C A;  1OO8 A;  3KCG I;  2ACH A;  2DUT A;  7API A;  1AS4 A;  4AJT A;  3Q03 A;  3H5C A;  3Q02 A;  3ZHA A;  1E03 I;  9API A;  4PYW A;  1XU8 A;  1OVA C;  3UT3 A;  1C8O A;  3DLW A;  3R4L A;  1IZ2 A;  4AFX A;  5BRR I;  2PEE A;  2HI9 A;  4BB2 A;  1XQJ A;  1D5S A;  1SNG A;  1LJ5 A;  2V95 A;  1OPH A;  3PB1 I;  4AU4 A;  4X30 A;  1BY7 A;  3F02 A;  1AZX I;  2WXZ C;  2WY1 A;  4R9I A;  1QMN A;  1IMV A;  2B4X I;  1JMJ A;  2ZV6 A;  1MTP A;  4CAA A;  4P0F A;  3NE4 A;  1JVQ I;  5C98 A;  1R1L I;  2OAY A;  2VDX A;  1ATH A;  2CEO A;  4KDS A;  1A7C A;  2XN6 A;  1QLP A;  4YIA A;  2OL2 A; 
#chains in the Genus database with same CATH homology
 3T1P A;  1HLE A;  1ATU A;  1E04 I;  1KCT A;  1DZG I;  2ANT I;  3OZQ A;  1OC0 A;  3CWM A;  5CE0 A;  2XN7 A;  1T1F A;  1EZX A;  4IC0 A;  3F1S A;  1QMB A;  1YXA A;  1DB2 A;  3CVM A;  3LE2 A;  2H4Q A;  2HIJ I;  2PEF A;  2RIV A;  3DRM A;  1JMO A;  1JRR A;  1NQ9 I;  3CAA A;  3NDD A;  2XN5 A;  2H4P A;  3EOX A;  3FGQ A;  3B9F I;  2HIJ L;  3DY0 A;  5EI0 A;  4AU3 A;  4GA7 A;  4AQH A;  2RIW A;  4EB1 I;  4AU2 A;  1TB6 I;  1ATT A;  1OYH I;  2B4X L;  1C5G A;  1BR8 I;  1WZ9 A;  1JTI A;  1K9O I;  2WY0 C;  2H4R A;  8API A;  3F5N A;  9PAI A;  4ZK0 A;  1OYH L;  4P0O A;  4C41 A;  3LW2 A;  2ZNH A;  1LQ8 A;  4ROB A;  4ZK3 A;  2GD4 C;  3CWL A;  5INW A;  4DY7 C;  1DZG L;  4ROA A;  1OVA A;  4DTE A;  5CDZ A;  5IO1 A;  1PSI A;  3VVJ A;  3DRU A;  3PZF A;  4DY0 A;  2B5T I;  4C49 A;  2D26 A;  1E05 I;  5HGC A;  4Y3K A;  4IF8 A;  1ANT I;  1SEK A;  2QUG A;  1B3K A;  2WXZ A;  4AU3 B;  2WXY C;  3EVJ I;  1HP7 A;  1JJO C;  2WXW A;  2VDY A;  4G8R A;  4EB1 L;  3STO A;  1DZH I;  1M93 B;  2BEH I;  2XN3 A;  2VH4 A;  1LK6 I;  1SR5 A;  1UHG A;  4RO9 A;  1XQG A;  2R9Y A;  2WXX A;  4Y40 A;  1DZH L;  2ARQ A;  2BEH L;  4RSQ A;  4AJU A;  5CDX A;  2ARR A;  1DVN A;  3NDA A;  1OVA B;  1DVM A;  4G8O A;  3NDF A;  1F0C A;  1OO8 A;  3KCG I;  2ACH A;  2DUT A;  7API A;  1AS4 A;  4AJT A;  3Q03 A;  3H5C A;  3Q02 A;  3ZHA A;  1E03 I;  9API A;  4PYW A;  1XU8 A;  1OVA C;  3UT3 A;  1C8O A;  3DLW A;  3R4L A;  1IZ2 A;  4AFX A;  5BRR I;  2PEE A;  2HI9 A;  4BB2 A;  1XQJ A;  1D5S A;  1SNG A;  1LJ5 A;  2V95 A;  1OPH A;  3PB1 I;  4AU4 A;  4X30 A;  1BY7 A;  3F02 A;  1AZX I;  2WXZ C;  2WY1 A;  4R9I A;  1QMN A;  1IMV A;  2B4X I;  1JMJ A;  2ZV6 A;  1MTP A;  4CAA A;  4P0F A;  3NE4 A;  1JVQ I;  5C98 A;  1R1L I;  2OAY A;  2VDX A;  1ATH A;  2CEO A;  4KDS A;  1A7C A;  2XN6 A;  1QLP A;  4YIA A;  2OL2 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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