4X30A

Crystal structure of human thyroxine-binding globulin complexed with thyroine at 1.55 angstrom resolution
Total Genus 114
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
114
sequence length
378
structure length
372
Chain Sequence
ATLYKMSSINADFAFNLYRRFTVETPDKNIFFSPVSISAALVMLSFGACCSTQTEIVETLGFNLTDTPMVEIQHGFQHLICSLNFPKKELELQIGNALFIGKHLKPLAKFLNDVKTLYETEVFSTDFSNISAAKQEINSHVEMQTKGKVVGLIQDLKPNTIMVLVNYIHFKAQWANPFDPSKTEDSSSFLIDKTTTVQVPMMHQMEQYYHLVDMELNCTVLQMDYSKNALALFVLPKEGQMESVEAAMSSKTLKKWNRLLQKGWVDLFVPKFSISATYDLGATLLKMGIQHAYSENADFSGLTEDNGLKLSNAAHKAVLHIGEKGTEAAAVPEVELTFLHPIIQIDRSFMLLILERSTRSILFLGKVVNPTE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Transport protein
molecule keywords Thyroxine-binding globulin
publication title Crystal structure of human Thyroxine-binding globulin complexed with thyroine at 1.55 Angstrom resolution
rcsb
source organism Homo sapiens
total genus 114
structure length 372
sequence length 378
ec nomenclature
pdb deposition date 2014-11-27

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00079 Serpin Serpin (serine protease inhibitor)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.30.39.10 Mainly Beta Roll Alpha-1-antitrypsin; domain 1 Alpha-1-antitrypsin, domain 1 4x30A02
3.30.497.10 Alpha Beta 2-Layer Sandwich Antithrombin; Chain I, domain 2 Antithrombin, subunit I, domain 2 4x30A01
3PB1I 3Q02A 4IC0A 4X30A 2HIJI 4AJTA 1AS4A 1OVAC 2ZNHA 1LJ5A 5HGCA 1DB2A 4AU3A 1OVAB 1DZHL 2WXYC 1E03I 1HP7A 1KCTA 1NQ9I 3B9FI 1AZXI 1C8OA 2XN6A 1YXAA 2B5TI 3ZHAA 5EI0A 1UHGA 3DRMA 1IMVA 1B3KA 1A7CA 3CWLA 1XQJA 3F1SA 4YIAA 1LK6I 5CDXA 3OZQA 2CEOA 3FGQA 8APIA 5IO1A 3LE2A 2ARQA 5CE0A 4AU4A 1M93B 2B4XL 1R1LI 2ZV6A 3KCGI 1F0CA 4G8RA 3CWMA 2BEHL 3R4LA 1ANTI 1DZGL 2QUGA 4AQHA 4DTEA 4DY7C 1PSIA 2ARRA 2OL2A 2BEHI 2VDYA 2WXZA 3H5CA 3NDDA 2VDXA 1DZGI 1JJOC 5BRRI 5C98A 3DLWA 1OPHA 1DZHI 4AU2A 1JMJA 2OAYA 2WXZC 4PYWA 2H4RA 2WY1A 1E04I 3DY0A 1D5SA 4R9IA 3PZFA 2D26A 4ZK3A 4KDSA 1BY7A 3CAAA 1IZ2A 1ATUA 1DVMA 4C49A 1WZ9A 1E05I 2PEFA 1JRRA 2H4QA 1OYHL 3NDAA 4ROBA 1OO8A 2B4XI 1SEKA 2GD4C 4RO9A 2WXWA 3NDFA 4Y3KA 3DRUA 2V95A 3F02A 1SNGA 1OYHI 1C5GA 3VVJA 4IF8A 4AJUA 3Q03A 1ATTA 9APIA 4C41A 1XU8A 5CDZA 4CAAA 1JMOA 2WXXA 4AFXA 2HI9A 3STOA 1QMBA 1TB6I 3LW2A 3EOXA 1BR8I 2HIJL 4Y40A 2PEEA 2DUTA 1K9OI 2XN7A 1JVQI 1ATHA 2ANTI 2VH4A 3CVMA 4P0FA 2XN5A 1EZXA 2RIWA 1LQ8A 3F5NA 4ZK0A 2R9YA 4GA7A 1SR5A 3EVJI 1OC0A 1XQGA 4RSQA 4EB1L 7APIA 4AU3B 4G8OA 3T1PA 2RIVA 3NE4A 2XN3A 1JTIA 2H4PA 2WY0C 4P0OA 5INWA 4EB1I 4BB2A 3UT3A 1MTPA 1QMNA 1T1FA 4ROAA 2ACHA 9PAIA 1OVAA 1HLEA 1DVNA 4DY0A 1QLPA
chains in the Genus database with same CATH superfamily
3PB1I 3Q02A 4IC0A 4X30A 2HIJI 4AJTA 1AS4A 1OVAC 2ZNHA 1LJ5A 5HGCA 1DB2A 4AU3A 1OVAB 1DZHL 2WXYC 1E03I 1HP7A 1KCTA 1NQ9I 3B9FI 1AZXI 1C8OA 2XN6A 1YXAA 2B5TI 3ZHAA 5EI0A 1UHGA 3DRMA 1IMVA 1B3KA 1A7CA 3CWLA 1XQJA 3F1SA 4YIAA 1LK6I 5CDXA 3OZQA 2CEOA 3FGQA 8APIA 5IO1A 3LE2A 2ARQA 5CE0A 4AU4A 1M93B 2B4XL 1R1LI 2ZV6A 3KCGI 1F0CA 4G8RA 3CWMA 2BEHL 3R4LA 1ANTI 1DZGL 2QUGA 4AQHA 4DTEA 4DY7C 1PSIA 2ARRA 2OL2A 2BEHI 2VDYA 2WXZA 3H5CA 3NDDA 2VDXA 1DZGI 1JJOC 5BRRI 5C98A 3DLWA 1OPHA 1DZHI 4AU2A 1JMJA 2OAYA 2WXZC 4PYWA 2H4RA 2WY1A 1E04I 3DY0A 1D5SA 4R9IA 3PZFA 2D26A 4ZK3A 4KDSA 1BY7A 3CAAA 1IZ2A 1ATUA 1DVMA 4C49A 1WZ9A 1E05I 2PEFA 1JRRA 2H4QA 1OYHL 3NDAA 4ROBA 1OO8A 2B4XI 1SEKA 2GD4C 4RO9A 2WXWA 3NDFA 4Y3KA 3DRUA 2V95A 3F02A 1SNGA 1OYHI 1C5GA 3VVJA 4IF8A 4AJUA 3Q03A 1ATTA 9APIA 4C41A 1XU8A 5CDZA 4CAAA 1JMOA 2WXXA 4AFXA 2HI9A 3STOA 1QMBA 1TB6I 3LW2A 3EOXA 1BR8I 2HIJL 4Y40A 2PEEA 2DUTA 1K9OI 2XN7A 1JVQI 1ATHA 2ANTI 2VH4A 3CVMA 4P0FA 2XN5A 1EZXA 2RIWA 1LQ8A 3F5NA 4ZK0A 2R9YA 4GA7A 1SR5A 3EVJI 1OC0A 1XQGA 4RSQA 4EB1L 7APIA 4AU3B 4G8OA 3T1PA 2RIVA 3NE4A 2XN3A 1JTIA 2H4PA 2WY0C 4P0OA 5INWA 4EB1I 4BB2A 3UT3A 1MTPA 1QMNA 1T1FA 4ROAA 2ACHA 9PAIA 1OVAA 1HLEA 1DVNA 4DY0A 1QLPA
chains in the Genus database with same CATH topology
3PB1I 3Q02A 4IC0A 4X30A 2HIJI 4AJTA 1AS4A 1OVAC 2ZNHA 1LJ5A 5HGCA 1DB2A 4AU3A 1OVAB 1DZHL 2WXYC 1E03I 1HP7A 1KCTA 1NQ9I 3B9FI 1AZXI 1C8OA 2XN6A 1YXAA 2B5TI 3ZHAA 5EI0A 1UHGA 3DRMA 1IMVA 1B3KA 1A7CA 3CWLA 1XQJA 3F1SA 4YIAA 1LK6I 5CDXA 3OZQA 2CEOA 3FGQA 8APIA 5IO1A 3LE2A 2ARQA 5CE0A 4AU4A 1M93B 2B4XL 1R1LI 2ZV6A 3KCGI 1F0CA 4G8RA 3CWMA 2BEHL 3R4LA 1ANTI 1DZGL 2QUGA 4AQHA 4DTEA 4DY7C 1PSIA 2ARRA 2OL2A 2BEHI 2VDYA 2WXZA 3H5CA 3NDDA 2VDXA 1DZGI 1JJOC 5BRRI 5C98A 3DLWA 1OPHA 1DZHI 4AU2A 1JMJA 2OAYA 2WXZC 4PYWA 2H4RA 2WY1A 1E04I 3DY0A 1D5SA 4R9IA 3PZFA 2D26A 4ZK3A 4KDSA 1BY7A 3CAAA 1IZ2A 1ATUA 1DVMA 4C49A 1WZ9A 1E05I 2PEFA 1JRRA 2H4QA 1OYHL 3NDAA 4ROBA 1OO8A 2B4XI 1SEKA 2GD4C 4RO9A 2WXWA 3NDFA 4Y3KA 3DRUA 2V95A 3F02A 1SNGA 1OYHI 1C5GA 3VVJA 4IF8A 4AJUA 3Q03A 1ATTA 9APIA 4C41A 1XU8A 5CDZA 4CAAA 1JMOA 2WXXA 4AFXA 2HI9A 3STOA 1QMBA 1TB6I 3LW2A 3EOXA 1BR8I 2HIJL 4Y40A 2PEEA 2DUTA 1K9OI 2XN7A 1JVQI 1ATHA 2ANTI 2VH4A 3CVMA 4P0FA 2XN5A 1EZXA 2RIWA 1LQ8A 3F5NA 4ZK0A 2R9YA 4GA7A 1SR5A 3EVJI 1OC0A 1XQGA 4RSQA 4EB1L 7APIA 4AU3B 4G8OA 3T1PA 2RIVA 3NE4A 2XN3A 1JTIA 2H4PA 2WY0C 4P0OA 5INWA 4EB1I 4BB2A 3UT3A 1MTPA 1QMNA 1T1FA 4ROAA 2ACHA 9PAIA 1OVAA 1HLEA 1DVNA 4DY0A 1QLPA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3PB1 I;  3Q02 A;  4IC0 A;  4X30 A;  2HIJ I;  4AJT A;  1AS4 A;  1OVA C;  2ZNH A;  1LJ5 A;  5HGC A;  1DB2 A;  4AU3 A;  1OVA B;  1DZH L;  2WXY C;  1E03 I;  1HP7 A;  1KCT A;  1NQ9 I;  3B9F I;  1AZX I;  1C8O A;  2XN6 A;  1YXA A;  2B5T I;  3ZHA A;  5EI0 A;  1UHG A;  3DRM A;  1IMV A;  1B3K A;  1A7C A;  3CWL A;  1XQJ A;  3F1S A;  4YIA A;  1LK6 I;  5CDX A;  3OZQ A;  2CEO A;  3FGQ A;  8API A;  5IO1 A;  3LE2 A;  2ARQ A;  5CE0 A;  4AU4 A;  1M93 B;  2B4X L;  1R1L I;  2ZV6 A;  3KCG I;  1F0C A;  4G8R A;  3CWM A;  2BEH L;  3R4L A;  1ANT I;  1DZG L;  2QUG A;  4AQH A;  4DTE A;  4DY7 C;  1PSI A;  2ARR A;  2OL2 A;  2BEH I;  2VDY A;  2WXZ A;  3H5C A;  3NDD A;  2VDX A;  1DZG I;  1JJO C;  5BRR I;  5C98 A;  3DLW A;  1OPH A;  1DZH I;  4AU2 A;  1JMJ A;  2OAY A;  2WXZ C;  4PYW A;  2H4R A;  2WY1 A;  1E04 I;  3DY0 A;  1D5S A;  4R9I A;  3PZF A;  2D26 A;  4ZK3 A;  4KDS A;  1BY7 A;  3CAA A;  1IZ2 A;  1ATU A;  1DVM A;  4C49 A;  1WZ9 A;  1E05 I;  2PEF A;  1JRR A;  2H4Q A;  1OYH L;  3NDA A;  4ROB A;  1OO8 A;  2B4X I;  1SEK A;  2GD4 C;  4RO9 A;  2WXW A;  3NDF A;  4Y3K A;  3DRU A;  2V95 A;  3F02 A;  1SNG A;  1OYH I;  1C5G A;  3VVJ A;  4IF8 A;  4AJU A;  3Q03 A;  1ATT A;  9API A;  4C41 A;  1XU8 A;  5CDZ A;  4CAA A;  1JMO A;  2WXX A;  4AFX A;  2HI9 A;  3STO A;  1QMB A;  1TB6 I;  3LW2 A;  3EOX A;  1BR8 I;  2HIJ L;  4Y40 A;  2PEE A;  2DUT A;  1K9O I;  2XN7 A;  1JVQ I;  1ATH A;  2ANT I;  2VH4 A;  3CVM A;  4P0F A;  2XN5 A;  1EZX A;  2RIW A;  1LQ8 A;  3F5N A;  4ZK0 A;  2R9Y A;  4GA7 A;  1SR5 A;  3EVJ I;  1OC0 A;  1XQG A;  4RSQ A;  4EB1 L;  7API A;  4AU3 B;  4G8O A;  3T1P A;  2RIV A;  3NE4 A;  2XN3 A;  1JTI A;  2H4P A;  2WY0 C;  4P0O A;  5INW A;  4EB1 I;  4BB2 A;  3UT3 A;  1MTP A;  1QMN A;  1T1F A;  4ROA A;  2ACH A;  9PAI A;  1OVA A;  1HLE A;  1DVN A;  4DY0 A;  1QLP A; 
#chains in the Genus database with same CATH topology
 3PB1 I;  3Q02 A;  4IC0 A;  4X30 A;  2HIJ I;  4AJT A;  1AS4 A;  1OVA C;  2ZNH A;  1LJ5 A;  5HGC A;  1DB2 A;  4AU3 A;  1OVA B;  1DZH L;  2WXY C;  1E03 I;  1HP7 A;  1KCT A;  1NQ9 I;  3B9F I;  1AZX I;  1C8O A;  2XN6 A;  1YXA A;  2B5T I;  3ZHA A;  5EI0 A;  1UHG A;  3DRM A;  1IMV A;  1B3K A;  1A7C A;  3CWL A;  1XQJ A;  3F1S A;  4YIA A;  1LK6 I;  5CDX A;  3OZQ A;  2CEO A;  3FGQ A;  8API A;  5IO1 A;  3LE2 A;  2ARQ A;  5CE0 A;  4AU4 A;  1M93 B;  2B4X L;  1R1L I;  2ZV6 A;  3KCG I;  1F0C A;  4G8R A;  3CWM A;  2BEH L;  3R4L A;  1ANT I;  1DZG L;  2QUG A;  4AQH A;  4DTE A;  4DY7 C;  1PSI A;  2ARR A;  2OL2 A;  2BEH I;  2VDY A;  2WXZ A;  3H5C A;  3NDD A;  2VDX A;  1DZG I;  1JJO C;  5BRR I;  5C98 A;  3DLW A;  1OPH A;  1DZH I;  4AU2 A;  1JMJ A;  2OAY A;  2WXZ C;  4PYW A;  2H4R A;  2WY1 A;  1E04 I;  3DY0 A;  1D5S A;  4R9I A;  3PZF A;  2D26 A;  4ZK3 A;  4KDS A;  1BY7 A;  3CAA A;  1IZ2 A;  1ATU A;  1DVM A;  4C49 A;  1WZ9 A;  1E05 I;  2PEF A;  1JRR A;  2H4Q A;  1OYH L;  3NDA A;  4ROB A;  1OO8 A;  2B4X I;  1SEK A;  2GD4 C;  4RO9 A;  2WXW A;  3NDF A;  4Y3K A;  3DRU A;  2V95 A;  3F02 A;  1SNG A;  1OYH I;  1C5G A;  3VVJ A;  4IF8 A;  4AJU A;  3Q03 A;  1ATT A;  9API A;  4C41 A;  1XU8 A;  5CDZ A;  4CAA A;  1JMO A;  2WXX A;  4AFX A;  2HI9 A;  3STO A;  1QMB A;  1TB6 I;  3LW2 A;  3EOX A;  1BR8 I;  2HIJ L;  4Y40 A;  2PEE A;  2DUT A;  1K9O I;  2XN7 A;  1JVQ I;  1ATH A;  2ANT I;  2VH4 A;  3CVM A;  4P0F A;  2XN5 A;  1EZX A;  2RIW A;  1LQ8 A;  3F5N A;  4ZK0 A;  2R9Y A;  4GA7 A;  1SR5 A;  3EVJ I;  1OC0 A;  1XQG A;  4RSQ A;  4EB1 L;  7API A;  4AU3 B;  4G8O A;  3T1P A;  2RIV A;  3NE4 A;  2XN3 A;  1JTI A;  2H4P A;  2WY0 C;  4P0O A;  5INW A;  4EB1 I;  4BB2 A;  3UT3 A;  1MTP A;  1QMN A;  1T1F A;  4ROA A;  2ACH A;  9PAI A;  1OVA A;  1HLE A;  1DVN A;  4DY0 A;  1QLP A; 
#chains in the Genus database with same CATH homology
 3PB1 I;  3Q02 A;  4IC0 A;  4X30 A;  2HIJ I;  4AJT A;  1AS4 A;  1OVA C;  2ZNH A;  1LJ5 A;  5HGC A;  1DB2 A;  4AU3 A;  1OVA B;  1DZH L;  2WXY C;  1E03 I;  1HP7 A;  1KCT A;  1NQ9 I;  3B9F I;  1AZX I;  1C8O A;  2XN6 A;  1YXA A;  2B5T I;  3ZHA A;  5EI0 A;  1UHG A;  3DRM A;  1IMV A;  1B3K A;  1A7C A;  3CWL A;  1XQJ A;  3F1S A;  4YIA A;  1LK6 I;  5CDX A;  3OZQ A;  2CEO A;  3FGQ A;  8API A;  5IO1 A;  3LE2 A;  2ARQ A;  5CE0 A;  4AU4 A;  1M93 B;  2B4X L;  1R1L I;  2ZV6 A;  3KCG I;  1F0C A;  4G8R A;  3CWM A;  2BEH L;  3R4L A;  1ANT I;  1DZG L;  2QUG A;  4AQH A;  4DTE A;  4DY7 C;  1PSI A;  2ARR A;  2OL2 A;  2BEH I;  2VDY A;  2WXZ A;  3H5C A;  3NDD A;  2VDX A;  1DZG I;  1JJO C;  5BRR I;  5C98 A;  3DLW A;  1OPH A;  1DZH I;  4AU2 A;  1JMJ A;  2OAY A;  2WXZ C;  4PYW A;  2H4R A;  2WY1 A;  1E04 I;  3DY0 A;  1D5S A;  4R9I A;  3PZF A;  2D26 A;  4ZK3 A;  4KDS A;  1BY7 A;  3CAA A;  1IZ2 A;  1ATU A;  1DVM A;  4C49 A;  1WZ9 A;  1E05 I;  2PEF A;  1JRR A;  2H4Q A;  1OYH L;  3NDA A;  4ROB A;  1OO8 A;  2B4X I;  1SEK A;  2GD4 C;  4RO9 A;  2WXW A;  3NDF A;  4Y3K A;  3DRU A;  2V95 A;  3F02 A;  1SNG A;  1OYH I;  1C5G A;  3VVJ A;  4IF8 A;  4AJU A;  3Q03 A;  1ATT A;  9API A;  4C41 A;  1XU8 A;  5CDZ A;  4CAA A;  1JMO A;  2WXX A;  4AFX A;  2HI9 A;  3STO A;  1QMB A;  1TB6 I;  3LW2 A;  3EOX A;  1BR8 I;  2HIJ L;  4Y40 A;  2PEE A;  2DUT A;  1K9O I;  2XN7 A;  1JVQ I;  1ATH A;  2ANT I;  2VH4 A;  3CVM A;  4P0F A;  2XN5 A;  1EZX A;  2RIW A;  1LQ8 A;  3F5N A;  4ZK0 A;  2R9Y A;  4GA7 A;  1SR5 A;  3EVJ I;  1OC0 A;  1XQG A;  4RSQ A;  4EB1 L;  7API A;  4AU3 B;  4G8O A;  3T1P A;  2RIV A;  3NE4 A;  2XN3 A;  1JTI A;  2H4P A;  2WY0 C;  4P0O A;  5INW A;  4EB1 I;  4BB2 A;  3UT3 A;  1MTP A;  1QMN A;  1T1F A;  4ROA A;  2ACH A;  9PAI A;  1OVA A;  1HLE A;  1DVN A;  4DY0 A;  1QLP A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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