4YIAA

Structural mechanism of hormone release in thyroxine binding globulin
Total Genus 99
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
99
sequence length
337
structure length
337
Chain Sequence
LYKMSSINADFAFNLYRRFTVETPDKNIFFSPVSISAALVMLSFGACCSTQTEIVETLGFNLTDTPMVEIQHGFQHLICSLNFPKKELELQIGNALFIGKHLKPLAKFLNDVKTLYETEVFSTDFSNISAAKQEINSHVEMQTKGKVVGLIQDLKPNTIMVLVNYIHFKAQWANPFDPSKTEDSSSFLIDKTTTVQVPMMHQMEQYYHLVDMELNCTVLQMDYSKNALALFVLPKEGQMESVEAAMSSKTLKKWNRLLQKGWVDLFVPKFSISATYDLGATLLKMGIQHAYSENADFSGLTEDNGLKLSNAAHKAVLHIGEKGTEAAGAMFLEAIPR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural mechanism of hormone release in thyroxine Binding globulin
rcsb
molecule tags Signaling protein
source organism Homo sapiens
molecule keywords Thyroxine-binding globulin
total genus 99
structure length 337
sequence length 337
ec nomenclature
pdb deposition date 2015-03-01
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.30.39.10 Mainly Beta Roll Alpha-1-antitrypsin; domain 1 Alpha-1-antitrypsin, domain 1 4yiaA02
3.30.497.10 Alpha Beta 2-Layer Sandwich Antithrombin; Chain I, domain 2 Antithrombin, subunit I, domain 2 4yiaA01
3DLWA 4AU3B 4CAAA 9PAIA 3NE4A 1AS4A 2PEFA 1DZGI 3CWMA 3LW2A 2WXZC 3DRUA 3F02A 3NDDA 4P0FA 1JVQI 3B9FI 3CAAA 2H4PA 1MTPA 2ARQA 1M93B 3LE2A 1HP7A 1SNGA 1T1FA 2D26A 2WXXA 5CE0A 2HIJI 2B4XL 1ANTI 3CWLA 1A7CA 2VDYA 1KCTA 1JJOC 1JMOA 4AJUA 1D5SA 2DUTA 2WY0C 1OYHL 1IMVA 1F0CA 4Y3KA 3F1SA 3KCGI 4Y40A 3NDFA 4AU2A 1OPHA 4GA7A 2OL2A 2OAYA 3VVJA 2WXYC 3DY0A 3STOA 3R4LA 4AJTA 1ATHA 2HI9A 1DVMA 1DVNA 2H4QA 2VH4A 1DZGL 7APIA 1IZ2A 1NQ9I 2BEHI 2QUGA 1SEKA 1DZHI 1B3KA 4AU3A 1AZXI 1SR5A 2ZV6A 4ROBA 3CVMA 2WXZA 9APIA 2PEEA 2B5TI 5INWA 3ZHAA 1PSIA 1OVAC 2HIJL 2RIVA 3OZQA 4ZK3A 1DB2A 5EI0A 3H5CA 4AU4A 4YIAA 4DY7C 4G8RA 2XN6A 4C41A 1XU8A 1XQGA 1C5GA 1HLEA 1TB6I 2R9YA 8APIA 1XQJA 1ATUA 2RIWA 1UHGA 2XN3A 2WXWA 2BEHL 1DZHL 4AFXA 4G8OA 1OC0A 5CDXA 4IF8A 4P0OA 5HGCA 3T1PA 2VDXA 2ANTI 1E05I 4AQHA 1R1LI 3NDAA 2XN7A 1QMBA 1BY7A 1LJ5A 4RO9A 1K9OI 3DRMA 5CDZA 4EB1I 1YXAA 1OVAB 1WZ9A 4C49A 3Q03A 1LQ8A 4ZK0A 4PYWA 3FGQA 2ZNHA 2GD4C 3Q02A 1OVAA 2XN5A 3PZFA 4DY0A 5IO1A 1QLPA 1JTIA 2ARRA 2V95A 5BRRI 1LK6I 1C8OA 1EZXA 2ACHA 4X30A 5C98A 1E04I 1ATTA 1BR8I 1JMJA 4BB2A 3EOXA 1QMNA 3F5NA 1OO8A 2WY1A 3UT3A 4RSQA 4EB1L 3PB1I 2B4XI 1E03I 4KDSA 1JRRA 4R9IA 4ROAA 3EVJI 2H4RA 1OYHI 4IC0A 2CEOA 4DTEA
chains in the Genus database with same CATH superfamily
3DLWA 4AU3B 4CAAA 9PAIA 3NE4A 1AS4A 2PEFA 1DZGI 3CWMA 3LW2A 2WXZC 3DRUA 3F02A 3NDDA 4P0FA 1JVQI 3B9FI 3CAAA 2H4PA 1MTPA 2ARQA 1M93B 3LE2A 1HP7A 1SNGA 1T1FA 2D26A 2WXXA 5CE0A 2HIJI 2B4XL 1ANTI 3CWLA 1A7CA 2VDYA 1KCTA 1JJOC 1JMOA 4AJUA 1D5SA 2DUTA 2WY0C 1OYHL 1IMVA 1F0CA 4Y3KA 3F1SA 3KCGI 4Y40A 3NDFA 4AU2A 1OPHA 4GA7A 2OL2A 2OAYA 3VVJA 2WXYC 3DY0A 3STOA 3R4LA 4AJTA 1ATHA 2HI9A 1DVMA 1DVNA 2H4QA 2VH4A 1DZGL 7APIA 1IZ2A 1NQ9I 2BEHI 2QUGA 1SEKA 1DZHI 1B3KA 4AU3A 1AZXI 1SR5A 2ZV6A 4ROBA 3CVMA 2WXZA 9APIA 2PEEA 2B5TI 5INWA 3ZHAA 1PSIA 1OVAC 2HIJL 2RIVA 3OZQA 4ZK3A 1DB2A 5EI0A 3H5CA 4AU4A 4YIAA 4DY7C 4G8RA 2XN6A 4C41A 1XU8A 1XQGA 1C5GA 1HLEA 1TB6I 2R9YA 8APIA 1XQJA 1ATUA 2RIWA 1UHGA 2XN3A 2WXWA 2BEHL 1DZHL 4AFXA 4G8OA 1OC0A 5CDXA 4IF8A 4P0OA 5HGCA 3T1PA 2VDXA 2ANTI 1E05I 4AQHA 1R1LI 3NDAA 2XN7A 1QMBA 1BY7A 1LJ5A 4RO9A 1K9OI 3DRMA 5CDZA 4EB1I 1YXAA 1OVAB 1WZ9A 4C49A 3Q03A 1LQ8A 4ZK0A 4PYWA 3FGQA 2ZNHA 2GD4C 3Q02A 1OVAA 2XN5A 3PZFA 4DY0A 5IO1A 1QLPA 1JTIA 2ARRA 2V95A 5BRRI 1LK6I 1C8OA 1EZXA 2ACHA 4X30A 5C98A 1E04I 1ATTA 1BR8I 1JMJA 4BB2A 3EOXA 1QMNA 3F5NA 1OO8A 2WY1A 3UT3A 4RSQA 4EB1L 3PB1I 2B4XI 1E03I 4KDSA 1JRRA 4R9IA 4ROAA 3EVJI 2H4RA 1OYHI 4IC0A 2CEOA 4DTEA
chains in the Genus database with same CATH topology
3DLWA 4AU3B 4CAAA 9PAIA 3NE4A 1AS4A 2PEFA 1DZGI 3CWMA 3LW2A 2WXZC 3DRUA 3F02A 3NDDA 4P0FA 1JVQI 3B9FI 3CAAA 2H4PA 1MTPA 2ARQA 1M93B 3LE2A 1HP7A 1SNGA 1T1FA 2D26A 2WXXA 5CE0A 2HIJI 2B4XL 1ANTI 3CWLA 1A7CA 2VDYA 1KCTA 1JJOC 1JMOA 4AJUA 1D5SA 2DUTA 2WY0C 1OYHL 1IMVA 1F0CA 4Y3KA 3F1SA 3KCGI 4Y40A 3NDFA 4AU2A 1OPHA 4GA7A 2OL2A 2OAYA 3VVJA 2WXYC 3DY0A 3STOA 3R4LA 4AJTA 1ATHA 2HI9A 1DVMA 1DVNA 2H4QA 2VH4A 1DZGL 7APIA 1IZ2A 1NQ9I 2BEHI 2QUGA 1SEKA 1DZHI 1B3KA 4AU3A 1AZXI 1SR5A 2ZV6A 4ROBA 3CVMA 2WXZA 9APIA 2PEEA 2B5TI 5INWA 3ZHAA 1PSIA 1OVAC 2HIJL 2RIVA 3OZQA 4ZK3A 1DB2A 5EI0A 3H5CA 4AU4A 4YIAA 4DY7C 4G8RA 2XN6A 4C41A 1XU8A 1XQGA 1C5GA 1HLEA 1TB6I 2R9YA 8APIA 1XQJA 1ATUA 2RIWA 1UHGA 2XN3A 2WXWA 2BEHL 1DZHL 4AFXA 4G8OA 1OC0A 5CDXA 4IF8A 4P0OA 5HGCA 3T1PA 2VDXA 2ANTI 1E05I 4AQHA 1R1LI 3NDAA 2XN7A 1QMBA 1BY7A 1LJ5A 4RO9A 1K9OI 3DRMA 5CDZA 4EB1I 1YXAA 1OVAB 1WZ9A 4C49A 3Q03A 1LQ8A 4ZK0A 4PYWA 3FGQA 2ZNHA 2GD4C 3Q02A 1OVAA 2XN5A 3PZFA 4DY0A 5IO1A 1QLPA 1JTIA 2ARRA 2V95A 5BRRI 1LK6I 1C8OA 1EZXA 2ACHA 4X30A 5C98A 1E04I 1ATTA 1BR8I 1JMJA 4BB2A 3EOXA 1QMNA 3F5NA 1OO8A 2WY1A 3UT3A 4RSQA 4EB1L 3PB1I 2B4XI 1E03I 4KDSA 1JRRA 4R9IA 4ROAA 3EVJI 2H4RA 1OYHI 4IC0A 2CEOA 4DTEA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3DLW A;  4AU3 B;  4CAA A;  9PAI A;  3NE4 A;  1AS4 A;  2PEF A;  1DZG I;  3CWM A;  3LW2 A;  2WXZ C;  3DRU A;  3F02 A;  3NDD A;  4P0F A;  1JVQ I;  3B9F I;  3CAA A;  2H4P A;  1MTP A;  2ARQ A;  1M93 B;  3LE2 A;  1HP7 A;  1SNG A;  1T1F A;  2D26 A;  2WXX A;  5CE0 A;  2HIJ I;  2B4X L;  1ANT I;  3CWL A;  1A7C A;  2VDY A;  1KCT A;  1JJO C;  1JMO A;  4AJU A;  1D5S A;  2DUT A;  2WY0 C;  1OYH L;  1IMV A;  1F0C A;  4Y3K A;  3F1S A;  3KCG I;  4Y40 A;  3NDF A;  4AU2 A;  1OPH A;  4GA7 A;  2OL2 A;  2OAY A;  3VVJ A;  2WXY C;  3DY0 A;  3STO A;  3R4L A;  4AJT A;  1ATH A;  2HI9 A;  1DVM A;  1DVN A;  2H4Q A;  2VH4 A;  1DZG L;  7API A;  1IZ2 A;  1NQ9 I;  2BEH I;  2QUG A;  1SEK A;  1DZH I;  1B3K A;  4AU3 A;  1AZX I;  1SR5 A;  2ZV6 A;  4ROB A;  3CVM A;  2WXZ A;  9API A;  2PEE A;  2B5T I;  5INW A;  3ZHA A;  1PSI A;  1OVA C;  2HIJ L;  2RIV A;  3OZQ A;  4ZK3 A;  1DB2 A;  5EI0 A;  3H5C A;  4AU4 A;  4YIA A;  4DY7 C;  4G8R A;  2XN6 A;  4C41 A;  1XU8 A;  1XQG A;  1C5G A;  1HLE A;  1TB6 I;  2R9Y A;  8API A;  1XQJ A;  1ATU A;  2RIW A;  1UHG A;  2XN3 A;  2WXW A;  2BEH L;  1DZH L;  4AFX A;  4G8O A;  1OC0 A;  5CDX A;  4IF8 A;  4P0O A;  5HGC A;  3T1P A;  2VDX A;  2ANT I;  1E05 I;  4AQH A;  1R1L I;  3NDA A;  2XN7 A;  1QMB A;  1BY7 A;  1LJ5 A;  4RO9 A;  1K9O I;  3DRM A;  5CDZ A;  4EB1 I;  1YXA A;  1OVA B;  1WZ9 A;  4C49 A;  3Q03 A;  1LQ8 A;  4ZK0 A;  4PYW A;  3FGQ A;  2ZNH A;  2GD4 C;  3Q02 A;  1OVA A;  2XN5 A;  3PZF A;  4DY0 A;  5IO1 A;  1QLP A;  1JTI A;  2ARR A;  2V95 A;  5BRR I;  1LK6 I;  1C8O A;  1EZX A;  2ACH A;  4X30 A;  5C98 A;  1E04 I;  1ATT A;  1BR8 I;  1JMJ A;  4BB2 A;  3EOX A;  1QMN A;  3F5N A;  1OO8 A;  2WY1 A;  3UT3 A;  4RSQ A;  4EB1 L;  3PB1 I;  2B4X I;  1E03 I;  4KDS A;  1JRR A;  4R9I A;  4ROA A;  3EVJ I;  2H4R A;  1OYH I;  4IC0 A;  2CEO A;  4DTE A; 
#chains in the Genus database with same CATH topology
 3DLW A;  4AU3 B;  4CAA A;  9PAI A;  3NE4 A;  1AS4 A;  2PEF A;  1DZG I;  3CWM A;  3LW2 A;  2WXZ C;  3DRU A;  3F02 A;  3NDD A;  4P0F A;  1JVQ I;  3B9F I;  3CAA A;  2H4P A;  1MTP A;  2ARQ A;  1M93 B;  3LE2 A;  1HP7 A;  1SNG A;  1T1F A;  2D26 A;  2WXX A;  5CE0 A;  2HIJ I;  2B4X L;  1ANT I;  3CWL A;  1A7C A;  2VDY A;  1KCT A;  1JJO C;  1JMO A;  4AJU A;  1D5S A;  2DUT A;  2WY0 C;  1OYH L;  1IMV A;  1F0C A;  4Y3K A;  3F1S A;  3KCG I;  4Y40 A;  3NDF A;  4AU2 A;  1OPH A;  4GA7 A;  2OL2 A;  2OAY A;  3VVJ A;  2WXY C;  3DY0 A;  3STO A;  3R4L A;  4AJT A;  1ATH A;  2HI9 A;  1DVM A;  1DVN A;  2H4Q A;  2VH4 A;  1DZG L;  7API A;  1IZ2 A;  1NQ9 I;  2BEH I;  2QUG A;  1SEK A;  1DZH I;  1B3K A;  4AU3 A;  1AZX I;  1SR5 A;  2ZV6 A;  4ROB A;  3CVM A;  2WXZ A;  9API A;  2PEE A;  2B5T I;  5INW A;  3ZHA A;  1PSI A;  1OVA C;  2HIJ L;  2RIV A;  3OZQ A;  4ZK3 A;  1DB2 A;  5EI0 A;  3H5C A;  4AU4 A;  4YIA A;  4DY7 C;  4G8R A;  2XN6 A;  4C41 A;  1XU8 A;  1XQG A;  1C5G A;  1HLE A;  1TB6 I;  2R9Y A;  8API A;  1XQJ A;  1ATU A;  2RIW A;  1UHG A;  2XN3 A;  2WXW A;  2BEH L;  1DZH L;  4AFX A;  4G8O A;  1OC0 A;  5CDX A;  4IF8 A;  4P0O A;  5HGC A;  3T1P A;  2VDX A;  2ANT I;  1E05 I;  4AQH A;  1R1L I;  3NDA A;  2XN7 A;  1QMB A;  1BY7 A;  1LJ5 A;  4RO9 A;  1K9O I;  3DRM A;  5CDZ A;  4EB1 I;  1YXA A;  1OVA B;  1WZ9 A;  4C49 A;  3Q03 A;  1LQ8 A;  4ZK0 A;  4PYW A;  3FGQ A;  2ZNH A;  2GD4 C;  3Q02 A;  1OVA A;  2XN5 A;  3PZF A;  4DY0 A;  5IO1 A;  1QLP A;  1JTI A;  2ARR A;  2V95 A;  5BRR I;  1LK6 I;  1C8O A;  1EZX A;  2ACH A;  4X30 A;  5C98 A;  1E04 I;  1ATT A;  1BR8 I;  1JMJ A;  4BB2 A;  3EOX A;  1QMN A;  3F5N A;  1OO8 A;  2WY1 A;  3UT3 A;  4RSQ A;  4EB1 L;  3PB1 I;  2B4X I;  1E03 I;  4KDS A;  1JRR A;  4R9I A;  4ROA A;  3EVJ I;  2H4R A;  1OYH I;  4IC0 A;  2CEO A;  4DTE A; 
#chains in the Genus database with same CATH homology
 3DLW A;  4AU3 B;  4CAA A;  9PAI A;  3NE4 A;  1AS4 A;  2PEF A;  1DZG I;  3CWM A;  3LW2 A;  2WXZ C;  3DRU A;  3F02 A;  3NDD A;  4P0F A;  1JVQ I;  3B9F I;  3CAA A;  2H4P A;  1MTP A;  2ARQ A;  1M93 B;  3LE2 A;  1HP7 A;  1SNG A;  1T1F A;  2D26 A;  2WXX A;  5CE0 A;  2HIJ I;  2B4X L;  1ANT I;  3CWL A;  1A7C A;  2VDY A;  1KCT A;  1JJO C;  1JMO A;  4AJU A;  1D5S A;  2DUT A;  2WY0 C;  1OYH L;  1IMV A;  1F0C A;  4Y3K A;  3F1S A;  3KCG I;  4Y40 A;  3NDF A;  4AU2 A;  1OPH A;  4GA7 A;  2OL2 A;  2OAY A;  3VVJ A;  2WXY C;  3DY0 A;  3STO A;  3R4L A;  4AJT A;  1ATH A;  2HI9 A;  1DVM A;  1DVN A;  2H4Q A;  2VH4 A;  1DZG L;  7API A;  1IZ2 A;  1NQ9 I;  2BEH I;  2QUG A;  1SEK A;  1DZH I;  1B3K A;  4AU3 A;  1AZX I;  1SR5 A;  2ZV6 A;  4ROB A;  3CVM A;  2WXZ A;  9API A;  2PEE A;  2B5T I;  5INW A;  3ZHA A;  1PSI A;  1OVA C;  2HIJ L;  2RIV A;  3OZQ A;  4ZK3 A;  1DB2 A;  5EI0 A;  3H5C A;  4AU4 A;  4YIA A;  4DY7 C;  4G8R A;  2XN6 A;  4C41 A;  1XU8 A;  1XQG A;  1C5G A;  1HLE A;  1TB6 I;  2R9Y A;  8API A;  1XQJ A;  1ATU A;  2RIW A;  1UHG A;  2XN3 A;  2WXW A;  2BEH L;  1DZH L;  4AFX A;  4G8O A;  1OC0 A;  5CDX A;  4IF8 A;  4P0O A;  5HGC A;  3T1P A;  2VDX A;  2ANT I;  1E05 I;  4AQH A;  1R1L I;  3NDA A;  2XN7 A;  1QMB A;  1BY7 A;  1LJ5 A;  4RO9 A;  1K9O I;  3DRM A;  5CDZ A;  4EB1 I;  1YXA A;  1OVA B;  1WZ9 A;  4C49 A;  3Q03 A;  1LQ8 A;  4ZK0 A;  4PYW A;  3FGQ A;  2ZNH A;  2GD4 C;  3Q02 A;  1OVA A;  2XN5 A;  3PZF A;  4DY0 A;  5IO1 A;  1QLP A;  1JTI A;  2ARR A;  2V95 A;  5BRR I;  1LK6 I;  1C8O A;  1EZX A;  2ACH A;  4X30 A;  5C98 A;  1E04 I;  1ATT A;  1BR8 I;  1JMJ A;  4BB2 A;  3EOX A;  1QMN A;  3F5N A;  1OO8 A;  2WY1 A;  3UT3 A;  4RSQ A;  4EB1 L;  3PB1 I;  2B4X I;  1E03 I;  4KDS A;  1JRR A;  4R9I A;  4ROA A;  3EVJ I;  2H4R A;  1OYH I;  4IC0 A;  2CEO A;  4DTE A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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