4YIAA

Structural mechanism of hormone release in thyroxine binding globulin
Total Genus 99
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
99
sequence length
337
structure length
337
Chain Sequence
LYKMSSINADFAFNLYRRFTVETPDKNIFFSPVSISAALVMLSFGACCSTQTEIVETLGFNLTDTPMVEIQHGFQHLICSLNFPKKELELQIGNALFIGKHLKPLAKFLNDVKTLYETEVFSTDFSNISAAKQEINSHVEMQTKGKVVGLIQDLKPNTIMVLVNYIHFKAQWANPFDPSKTEDSSSFLIDKTTTVQVPMMHQMEQYYHLVDMELNCTVLQMDYSKNALALFVLPKEGQMESVEAAMSSKTLKKWNRLLQKGWVDLFVPKFSISATYDLGATLLKMGIQHAYSENADFSGLTEDNGLKLSNAAHKAVLHIGEKGTEAAGAMFLEAIPR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Signaling protein
molecule keywords Thyroxine-binding globulin
publication title Structural mechanism of hormone release in thyroxine Binding globulin
rcsb
source organism Homo sapiens
total genus 99
structure length 337
sequence length 337
ec nomenclature
pdb deposition date 2015-03-01
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.30.39.10 Mainly Beta Roll Alpha-1-antitrypsin; domain 1 Alpha-1-antitrypsin, domain 1 4yiaA02
3.30.497.10 Alpha Beta 2-Layer Sandwich Antithrombin; Chain I, domain 2 Antithrombin, subunit I, domain 2 4yiaA01
1IMVA 4P0OA 5CDZA 1EZXA 2ANTI 1QLPA 2XN7A 4Y40A 3NDDA 1LJ5A 2R9YA 4GA7A 2HI9A 3H5CA 4P0FA 1E04I 4YIAA 5CDXA 5INWA 2OAYA 1A7CA 3DLWA 1JMOA 1OYHI 1R1LI 2HIJL 3EOXA 1LK6I 1SNGA 4Y3KA 4R9IA 3KCGI 1PSIA 1OVAB 1M93B 1QMBA 1KCTA 2VDXA 4CAAA 3STOA 5IO1A 1OO8A 8APIA 1XQGA 1DZGI 2XN6A 3FGQA 3Q02A 4G8OA 4RO9A 1D5SA 1HLEA 1IZ2A 3R4LA 4C49A 4ZK0A 2OL2A 2B4XI 2H4RA 3CWMA 1JJOC 1JMJA 2PEEA 2ARRA 3F5NA 4G8RA 1XU8A 3F1SA 4PYWA 1WZ9A 3NE4A 1HP7A 4DTEA 4EB1L 1QMNA 4ZK3A 1ANTI 2WXXA 1JVQI 2BEHL 2WY1A 2RIVA 3CWLA 1UHGA 4RSQA 2V95A 1LQ8A 1TB6I 2WXYC 3EVJI 2VDYA 4DY7C 3ZHAA 9APIA 1C5GA 3PB1I 4AU3A 3NDFA 3LW2A 2H4QA 2BEHI 4C41A 1BY7A 3B9FI 1DZHL 4IF8A 2HIJI 9PAIA 5C98A 1XQJA 3F02A 2H4PA 3PZFA 2WY0C 1OPHA 2VH4A 1K9OI 4KDSA 2PEFA 1AZXI 1DB2A 1C8OA 3OZQA 2CEOA 4AJUA 3CVMA 4AFXA 2QUGA 3T1PA 1F0CA 2WXZA 4X30A 1E05I 2WXWA 1JTIA 5EI0A 2WXZC 2XN5A 3CAAA 3DRMA 1ATHA 1BR8I 4ROBA 2XN3A 4EB1I 3DY0A 2GD4C 4IC0A 1ATTA 1T1FA 3Q03A 3VVJA 2RIWA 4AJTA 4AU2A 4DY0A 1JRRA 1SEKA 3DRUA 3LE2A 1E03I 4ROAA 1DZGL 4AU3B 5CE0A 7APIA 3UT3A 1B3KA 1OVAA 5HGCA 3NDAA 2B4XL 2B5TI 1DVMA 4AQHA 4BB2A 2DUTA 1OC0A 1NQ9I 1DVNA 1ATUA 1AS4A 1OVAC 1SR5A 2ZNHA 2ACHA 2ARQA 5BRRI 2ZV6A 1DZHI 1YXAA 1MTPA 4AU4A 1OYHL 2D26A
chains in the Genus database with same CATH superfamily
1IMVA 4P0OA 5CDZA 1EZXA 2ANTI 1QLPA 2XN7A 4Y40A 3NDDA 1LJ5A 2R9YA 4GA7A 2HI9A 3H5CA 4P0FA 1E04I 4YIAA 5CDXA 5INWA 2OAYA 1A7CA 3DLWA 1JMOA 1OYHI 1R1LI 2HIJL 3EOXA 1LK6I 1SNGA 4Y3KA 4R9IA 3KCGI 1PSIA 1OVAB 1M93B 1QMBA 1KCTA 2VDXA 4CAAA 3STOA 5IO1A 1OO8A 8APIA 1XQGA 1DZGI 2XN6A 3FGQA 3Q02A 4G8OA 4RO9A 1D5SA 1HLEA 1IZ2A 3R4LA 4C49A 4ZK0A 2OL2A 2B4XI 2H4RA 3CWMA 1JJOC 1JMJA 2PEEA 2ARRA 3F5NA 4G8RA 1XU8A 3F1SA 4PYWA 1WZ9A 3NE4A 1HP7A 4DTEA 4EB1L 1QMNA 4ZK3A 1ANTI 2WXXA 1JVQI 2BEHL 2WY1A 2RIVA 3CWLA 1UHGA 4RSQA 2V95A 1LQ8A 1TB6I 2WXYC 3EVJI 2VDYA 4DY7C 3ZHAA 9APIA 1C5GA 3PB1I 4AU3A 3NDFA 3LW2A 2H4QA 2BEHI 4C41A 1BY7A 3B9FI 1DZHL 4IF8A 2HIJI 9PAIA 5C98A 1XQJA 3F02A 2H4PA 3PZFA 2WY0C 1OPHA 2VH4A 1K9OI 4KDSA 2PEFA 1AZXI 1DB2A 1C8OA 3OZQA 2CEOA 4AJUA 3CVMA 4AFXA 2QUGA 3T1PA 1F0CA 2WXZA 4X30A 1E05I 2WXWA 1JTIA 5EI0A 2WXZC 2XN5A 3CAAA 3DRMA 1ATHA 1BR8I 4ROBA 2XN3A 4EB1I 3DY0A 2GD4C 4IC0A 1ATTA 1T1FA 3Q03A 3VVJA 2RIWA 4AJTA 4AU2A 4DY0A 1JRRA 1SEKA 3DRUA 3LE2A 1E03I 4ROAA 1DZGL 4AU3B 5CE0A 7APIA 3UT3A 1B3KA 1OVAA 5HGCA 3NDAA 2B4XL 2B5TI 1DVMA 4AQHA 4BB2A 2DUTA 1OC0A 1NQ9I 1DVNA 1ATUA 1AS4A 1OVAC 1SR5A 2ZNHA 2ACHA 2ARQA 5BRRI 2ZV6A 1DZHI 1YXAA 1MTPA 4AU4A 1OYHL 2D26A
chains in the Genus database with same CATH topology
1IMVA 4P0OA 5CDZA 1EZXA 2ANTI 1QLPA 2XN7A 4Y40A 3NDDA 1LJ5A 2R9YA 4GA7A 2HI9A 3H5CA 4P0FA 1E04I 4YIAA 5CDXA 5INWA 2OAYA 1A7CA 3DLWA 1JMOA 1OYHI 1R1LI 2HIJL 3EOXA 1LK6I 1SNGA 4Y3KA 4R9IA 3KCGI 1PSIA 1OVAB 1M93B 1QMBA 1KCTA 2VDXA 4CAAA 3STOA 5IO1A 1OO8A 8APIA 1XQGA 1DZGI 2XN6A 3FGQA 3Q02A 4G8OA 4RO9A 1D5SA 1HLEA 1IZ2A 3R4LA 4C49A 4ZK0A 2OL2A 2B4XI 2H4RA 3CWMA 1JJOC 1JMJA 2PEEA 2ARRA 3F5NA 4G8RA 1XU8A 3F1SA 4PYWA 1WZ9A 3NE4A 1HP7A 4DTEA 4EB1L 1QMNA 4ZK3A 1ANTI 2WXXA 1JVQI 2BEHL 2WY1A 2RIVA 3CWLA 1UHGA 4RSQA 2V95A 1LQ8A 1TB6I 2WXYC 3EVJI 2VDYA 4DY7C 3ZHAA 9APIA 1C5GA 3PB1I 4AU3A 3NDFA 3LW2A 2H4QA 2BEHI 4C41A 1BY7A 3B9FI 1DZHL 4IF8A 2HIJI 9PAIA 5C98A 1XQJA 3F02A 2H4PA 3PZFA 2WY0C 1OPHA 2VH4A 1K9OI 4KDSA 2PEFA 1AZXI 1DB2A 1C8OA 3OZQA 2CEOA 4AJUA 3CVMA 4AFXA 2QUGA 3T1PA 1F0CA 2WXZA 4X30A 1E05I 2WXWA 1JTIA 5EI0A 2WXZC 2XN5A 3CAAA 3DRMA 1ATHA 1BR8I 4ROBA 2XN3A 4EB1I 3DY0A 2GD4C 4IC0A 1ATTA 1T1FA 3Q03A 3VVJA 2RIWA 4AJTA 4AU2A 4DY0A 1JRRA 1SEKA 3DRUA 3LE2A 1E03I 4ROAA 1DZGL 4AU3B 5CE0A 7APIA 3UT3A 1B3KA 1OVAA 5HGCA 3NDAA 2B4XL 2B5TI 1DVMA 4AQHA 4BB2A 2DUTA 1OC0A 1NQ9I 1DVNA 1ATUA 1AS4A 1OVAC 1SR5A 2ZNHA 2ACHA 2ARQA 5BRRI 2ZV6A 1DZHI 1YXAA 1MTPA 4AU4A 1OYHL 2D26A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1IMV A;  4P0O A;  5CDZ A;  1EZX A;  2ANT I;  1QLP A;  2XN7 A;  4Y40 A;  3NDD A;  1LJ5 A;  2R9Y A;  4GA7 A;  2HI9 A;  3H5C A;  4P0F A;  1E04 I;  4YIA A;  5CDX A;  5INW A;  2OAY A;  1A7C A;  3DLW A;  1JMO A;  1OYH I;  1R1L I;  2HIJ L;  3EOX A;  1LK6 I;  1SNG A;  4Y3K A;  4R9I A;  3KCG I;  1PSI A;  1OVA B;  1M93 B;  1QMB A;  1KCT A;  2VDX A;  4CAA A;  3STO A;  5IO1 A;  1OO8 A;  8API A;  1XQG A;  1DZG I;  2XN6 A;  3FGQ A;  3Q02 A;  4G8O A;  4RO9 A;  1D5S A;  1HLE A;  1IZ2 A;  3R4L A;  4C49 A;  4ZK0 A;  2OL2 A;  2B4X I;  2H4R A;  3CWM A;  1JJO C;  1JMJ A;  2PEE A;  2ARR A;  3F5N A;  4G8R A;  1XU8 A;  3F1S A;  4PYW A;  1WZ9 A;  3NE4 A;  1HP7 A;  4DTE A;  4EB1 L;  1QMN A;  4ZK3 A;  1ANT I;  2WXX A;  1JVQ I;  2BEH L;  2WY1 A;  2RIV A;  3CWL A;  1UHG A;  4RSQ A;  2V95 A;  1LQ8 A;  1TB6 I;  2WXY C;  3EVJ I;  2VDY A;  4DY7 C;  3ZHA A;  9API A;  1C5G A;  3PB1 I;  4AU3 A;  3NDF A;  3LW2 A;  2H4Q A;  2BEH I;  4C41 A;  1BY7 A;  3B9F I;  1DZH L;  4IF8 A;  2HIJ I;  9PAI A;  5C98 A;  1XQJ A;  3F02 A;  2H4P A;  3PZF A;  2WY0 C;  1OPH A;  2VH4 A;  1K9O I;  4KDS A;  2PEF A;  1AZX I;  1DB2 A;  1C8O A;  3OZQ A;  2CEO A;  4AJU A;  3CVM A;  4AFX A;  2QUG A;  3T1P A;  1F0C A;  2WXZ A;  4X30 A;  1E05 I;  2WXW A;  1JTI A;  5EI0 A;  2WXZ C;  2XN5 A;  3CAA A;  3DRM A;  1ATH A;  1BR8 I;  4ROB A;  2XN3 A;  4EB1 I;  3DY0 A;  2GD4 C;  4IC0 A;  1ATT A;  1T1F A;  3Q03 A;  3VVJ A;  2RIW A;  4AJT A;  4AU2 A;  4DY0 A;  1JRR A;  1SEK A;  3DRU A;  3LE2 A;  1E03 I;  4ROA A;  1DZG L;  4AU3 B;  5CE0 A;  7API A;  3UT3 A;  1B3K A;  1OVA A;  5HGC A;  3NDA A;  2B4X L;  2B5T I;  1DVM A;  4AQH A;  4BB2 A;  2DUT A;  1OC0 A;  1NQ9 I;  1DVN A;  1ATU A;  1AS4 A;  1OVA C;  1SR5 A;  2ZNH A;  2ACH A;  2ARQ A;  5BRR I;  2ZV6 A;  1DZH I;  1YXA A;  1MTP A;  4AU4 A;  1OYH L;  2D26 A; 
#chains in the Genus database with same CATH topology
 1IMV A;  4P0O A;  5CDZ A;  1EZX A;  2ANT I;  1QLP A;  2XN7 A;  4Y40 A;  3NDD A;  1LJ5 A;  2R9Y A;  4GA7 A;  2HI9 A;  3H5C A;  4P0F A;  1E04 I;  4YIA A;  5CDX A;  5INW A;  2OAY A;  1A7C A;  3DLW A;  1JMO A;  1OYH I;  1R1L I;  2HIJ L;  3EOX A;  1LK6 I;  1SNG A;  4Y3K A;  4R9I A;  3KCG I;  1PSI A;  1OVA B;  1M93 B;  1QMB A;  1KCT A;  2VDX A;  4CAA A;  3STO A;  5IO1 A;  1OO8 A;  8API A;  1XQG A;  1DZG I;  2XN6 A;  3FGQ A;  3Q02 A;  4G8O A;  4RO9 A;  1D5S A;  1HLE A;  1IZ2 A;  3R4L A;  4C49 A;  4ZK0 A;  2OL2 A;  2B4X I;  2H4R A;  3CWM A;  1JJO C;  1JMJ A;  2PEE A;  2ARR A;  3F5N A;  4G8R A;  1XU8 A;  3F1S A;  4PYW A;  1WZ9 A;  3NE4 A;  1HP7 A;  4DTE A;  4EB1 L;  1QMN A;  4ZK3 A;  1ANT I;  2WXX A;  1JVQ I;  2BEH L;  2WY1 A;  2RIV A;  3CWL A;  1UHG A;  4RSQ A;  2V95 A;  1LQ8 A;  1TB6 I;  2WXY C;  3EVJ I;  2VDY A;  4DY7 C;  3ZHA A;  9API A;  1C5G A;  3PB1 I;  4AU3 A;  3NDF A;  3LW2 A;  2H4Q A;  2BEH I;  4C41 A;  1BY7 A;  3B9F I;  1DZH L;  4IF8 A;  2HIJ I;  9PAI A;  5C98 A;  1XQJ A;  3F02 A;  2H4P A;  3PZF A;  2WY0 C;  1OPH A;  2VH4 A;  1K9O I;  4KDS A;  2PEF A;  1AZX I;  1DB2 A;  1C8O A;  3OZQ A;  2CEO A;  4AJU A;  3CVM A;  4AFX A;  2QUG A;  3T1P A;  1F0C A;  2WXZ A;  4X30 A;  1E05 I;  2WXW A;  1JTI A;  5EI0 A;  2WXZ C;  2XN5 A;  3CAA A;  3DRM A;  1ATH A;  1BR8 I;  4ROB A;  2XN3 A;  4EB1 I;  3DY0 A;  2GD4 C;  4IC0 A;  1ATT A;  1T1F A;  3Q03 A;  3VVJ A;  2RIW A;  4AJT A;  4AU2 A;  4DY0 A;  1JRR A;  1SEK A;  3DRU A;  3LE2 A;  1E03 I;  4ROA A;  1DZG L;  4AU3 B;  5CE0 A;  7API A;  3UT3 A;  1B3K A;  1OVA A;  5HGC A;  3NDA A;  2B4X L;  2B5T I;  1DVM A;  4AQH A;  4BB2 A;  2DUT A;  1OC0 A;  1NQ9 I;  1DVN A;  1ATU A;  1AS4 A;  1OVA C;  1SR5 A;  2ZNH A;  2ACH A;  2ARQ A;  5BRR I;  2ZV6 A;  1DZH I;  1YXA A;  1MTP A;  4AU4 A;  1OYH L;  2D26 A; 
#chains in the Genus database with same CATH homology
 1IMV A;  4P0O A;  5CDZ A;  1EZX A;  2ANT I;  1QLP A;  2XN7 A;  4Y40 A;  3NDD A;  1LJ5 A;  2R9Y A;  4GA7 A;  2HI9 A;  3H5C A;  4P0F A;  1E04 I;  4YIA A;  5CDX A;  5INW A;  2OAY A;  1A7C A;  3DLW A;  1JMO A;  1OYH I;  1R1L I;  2HIJ L;  3EOX A;  1LK6 I;  1SNG A;  4Y3K A;  4R9I A;  3KCG I;  1PSI A;  1OVA B;  1M93 B;  1QMB A;  1KCT A;  2VDX A;  4CAA A;  3STO A;  5IO1 A;  1OO8 A;  8API A;  1XQG A;  1DZG I;  2XN6 A;  3FGQ A;  3Q02 A;  4G8O A;  4RO9 A;  1D5S A;  1HLE A;  1IZ2 A;  3R4L A;  4C49 A;  4ZK0 A;  2OL2 A;  2B4X I;  2H4R A;  3CWM A;  1JJO C;  1JMJ A;  2PEE A;  2ARR A;  3F5N A;  4G8R A;  1XU8 A;  3F1S A;  4PYW A;  1WZ9 A;  3NE4 A;  1HP7 A;  4DTE A;  4EB1 L;  1QMN A;  4ZK3 A;  1ANT I;  2WXX A;  1JVQ I;  2BEH L;  2WY1 A;  2RIV A;  3CWL A;  1UHG A;  4RSQ A;  2V95 A;  1LQ8 A;  1TB6 I;  2WXY C;  3EVJ I;  2VDY A;  4DY7 C;  3ZHA A;  9API A;  1C5G A;  3PB1 I;  4AU3 A;  3NDF A;  3LW2 A;  2H4Q A;  2BEH I;  4C41 A;  1BY7 A;  3B9F I;  1DZH L;  4IF8 A;  2HIJ I;  9PAI A;  5C98 A;  1XQJ A;  3F02 A;  2H4P A;  3PZF A;  2WY0 C;  1OPH A;  2VH4 A;  1K9O I;  4KDS A;  2PEF A;  1AZX I;  1DB2 A;  1C8O A;  3OZQ A;  2CEO A;  4AJU A;  3CVM A;  4AFX A;  2QUG A;  3T1P A;  1F0C A;  2WXZ A;  4X30 A;  1E05 I;  2WXW A;  1JTI A;  5EI0 A;  2WXZ C;  2XN5 A;  3CAA A;  3DRM A;  1ATH A;  1BR8 I;  4ROB A;  2XN3 A;  4EB1 I;  3DY0 A;  2GD4 C;  4IC0 A;  1ATT A;  1T1F A;  3Q03 A;  3VVJ A;  2RIW A;  4AJT A;  4AU2 A;  4DY0 A;  1JRR A;  1SEK A;  3DRU A;  3LE2 A;  1E03 I;  4ROA A;  1DZG L;  4AU3 B;  5CE0 A;  7API A;  3UT3 A;  1B3K A;  1OVA A;  5HGC A;  3NDA A;  2B4X L;  2B5T I;  1DVM A;  4AQH A;  4BB2 A;  2DUT A;  1OC0 A;  1NQ9 I;  1DVN A;  1ATU A;  1AS4 A;  1OVA C;  1SR5 A;  2ZNH A;  2ACH A;  2ARQ A;  5BRR I;  2ZV6 A;  1DZH I;  1YXA A;  1MTP A;  4AU4 A;  1OYH L;  2D26 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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