4ZK0A

Psoriasis pathogenesis - pso p27 constitute a compact structure forming large aggregates. high ph structure
Total Genus 113
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
113
sequence length
388
structure length
367
Chain Sequence
SLSEANTKFMFDLFQQFRKSKENNIFYSPISITSALGMVLLGAKDNTAQQIKKVLHFDQVTEGNVHHQFQKLLTEFNKSTDAYELKIANKLFGEKTYLFLQEYLDAIKKFYQTSVESVDFANAPEESRKKINSWVESQTNEKIKNLIPEGNIGSNTTLVLVNAIYFKGQWEKKFNKEDTKEEKFWPNKNTYKSIQMMRQYTSFHFASLEDVQAKVLEIPYKGKDLSMIVLLPNEIDGLQKLEEKLTAEKLMEWTSLQNMRETRVDLHLPRFKVEESYDLKDTLRTMGMVDIFNGDADLSGMTGSRGLVLSGVLHKAFVEVTEEGAEAAAATAVVGFNEEFHCNHPFLFFIRQNKTNSILFYGRFSSP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Psoriasis pathogenesis - Pso p27 constitutes a compact structure forming large aggregates.
pubmed doi rcsb
molecule tags Immune system
source organism Homo sapiens
molecule keywords Serpin B4
total genus 113
structure length 367
sequence length 388
ec nomenclature
pdb deposition date 2015-04-29

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00079 Serpin Serpin (serine protease inhibitor)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.30.39.10 Mainly Beta Roll Alpha-1-antitrypsin; domain 1 Alpha-1-antitrypsin, domain 1 4zk0A02
3.30.497.10 Alpha Beta 2-Layer Sandwich Antithrombin; Chain I, domain 2 Antithrombin, subunit I, domain 2 4zk0A01
4X30A 1E04I 3FGQA 1QLPA 2VDYA 3KCGI 1OVAC 2DUTA 3F5NA 2CEOA 1JMOA 3OZQA 4P0FA 2ACHA 4IF8A 3Q03A 1YXAA 3Q02A 4AJTA 1JMJA 4DY7C 4ROBA 3DRMA 1C5GA 2H4RA 1ANTI 1EZXA 4DY0A 1TB6I 1K9OI 2PEEA 1DZGI 4G8RA 1SNGA 4AQHA 4Y3KA 4DTEA 1SR5A 1JTIA 4EB1L 1QMBA 5IO1A 9APIA 7APIA 8APIA 3PB1I 2OAYA 5HGCA 1D5SA 1DZHL 2B5TI 2ZV6A 3CWLA 3UT3A 1M93B 3LW2A 5CDZA 4EB1I 2V95A 3B9FI 1KCTA 2RIVA 1DZGL 1XU8A 2VDXA 3T1PA 2WXZC 3ZHAA 1DVNA 1PSIA 4G8OA 3CWMA 1SEKA 1DZHI 2HI9A 4AU3A 1ATHA 1BR8I 1C8OA 1HLEA 2OL2A 1LQ8A 3NDDA 1HP7A 4CAAA 9PAIA 1MTPA 4AU2A 1AS4A 2H4QA 2WXWA 4AFXA 1DB2A 1JJOC 2D26A 3F1SA 1F0CA 2HIJI 1ATTA 1WZ9A 2RIWA 4KDSA 1XQJA 4AU3B 1OC0A 2WXYC 2XN7A 5EI0A 3PZFA 3DLWA 1IZ2A 2ZNHA 3R4LA 3VVJA 2QUGA 2XN3A 3DRUA 1LJ5A 2HIJL 3NE4A 2WY1A 4ZK3A 2XN6A 4GA7A 5INWA 4AJUA 5BRRI 1BY7A 1OYHI 3CAAA 4AU4A 1ATUA 2PEFA 1T1FA 2B4XL 2VH4A 2WXXA 4IC0A 4BB2A 3NDFA 1QMNA 3LE2A 3NDAA 2WY0C 3DY0A 3STOA 3CVMA 4C49A 2ARRA 2ARQA 1A7CA 1R1LI 4PYWA 2B4XI 4RSQA 3EVJI 5CE0A 1B3KA 1DVMA 4YIAA 4ROAA 4RO9A 1OO8A 5CDXA 1JVQI 1E03I 1OYHL 1E05I 2H4PA 1LK6I 1OPHA 1OVAA 2WXZA 1AZXI 3F02A 1XQGA 2ANTI 2BEHL 4P0OA 4R9IA 3EOXA 1NQ9I 1IMVA 4C41A 2XN5A 4Y40A 1JRRA 1UHGA 4ZK0A 1OVAB 2GD4C 3H5CA 5C98A 2BEHI 2R9YA
chains in the Genus database with same CATH superfamily
4X30A 1E04I 3FGQA 1QLPA 2VDYA 3KCGI 1OVAC 2DUTA 3F5NA 2CEOA 1JMOA 3OZQA 4P0FA 2ACHA 4IF8A 3Q03A 1YXAA 3Q02A 4AJTA 1JMJA 4DY7C 4ROBA 3DRMA 1C5GA 2H4RA 1ANTI 1EZXA 4DY0A 1TB6I 1K9OI 2PEEA 1DZGI 4G8RA 1SNGA 4AQHA 4Y3KA 4DTEA 1SR5A 1JTIA 4EB1L 1QMBA 5IO1A 9APIA 7APIA 8APIA 3PB1I 2OAYA 5HGCA 1D5SA 1DZHL 2B5TI 2ZV6A 3CWLA 3UT3A 1M93B 3LW2A 5CDZA 4EB1I 2V95A 3B9FI 1KCTA 2RIVA 1DZGL 1XU8A 2VDXA 3T1PA 2WXZC 3ZHAA 1DVNA 1PSIA 4G8OA 3CWMA 1SEKA 1DZHI 2HI9A 4AU3A 1ATHA 1BR8I 1C8OA 1HLEA 2OL2A 1LQ8A 3NDDA 1HP7A 4CAAA 9PAIA 1MTPA 4AU2A 1AS4A 2H4QA 2WXWA 4AFXA 1DB2A 1JJOC 2D26A 3F1SA 1F0CA 2HIJI 1ATTA 1WZ9A 2RIWA 4KDSA 1XQJA 4AU3B 1OC0A 2WXYC 2XN7A 5EI0A 3PZFA 3DLWA 1IZ2A 2ZNHA 3R4LA 3VVJA 2QUGA 2XN3A 3DRUA 1LJ5A 2HIJL 3NE4A 2WY1A 4ZK3A 2XN6A 4GA7A 5INWA 4AJUA 5BRRI 1BY7A 1OYHI 3CAAA 4AU4A 1ATUA 2PEFA 1T1FA 2B4XL 2VH4A 2WXXA 4IC0A 4BB2A 3NDFA 1QMNA 3LE2A 3NDAA 2WY0C 3DY0A 3STOA 3CVMA 4C49A 2ARRA 2ARQA 1A7CA 1R1LI 4PYWA 2B4XI 4RSQA 3EVJI 5CE0A 1B3KA 1DVMA 4YIAA 4ROAA 4RO9A 1OO8A 5CDXA 1JVQI 1E03I 1OYHL 1E05I 2H4PA 1LK6I 1OPHA 1OVAA 2WXZA 1AZXI 3F02A 1XQGA 2ANTI 2BEHL 4P0OA 4R9IA 3EOXA 1NQ9I 1IMVA 4C41A 2XN5A 4Y40A 1JRRA 1UHGA 4ZK0A 1OVAB 2GD4C 3H5CA 5C98A 2BEHI 2R9YA
chains in the Genus database with same CATH topology
4X30A 1E04I 3FGQA 1QLPA 2VDYA 3KCGI 1OVAC 2DUTA 3F5NA 2CEOA 1JMOA 3OZQA 4P0FA 2ACHA 4IF8A 3Q03A 1YXAA 3Q02A 4AJTA 1JMJA 4DY7C 4ROBA 3DRMA 1C5GA 2H4RA 1ANTI 1EZXA 4DY0A 1TB6I 1K9OI 2PEEA 1DZGI 4G8RA 1SNGA 4AQHA 4Y3KA 4DTEA 1SR5A 1JTIA 4EB1L 1QMBA 5IO1A 9APIA 7APIA 8APIA 3PB1I 2OAYA 5HGCA 1D5SA 1DZHL 2B5TI 2ZV6A 3CWLA 3UT3A 1M93B 3LW2A 5CDZA 4EB1I 2V95A 3B9FI 1KCTA 2RIVA 1DZGL 1XU8A 2VDXA 3T1PA 2WXZC 3ZHAA 1DVNA 1PSIA 4G8OA 3CWMA 1SEKA 1DZHI 2HI9A 4AU3A 1ATHA 1BR8I 1C8OA 1HLEA 2OL2A 1LQ8A 3NDDA 1HP7A 4CAAA 9PAIA 1MTPA 4AU2A 1AS4A 2H4QA 2WXWA 4AFXA 1DB2A 1JJOC 2D26A 3F1SA 1F0CA 2HIJI 1ATTA 1WZ9A 2RIWA 4KDSA 1XQJA 4AU3B 1OC0A 2WXYC 2XN7A 5EI0A 3PZFA 3DLWA 1IZ2A 2ZNHA 3R4LA 3VVJA 2QUGA 2XN3A 3DRUA 1LJ5A 2HIJL 3NE4A 2WY1A 4ZK3A 2XN6A 4GA7A 5INWA 4AJUA 5BRRI 1BY7A 1OYHI 3CAAA 4AU4A 1ATUA 2PEFA 1T1FA 2B4XL 2VH4A 2WXXA 4IC0A 4BB2A 3NDFA 1QMNA 3LE2A 3NDAA 2WY0C 3DY0A 3STOA 3CVMA 4C49A 2ARRA 2ARQA 1A7CA 1R1LI 4PYWA 2B4XI 4RSQA 3EVJI 5CE0A 1B3KA 1DVMA 4YIAA 4ROAA 4RO9A 1OO8A 5CDXA 1JVQI 1E03I 1OYHL 1E05I 2H4PA 1LK6I 1OPHA 1OVAA 2WXZA 1AZXI 3F02A 1XQGA 2ANTI 2BEHL 4P0OA 4R9IA 3EOXA 1NQ9I 1IMVA 4C41A 2XN5A 4Y40A 1JRRA 1UHGA 4ZK0A 1OVAB 2GD4C 3H5CA 5C98A 2BEHI 2R9YA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4X30 A;  1E04 I;  3FGQ A;  1QLP A;  2VDY A;  3KCG I;  1OVA C;  2DUT A;  3F5N A;  2CEO A;  1JMO A;  3OZQ A;  4P0F A;  2ACH A;  4IF8 A;  3Q03 A;  1YXA A;  3Q02 A;  4AJT A;  1JMJ A;  4DY7 C;  4ROB A;  3DRM A;  1C5G A;  2H4R A;  1ANT I;  1EZX A;  4DY0 A;  1TB6 I;  1K9O I;  2PEE A;  1DZG I;  4G8R A;  1SNG A;  4AQH A;  4Y3K A;  4DTE A;  1SR5 A;  1JTI A;  4EB1 L;  1QMB A;  5IO1 A;  9API A;  7API A;  8API A;  3PB1 I;  2OAY A;  5HGC A;  1D5S A;  1DZH L;  2B5T I;  2ZV6 A;  3CWL A;  3UT3 A;  1M93 B;  3LW2 A;  5CDZ A;  4EB1 I;  2V95 A;  3B9F I;  1KCT A;  2RIV A;  1DZG L;  1XU8 A;  2VDX A;  3T1P A;  2WXZ C;  3ZHA A;  1DVN A;  1PSI A;  4G8O A;  3CWM A;  1SEK A;  1DZH I;  2HI9 A;  4AU3 A;  1ATH A;  1BR8 I;  1C8O A;  1HLE A;  2OL2 A;  1LQ8 A;  3NDD A;  1HP7 A;  4CAA A;  9PAI A;  1MTP A;  4AU2 A;  1AS4 A;  2H4Q A;  2WXW A;  4AFX A;  1DB2 A;  1JJO C;  2D26 A;  3F1S A;  1F0C A;  2HIJ I;  1ATT A;  1WZ9 A;  2RIW A;  4KDS A;  1XQJ A;  4AU3 B;  1OC0 A;  2WXY C;  2XN7 A;  5EI0 A;  3PZF A;  3DLW A;  1IZ2 A;  2ZNH A;  3R4L A;  3VVJ A;  2QUG A;  2XN3 A;  3DRU A;  1LJ5 A;  2HIJ L;  3NE4 A;  2WY1 A;  4ZK3 A;  2XN6 A;  4GA7 A;  5INW A;  4AJU A;  5BRR I;  1BY7 A;  1OYH I;  3CAA A;  4AU4 A;  1ATU A;  2PEF A;  1T1F A;  2B4X L;  2VH4 A;  2WXX A;  4IC0 A;  4BB2 A;  3NDF A;  1QMN A;  3LE2 A;  3NDA A;  2WY0 C;  3DY0 A;  3STO A;  3CVM A;  4C49 A;  2ARR A;  2ARQ A;  1A7C A;  1R1L I;  4PYW A;  2B4X I;  4RSQ A;  3EVJ I;  5CE0 A;  1B3K A;  1DVM A;  4YIA A;  4ROA A;  4RO9 A;  1OO8 A;  5CDX A;  1JVQ I;  1E03 I;  1OYH L;  1E05 I;  2H4P A;  1LK6 I;  1OPH A;  1OVA A;  2WXZ A;  1AZX I;  3F02 A;  1XQG A;  2ANT I;  2BEH L;  4P0O A;  4R9I A;  3EOX A;  1NQ9 I;  1IMV A;  4C41 A;  2XN5 A;  4Y40 A;  1JRR A;  1UHG A;  4ZK0 A;  1OVA B;  2GD4 C;  3H5C A;  5C98 A;  2BEH I;  2R9Y A; 
#chains in the Genus database with same CATH topology
 4X30 A;  1E04 I;  3FGQ A;  1QLP A;  2VDY A;  3KCG I;  1OVA C;  2DUT A;  3F5N A;  2CEO A;  1JMO A;  3OZQ A;  4P0F A;  2ACH A;  4IF8 A;  3Q03 A;  1YXA A;  3Q02 A;  4AJT A;  1JMJ A;  4DY7 C;  4ROB A;  3DRM A;  1C5G A;  2H4R A;  1ANT I;  1EZX A;  4DY0 A;  1TB6 I;  1K9O I;  2PEE A;  1DZG I;  4G8R A;  1SNG A;  4AQH A;  4Y3K A;  4DTE A;  1SR5 A;  1JTI A;  4EB1 L;  1QMB A;  5IO1 A;  9API A;  7API A;  8API A;  3PB1 I;  2OAY A;  5HGC A;  1D5S A;  1DZH L;  2B5T I;  2ZV6 A;  3CWL A;  3UT3 A;  1M93 B;  3LW2 A;  5CDZ A;  4EB1 I;  2V95 A;  3B9F I;  1KCT A;  2RIV A;  1DZG L;  1XU8 A;  2VDX A;  3T1P A;  2WXZ C;  3ZHA A;  1DVN A;  1PSI A;  4G8O A;  3CWM A;  1SEK A;  1DZH I;  2HI9 A;  4AU3 A;  1ATH A;  1BR8 I;  1C8O A;  1HLE A;  2OL2 A;  1LQ8 A;  3NDD A;  1HP7 A;  4CAA A;  9PAI A;  1MTP A;  4AU2 A;  1AS4 A;  2H4Q A;  2WXW A;  4AFX A;  1DB2 A;  1JJO C;  2D26 A;  3F1S A;  1F0C A;  2HIJ I;  1ATT A;  1WZ9 A;  2RIW A;  4KDS A;  1XQJ A;  4AU3 B;  1OC0 A;  2WXY C;  2XN7 A;  5EI0 A;  3PZF A;  3DLW A;  1IZ2 A;  2ZNH A;  3R4L A;  3VVJ A;  2QUG A;  2XN3 A;  3DRU A;  1LJ5 A;  2HIJ L;  3NE4 A;  2WY1 A;  4ZK3 A;  2XN6 A;  4GA7 A;  5INW A;  4AJU A;  5BRR I;  1BY7 A;  1OYH I;  3CAA A;  4AU4 A;  1ATU A;  2PEF A;  1T1F A;  2B4X L;  2VH4 A;  2WXX A;  4IC0 A;  4BB2 A;  3NDF A;  1QMN A;  3LE2 A;  3NDA A;  2WY0 C;  3DY0 A;  3STO A;  3CVM A;  4C49 A;  2ARR A;  2ARQ A;  1A7C A;  1R1L I;  4PYW A;  2B4X I;  4RSQ A;  3EVJ I;  5CE0 A;  1B3K A;  1DVM A;  4YIA A;  4ROA A;  4RO9 A;  1OO8 A;  5CDX A;  1JVQ I;  1E03 I;  1OYH L;  1E05 I;  2H4P A;  1LK6 I;  1OPH A;  1OVA A;  2WXZ A;  1AZX I;  3F02 A;  1XQG A;  2ANT I;  2BEH L;  4P0O A;  4R9I A;  3EOX A;  1NQ9 I;  1IMV A;  4C41 A;  2XN5 A;  4Y40 A;  1JRR A;  1UHG A;  4ZK0 A;  1OVA B;  2GD4 C;  3H5C A;  5C98 A;  2BEH I;  2R9Y A; 
#chains in the Genus database with same CATH homology
 4X30 A;  1E04 I;  3FGQ A;  1QLP A;  2VDY A;  3KCG I;  1OVA C;  2DUT A;  3F5N A;  2CEO A;  1JMO A;  3OZQ A;  4P0F A;  2ACH A;  4IF8 A;  3Q03 A;  1YXA A;  3Q02 A;  4AJT A;  1JMJ A;  4DY7 C;  4ROB A;  3DRM A;  1C5G A;  2H4R A;  1ANT I;  1EZX A;  4DY0 A;  1TB6 I;  1K9O I;  2PEE A;  1DZG I;  4G8R A;  1SNG A;  4AQH A;  4Y3K A;  4DTE A;  1SR5 A;  1JTI A;  4EB1 L;  1QMB A;  5IO1 A;  9API A;  7API A;  8API A;  3PB1 I;  2OAY A;  5HGC A;  1D5S A;  1DZH L;  2B5T I;  2ZV6 A;  3CWL A;  3UT3 A;  1M93 B;  3LW2 A;  5CDZ A;  4EB1 I;  2V95 A;  3B9F I;  1KCT A;  2RIV A;  1DZG L;  1XU8 A;  2VDX A;  3T1P A;  2WXZ C;  3ZHA A;  1DVN A;  1PSI A;  4G8O A;  3CWM A;  1SEK A;  1DZH I;  2HI9 A;  4AU3 A;  1ATH A;  1BR8 I;  1C8O A;  1HLE A;  2OL2 A;  1LQ8 A;  3NDD A;  1HP7 A;  4CAA A;  9PAI A;  1MTP A;  4AU2 A;  1AS4 A;  2H4Q A;  2WXW A;  4AFX A;  1DB2 A;  1JJO C;  2D26 A;  3F1S A;  1F0C A;  2HIJ I;  1ATT A;  1WZ9 A;  2RIW A;  4KDS A;  1XQJ A;  4AU3 B;  1OC0 A;  2WXY C;  2XN7 A;  5EI0 A;  3PZF A;  3DLW A;  1IZ2 A;  2ZNH A;  3R4L A;  3VVJ A;  2QUG A;  2XN3 A;  3DRU A;  1LJ5 A;  2HIJ L;  3NE4 A;  2WY1 A;  4ZK3 A;  2XN6 A;  4GA7 A;  5INW A;  4AJU A;  5BRR I;  1BY7 A;  1OYH I;  3CAA A;  4AU4 A;  1ATU A;  2PEF A;  1T1F A;  2B4X L;  2VH4 A;  2WXX A;  4IC0 A;  4BB2 A;  3NDF A;  1QMN A;  3LE2 A;  3NDA A;  2WY0 C;  3DY0 A;  3STO A;  3CVM A;  4C49 A;  2ARR A;  2ARQ A;  1A7C A;  1R1L I;  4PYW A;  2B4X I;  4RSQ A;  3EVJ I;  5CE0 A;  1B3K A;  1DVM A;  4YIA A;  4ROA A;  4RO9 A;  1OO8 A;  5CDX A;  1JVQ I;  1E03 I;  1OYH L;  1E05 I;  2H4P A;  1LK6 I;  1OPH A;  1OVA A;  2WXZ A;  1AZX I;  3F02 A;  1XQG A;  2ANT I;  2BEH L;  4P0O A;  4R9I A;  3EOX A;  1NQ9 I;  1IMV A;  4C41 A;  2XN5 A;  4Y40 A;  1JRR A;  1UHG A;  4ZK0 A;  1OVA B;  2GD4 C;  3H5C A;  5C98 A;  2BEH I;  2R9Y A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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