4ZK3A

Psoriasis pathogenesis - pso p27 constitute a compact structure forming large aggregates. low ph structure
Total Genus 112
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
112
sequence length
388
structure length
366
Chain Sequence
SLSEANTKFMFDLFQQFRKSKENNIFYSPISITSALGMVLLGAKDNTAQQIKKVLHFDQVTENVHHQFQKLLTEFNKSTDAYELKIANKLFGEKTYLFLQEYLDAIKKFYQTSVESVDFANAPEESRKKINSWVESQTNEKIKNLIPEGNIGSNTTLVLVNAIYFKGQWEKKFNKEDTKEEKFWPNKNTYKSIQMMRQYTSFHFASLEDVQAKVLEIPYKGKDLSMIVLLPNEIDGLQKLEEKLTAEKLMEWTSLQNMRETRVDLHLPRFKVEESYDLKDTLRTMGMVDIFNGDADLSGMTGSRGLVLSGVLHKAFVEVTEEGAEAAAATAVVGFNEEFHCNHPFLFFIRQNKTNSILFYGRFSSP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Psoriasis pathogenesis - Pso p27 constitutes a compact structure forming large aggregates.
pubmed doi rcsb
molecule tags Immune system
source organism Homo sapiens
molecule keywords Serpin B3
total genus 112
structure length 366
sequence length 388
ec nomenclature
pdb deposition date 2015-04-29

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00079 Serpin Serpin (serine protease inhibitor)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.30.39.10 Mainly Beta Roll Alpha-1-antitrypsin; domain 1 Alpha-1-antitrypsin, domain 1 4zk3A02
3.30.497.10 Alpha Beta 2-Layer Sandwich Antithrombin; Chain I, domain 2 Antithrombin, subunit I, domain 2 4zk3A01
2BEHI 3PB1I 1A7CA 1OPHA 3CWLA 4YIAA 1OO8A 1SR5A 3CAAA 3VVJA 2ACHA 3F1SA 1ANTI 1DZHL 1NQ9I 1OYHL 2XN5A 4P0FA 2RIVA 1KCTA 1XU8A 1TB6I 4AU3A 1AZXI 2ARRA 8APIA 5IO1A 4EB1I 4IC0A 3NDDA 4AU3B 1UHGA 3DY0A 5C98A 1PSIA 1DZHI 1OC0A 1JRRA 2WXYC 2H4RA 2WXWA 1R1LI 3KCGI 3STOA 4ROBA 2VDYA 2H4QA 1XQGA 5CE0A 2B4XL 1E05I 4RO9A 1ATTA 2VH4A 3DRMA 3ZHAA 1DB2A 2HIJL 2V95A 2WXXA 1HLEA 2RIWA 2ZNHA 4AFXA 5INWA 2XN3A 1OVAA 1C5GA 2ZV6A 2DUTA 1T1FA 1OVAC 1DVMA 1HP7A 4DY7C 5EI0A 1OVAB 1F0CA 3CVMA 1JMOA 3Q02A 4ROAA 3PZFA 1ATHA 2GD4C 5HGCA 1OYHI 2HIJI 1ATUA 2OL2A 1M93B 1C8OA 2OAYA 3FGQA 1DVNA 1EZXA 4AU2A 7APIA 4PYWA 1JVQI 3CWMA 1BR8I 2ANTI 2WY0C 4P0OA 2WY1A 1BY7A 4C49A 2HI9A 1XQJA 4AJTA 5BRRI 5CDXA 3DRUA 1JTIA 2H4PA 4Y40A 1D5SA 3NDAA 2XN6A 4GA7A 4Y3KA 3NE4A 4DY0A 2R9YA 3UT3A 9APIA 2CEOA 4BB2A 1K9OI 1IZ2A 2B4XI 3LW2A 4ZK0A 4AQHA 2WXZA 2VDXA 3NDFA 1IMVA 3EOXA 1LQ8A 1AS4A 1LK6I 2WXZC 1JMJA 4CAAA 4RSQA 3LE2A 2D26A 4ZK3A 4AU4A 2B5TI 1DZGL 2PEEA 4IF8A 1LJ5A 3OZQA 1B3KA 1JJOC 3F5NA 3R4LA 1QMBA 4R9IA 4C41A 1E04I 1WZ9A 1YXAA 4AJUA 2BEHL 4G8OA 1E03I 1SEKA 3F02A 5CDZA 1QMNA 3EVJI 1SNGA 3DLWA 1QLPA 4X30A 1DZGI 4G8RA 1MTPA 2PEFA 4KDSA 4DTEA 2XN7A 9PAIA 3T1PA 4EB1L 3H5CA 2ARQA 2QUGA 3B9FI 3Q03A
chains in the Genus database with same CATH superfamily
2BEHI 3PB1I 1A7CA 1OPHA 3CWLA 4YIAA 1OO8A 1SR5A 3CAAA 3VVJA 2ACHA 3F1SA 1ANTI 1DZHL 1NQ9I 1OYHL 2XN5A 4P0FA 2RIVA 1KCTA 1XU8A 1TB6I 4AU3A 1AZXI 2ARRA 8APIA 5IO1A 4EB1I 4IC0A 3NDDA 4AU3B 1UHGA 3DY0A 5C98A 1PSIA 1DZHI 1OC0A 1JRRA 2WXYC 2H4RA 2WXWA 1R1LI 3KCGI 3STOA 4ROBA 2VDYA 2H4QA 1XQGA 5CE0A 2B4XL 1E05I 4RO9A 1ATTA 2VH4A 3DRMA 3ZHAA 1DB2A 2HIJL 2V95A 2WXXA 1HLEA 2RIWA 2ZNHA 4AFXA 5INWA 2XN3A 1OVAA 1C5GA 2ZV6A 2DUTA 1T1FA 1OVAC 1DVMA 1HP7A 4DY7C 5EI0A 1OVAB 1F0CA 3CVMA 1JMOA 3Q02A 4ROAA 3PZFA 1ATHA 2GD4C 5HGCA 1OYHI 2HIJI 1ATUA 2OL2A 1M93B 1C8OA 2OAYA 3FGQA 1DVNA 1EZXA 4AU2A 7APIA 4PYWA 1JVQI 3CWMA 1BR8I 2ANTI 2WY0C 4P0OA 2WY1A 1BY7A 4C49A 2HI9A 1XQJA 4AJTA 5BRRI 5CDXA 3DRUA 1JTIA 2H4PA 4Y40A 1D5SA 3NDAA 2XN6A 4GA7A 4Y3KA 3NE4A 4DY0A 2R9YA 3UT3A 9APIA 2CEOA 4BB2A 1K9OI 1IZ2A 2B4XI 3LW2A 4ZK0A 4AQHA 2WXZA 2VDXA 3NDFA 1IMVA 3EOXA 1LQ8A 1AS4A 1LK6I 2WXZC 1JMJA 4CAAA 4RSQA 3LE2A 2D26A 4ZK3A 4AU4A 2B5TI 1DZGL 2PEEA 4IF8A 1LJ5A 3OZQA 1B3KA 1JJOC 3F5NA 3R4LA 1QMBA 4R9IA 4C41A 1E04I 1WZ9A 1YXAA 4AJUA 2BEHL 4G8OA 1E03I 1SEKA 3F02A 5CDZA 1QMNA 3EVJI 1SNGA 3DLWA 1QLPA 4X30A 1DZGI 4G8RA 1MTPA 2PEFA 4KDSA 4DTEA 2XN7A 9PAIA 3T1PA 4EB1L 3H5CA 2ARQA 2QUGA 3B9FI 3Q03A
chains in the Genus database with same CATH topology
2BEHI 3PB1I 1A7CA 1OPHA 3CWLA 4YIAA 1OO8A 1SR5A 3CAAA 3VVJA 2ACHA 3F1SA 1ANTI 1DZHL 1NQ9I 1OYHL 2XN5A 4P0FA 2RIVA 1KCTA 1XU8A 1TB6I 4AU3A 1AZXI 2ARRA 8APIA 5IO1A 4EB1I 4IC0A 3NDDA 4AU3B 1UHGA 3DY0A 5C98A 1PSIA 1DZHI 1OC0A 1JRRA 2WXYC 2H4RA 2WXWA 1R1LI 3KCGI 3STOA 4ROBA 2VDYA 2H4QA 1XQGA 5CE0A 2B4XL 1E05I 4RO9A 1ATTA 2VH4A 3DRMA 3ZHAA 1DB2A 2HIJL 2V95A 2WXXA 1HLEA 2RIWA 2ZNHA 4AFXA 5INWA 2XN3A 1OVAA 1C5GA 2ZV6A 2DUTA 1T1FA 1OVAC 1DVMA 1HP7A 4DY7C 5EI0A 1OVAB 1F0CA 3CVMA 1JMOA 3Q02A 4ROAA 3PZFA 1ATHA 2GD4C 5HGCA 1OYHI 2HIJI 1ATUA 2OL2A 1M93B 1C8OA 2OAYA 3FGQA 1DVNA 1EZXA 4AU2A 7APIA 4PYWA 1JVQI 3CWMA 1BR8I 2ANTI 2WY0C 4P0OA 2WY1A 1BY7A 4C49A 2HI9A 1XQJA 4AJTA 5BRRI 5CDXA 3DRUA 1JTIA 2H4PA 4Y40A 1D5SA 3NDAA 2XN6A 4GA7A 4Y3KA 3NE4A 4DY0A 2R9YA 3UT3A 9APIA 2CEOA 4BB2A 1K9OI 1IZ2A 2B4XI 3LW2A 4ZK0A 4AQHA 2WXZA 2VDXA 3NDFA 1IMVA 3EOXA 1LQ8A 1AS4A 1LK6I 2WXZC 1JMJA 4CAAA 4RSQA 3LE2A 2D26A 4ZK3A 4AU4A 2B5TI 1DZGL 2PEEA 4IF8A 1LJ5A 3OZQA 1B3KA 1JJOC 3F5NA 3R4LA 1QMBA 4R9IA 4C41A 1E04I 1WZ9A 1YXAA 4AJUA 2BEHL 4G8OA 1E03I 1SEKA 3F02A 5CDZA 1QMNA 3EVJI 1SNGA 3DLWA 1QLPA 4X30A 1DZGI 4G8RA 1MTPA 2PEFA 4KDSA 4DTEA 2XN7A 9PAIA 3T1PA 4EB1L 3H5CA 2ARQA 2QUGA 3B9FI 3Q03A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2BEH I;  3PB1 I;  1A7C A;  1OPH A;  3CWL A;  4YIA A;  1OO8 A;  1SR5 A;  3CAA A;  3VVJ A;  2ACH A;  3F1S A;  1ANT I;  1DZH L;  1NQ9 I;  1OYH L;  2XN5 A;  4P0F A;  2RIV A;  1KCT A;  1XU8 A;  1TB6 I;  4AU3 A;  1AZX I;  2ARR A;  8API A;  5IO1 A;  4EB1 I;  4IC0 A;  3NDD A;  4AU3 B;  1UHG A;  3DY0 A;  5C98 A;  1PSI A;  1DZH I;  1OC0 A;  1JRR A;  2WXY C;  2H4R A;  2WXW A;  1R1L I;  3KCG I;  3STO A;  4ROB A;  2VDY A;  2H4Q A;  1XQG A;  5CE0 A;  2B4X L;  1E05 I;  4RO9 A;  1ATT A;  2VH4 A;  3DRM A;  3ZHA A;  1DB2 A;  2HIJ L;  2V95 A;  2WXX A;  1HLE A;  2RIW A;  2ZNH A;  4AFX A;  5INW A;  2XN3 A;  1OVA A;  1C5G A;  2ZV6 A;  2DUT A;  1T1F A;  1OVA C;  1DVM A;  1HP7 A;  4DY7 C;  5EI0 A;  1OVA B;  1F0C A;  3CVM A;  1JMO A;  3Q02 A;  4ROA A;  3PZF A;  1ATH A;  2GD4 C;  5HGC A;  1OYH I;  2HIJ I;  1ATU A;  2OL2 A;  1M93 B;  1C8O A;  2OAY A;  3FGQ A;  1DVN A;  1EZX A;  4AU2 A;  7API A;  4PYW A;  1JVQ I;  3CWM A;  1BR8 I;  2ANT I;  2WY0 C;  4P0O A;  2WY1 A;  1BY7 A;  4C49 A;  2HI9 A;  1XQJ A;  4AJT A;  5BRR I;  5CDX A;  3DRU A;  1JTI A;  2H4P A;  4Y40 A;  1D5S A;  3NDA A;  2XN6 A;  4GA7 A;  4Y3K A;  3NE4 A;  4DY0 A;  2R9Y A;  3UT3 A;  9API A;  2CEO A;  4BB2 A;  1K9O I;  1IZ2 A;  2B4X I;  3LW2 A;  4ZK0 A;  4AQH A;  2WXZ A;  2VDX A;  3NDF A;  1IMV A;  3EOX A;  1LQ8 A;  1AS4 A;  1LK6 I;  2WXZ C;  1JMJ A;  4CAA A;  4RSQ A;  3LE2 A;  2D26 A;  4ZK3 A;  4AU4 A;  2B5T I;  1DZG L;  2PEE A;  4IF8 A;  1LJ5 A;  3OZQ A;  1B3K A;  1JJO C;  3F5N A;  3R4L A;  1QMB A;  4R9I A;  4C41 A;  1E04 I;  1WZ9 A;  1YXA A;  4AJU A;  2BEH L;  4G8O A;  1E03 I;  1SEK A;  3F02 A;  5CDZ A;  1QMN A;  3EVJ I;  1SNG A;  3DLW A;  1QLP A;  4X30 A;  1DZG I;  4G8R A;  1MTP A;  2PEF A;  4KDS A;  4DTE A;  2XN7 A;  9PAI A;  3T1P A;  4EB1 L;  3H5C A;  2ARQ A;  2QUG A;  3B9F I;  3Q03 A; 
#chains in the Genus database with same CATH topology
 2BEH I;  3PB1 I;  1A7C A;  1OPH A;  3CWL A;  4YIA A;  1OO8 A;  1SR5 A;  3CAA A;  3VVJ A;  2ACH A;  3F1S A;  1ANT I;  1DZH L;  1NQ9 I;  1OYH L;  2XN5 A;  4P0F A;  2RIV A;  1KCT A;  1XU8 A;  1TB6 I;  4AU3 A;  1AZX I;  2ARR A;  8API A;  5IO1 A;  4EB1 I;  4IC0 A;  3NDD A;  4AU3 B;  1UHG A;  3DY0 A;  5C98 A;  1PSI A;  1DZH I;  1OC0 A;  1JRR A;  2WXY C;  2H4R A;  2WXW A;  1R1L I;  3KCG I;  3STO A;  4ROB A;  2VDY A;  2H4Q A;  1XQG A;  5CE0 A;  2B4X L;  1E05 I;  4RO9 A;  1ATT A;  2VH4 A;  3DRM A;  3ZHA A;  1DB2 A;  2HIJ L;  2V95 A;  2WXX A;  1HLE A;  2RIW A;  2ZNH A;  4AFX A;  5INW A;  2XN3 A;  1OVA A;  1C5G A;  2ZV6 A;  2DUT A;  1T1F A;  1OVA C;  1DVM A;  1HP7 A;  4DY7 C;  5EI0 A;  1OVA B;  1F0C A;  3CVM A;  1JMO A;  3Q02 A;  4ROA A;  3PZF A;  1ATH A;  2GD4 C;  5HGC A;  1OYH I;  2HIJ I;  1ATU A;  2OL2 A;  1M93 B;  1C8O A;  2OAY A;  3FGQ A;  1DVN A;  1EZX A;  4AU2 A;  7API A;  4PYW A;  1JVQ I;  3CWM A;  1BR8 I;  2ANT I;  2WY0 C;  4P0O A;  2WY1 A;  1BY7 A;  4C49 A;  2HI9 A;  1XQJ A;  4AJT A;  5BRR I;  5CDX A;  3DRU A;  1JTI A;  2H4P A;  4Y40 A;  1D5S A;  3NDA A;  2XN6 A;  4GA7 A;  4Y3K A;  3NE4 A;  4DY0 A;  2R9Y A;  3UT3 A;  9API A;  2CEO A;  4BB2 A;  1K9O I;  1IZ2 A;  2B4X I;  3LW2 A;  4ZK0 A;  4AQH A;  2WXZ A;  2VDX A;  3NDF A;  1IMV A;  3EOX A;  1LQ8 A;  1AS4 A;  1LK6 I;  2WXZ C;  1JMJ A;  4CAA A;  4RSQ A;  3LE2 A;  2D26 A;  4ZK3 A;  4AU4 A;  2B5T I;  1DZG L;  2PEE A;  4IF8 A;  1LJ5 A;  3OZQ A;  1B3K A;  1JJO C;  3F5N A;  3R4L A;  1QMB A;  4R9I A;  4C41 A;  1E04 I;  1WZ9 A;  1YXA A;  4AJU A;  2BEH L;  4G8O A;  1E03 I;  1SEK A;  3F02 A;  5CDZ A;  1QMN A;  3EVJ I;  1SNG A;  3DLW A;  1QLP A;  4X30 A;  1DZG I;  4G8R A;  1MTP A;  2PEF A;  4KDS A;  4DTE A;  2XN7 A;  9PAI A;  3T1P A;  4EB1 L;  3H5C A;  2ARQ A;  2QUG A;  3B9F I;  3Q03 A; 
#chains in the Genus database with same CATH homology
 2BEH I;  3PB1 I;  1A7C A;  1OPH A;  3CWL A;  4YIA A;  1OO8 A;  1SR5 A;  3CAA A;  3VVJ A;  2ACH A;  3F1S A;  1ANT I;  1DZH L;  1NQ9 I;  1OYH L;  2XN5 A;  4P0F A;  2RIV A;  1KCT A;  1XU8 A;  1TB6 I;  4AU3 A;  1AZX I;  2ARR A;  8API A;  5IO1 A;  4EB1 I;  4IC0 A;  3NDD A;  4AU3 B;  1UHG A;  3DY0 A;  5C98 A;  1PSI A;  1DZH I;  1OC0 A;  1JRR A;  2WXY C;  2H4R A;  2WXW A;  1R1L I;  3KCG I;  3STO A;  4ROB A;  2VDY A;  2H4Q A;  1XQG A;  5CE0 A;  2B4X L;  1E05 I;  4RO9 A;  1ATT A;  2VH4 A;  3DRM A;  3ZHA A;  1DB2 A;  2HIJ L;  2V95 A;  2WXX A;  1HLE A;  2RIW A;  2ZNH A;  4AFX A;  5INW A;  2XN3 A;  1OVA A;  1C5G A;  2ZV6 A;  2DUT A;  1T1F A;  1OVA C;  1DVM A;  1HP7 A;  4DY7 C;  5EI0 A;  1OVA B;  1F0C A;  3CVM A;  1JMO A;  3Q02 A;  4ROA A;  3PZF A;  1ATH A;  2GD4 C;  5HGC A;  1OYH I;  2HIJ I;  1ATU A;  2OL2 A;  1M93 B;  1C8O A;  2OAY A;  3FGQ A;  1DVN A;  1EZX A;  4AU2 A;  7API A;  4PYW A;  1JVQ I;  3CWM A;  1BR8 I;  2ANT I;  2WY0 C;  4P0O A;  2WY1 A;  1BY7 A;  4C49 A;  2HI9 A;  1XQJ A;  4AJT A;  5BRR I;  5CDX A;  3DRU A;  1JTI A;  2H4P A;  4Y40 A;  1D5S A;  3NDA A;  2XN6 A;  4GA7 A;  4Y3K A;  3NE4 A;  4DY0 A;  2R9Y A;  3UT3 A;  9API A;  2CEO A;  4BB2 A;  1K9O I;  1IZ2 A;  2B4X I;  3LW2 A;  4ZK0 A;  4AQH A;  2WXZ A;  2VDX A;  3NDF A;  1IMV A;  3EOX A;  1LQ8 A;  1AS4 A;  1LK6 I;  2WXZ C;  1JMJ A;  4CAA A;  4RSQ A;  3LE2 A;  2D26 A;  4ZK3 A;  4AU4 A;  2B5T I;  1DZG L;  2PEE A;  4IF8 A;  1LJ5 A;  3OZQ A;  1B3K A;  1JJO C;  3F5N A;  3R4L A;  1QMB A;  4R9I A;  4C41 A;  1E04 I;  1WZ9 A;  1YXA A;  4AJU A;  2BEH L;  4G8O A;  1E03 I;  1SEK A;  3F02 A;  5CDZ A;  1QMN A;  3EVJ I;  1SNG A;  3DLW A;  1QLP A;  4X30 A;  1DZG I;  4G8R A;  1MTP A;  2PEF A;  4KDS A;  4DTE A;  2XN7 A;  9PAI A;  3T1P A;  4EB1 L;  3H5C A;  2ARQ A;  2QUG A;  3B9F I;  3Q03 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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