5BRRI

Michaelis complex of tpa-s195a:pai-1
Total Genus 91
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
91
sequence length
372
structure length
372
Chain Sequence
VAHLASDFGVRVFQQVAQASKDRNVVFSPYGVASVLAMLQLTTGGETQQQIQAAMGFKIDDKGMAPALRHLYKELMGPWNKDEISTTDAIFVQRDLKLVQGFMPHFFRLFRSTVKQVDFSEVERARFIINDWVKTHTKGMISHLLGTGAVDQLTRLVLVNALYFNGQWKTPFPDSSTHRRLFHKSDGSTVSVPMMAQTNKFNYTEFTTPDGHYYDILELPYHGDTLSMFIAAPYEKEVPLSALTNILSAQLISHWKGNMTRLPRLLVLPKFSLETEVDLRKPLENLGMTDMFRQFQADFTSLSDQEPLHVALALQKVKIEVNESGTVASSSTAVIVSARMAPEEIIIDRPFLFVVRHNPTGTVLFMGQVMEP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase inhibitor/hydrolase
molecule keywords Plasminogen activator inhibitor 1
publication title Crystal Structure of the Michaelis Complex between Tissue-type Plasminogen Activator and Plasminogen Activators Inhibitor-1
pubmed doi rcsb
source organism Homo sapiens
total genus 91
structure length 372
sequence length 372
ec nomenclature
pdb deposition date 2015-06-01

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
I PF00079 Serpin Serpin (serine protease inhibitor)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.30.39.10 Mainly Beta Roll Alpha-1-antitrypsin; domain 1 Alpha-1-antitrypsin, domain 1 5brrI02
3.30.497.10 Alpha Beta 2-Layer Sandwich Antithrombin; Chain I, domain 2 Antithrombin, subunit I, domain 2 5brrI01
1OO8A 1YXAA 3B9FI 2XN7A 2H4QA 4G8RA 4YIAA 1E04I 4AFXA 8APIA 3STOA 1OYHL 4X30A 7APIA 1OVAA 4AU3B 9APIA 1D5SA 4AJTA 1JVQI 1DVMA 1AZXI 2WXXA 4IF8A 1TB6I 3FGQA 3ZHAA 2BEHI 3LW2A 3KCGI 4ROAA 1C8OA 1DZHL 1OC0A 1ANTI 3DLWA 4P0OA 1B3KA 5IO1A 2V95A 1DB2A 1DZHI 3T1PA 1UHGA 3OZQA 2HI9A 4P0FA 2XN3A 1EZXA 4R9IA 1M93B 1SEKA 1OVAC 2HIJI 2XN6A 1C5GA 1SR5A 3DY0A 5INWA 1WZ9A 4C41A 1IZ2A 1K9OI 3DRMA 3EOXA 5HGCA 1QLPA 1BR8I 1OPHA 2ZNHA 3CWLA 3Q02A 2CEOA 2PEEA 2ZV6A 4Y40A 2VDYA 4RSQA 1NQ9I 4RO9A 3CWMA 3NDDA 2BEHL 2GD4C 2WXZA 3PZFA 1BY7A 2OL2A 4EB1L 2XN5A 2VH4A 5EI0A 2RIWA 1XQJA 4DY0A 1R1LI 3F02A 4EB1I 1LK6I 3Q03A 2PEFA 2R9YA 1JMOA 2HIJL 3F5NA 1ATUA 9PAIA 2ARQA 4IC0A 5CDXA 1JTIA 3PB1I 2D26A 4AU3A 3VVJA 3EVJI 2WY0C 2ARRA 2ACHA 1DVNA 1QMBA 1PSIA 4KDSA 2QUGA 2ANTI 1OVAB 1ATTA 1LJ5A 1E03I 4ZK3A 1F0CA 1ATHA 4DY7C 1LQ8A 1IMVA 1JJOC 1MTPA 3NDFA 3NE4A 4AQHA 4DTEA 5BRRI 4BB2A 4Y3KA 3CVMA 5C98A 2B4XL 1DZGL 3H5CA 2WXWA 2WXYC 2WY1A 2WXZC 3DRUA 1KCTA 1JMJA 2B4XI 4GA7A 1DZGI 4AU2A 1T1FA 2RIVA 2DUTA 4G8OA 4ZK0A 1HLEA 4ROBA 3R4LA 4PYWA 2VDXA 1OYHI 4AU4A 1JRRA 1XQGA 2B5TI 1QMNA 3UT3A 4CAAA 2H4RA 5CDZA 3F1SA 3LE2A 1AS4A 1XU8A 3CAAA 1SNGA 1A7CA 1HP7A 3NDAA 2H4PA 5CE0A 4C49A 1E05I 2OAYA 4AJUA
chains in the Genus database with same CATH superfamily
1OO8A 1YXAA 3B9FI 2XN7A 2H4QA 4G8RA 4YIAA 1E04I 4AFXA 8APIA 3STOA 1OYHL 4X30A 7APIA 1OVAA 4AU3B 9APIA 1D5SA 4AJTA 1JVQI 1DVMA 1AZXI 2WXXA 4IF8A 1TB6I 3FGQA 3ZHAA 2BEHI 3LW2A 3KCGI 4ROAA 1C8OA 1DZHL 1OC0A 1ANTI 3DLWA 4P0OA 1B3KA 5IO1A 2V95A 1DB2A 1DZHI 3T1PA 1UHGA 3OZQA 2HI9A 4P0FA 2XN3A 1EZXA 4R9IA 1M93B 1SEKA 1OVAC 2HIJI 2XN6A 1C5GA 1SR5A 3DY0A 5INWA 1WZ9A 4C41A 1IZ2A 1K9OI 3DRMA 3EOXA 5HGCA 1QLPA 1BR8I 1OPHA 2ZNHA 3CWLA 3Q02A 2CEOA 2PEEA 2ZV6A 4Y40A 2VDYA 4RSQA 1NQ9I 4RO9A 3CWMA 3NDDA 2BEHL 2GD4C 2WXZA 3PZFA 1BY7A 2OL2A 4EB1L 2XN5A 2VH4A 5EI0A 2RIWA 1XQJA 4DY0A 1R1LI 3F02A 4EB1I 1LK6I 3Q03A 2PEFA 2R9YA 1JMOA 2HIJL 3F5NA 1ATUA 9PAIA 2ARQA 4IC0A 5CDXA 1JTIA 3PB1I 2D26A 4AU3A 3VVJA 3EVJI 2WY0C 2ARRA 2ACHA 1DVNA 1QMBA 1PSIA 4KDSA 2QUGA 2ANTI 1OVAB 1ATTA 1LJ5A 1E03I 4ZK3A 1F0CA 1ATHA 4DY7C 1LQ8A 1IMVA 1JJOC 1MTPA 3NDFA 3NE4A 4AQHA 4DTEA 5BRRI 4BB2A 4Y3KA 3CVMA 5C98A 2B4XL 1DZGL 3H5CA 2WXWA 2WXYC 2WY1A 2WXZC 3DRUA 1KCTA 1JMJA 2B4XI 4GA7A 1DZGI 4AU2A 1T1FA 2RIVA 2DUTA 4G8OA 4ZK0A 1HLEA 4ROBA 3R4LA 4PYWA 2VDXA 1OYHI 4AU4A 1JRRA 1XQGA 2B5TI 1QMNA 3UT3A 4CAAA 2H4RA 5CDZA 3F1SA 3LE2A 1AS4A 1XU8A 3CAAA 1SNGA 1A7CA 1HP7A 3NDAA 2H4PA 5CE0A 4C49A 1E05I 2OAYA 4AJUA
chains in the Genus database with same CATH topology
1OO8A 1YXAA 3B9FI 2XN7A 2H4QA 4G8RA 4YIAA 1E04I 4AFXA 8APIA 3STOA 1OYHL 4X30A 7APIA 1OVAA 4AU3B 9APIA 1D5SA 4AJTA 1JVQI 1DVMA 1AZXI 2WXXA 4IF8A 1TB6I 3FGQA 3ZHAA 2BEHI 3LW2A 3KCGI 4ROAA 1C8OA 1DZHL 1OC0A 1ANTI 3DLWA 4P0OA 1B3KA 5IO1A 2V95A 1DB2A 1DZHI 3T1PA 1UHGA 3OZQA 2HI9A 4P0FA 2XN3A 1EZXA 4R9IA 1M93B 1SEKA 1OVAC 2HIJI 2XN6A 1C5GA 1SR5A 3DY0A 5INWA 1WZ9A 4C41A 1IZ2A 1K9OI 3DRMA 3EOXA 5HGCA 1QLPA 1BR8I 1OPHA 2ZNHA 3CWLA 3Q02A 2CEOA 2PEEA 2ZV6A 4Y40A 2VDYA 4RSQA 1NQ9I 4RO9A 3CWMA 3NDDA 2BEHL 2GD4C 2WXZA 3PZFA 1BY7A 2OL2A 4EB1L 2XN5A 2VH4A 5EI0A 2RIWA 1XQJA 4DY0A 1R1LI 3F02A 4EB1I 1LK6I 3Q03A 2PEFA 2R9YA 1JMOA 2HIJL 3F5NA 1ATUA 9PAIA 2ARQA 4IC0A 5CDXA 1JTIA 3PB1I 2D26A 4AU3A 3VVJA 3EVJI 2WY0C 2ARRA 2ACHA 1DVNA 1QMBA 1PSIA 4KDSA 2QUGA 2ANTI 1OVAB 1ATTA 1LJ5A 1E03I 4ZK3A 1F0CA 1ATHA 4DY7C 1LQ8A 1IMVA 1JJOC 1MTPA 3NDFA 3NE4A 4AQHA 4DTEA 5BRRI 4BB2A 4Y3KA 3CVMA 5C98A 2B4XL 1DZGL 3H5CA 2WXWA 2WXYC 2WY1A 2WXZC 3DRUA 1KCTA 1JMJA 2B4XI 4GA7A 1DZGI 4AU2A 1T1FA 2RIVA 2DUTA 4G8OA 4ZK0A 1HLEA 4ROBA 3R4LA 4PYWA 2VDXA 1OYHI 4AU4A 1JRRA 1XQGA 2B5TI 1QMNA 3UT3A 4CAAA 2H4RA 5CDZA 3F1SA 3LE2A 1AS4A 1XU8A 3CAAA 1SNGA 1A7CA 1HP7A 3NDAA 2H4PA 5CE0A 4C49A 1E05I 2OAYA 4AJUA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1OO8 A;  1YXA A;  3B9F I;  2XN7 A;  2H4Q A;  4G8R A;  4YIA A;  1E04 I;  4AFX A;  8API A;  3STO A;  1OYH L;  4X30 A;  7API A;  1OVA A;  4AU3 B;  9API A;  1D5S A;  4AJT A;  1JVQ I;  1DVM A;  1AZX I;  2WXX A;  4IF8 A;  1TB6 I;  3FGQ A;  3ZHA A;  2BEH I;  3LW2 A;  3KCG I;  4ROA A;  1C8O A;  1DZH L;  1OC0 A;  1ANT I;  3DLW A;  4P0O A;  1B3K A;  5IO1 A;  2V95 A;  1DB2 A;  1DZH I;  3T1P A;  1UHG A;  3OZQ A;  2HI9 A;  4P0F A;  2XN3 A;  1EZX A;  4R9I A;  1M93 B;  1SEK A;  1OVA C;  2HIJ I;  2XN6 A;  1C5G A;  1SR5 A;  3DY0 A;  5INW A;  1WZ9 A;  4C41 A;  1IZ2 A;  1K9O I;  3DRM A;  3EOX A;  5HGC A;  1QLP A;  1BR8 I;  1OPH A;  2ZNH A;  3CWL A;  3Q02 A;  2CEO A;  2PEE A;  2ZV6 A;  4Y40 A;  2VDY A;  4RSQ A;  1NQ9 I;  4RO9 A;  3CWM A;  3NDD A;  2BEH L;  2GD4 C;  2WXZ A;  3PZF A;  1BY7 A;  2OL2 A;  4EB1 L;  2XN5 A;  2VH4 A;  5EI0 A;  2RIW A;  1XQJ A;  4DY0 A;  1R1L I;  3F02 A;  4EB1 I;  1LK6 I;  3Q03 A;  2PEF A;  2R9Y A;  1JMO A;  2HIJ L;  3F5N A;  1ATU A;  9PAI A;  2ARQ A;  4IC0 A;  5CDX A;  1JTI A;  3PB1 I;  2D26 A;  4AU3 A;  3VVJ A;  3EVJ I;  2WY0 C;  2ARR A;  2ACH A;  1DVN A;  1QMB A;  1PSI A;  4KDS A;  2QUG A;  2ANT I;  1OVA B;  1ATT A;  1LJ5 A;  1E03 I;  4ZK3 A;  1F0C A;  1ATH A;  4DY7 C;  1LQ8 A;  1IMV A;  1JJO C;  1MTP A;  3NDF A;  3NE4 A;  4AQH A;  4DTE A;  5BRR I;  4BB2 A;  4Y3K A;  3CVM A;  5C98 A;  2B4X L;  1DZG L;  3H5C A;  2WXW A;  2WXY C;  2WY1 A;  2WXZ C;  3DRU A;  1KCT A;  1JMJ A;  2B4X I;  4GA7 A;  1DZG I;  4AU2 A;  1T1F A;  2RIV A;  2DUT A;  4G8O A;  4ZK0 A;  1HLE A;  4ROB A;  3R4L A;  4PYW A;  2VDX A;  1OYH I;  4AU4 A;  1JRR A;  1XQG A;  2B5T I;  1QMN A;  3UT3 A;  4CAA A;  2H4R A;  5CDZ A;  3F1S A;  3LE2 A;  1AS4 A;  1XU8 A;  3CAA A;  1SNG A;  1A7C A;  1HP7 A;  3NDA A;  2H4P A;  5CE0 A;  4C49 A;  1E05 I;  2OAY A;  4AJU A; 
#chains in the Genus database with same CATH topology
 1OO8 A;  1YXA A;  3B9F I;  2XN7 A;  2H4Q A;  4G8R A;  4YIA A;  1E04 I;  4AFX A;  8API A;  3STO A;  1OYH L;  4X30 A;  7API A;  1OVA A;  4AU3 B;  9API A;  1D5S A;  4AJT A;  1JVQ I;  1DVM A;  1AZX I;  2WXX A;  4IF8 A;  1TB6 I;  3FGQ A;  3ZHA A;  2BEH I;  3LW2 A;  3KCG I;  4ROA A;  1C8O A;  1DZH L;  1OC0 A;  1ANT I;  3DLW A;  4P0O A;  1B3K A;  5IO1 A;  2V95 A;  1DB2 A;  1DZH I;  3T1P A;  1UHG A;  3OZQ A;  2HI9 A;  4P0F A;  2XN3 A;  1EZX A;  4R9I A;  1M93 B;  1SEK A;  1OVA C;  2HIJ I;  2XN6 A;  1C5G A;  1SR5 A;  3DY0 A;  5INW A;  1WZ9 A;  4C41 A;  1IZ2 A;  1K9O I;  3DRM A;  3EOX A;  5HGC A;  1QLP A;  1BR8 I;  1OPH A;  2ZNH A;  3CWL A;  3Q02 A;  2CEO A;  2PEE A;  2ZV6 A;  4Y40 A;  2VDY A;  4RSQ A;  1NQ9 I;  4RO9 A;  3CWM A;  3NDD A;  2BEH L;  2GD4 C;  2WXZ A;  3PZF A;  1BY7 A;  2OL2 A;  4EB1 L;  2XN5 A;  2VH4 A;  5EI0 A;  2RIW A;  1XQJ A;  4DY0 A;  1R1L I;  3F02 A;  4EB1 I;  1LK6 I;  3Q03 A;  2PEF A;  2R9Y A;  1JMO A;  2HIJ L;  3F5N A;  1ATU A;  9PAI A;  2ARQ A;  4IC0 A;  5CDX A;  1JTI A;  3PB1 I;  2D26 A;  4AU3 A;  3VVJ A;  3EVJ I;  2WY0 C;  2ARR A;  2ACH A;  1DVN A;  1QMB A;  1PSI A;  4KDS A;  2QUG A;  2ANT I;  1OVA B;  1ATT A;  1LJ5 A;  1E03 I;  4ZK3 A;  1F0C A;  1ATH A;  4DY7 C;  1LQ8 A;  1IMV A;  1JJO C;  1MTP A;  3NDF A;  3NE4 A;  4AQH A;  4DTE A;  5BRR I;  4BB2 A;  4Y3K A;  3CVM A;  5C98 A;  2B4X L;  1DZG L;  3H5C A;  2WXW A;  2WXY C;  2WY1 A;  2WXZ C;  3DRU A;  1KCT A;  1JMJ A;  2B4X I;  4GA7 A;  1DZG I;  4AU2 A;  1T1F A;  2RIV A;  2DUT A;  4G8O A;  4ZK0 A;  1HLE A;  4ROB A;  3R4L A;  4PYW A;  2VDX A;  1OYH I;  4AU4 A;  1JRR A;  1XQG A;  2B5T I;  1QMN A;  3UT3 A;  4CAA A;  2H4R A;  5CDZ A;  3F1S A;  3LE2 A;  1AS4 A;  1XU8 A;  3CAA A;  1SNG A;  1A7C A;  1HP7 A;  3NDA A;  2H4P A;  5CE0 A;  4C49 A;  1E05 I;  2OAY A;  4AJU A; 
#chains in the Genus database with same CATH homology
 1OO8 A;  1YXA A;  3B9F I;  2XN7 A;  2H4Q A;  4G8R A;  4YIA A;  1E04 I;  4AFX A;  8API A;  3STO A;  1OYH L;  4X30 A;  7API A;  1OVA A;  4AU3 B;  9API A;  1D5S A;  4AJT A;  1JVQ I;  1DVM A;  1AZX I;  2WXX A;  4IF8 A;  1TB6 I;  3FGQ A;  3ZHA A;  2BEH I;  3LW2 A;  3KCG I;  4ROA A;  1C8O A;  1DZH L;  1OC0 A;  1ANT I;  3DLW A;  4P0O A;  1B3K A;  5IO1 A;  2V95 A;  1DB2 A;  1DZH I;  3T1P A;  1UHG A;  3OZQ A;  2HI9 A;  4P0F A;  2XN3 A;  1EZX A;  4R9I A;  1M93 B;  1SEK A;  1OVA C;  2HIJ I;  2XN6 A;  1C5G A;  1SR5 A;  3DY0 A;  5INW A;  1WZ9 A;  4C41 A;  1IZ2 A;  1K9O I;  3DRM A;  3EOX A;  5HGC A;  1QLP A;  1BR8 I;  1OPH A;  2ZNH A;  3CWL A;  3Q02 A;  2CEO A;  2PEE A;  2ZV6 A;  4Y40 A;  2VDY A;  4RSQ A;  1NQ9 I;  4RO9 A;  3CWM A;  3NDD A;  2BEH L;  2GD4 C;  2WXZ A;  3PZF A;  1BY7 A;  2OL2 A;  4EB1 L;  2XN5 A;  2VH4 A;  5EI0 A;  2RIW A;  1XQJ A;  4DY0 A;  1R1L I;  3F02 A;  4EB1 I;  1LK6 I;  3Q03 A;  2PEF A;  2R9Y A;  1JMO A;  2HIJ L;  3F5N A;  1ATU A;  9PAI A;  2ARQ A;  4IC0 A;  5CDX A;  1JTI A;  3PB1 I;  2D26 A;  4AU3 A;  3VVJ A;  3EVJ I;  2WY0 C;  2ARR A;  2ACH A;  1DVN A;  1QMB A;  1PSI A;  4KDS A;  2QUG A;  2ANT I;  1OVA B;  1ATT A;  1LJ5 A;  1E03 I;  4ZK3 A;  1F0C A;  1ATH A;  4DY7 C;  1LQ8 A;  1IMV A;  1JJO C;  1MTP A;  3NDF A;  3NE4 A;  4AQH A;  4DTE A;  5BRR I;  4BB2 A;  4Y3K A;  3CVM A;  5C98 A;  2B4X L;  1DZG L;  3H5C A;  2WXW A;  2WXY C;  2WY1 A;  2WXZ C;  3DRU A;  1KCT A;  1JMJ A;  2B4X I;  4GA7 A;  1DZG I;  4AU2 A;  1T1F A;  2RIV A;  2DUT A;  4G8O A;  4ZK0 A;  1HLE A;  4ROB A;  3R4L A;  4PYW A;  2VDX A;  1OYH I;  4AU4 A;  1JRR A;  1XQG A;  2B5T I;  1QMN A;  3UT3 A;  4CAA A;  2H4R A;  5CDZ A;  3F1S A;  3LE2 A;  1AS4 A;  1XU8 A;  3CAA A;  1SNG A;  1A7C A;  1HP7 A;  3NDA A;  2H4P A;  5CE0 A;  4C49 A;  1E05 I;  2OAY A;  4AJU A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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